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PROSITE entry PS00262


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General information about the entry

Entry name [info] INSULIN
Accession [info] PS00262
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00235

Name and characterization of the entry

Description [info] Insulin family signature.
Pattern [info]
C-C-{P}-{P}-x-C-[STDNEKPI]-x(3)-[LIVMFS]-x(3)-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_03 which contains 571'609 sequence entries.


Total number of hits 262 in 262 different sequences
Number of true positive hits 254 in 254 different sequences
Number of 'unknown' hits 0
Number of false positive hits 8 in 8 different sequences
Number of false negative sequences 10
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 96.95 %
Recall (true positives / (true positives + false negatives)) 96.21 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 1
Site [info] disulfide at position 2
Site [info] disulfide at position 6
Site [info] disulfide at position 11
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
254 sequences

BXA1_BOMMO  (Q17192), BXA1_SAMCY  (P33718), BXA2_BOMMO  (P15411), 
BXA2_SAMCY  (P33719), BXA3_BOMMO  (P26726), BXA3_SAMCY  (P33720), 
BXA4_BOMMO  (P26727), BXA5_BOMMO  (P26728), BXA6_BOMMO  (P26729), 
BXA7_BOMMO  (P26730), BXA8_BOMMO  (P26731), BXA9_BOMMO  (P26732), 
BXB10_BOMMO (Q17194), BXB12_BOMMO (P29519), BXB1_BOMMO  (P26733), 
BXB1_SAMCY  (P33721), BXB2_BOMMO  (P26734), BXB2_SAMCY  (P33722), 
BXB3_BOMMO  (P26737), BXB4_BOMMO  (P26738), BXB5_BOMMO  (P26739), 
BXB6_BOMMO  (P26740), BXB7_BOMMO  (P26741), BXB8_BOMMO  (P26742), 
BXB9_BOMMO  (P26743), BXC1_BOMMO  (P15410), BXC2_BOMMO  (P26735), 
BXD1_BOMMO  (P26736), BXE1_BOMMO  (P21808), BXF1_BOMMO  (P91896), 
BXG1_BOMMO  (O61271), BXRA_AGRCO  (O09209), BXRB_AGRCO  (O09210), 
GSS_PATPE   (C9K4X8), IGF1A_CYPCA (Q90325), IGF1A_XENLA (P16501), 
IGF1B_CYPCA (Q90326), IGF1B_XENLA (P84775), IGF1_AILFU  (Q6IVA5), 
IGF1_AILME  (Q6JLX1), IGF1_BOVIN  (P07455), IGF1_CANLF  (P33712), 
IGF1_CAPHI  (P51457), IGF1_CAVPO  (P17647), IGF1_CHICK  (P18254), 
IGF1_COTJA  (P51462), IGF1_HORSE  (P51458), IGF1_HUMAN  (P05019), 
IGF1_MOUSE  (P05017), IGF1_ONCKI  (P17085), IGF1_ONCMY  (Q02815), 
