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PROSITE entry PS00187


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General information about the entry

Entry name [info] TPP_ENZYMES
Accession [info] PS00187
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1995 DATA UPDATE;
08-NOV-2023 INFO UPDATE.
PROSITE Doc. [info] PDOC00166

Name and characterization of the entry

Description [info] Thiamine pyrophosphate enzymes signature.
Pattern [info] 
[LIVMF]-[GSA]-x(5)-P-x(4)-[LIVMFYW]-x-[LIVMF]-x-G-D-[GSA]-[GSAC].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_05 which contains 570'420 sequence entries.


Total number of hits 115 in 115 different sequences
Number of true positive hits 108 in 108 different sequences
Number of 'unknown' hits 0
Number of false positive hits 7 in 7 different sequences
Number of false negative sequences 82
Number of 'partial' sequences 5
Precision (true positives / (true positives + false positives)) 93.91 %
Recall (true positives / (true positives + false negatives)) 56.84 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 108 sequences 

ARUI_PSEAE  (Q9HUI8), CEAS_STRCL  (Q9LCV9), DCIP_ENTCL  (P23234), 

HACL1_DICDI (Q54DA9), HACL2_BOVIN (A6QQT9), HACL2_CAEEL (O61856), 
HACL2_DANRE (Q6NV04), HACL2_HUMAN (A1L0T0), HACL2_MOUSE (Q8BU33), 
HACL2_XENLA (Q6DDK5), HACL_ACTC0  (P0DUV9), HACL_ARATH  (Q9LF46), 
HACL_ORYSJ  (Q0JMH0), ILVB1_BRANA (P27818), ILVB1_MYCTO (P9WG40), 
ILVB1_MYCTU (P9WG41), ILVB1_TOBAC (P09342), ILVB2_BRANA (P14874), 
ILVB2_MYCTU (O06335), ILVB2_TOBAC (P09114), ILVB3_BRANA (P27819), 
ILVB_ARATH  (P17597), ILVB_CORGL  (P42463), ILVB_CRYNH  (Q6SSJ3), 
ILVB_CRYNJ  (Q5KPJ5), ILVB_CYACA  (O19929), ILVB_ECOLI  (P08142), 
ILVB_GUITH  (O78518), ILVB_KLEPN  (P27696), ILVB_LACLA  (Q02137), 
ILVB_METAO  (O08353), ILVB_METJA  (Q57725), ILVB_MYCAV  (Q59498), 
ILVB_MYCBO  (P0A623), ILVB_MYCLE  (O33112), ILVB_NEOYE  (Q1XDF6), 
ILVB_PARMW  (Q7U5G1), ILVB_PORPU  (P69683), ILVB_PORUM  (P69684), 
ILVB_RAOTE  (Q04524), ILVB_SCHPO  (P36620), ILVB_YEAST  (P07342), 
ILVG_ECOLI  (P0DP90), ILVG_MYCBO  (P66947), ILVG_MYCTO  (P9WG38), 
ILVG_MYCTU  (P9WG39), ILVI_BUCAI  (P57321), ILVI_BUCAP  (O85293), 
ILVI_BUCBP  (Q89AP7), ILVI_BUCSC  (Q9RQ65), ILVI_ECOLI  (P00893), 
ILVI_HAEIN  (P45261), ILVI_SALTY  (P40811), ILVX_BACSU  (Q04789), 
IOLD1_BACCZ (Q63B73), IOLD2_BACCZ (Q4V1F5), IOLD_ALKCK  (Q5WKY8), 
IOLD_BACAA  (C3PAZ3), IOLD_BACAC  (C3LHY1), IOLD_BACAH  (A0REB6), 
IOLD_BACAN  (Q81QB5), IOLD_BACC0  (B7JPM3), IOLD_BACC3  (C1EVJ3), 
IOLD_BACHK  (Q6HIK2), IOLD_BACLD  (Q65D03), IOLD_BACSU  (P42415), 
IOLD_BACVZ  (A7ZAH8), IOLD_CLOBA  (B2V4K0), IOLD_CLOBB  (B2TJ86), 
IOLD_CLOP1  (Q0TUZ2), IOLD_CLOPE  (Q8XP76), IOLD_GEOKA  (Q5KYR0), 
IOLD_GEOTN  (A4IPB6), IOLD_HALH5  (Q9KAG9), IOLD_LACCA  (A5YBJ6), 
KDC_MYCA1   (A0QBE6), KDC_MYCBO   (Q7U140), KDC_MYCBP   (A1KGY5), 
KDC_MYCPA   (Q742Q2), KDC_MYCTA   (A5U0P1), KDC_MYCTO   (P9WG36), 
KDC_MYCTU   (P9WG37), KDC_MYCUA   (A0PL16), MDLC_PSEAE  (Q9HUR2), 
MDLC_PSEPU  (P20906), PDC1_ARATH  (O82647), PDC1_CANAL  (P83779), 
PDC1_CANGA  (Q6FJA3), PDC1_KLULA  (Q12629), PDC1_KLUMA  (P33149), 
PDC1_YEAST  (P06169), PDC2_SCHPO  (Q92345), PDC3_ARATH  (Q9M039), 
PDC3_SCHPO  (Q9P7P6), PDC4_ARATH  (Q9M040), PDC5_YEAST  (P16467), 
PDC6_YEAST  (P26263), PDC_NEUCR   (P33287), PDC_ZYMMO   (P06672), 
POXB_ECOLI  (P07003), POXB_LACPL  (P37063), POXB_STRPN  (Q54970), 
PXP1_YEAST  (P39994), XSC_DESTI   (Q93PS3), XSC_RHIME   (Q92UW6), 
XSC_RHOCB   (D5AKX8), XSC_ROSNI   (A3SR25), YDAP_BACSU  (P96591)
» more

