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PROSITE entry PS00262


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PURL: https://purl.expasy.org/prosite/signature/PS00262

Direct ScanProsite submission
General information about the entry

Entry name [info] INSULIN
Accession [info] PS00262
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00235

Name and characterization of the entry

Description [info] Insulin family signature.
Pattern [info]
C-C-{P}-{P}-x-C-[STDNEKPI]-x(3)-[LIVMFS]-x(3)-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 266 in 266 different sequences
Number of true positive hits 258 in 258 different sequences
Number of 'unknown' hits 0
Number of false positive hits 8 in 8 different sequences
Number of false negative sequences 12
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 96.99 %
Recall (true positives / (true positives + false negatives)) 95.56 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 1
Site [info] disulfide at position 2
Site [info] disulfide at position 6
Site [info] disulfide at position 11
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
258 sequences

BXA1_BOMMO  (Q17192), BXA1_SAMCY  (P33718), BXA2_BOMMO  (P15411), 
BXA2_SAMCY  (P33719), BXA3_BOMMO  (P26726), BXA3_SAMCY  (P33720), 
BXA4_BOMMO  (P26727), BXA5_BOMMO  (P26728), BXA6_BOMMO  (P26729), 
BXA7_BOMMO  (P26730), BXA8_BOMMO  (P26731), BXA9_BOMMO  (P26732), 
BXB10_BOMMO (Q17194), BXB12_BOMMO (P29519), BXB1_BOMMO  (P26733), 
BXB1_SAMCY  (P33721), BXB2_BOMMO  (P26734), BXB2_SAMCY  (P33722), 
BXB3_BOMMO  (P26737), BXB4_BOMMO  (P26738), BXB5_BOMMO  (P26739), 
BXB6_BOMMO  (P26740), BXB7_BOMMO  (P26741), BXB8_BOMMO  (P26742), 
BXB9_BOMMO  (P26743), BXC1_BOMMO  (P15410), BXC2_BOMMO  (P26735), 
BXD1_BOMMO  (P26736), BXE1_BOMMO  (P21808), BXF1_BOMMO  (P91896), 
BXG1_BOMMO  (O61271), BXRA_AGRCO  (O09209), BXRB_AGRCO  (O09210), 
GSS_PATPE   (C9K4X8), IGF1A_CYPCA (Q90325), IGF1A_XENLA (P16501), 
IGF1B_CYPCA (Q90326), IGF1B_XENLA (P84775), IGF1_AILFU  (Q6IVA5), 
IGF1_AILME  (Q6JLX1), IGF1_BOVIN  (P07455), IGF1_CANLF  (P33712), 
IGF1_CAPHI  (P51457), IGF1_CAVPO  (P17647), IGF1_CHICK  (P18254), 
IGF1_COTJA  (P51462), IGF1_HORSE  (P51458), IGF1_HUMAN  (P05019), 
IGF1_MOUSE  (P05017), IGF1_ONCKI  (P17085), IGF1_ONCMY  (Q02815), 
IGF1_PANTA  (Q6GUL6), IGF1_PIG(P16545), IGF1_RABIT  (Q95222), 
IGF1_RAT(P08025), IGF1_RHIRO  (Q68LC0), IGF1_SHEEP  (P10763), 
IGF1_SUNMU  (Q28933), IGF2A_XENLA (Q90WW4), IGF2B_XENLA (Q6INW9), 
IGF2_BOVIN  (P07456), IGF2_CAVPO  (Q08279), IGF2_CHICK  (P33717), 
IGF2_HORSE  (P51459), IGF2_HUMAN  (P01344), IGF2_MOUSE  (P09535), 
IGF2_NEOVI  (P41694), IGF2_ONCMY  (Q02816), IGF2_PIG(P23695), 
IGF2_RAT(P01346), IGF2_SHEEP  (P10764), IGF3_XENLA  (Q90WX8), 
IGF_MYXGL   (P22618), ILB1_CAEEL  (Q09626), ILB2_CAEEL  (Q09627), 
ILB3_CAEEL  (Q09628), ILB4_CAEEL  (Q23430), ILB5_CAEEL  (P56174), 
ILB6_CAEEL  (P56173), ILG1_CAEEL  (Q18060), ILP_BRACL   (P22334), 
INS17_CAEEL (G5EFH1), INS1A_CONGE (A0A0B5AC95), INS1A_CONQU (A0A0B5ABE6), 
INS1A_CONTU (A0A0B5ADU4), INS1B_CONGE (A0A0B5A8Q2), INS1B_CONQU (A0A0B5ABE4), 
INS1B_CONTU (A0A0B5AC90), INS1C_CONGE (A0A0B5A7P2), INS1_BATSP  (P01337), 
INS1_CONFO  (A0A0B5AC98), INS1_CONIM  (A0A0B5A7M7), INS1_CONKI  (A0A3S9V8L7), 
INS1_CONME  (A0A0B5ADV0), INS1_CONMR  (A0A0B5A8Q6), INS1_CONTE  (A0A0B5A7N8), 
INS1_HUSDA  (C0HJI7), INS1_KATPE  (C0HJI2), INS1_MOUSE  (P01325), 
INS1_RAT(P01322), INS1_THUOR  (C0HJI5), INS1_XENLA  (P12706), 