IGF1_PANTA  (Q6GUL6), IGF1_PIG(P16545), IGF1_RABIT  (Q95222), 
IGF1_RAT(P08025), IGF1_RHIRO  (Q68LC0), IGF1_SHEEP  (P10763), 
IGF1_SUNMU  (Q28933), IGF2A_XENLA (Q90WW4), IGF2B_XENLA (Q6INW9), 
IGF2_BOVIN  (P07456), IGF2_CAVPO  (Q08279), IGF2_CHICK  (P33717), 
IGF2_HORSE  (P51459), IGF2_HUMAN  (P01344), IGF2_MOUSE  (P09535), 
IGF2_NEOVI  (P41694), IGF2_ONCMY  (Q02816), IGF2_PIG(P23695), 
IGF2_RAT(P01346), IGF2_SHEEP  (P10764), IGF3_XENLA  (Q90WX8), 
IGF_MYXGL   (P22618), ILB1_CAEEL  (Q09626), ILB2_CAEEL  (Q09627), 
ILB3_CAEEL  (Q09628), ILB4_CAEEL  (Q23430), ILB5_CAEEL  (P56174), 
ILB6_CAEEL  (P56173), ILG1_CAEEL  (Q18060), ILP_BRACL   (P22334), 
INS17_CAEEL (G5EFH1), INS1A_CONGE (A0A0B5AC95), INS1A_CONQU (A0A0B5ABE6), 
INS1A_CONTU (A0A0B5ADU4), INS1B_CONGE (A0A0B5A8Q2), INS1B_CONQU (A0A0B5ABE4), 
INS1B_CONTU (A0A0B5AC90), INS1C_CONGE (A0A0B5A7P2), INS1_BATSP  (P01337), 
INS1_CONFO  (A0A0B5AC98), INS1_CONIM  (A0A0B5A7M7), INS1_CONKI  (A0A3S9V8L7), 
INS1_CONME  (A0A0B5ADV0), INS1_CONMR  (A0A0B5A8Q6), INS1_CONTE  (A0A0B5A7N8), 
INS1_HUSDA  (C0HJI7), INS1_KATPE  (C0HJI2), INS1_MOUSE  (P01325), 
INS1_RAT(P01322), INS1_THUOR  (C0HJI5), INS1_XENLA  (P12706), 
INS2A_CONFO (A0A0B5ADT9), INS2A_CONGE (A0A0B5ABD9), INS2B_CONFO (A0A0B5A7N1), 
INS2B_CONGE (A0A0B5ADT3), INS2C_CONFO (A0A0B5A7N5), INS2_BATSP  (P01338), 
INS2_CONIM  (A0A0B5A8P8), INS2_CONKI  (A0A3S9V8K6), INS2_CONTU  (A0A3S9V8L9), 
INS2_HUSDA  (C0HJI8), INS2_KATPE  (C0HJI3), INS2_MOUSE  (P01326), 
INS2_RAT(P01323), INS2_THUOR  (C0HJI6), INS2_XENLA  (P12707), 
INS3A_CONGE (A0A0B5A8P4), INS3B_CONGE (A0A0B5AC86), INS3_CONTU  (A0A0B5ABD5), 
INSL1_DROME (Q9VT50), INSL2_DROME (Q9VT51), INSL3_BOVIN (O77801), 
INSL3_CALJA (O97937), INSL3_CANLF (Q6X7V3), INSL3_DROME (Q9VT52), 
INSL3_HUMAN (P51460), INSL3_MOUSE (O09107), INSL3_PANTR (Q5CZK3), 
INSL3_PIG   (P51461), INSL3_RAT   (Q9WUK0), INSL4_DROME (Q9VT53), 
INSL4_HUMAN (Q14641), INSL4_PANTR (Q5CZK6), INSL5_DROME (Q7KUD5), 
INSL5_HUMAN (Q9Y5Q6), INSL5_MOUSE (Q9WUG6), INSL5_PANTR (Q5CZK5), 
INSL6_BOVIN (Q32L79), INSL6_HUMAN (Q9Y581), INSL6_MOUSE (Q9QY05), 
INSL6_RAT   (Q9WV41), INS_ACIGU   (P81423), INS_ACOCA   (P01324), 
INS_ALLMI   (P12703), INS_AMICA   (P29335), INS_ANAPL   (P01333), 
INS_ANGAN   (P41522), INS_ANGRO   (P42633), INS_ANSAN   (P68245), 
