We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE entry PS00187
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PURL: https://purl.expasy.org/prosite/signature/PS00187
Direct ScanProsite submission
General information about the entry
| Entry name [info] | TPP_ENZYMES |
| Accession [info] | PS00187 |
| Entry type [info] | PATTERN |
| Date [info] |
01-APR-1990 CREATED;
01-NOV-1995 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00166 |
Name and characterization of the entry
| Description [info] | Thiamine pyrophosphate enzymes signature. |
| Pattern [info] |
[LIVMF]-[GSA]-x(5)-P-x(4)-[LIVMFYW]-x-[LIVMF]-x-G-D-[GSA]-[GSAC]. |
Numerical results [info]
| Total number of hits | 116 in 116 different sequences |
| Number of true positive hits | 109 in 109 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 7 in 7 different sequences |
| Number of false negative sequences | 83 |
| Number of 'partial' sequences | 5 |
| Precision (true positives / (true positives + false positives)) | 93.97 % |
| Recall (true positives / (true positives + false negatives)) | 56.77 % |
Comments [info]
| Taxonomic range [info] | Archaea, Eukaryotes, Prokaryotes (Bacteria) |
| Maximum number of repetitions [info] | 1 |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
109 sequences
ARUI_PSEAE (Q9HUI8), CEAS_STRCL (Q9LCV9), CFOL_ASPCN (A0A2I2F2I5), DCIP_ENTCL (P23234), HACL1_DICDI (Q54DA9), HACL2_BOVIN (A6QQT9), HACL2_CAEEL (O61856), HACL2_DANRE (Q6NV04), HACL2_HUMAN (A1L0T0), HACL2_MOUSE (Q8BU33), HACL2_XENLA (Q6DDK5), HACL_ACTC0 (P0DUV9), HACL_ARATH (Q9LF46), HACL_ORYSJ (Q0JMH0), ILVB1_BRANA (P27818), ILVB1_MYCTO (P9WG40), ILVB1_MYCTU (P9WG41), ILVB1_TOBAC (P09342), ILVB2_BRANA (P14874), ILVB2_MYCTU (O06335), ILVB2_TOBAC (P09114), ILVB3_BRANA (P27819), ILVB_ARATH (P17597), ILVB_CORGL (P42463), ILVB_CRYNH (Q6SSJ3), ILVB_CRYNJ (Q5KPJ5), ILVB_CYACA (O19929), ILVB_ECOLI (P08142), ILVB_GUITH (O78518), ILVB_KLEPN (P27696), ILVB_LACLA (Q02137), ILVB_METAO (O08353), ILVB_METJA (Q57725), ILVB_MYCAV (Q59498), ILVB_MYCBO (P0A623), ILVB_MYCLE (O33112), ILVB_PARMW (Q7U5G1), ILVB_PORPU (P69683), ILVB_PORUM (P69684), ILVB_PYRYE (Q1XDF6), ILVB_RAOTE (Q04524), ILVB_SCHPO (P36620), ILVB_YEAST (P07342), ILVG_ECOLI (P0DP90), ILVG_MYCBO (P66947), ILVG_MYCTO (P9WG38), ILVG_MYCTU (P9WG39), ILVI_BUCAI (P57321), ILVI_BUCAP (O85293), ILVI_BUCBP (Q89AP7), ILVI_BUCSC (Q9RQ65), ILVI_ECOLI (P00893), ILVI_HAEIN (P45261), ILVI_SALTY (P40811), ILVX_BACSU (Q04789), IOLD1_BACCZ (Q63B73), IOLD2_BACCZ (Q4V1F5), IOLD_BACAA (C3PAZ3), IOLD_BACAC (C3LHY1), IOLD_BACAH (A0REB6), IOLD_BACAN (Q81QB5), IOLD_BACC0 (B7JPM3), IOLD_BACC3 (C1EVJ3), IOLD_BACHK (Q6HIK2), IOLD_BACLD (Q65D03), IOLD_BACSU (P42415), IOLD_BACVZ (A7ZAH8), IOLD_CLOBA (B2V4K0), IOLD_CLOBB (B2TJ86), IOLD_CLOP1 (Q0TUZ2), IOLD_CLOPE (Q8XP76), IOLD_GEOKA (Q5KYR0), IOLD_GEOTN (A4IPB6), IOLD_HALH5 (Q9KAG9), IOLD_LACCA (A5YBJ6), IOLD_SHOC1 (Q5WKY8), KDC_MYCA1 (A0QBE6), KDC_MYCBO (Q7U140), KDC_MYCBP (A1KGY5), KDC_MYCPA (Q742Q2), KDC_MYCTA (A5U0P1), KDC_MYCTO (P9WG36), KDC_MYCTU (P9WG37), KDC_MYCUA (A0PL16), MDLC_PSEAE (Q9HUR2), MDLC_PSEPU (P20906), PDC1_ARATH (O82647), PDC1_CANAL (P83779), PDC1_CANGA (Q6FJA3), PDC1_KLULA (Q12629), PDC1_KLUMA (P33149), PDC1_YEAST (P06169), PDC2_SCHPO (Q92345), PDC3_ARATH (Q9M039), PDC3_SCHPO (Q9P7P6), PDC4_ARATH (Q9M040), PDC5_YEAST (P16467), PDC6_YEAST (P26263), PDC_NEUCR (P33287), PDC_ZYMMO (P06672), POXB_ECOLI (P07003), POXB_LACPL (P37063), POXB_STRPN (Q54970), PXP1_YEAST (P39994), XSC_DESTI (Q93PS3), XSC_RHIME (Q92UW6), XSC_RHOCB (D5AKX8), XSC_ROSNI (A3SR25), YDAP_BACSU (P96591)» more
|
| UniProtKB/Swiss-Prot False negative sequences |
83 sequences
COMDE_METAC (Q8TKU6), COME_METJA (P58416), COME_METTH (O27275), DCIP_AZOBR (P51852), HACL1_HUMAN (Q9UJ83), HACL1_MOUSE (Q9QXE0), HACL1_RAT (Q8CHM7), ILVB_BACSU (P37251), IOLD_CLOTE (Q898E8), IOLD_LISIN (Q92EQ4), IOLD_LISMF (Q723S8), IOLD_LISMO (Q8Y9Y1), KDC_MYCLE (Q9CBD6), KDC_MYCS2 (A0R480), OXC_ECO57 (P0AFI1), OXC_ECOLI (P0AFI0), OXC_OXAFO (P40149), PDC1_MAIZE (P28516), PDC1_ORYSI (A2Y5L9), PDC1_ORYSJ (Q0DHF6), PDC1_PEA(P51850), PDC1_SCHPO (Q09737), PDC2_ARATH (Q9FFT4), PDC2_ORYSI (A2XFI3), PDC2_ORYSJ (Q10MW3), PDC2_TOBAC (P51846), PDC3_ORYSI (A2YQ76), PDC3_ORYSJ (Q0D3D2), PDC4_SCHPO (O42873), PDC_ASPFU (Q4WXX9), PDC_ASPOR (Q2UKV4), PDC_ASPPA (P51844), PDC_ASPTN (Q0CNV1), PDC_EMENI (P87208), PDC_HANUV (P34734), PHK1_LACPL (Q88U67), PHK1_NOSS1 (Q8YWW1), PHK1_RHIME (Q92T74), PHK2_LACPL (Q88S87), PHK2_NOSS1 (Q8YTZ6), PHK2_RHIME (Q92ZA4), PHK_BEII9 (B2IGR2), PHK_BIFA0 (B8DUT6), PHK_BRADU (Q89S87), PHK_BRUA2 (Q2YK44), PHK_BRUME (Q8YBL8), PHK_BRUSU (Q8FWR0), PHK_CHLTE (Q8KCA0), PHK_CLOAB (Q97JE3), PHK_GLOVI (Q7NLX2), PHK_LACLA (Q9CFH4), PHK_LATSS (Q38YY6), PHK_METCA (Q608B0), PHK_MYCA1 (A0QGK3), PHK_MYCPA (Q73ZM8), PHK_NITEU (Q82T07), PHK_NITMU (Q2YAC5), PHK_NOCFA (Q5Z066), PHK_PARUW (Q6MFC0), PHK_PEDPA (Q03H73), PHK_PSEP1 (A5W384), PHK_RHILO (Q988V7), PHK_RHOBA (Q7UH14), PHK_RHOP2 (Q2ITA9), PHK_RHOPA (Q6N976), PHK_RHOPB (Q20ZU5), PHK_RHOPS (Q13B10), PHK_RHOPT (B3Q8J5), PHK_SCHPO (O74770), PHK_STRAW (Q82NM9), PHK_STRCO (Q8CK51), PHK_SYNE7 (Q31LF9), PHK_SYNP6 (Q5N0G7), PHK_SYNY3 (P74690), PHK_THEVB (Q8DJN6), PIGD_SERMA (Q5W251), PIGD_SERS3 (Q5W268), PPD_STRHY (Q54271), PPD_STRVT (O86938), XFP_BIFAS (Q9AEM9), XPKA_LACPE (Q937F6), XSC_ALCXX (Q84H41), XSC_CASDE (Q84H44)» more |