INS2A_CONFO (A0A0B5ADT9), INS2A_CONGE (A0A0B5ABD9), INS2B_CONFO (A0A0B5A7N1), 
INS2B_CONGE (A0A0B5ADT3), INS2C_CONFO (A0A0B5A7N5), INS2_BATSP  (P01338), 
INS2_CONIM  (A0A0B5A8P8), INS2_CONKI  (A0A3S9V8K6), INS2_CONTU  (A0A3S9V8L9), 
INS2_EXADI  (P0DRI0), INS2_HUSDA  (C0HJI8), INS2_KATPE  (C0HJI3), 
INS2_MOUSE  (P01326), INS2_RAT(P01323), INS2_THUOR  (C0HJI6), 
INS2_XENLA  (P12707), INS3A_CONGE (A0A0B5A8P4), INS3B_CONGE (A0A0B5AC86), 
INS3_CONTU  (A0A0B5ABD5), INS4_EXADI  (P0DRI2), INS5_EXADI  (P0DRI3), 
INSL1_DROME (Q9VT50), INSL2_DROME (Q9VT51), INSL3_BOVIN (O77801), 
INSL3_CALJA (O97937), INSL3_CANLF (Q6X7V3), INSL3_DROME (Q9VT52), 
INSL3_HUMAN (P51460), INSL3_MOUSE (O09107), INSL3_PANTR (Q5CZK3), 
INSL3_PIG   (P51461), INSL3_RAT   (Q9WUK0), INSL4_DROME (Q9VT53), 
INSL4_HUMAN (Q14641), INSL4_PANTR (Q5CZK6), INSL5_DROME (Q7KUD5), 
INSL5_HUMAN (Q9Y5Q6), INSL5_MOUSE (Q9WUG6), INSL5_PANTR (Q5CZK5), 
INSL6_BOVIN (Q32L79), INSL6_HUMAN (Q9Y581), INSL6_MOUSE (Q9QY05), 
INSL6_RAT   (Q9WV41), INS_ACIGU   (P81423), INS_ACOCA   (P01324), 
INS_ALLMI   (P12703), INS_AMICA   (P29335), INS_ANAPL   (P01333), 
INS_ANGAN   (P41522), INS_ANGRO   (P42633), INS_ANSAN   (P68245), 
INS_AOTTR   (P67972), INS_ATRSP   (P09476), INS_BALBO   (P01314), 
INS_BALPH   (P67973), INS_BOVIN   (P01317), INS_CAIMO   (P68243), 
INS_CALMI   (P13190), INS_CAMDR   (P01320), INS_CANLF   (P01321), 
INS_CAPHI   (P01319), INS_CARSE   (C0HJI1), INS_CAVPO   (P01329), 
INS_CHICH   (P01327), INS_CHICK   (P67970), INS_CHIMO   (P68991), 
INS_CHLAE   (P30407), INS_CONVC   (A0A0F7YYV0), INS_CRILO   (P01313), 
INS_CROAT   (P01334), INS_CYPCA   (P01335), INS_DANRE   (O73727), 
INS_DIDVI   (P18109), INS_ELEMA   (P01316), INS_FELCA   (P06306), 
INS_GADMC   (P01336), INS_GORGO   (Q6YK33), INS_HORSE   (P01310), 
INS_HUMAN   (P01308), INS_HYDCO   (P68992), INS_HYSCR   (P01328), 
INS_ICTTR   (Q91XI3), INS_KATPE   (P01340), INS_LAMFL   (P68988), 
INS_LOPAM   (P69045), INS_LOPPI   (P69046), INS_MACFA   (P30406), 
INS_MELGA   (P67968), INS_MYOCO   (P01330), INS_MYOSC   (P07453), 
INS_MYXGL   (P01342), INS_OCTDE   (P17715), INS_ONCGO   (P68989), 
INS_ONCKE   (P04667), INS_ONCKI   (P68990), INS_ORENI   (P81025), 
INS_ORNAN   (Q9TQY7), INS_OULSP   (P0DY19), INS_PAGMA   (C0HJI4), 
INS_PANBU   (Q98TA8), INS_PANTR   (P30410), INS_PETMA   (P68987), 
INS_PHYMC   (P67974), INS_PIAME   (P81881), INS_PIG (P01315), 
INS_PLAFE   (P09477), INS_PLATA   (C0HJU0), INS_PONPY   (Q8HXV2), 
INS_PROGU   (P01331), INS_PSAOB   (Q62587), INS_PTYDH   (P12708), 
INS_RABIT   (P01311), INS_SAISC   (P67971), INS_SELRF   (P51463), 
INS_SERQU   (C0HJT9), INS_SHEEP   (P01318), INS_SQUAC   (P12704), 
INS_STRCA   (P67969), INS_THUTH   (P01339), INS_TORMA   (P12705), 
INS_TRADO   (P69047), INS_TRASC   (P69048), INS_VERMO   (Q9W7R2), 
IRP1_AGRIP  (C0HKS3), IRP2_AGRIP  (C0HKS4), IRP4_AGRIP  (C0HKS5), 
LIRP_LOCMI  (P15131), MPI1_LYMST  (P07223), MPI2_LYMST  (P25289), 
MPI3_LYMST  (P80090), MPI5_LYMST  (P31241), MPI7_LYMST  (P91797), 
REL1_HUMAN  (P04808), REL1_PANTR  (P51454), REL1_RAT(P01347), 
REL2_HUMAN  (P04090), REL2_PANTR  (P51455), REL3_HUMAN  (Q8WXF3), 
REL3_MOUSE  (Q8CHK2), REL3_PANTR  (Q5CZK2), REL3_PIG(Q8HY17), 
REL3_RAT(Q8BFS3), RELH_RABIT  (P51456), RELX_BALAC  (P11184), 
RELX_BALED  (P11185), RELX_CANLF  (Q9TRM8), RELX_CARTA  (P01349), 
RELX_CAVPO  (P51453), RELX_FELCA  (Q9MYK8), RELX_HORSE  (P22969), 
RELX_HYPSI  (P81191), RELX_LEUER  (P11952), RELX_MACMU  (P19884), 
RELX_MESAU  (Q64171), RELX_PIG(P01348), RELX_SQUAC  (P11953)
» more