INS_AOTTR   (P67972), INS_ATRSP   (P09476), INS_BALBO   (P01314), 
INS_BALPH   (P67973), INS_BOVIN   (P01317), INS_CAIMO   (P68243), 
INS_CALMI   (P13190), INS_CAMDR   (P01320), INS_CANLF   (P01321), 
INS_CAPHI   (P01319), INS_CARSE   (C0HJI1), INS_CAVPO   (P01329), 
INS_CHICH   (P01327), INS_CHICK   (P67970), INS_CHIMO   (P68991), 
INS_CHLAE   (P30407), INS_CONVC   (A0A0F7YYV0), INS_CRILO   (P01313), 
INS_CROAT   (P01334), INS_CYPCA   (P01335), INS_DANRE   (O73727), 
INS_DIDVI   (P18109), INS_ELEMA   (P01316), INS_FELCA   (P06306), 
INS_GADMC   (P01336), INS_GORGO   (Q6YK33), INS_HORSE   (P01310), 
INS_HUMAN   (P01308), INS_HYDCO   (P68992), INS_HYSCR   (P01328), 
INS_ICTTR   (Q91XI3), INS_KATPE   (P01340), INS_LAMFL   (P68988), 
INS_LOPAM   (P69045), INS_LOPPI   (P69046), INS_MACFA   (P30406), 
INS_MELGA   (P67968), INS_MYOCO   (P01330), INS_MYOSC   (P07453), 
INS_MYXGL   (P01342), INS_OCTDE   (P17715), INS_ONCGO   (P68989), 
INS_ONCKE   (P04667), INS_ONCKI   (P68990), INS_ORENI   (P81025), 
INS_ORNAN   (Q9TQY7), INS_PAGMA   (C0HJI4), INS_PANBU   (Q98TA8), 
INS_PANTR   (P30410), INS_PETMA   (P68987), INS_PHYMC   (P67974), 
INS_PIAME   (P81881), INS_PIG (P01315), INS_PLAFE   (P09477), 
INS_PLATA   (C0HJU0), INS_PONPY   (Q8HXV2), INS_PROGU   (P01331), 
INS_PSAOB   (Q62587), INS_PTYDH   (P12708), INS_RABIT   (P01311), 
INS_SAISC   (P67971), INS_SELRF   (P51463), INS_SERQU   (C0HJT9), 
INS_SHEEP   (P01318), INS_SQUAC   (P12704), INS_STRCA   (P67969), 
INS_THUTH   (P01339), INS_TORMA   (P12705), INS_TRADO   (P69047), 
INS_TRASC   (P69048), INS_VERMO   (Q9W7R2), IRP1_AGRIP  (C0HKS3), 
IRP2_AGRIP  (C0HKS4), IRP4_AGRIP  (C0HKS5), LIRP_LOCMI  (P15131), 
MPI1_LYMST  (P07223), MPI2_LYMST  (P25289), MPI3_LYMST  (P80090), 
MPI5_LYMST  (P31241), MPI7_LYMST  (P91797), REL1_HUMAN  (P04808), 
REL1_PANTR  (P51454), REL1_RAT(P01347), REL2_HUMAN  (P04090), 
REL2_PANTR  (P51455), REL3_HUMAN  (Q8WXF3), REL3_MOUSE  (Q8CHK2), 
REL3_PANTR  (Q5CZK2), REL3_PIG(Q8HY17), REL3_RAT(Q8BFS3), 
RELH_RABIT  (P51456), RELX_BALAC  (P11184), RELX_BALED  (P11185), 
RELX_CANLF  (Q9TRM8), RELX_CARTA  (P01349), RELX_CAVPO  (P51453), 
RELX_FELCA  (Q9MYK8), RELX_HORSE  (P22969), RELX_HYPSI  (P81191), 
RELX_LEUER  (P11952), RELX_MACMU  (P19884), RELX_MESAU  (Q64171), 
RELX_PIG(P01348), RELX_SQUAC  (P11953)
» more