| UniProtKB/Swiss-Prot 'Partial' sequences |
5 sequences
ILVB_ARTPT (P27868), PDC1_TOBAC (P51845), PDC2_MAIZE (Q05326), PDC2_PEA(P51851), PDC3_MAIZE (Q05327)» more |
| UniProtKB/Swiss-Prot False positive sequences |
7 sequences
COLB_DICDI (Q8T2A1), DXS1_CERS4 (Q3J1A8), DXS1_ROSDO (Q16DV7), DXS_FUSNN (Q8R639), DXS_RHOCA (P26242), ISOA2_ORYSJ (Q6AU80), NPHN_MOUSE (Q9QZS7)» more |
| PDB [Detailed view] |
131 PDB
pdb_00001bfd; pdb_00001jsc; pdb_00001mcz; pdb_00001n0h; pdb_00001ovm; pdb_00001ozf; pdb_00001ozg; pdb_00001ozh; pdb_00001pi3; pdb_00001po7; pdb_00001pow; pdb_00001pox; pdb_00001pvd; pdb_00001pyd; pdb_00001q6z; pdb_00001qpb; pdb_00001t9a; pdb_00001t9b; pdb_00001t9c; pdb_00001t9d; pdb_00001upa; pdb_00001upb; pdb_00001upc; pdb_00001y9d; pdb_00001ybh; pdb_00001yhy; pdb_00001yhz; pdb_00001yi0; pdb_00001yi1; pdb_00001yno; pdb_00001z8n; pdb_00001zpd; pdb_00002ez4; pdb_00002ez8; pdb_00002ez9; pdb_00002ezt; pdb_00002ezu; pdb_00002fn3; pdb_00002fwn; pdb_00002iht; pdb_00002ihu; pdb_00002ihv; pdb_00002v3w; pdb_00002vjy; pdb_00002vk1; pdb_00002vk4; pdb_00002vk8; pdb_00002w93; pdb_00002wva; pdb_00002wvg; pdb_00002wvh; pdb_00003e9y; pdb_00003ea4; pdb_00003ey9; pdb_00003eya; pdb_00003f6b; pdb_00003f6e; pdb_00003fsj; pdb_00003fzn; pdb_00003oe1; pdb_00004gg1; pdb_00004gm0; pdb_00004gm1; pdb_00004gm4; pdb_00004gp9; pdb_00004gpe; pdb_00004jd5; pdb_00004ju8; pdb_00004ju9; pdb_00004jua; pdb_00004jub; pdb_00004juc; pdb_00004jud; pdb_00004juf; pdb_00004k9k; pdb_00004k9l; pdb_00004k9m; pdb_00004k9n; pdb_00004k9o; pdb_00004k9p; pdb_00004mpj; pdb_00004mpp; pdb_00004mpr; pdb_00004mq5; pdb_00004mzx; pdb_00004qel; pdb_00004zp1; pdb_00005d6r; pdb_00005dei; pdb_00005dgd; pdb_00005dgt; pdb_00005dx6; pdb_00005fem; pdb_00005ims; pdb_00005k2o; pdb_00005k3s; pdb_00005k6q; pdb_00005k6r; pdb_00005k6t; pdb_00005tma; pdb_00005wdg; pdb_00005wj1; pdb_00005wkc; pdb_00006bd3; pdb_00006bd9; pdb_00006efg; pdb_00006efh; pdb_00006haf; pdb_00006lpi; pdb_00006m2y; pdb_00006m2z; pdb_00006u9d; pdb_00006u9h; pdb_00006vz8; pdb_00007pt1; pdb_00007pt2; pdb_00007pt3; pdb_00007pt4; pdb_00007stq; pdb_00007tzz; pdb_00007u1d; pdb_00007u1u; pdb_00007u25; pdb_00008et4; pdb_00008et5; pdb_00008xbo; pdb_00008xbq; pdb_00008xbr; pdb_00009c4p; pdb_00009c4q; pdb_00009c4r » more |