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PROSITE entry PS00195


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00195
Entry name [info] GLUTAREDOXIN_1
Accession [info] PS00195
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2001 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00173

Name and characterization of the entry

Description [info] Glutaredoxin active site.
Pattern [info] 
[LIVMD]-[FYSA]-x(4)-C-[PV]-[FYWH]-C-x(2)-[TAV]-x(2,3)-[LIV].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 73 in 73 different sequences
Number of true positive hits 70 in 70 different sequences
Number of 'unknown' hits 0
Number of false positive hits 3 in 3 different sequences
Number of false negative sequences 40
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 95.89 %
Recall (true positives / (true positives + false negatives)) 63.64 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] disulfide at position 4
Site [info] disulfide at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 70 sequences 

GLRX1_BOVIN (P10575), GLRX1_CAMPM (Q8V2V1), GLRX1_CAMPS (Q775X4), 

GLRX1_CHICK (P79764), GLRX1_CWPXB (Q8QMY9), GLRX1_CWPXG (Q80E01), 
GLRX1_ECOLI (P68688), GLRX1_ECTVM (Q8JLF5), GLRX1_HUMAN (P35754), 
GLRX1_MONPV (A0A7H0DN48), GLRX1_MOUSE (Q9QUH0), GLRX1_PIG   (P12309), 
GLRX1_RABIT (P12864), GLRX1_RABPU (Q6RZN3), GLRX1_RAT   (Q9ESH6), 
GLRX1_RHIID (B7ZFT1), GLRX1_RICBR (Q1RHJ0), GLRX1_RICCN (Q92J02), 
GLRX1_RICFE (Q4UKL7), GLRX1_RICPR (Q9ZDW1), GLRX1_RICTY (Q68XG4), 
GLRX1_SALTI (P0A1P9), GLRX1_SALTY (P0A1P8), GLRX1_SCHPO (O36032), 
GLRX1_SHIFL (P68689), GLRX1_SYNY3 (P74593), GLRX1_VACCA (Q76ZV3), 
GLRX1_VACCC (P68690), GLRX1_VACCP (P68691), GLRX1_VACCT (Q77TL9), 
GLRX1_VACCW (P68692), GLRX1_VAR67 (P0DOQ9), GLRX1_VARV  (P0DOR0), 
GLRX1_YEAST (P25373), GLRX2_ECO57 (P0AC61), GLRX2_ECOL6 (P0AC60), 
GLRX2_ECOLI (P0AC59), GLRX2_SCHPO (Q9UTI2), GLRX2_SYNY3 (P73492), 
GLRX2_YEAST (P17695), GLRX3_ECO57 (P0AC64), GLRX3_ECOL6 (P0AC63), 
GLRX3_ECOLI (P0AC62), GLRX_BPT4   (P00276), GLRX_DICDI  (Q54GP8), 
GLRX_HAEIN  (P45242), GLRX_MIMIV  (Q5UQ14), GLRX_NEIMA  (Q9JVU9), 
GLRX_NEIMB  (Q9JY15), GLRX_PSEAE  (Q9HU55), GLRX_RICCO  (P55143), 
GLRX_SOLLC  (Q9ZR41), GLRX_VERFO  (O81187), GRXC2_ARATH (Q9FNE2), 
GRXC4_ARATH (Q8LFQ6), GRXC4_ORYSJ (Q6K953), GRXC6_ORYSJ (P55142), 
GRXC8_ORYSJ (Q0DAE4), GSPRX_MARGR (B3EWI1), PGES2_BOVIN (Q66LN0), 
PGES2_DANRE (Q7ZUC7), PGES2_HUMAN (Q9H7Z7), PGES2_MACFA (Q9N0A4), 
PGES2_MOUSE (Q8BWM0), PRX5_HAEIN  (P44758), THIO_ARCFU  (O28137), 
THIO_METJA  (Q57755), THIO_METTH  (O26898), THIO_METTM  (P42035), 
YRUB_CLOPA  (P23171)
» more

UniProtKB/Swiss-Prot
False negative sequences		 40 sequences 

CMOI_BACSU  (O34639), GLRX2_BOVIN (Q32L67), GLRX2_HUMAN (Q9NS18), 

GLRX2_MOUSE (Q923X4), GLRX2_PONAB (Q5RC53), GLRX2_RAT   (Q6AXW1), 
GLRX8_YEAST (Q05926), GLRX_ENCCU  (Q8SUM8), GLRX_VIBCH  (Q9KSW0), 
GRC10_ARATH (Q29PZ1), GRC10_ORYSJ (Q2R076), GRC11_ARATH (Q9LYC6), 
GRC11_ORYSJ (Q2R075), GRC12_ARATH (O82254), GRC12_ORYSJ (Q2R073), 
GRC13_ARATH (O82255), GRC13_ORYSJ (Q0IRB0), GRC14_ARATH (Q9LYC5), 
GRC14_ORYSJ (Q0IMV4), GRC15_ORYSJ (Q2QP86), GRCR1_DROME (Q9VNL4), 
GRCR1_HUMAN (A8MXD5), GRCR1_MOUSE (Q50H32), GRCR2_DROME (Q9W4S1), 
GRXC1_ARATH (Q8L8T2), GRXC1_ORYSJ (Q7G8Y5), GRXC2_ORYSJ (Q0JG89), 
GRXC3_ARATH (Q9FVX1), GRXC3_ORYSJ (Q6K609), GRXC5_ARATH (Q8GWS0), 
GRXC5_ORYSJ (Q0JDM4), GRXC6_ARATH (Q8L9S3), GRXC7_ARATH (Q96305), 
GRXC7_ORYSJ (Q0DK35), GRXC8_ARATH (Q8LF89), GRXC9_ARATH (Q9SGP6), 
GRXC9_ORYSJ (Q7XIZ1), TRXR1_HUMAN (Q16881), TRXR3_HUMAN (Q86VQ6), 
TRXR3_MOUSE (Q99MD6)
» more

UniProtKB/Swiss-Prot
False positive sequences		 3 sequences 

NUON_CAMC1  (A7ZBF3), SIP5_PICGU  (A5DQJ8), Y3476_BRADU (Q89PK4)


				
	

	

		PDB
[Detailed view]		
		
			32 PDB
			


			1AAZ; 1DE1; 1DE2; 1EGO; 1EGR; 1FO5; 1FOV; 1G7O; 1JHB; 1KTE; 1NHO; 1NM3; 
			
				1Z9H; 2HZE; 2HZF; 2PBJ; 3C1R; 3C1S; 3CTF; 3CTG; 3D4M; 3QMX; 4KX4; 4MJA; 
				4MJB; 4MJC; 4MJE; 4RQR; 6MWS; 7D9L; 7DKP; 7DKR
			
			

			» more