UniProtKB/Swiss-Prot
False negative sequences
10 sequences

BXB11_BOMMO (Q17196), ILA1_CAEEL  (Q21507), ILA2_CAEEL  (Q21508), 
ILA3_CAEEL  (Q21506), INSL6_DROME (Q9W4Z4), INSL7_DROME (Q9W4Q9), 
INSL_VIGUN  (P83770), INS_POLSE   (P0C236), INS_RODSP   (P21563), 
REL1_MOUSE  (P47932)
» more

UniProtKB/Swiss-Prot
'Partial' sequences
1 sequence

RELX_PHODA  (Q7M3C4)

		
UniProtKB/Swiss-Prot
False positive sequences
8 sequences

ADA18_MACFA (Q95194), ADAM5_RAT   (Q5BK84), F256_CTEON  (P85032), 
GG3_ARATH   (Q6AWT8), O161_CONCE  (Q5K0C4), O165_CONLI  (Q3YEE6), 
PRMC_CHLT2  (B0B9D1), PRMC_CHLTR  (O84027)
» more

PDB
[Detailed view]
460 PDB

1A7F; 1AI0; 1AIY; 1APH; 1B17; 1B18; 1B19; 1B2A; 1B2B; 1B2C; 1B2D; 1B2E; 1B2F; 1B2G; 1B9E; 1B9G; 1BEN; 1BOM; 1BON; 1BPH; 1BQT; 1BZV; 1CPH; 1DEI; 1DPH; 1EFE; 1EV3; 1EV6; 1EVR; 1FU2; 1FUB; 1G7A; 1G7B; 1GUJ; 1GZR; 1GZY; 1GZZ; 1H02; 1H59; 1HIQ; 1HIS; 1HIT; 1HLS; 1HTV; 1HUI; 1IGL; 1IMX; 1IOG; 1IOH; 1IZA; 1IZB; 1J73; 1JCA; 1JCO; 1K3M; 1KMF; 1LKQ; 1LPH; 1M5A; 1MHI; 1MHJ; 1MPJ; 1MSO; 1OS3; 1OS4; 1PID; 1PMX; 1Q4V; 1QIY; 1QIZ; 1QJ0; 1RWE; 1SDB; 1SF1; 1SJT; 1SJU; 1T1K; 1T1P; 1T1Q; 1TGR; 1TRZ; 1TYL; 1TYM; 1UZ9; 1W8P; 1WAV; 1WQJ; 1XDA; 1XGL; 1XW7; 1ZEG; 1ZEH; 1ZEI; 1ZNI; 1ZNJ; 2A3G; 2AIY; 2BN1; 2BN3; 2C8Q; 2C8R; 2CEU; 2DSP; 2DSQ; 2DSR; 2EFA; 2FHW; 2G4M; 2GF1; 2H67; 2H8B; 2HH4; 2HHO; 2HIU; 2INS; 2JMN; 2JUM; 2JUU; 2JUV; 2JV1; 2JZQ; 2K1V; 2K6T; 2K6U; 2K91; 2K9R; 2KBC; 2KJI; 2KJJ; 2KJU; 2KQP; 2KQQ; 2KXK; 2L1Y; 2L1Z; 2L29; 2LGB; 2LWZ; 2M1D; 2M1E; 2M2M; 2M2N; 2M2O; 2M2P; 2MLI; 2MPG; 2MPI; 2MV1; 2MVC; 2MVD; 2N2V; 2N2W; 2N2X; 2OLY; 2OLZ; 2OM0; 2OM1; 2OMG; 2OMH; 2OMI; 2QIU; 2R34; 2R35; 2R36; 2RN5; 2TCI; 2V5P; 2VJZ; 2VK0; 2W44; 2WBY; 2WC0; 2WFU; 2WFV; 2WRU; 2WRV; 2WRW; 2WRX; 2WS0; 2WS1; 2WS4; 