UniProtKB/Swiss-Prot
False negative sequences		 82 sequences 

COMDE_METAC (Q8TKU6), COME_METJA  (P58416), COME_METTH  (O27275), 

DCIP_AZOBR  (P51852), HACL1_HUMAN (Q9UJ83), HACL1_MOUSE (Q9QXE0), 
HACL1_RAT   (Q8CHM7), ILVB_BACSU  (P37251), IOLD_CLOTE  (Q898E8), 
IOLD_LISIN  (Q92EQ4), IOLD_LISMF  (Q723S8), IOLD_LISMO  (Q8Y9Y1), 
KDC_MYCLE   (Q9CBD6), KDC_MYCS2   (A0R480), OXC_ECO57   (P0AFI1), 
OXC_ECOLI   (P0AFI0), OXC_OXAFO   (P40149), PDC1_MAIZE  (P28516), 
PDC1_ORYSI  (A2Y5L9), PDC1_ORYSJ  (Q0DHF6), PDC1_PEA(P51850), 
PDC1_SCHPO  (Q09737), PDC2_ARATH  (Q9FFT4), PDC2_ORYSI  (A2XFI3), 
PDC2_ORYSJ  (Q10MW3), PDC2_TOBAC  (P51846), PDC3_ORYSI  (A2YQ76), 
PDC3_ORYSJ  (Q0D3D2), PDC4_SCHPO  (O42873), PDC_ASPFU   (Q4WXX9), 
PDC_ASPOR   (Q2UKV4), PDC_ASPPA   (P51844), PDC_ASPTN   (Q0CNV1), 
PDC_EMENI   (P87208), PDC_HANUV   (P34734), PHK1_LACPL  (Q88U67), 
PHK1_NOSS1  (Q8YWW1), PHK1_RHIME  (Q92T74), PHK2_LACPL  (Q88S87), 
PHK2_NOSS1  (Q8YTZ6), PHK2_RHIME  (Q92ZA4), PHK_BEII9   (B2IGR2), 
PHK_BIFA0   (B8DUT6), PHK_BRADU   (Q89S87), PHK_BRUA2   (Q2YK44), 
PHK_BRUME   (Q8YBL8), PHK_BRUSU   (Q8FWR0), PHK_CHLTE   (Q8KCA0), 
PHK_CLOAB   (Q97JE3), PHK_GLOVI   (Q7NLX2), PHK_LACLA   (Q9CFH4), 
PHK_LATSS   (Q38YY6), PHK_METCA   (Q608B0), PHK_MYCA1   (A0QGK3), 
PHK_MYCPA   (Q73ZM8), PHK_NITEU   (Q82T07), PHK_NITMU   (Q2YAC5), 
PHK_NOCFA   (Q5Z066), PHK_PARUW   (Q6MFC0), PHK_PEDPA   (Q03H73), 
PHK_PSEP1   (A5W384), PHK_RHILO   (Q988V7), PHK_RHOBA   (Q7UH14), 
PHK_RHOP2   (Q2ITA9), PHK_RHOPA   (Q6N976), PHK_RHOPB   (Q20ZU5), 
PHK_RHOPS   (Q13B10), PHK_RHOPT   (B3Q8J5), PHK_SCHPO   (O74770), 
PHK_STRAW   (Q82NM9), PHK_STRCO   (Q8CK51), PHK_SYNE7   (Q31LF9), 
PHK_SYNP6   (Q5N0G7), PHK_SYNY3   (P74690), PHK_THEVB   (Q8DJN6), 
PIGD_SERMA  (Q5W251), PIGD_SERS3  (Q5W268), PPD_STRHY   (Q54271), 
XFP_BIFAS   (Q9AEM9), XPKA_LACPE  (Q937F6), XSC_ALCXX   (Q84H41), 
XSC_CASDE   (Q84H44)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 5 sequences 