2WS6; 2WS7; 2ZP6; 2ZPP; 3AIY; 3BXQ; 3E4Z; 3E7Y; 3E7Z; 3EXX; 3FHP; 3FQ9; 3GF1; 3GKY; 3I3Z; 3I40; 3ILG; 3INC; 3INS; 3IR0; 3JSD; 3KQ6; 3KR3; 3LRI; 3MTH; 3P2X; 3P33; 3Q6E; 3ROV; 3RTO; 3T2A; 3TT8; 3U4N; 3V19; 3V1G; 3W11; 3W12; 3W13; 3W7Y; 3W7Z; 3W80; 3ZI3; 3ZQR; 3ZS2; 3ZU1; 4A7E; 4AIY; 4AJX; 4AJZ; 4AK0; 4AKJ; 4BS3; 4CXL; 4CXN; 4CY7; 4E7T; 4E7U; 4E7V; 4EFX; 4EWW; 4EWX; 4EWZ; 4EX0; 4EX1; 4EXX; 4EY1; 4EY9; 4EYD; 4EYN; 4EYP; 4F0N; 4F0O; 4F1A; 4F1B; 4F1C; 4F1D; 4F1F; 4F1G; 4F4T; 4F4V; 4F51; 4F8F; 4FG3; 4FKA; 4GBC; 4GBI; 4GBK; 4GBL; 4GBN; 4I5Y; 4I5Z; 4IDW; 4IHN; 4INS; 4IUZ; 4IYD; 4IYF; 4M4F; 4M4H; 4M4I; 4M4J; 4M4L; 4M4M; 4NIB; 4OGA; 4P65; 4RXW; 4UNE; 4UNG; 4UNH; 4XC4; 4XSS; 5AIY; 5BOQ; 5BPO; 5BQQ; 5BTS; 5CJO; 5CNY; 5CO2; 5CO6; 5CO9; 5D52; 5D53; 5D54; 5D5E; 5E7W; 5EMS; 5EN9; 5ENA; 5FB6; 5HPR; 5HPU; 5HQI; 5HRQ; 5JYQ; 5KQV; 5L3L; 5L3M; 5L3N; 5LIS; 5MAM; 5MHD; 5MIZ; 5MT3; 5MT9; 5MWQ; 5U8Q; 5UDP; 5UOZ; 5UQA; 5URT; 5URU; 5USP; 5USS; 5USV; 5UU2; 5UU3; 5UU4; 5VIZ; 5WBT; 5WDM; 5WOB; 6B3Q; 6B70; 6BFC; 6CE7; 6CE9; 6CEB; 6CK2; 6FEY; 6FF3; 6GNQ; 6GV0; 6HN5; 6INS; 6JK8; 6JR3; 6K59; 6KH8; 6KH9; 6KHA; 6NWV; 6O17; 6OR0; 6P4Z; 6PYH; 6Q8Q; 6QQ7; 6QQG; 6QRH; 6QRK; 6RLX; 6RVA; 6S34; 6S4I; 6S4J; 6SOF; 6TC2; 6TYH; 6U46; 6UM2; 6VEP; 6VEQ; 6VER; 6VES; 6VET; 6VWG; 6VWI; 6X4X; 6Z7W; 6Z7Y; 6Z7Z; 6ZHB; 6ZI8; 7AC4; 7BW7; 7BW8; 7BWA; 7ELJ; 7INS; 7JP3; 7KD6; 7MD4; 7MD5; 7MQO; 7MQR; 7MQS; 7NHU; 7PG0; 7PG2; 7PG3; 7PG4; 7QAC; 7QGF; 7QID; 7RKD; 7RZE; 7RZF; 7RZI; 7S0Q; 7S4Y; 7SL1; 7SL2; 7SL3; 7SL4; 7SL6; 7SL7; 7STH; 7STI; 7STJ; 7STK; 7U6E; 7V3P; 7WRQ; 7YJ4; 7YQ3; 7YQ4; 7YQ5; 7YRR; 7Z5L; 7Z5Q; 8CLS; 8EYR; 8EYX; 8EYY; 8EZ0; 8GSG; 8GUY; 8HSF; 8HSK; 8IPZ; 8PI4; 8PI5; 8PI6; 8PJC; 8PJH; 8SBD; 9INS
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