ILVB_ARTPT  (P27868), PDC1_TOBAC  (P51845), PDC2_MAIZE  (Q05326), 

PDC2_PEA(P51851), PDC3_MAIZE  (Q05327)
» more

UniProtKB/Swiss-Prot
False positive sequences		 7 sequences 

COLB_DICDI  (Q8T2A1), DXS1_CERS4  (Q3J1A8), DXS1_ROSDO  (Q16DV7), 

DXS_FUSNN   (Q8R639), DXS_RHOCA   (P26242), ISOA2_ORYSJ (Q6AU80), 
NPHN_MOUSE  (Q9QZS7)
» more

PDB
[Detailed view]		 125 PDB

1BFD; 1JSC; 1MCZ; 1N0H; 1OVM; 1OZF; 1OZG; 1OZH; 1PI3; 1PO7; 1POW; 1POX; 1PVD; 1PYD; 1Q6Z; 1QPB; 1T9A; 1T9B; 1T9C; 1T9D; 1UPA; 1UPB; 1UPC; 1Y9D; 1YBH; 1YHY; 1YHZ; 1YI0; 1YI1; 1YNO; 1Z8N; 1ZPD; 2EZ4; 2EZ8; 2EZ9; 2EZT; 2EZU; 2FN3; 2FWN; 2IHT; 2IHU; 2IHV; 2V3W; 2VJY; 2VK1; 2VK4; 2VK8; 2W93; 2WVA; 2WVG; 2WVH; 3E9Y; 3EA4; 3EY9; 3EYA; 3F6B; 3F6E; 3FSJ; 3FZN; 3OE1; 4GG1; 4GM0; 4GM1; 4GM4; 4GP9; 4GPE; 4JD5; 4JU8; 4JU9; 4JUA; 4JUB; 4JUC; 4JUD; 4JUF; 4K9K; 4K9L; 4K9M; 4K9N; 4K9O; 4K9P; 4MPJ; 4MPP; 4MPR; 4MQ5; 4MZX; 4QEL; 4ZP1; 5D6R; 5DEI; 5DGD; 5DGT; 5DX6; 5FEM; 5IMS; 5K2O; 5K3S; 5K6Q; 5K6R; 5K6T; 5TMA; 5WDG; 5WJ1; 5WKC; 6BD3; 6BD9; 6EFG; 6EFH; 6HAF; 6LPI; 6M2Y; 6M2Z; 6U9D; 6U9H; 6VZ8; 7PT1; 7PT2; 7PT3; 7PT4; 7STQ; 7TZZ; 7U1D; 7U1U; 7U25; 8ET4; 8ET5
» more