UniProtKB/Swiss-Prot
False negative sequences
12 sequences

BXB11_BOMMO (Q17196), ILA1_CAEEL  (Q21507), ILA2_CAEEL  (Q21508), 
ILA3_CAEEL  (Q21506), INS1_EXADI  (P0DRH9), INS3_EXADI  (P0DRI1), 
INSL6_DROME (Q9W4Z4), INSL7_DROME (Q9W4Q9), INSL_VIGUN  (P83770), 
INS_POLSE   (P0C236), INS_RODSP   (P21563), REL1_MOUSE  (P47932)
» more

UniProtKB/Swiss-Prot
'Partial' sequences
1 sequence

RELX_PHODA  (Q7M3C4)

		
UniProtKB/Swiss-Prot
False positive sequences
8 sequences

ADA18_MACFA (Q95194), ADAM5_RAT   (Q5BK84), F256_CTEON  (P85032), 
GG3_ARATH   (Q6AWT8), O161_CONCE  (Q5K0C4), O165_CONLI  (Q3YEE6), 
PRMC_CHLT2  (B0B9D1), PRMC_CHLTR  (O84027)
» more

PDB
[Detailed view]
493 PDB

pdb_00001a7f; pdb_00001ai0; pdb_00001aiy; pdb_00001aph; pdb_00001b17; pdb_00001b18; pdb_00001b19; pdb_00001b2a; pdb_00001b2b; pdb_00001b2c; pdb_00001b2d; pdb_00001b2e; pdb_00001b2f; pdb_00001b2g; pdb_00001b9e; pdb_00001b9g; pdb_00001ben; pdb_00001bom; pdb_00001bon; pdb_00001bph; pdb_00001bqt; pdb_00001bzv; pdb_00001cph; pdb_00001dei; pdb_00001dph; pdb_00001efe; pdb_00001ev3; pdb_00001ev6; pdb_00001evr; pdb_00001fu2; pdb_00001fub; pdb_00001g7a; pdb_00001g7b; pdb_00001guj; pdb_00001gzr; pdb_00001gzy; pdb_00001gzz; pdb_00001h02; pdb_00001h59; pdb_00001hiq; pdb_00001his; pdb_00001hit; pdb_00001hls; pdb_00001htv; pdb_00001hui; pdb_00001igl; pdb_00001imx; pdb_00001iog; pdb_00001ioh; pdb_00001iza; pdb_00001izb; pdb_00001j73; pdb_00001jca; pdb_00001jco; pdb_00001k3m; pdb_00001kmf; pdb_00001lkq; pdb_00001lph; pdb_00001m5a; pdb_00001mhi; pdb_00001mhj; pdb_00001mpj; pdb_00001mso; pdb_00001os3; pdb_00001os4; pdb_00001pid; pdb_00001pmx; pdb_00001q4v; pdb_00001qiy; pdb_00001qiz; pdb_00001qj0; pdb_00001rwe; pdb_00001sdb; pdb_00001sf1; pdb_00001sjt; pdb_00001sju; pdb_00001t1k; pdb_00001t1p; pdb_00001t1q; pdb_00001tgr; pdb_00001trz; pdb_00001tyl; pdb_00001tym; pdb_00001uz9; pdb_00001w8p; pdb_00001wav; pdb_00001wqj; pdb_00001xda; pdb_00001xgl; pdb_00001xw7; pdb_00001zeg; pdb_00001zeh; pdb_00001zei; pdb_00001zni; pdb_00001znj; pdb_00002a3g; pdb_00002aiy; pdb_00002bn1; pdb_00002bn3; pdb_00002c8q; pdb_00002c8r; pdb_00002ceu; pdb_00002dsp; pdb_00002dsq; pdb_00002dsr; pdb_00002efa; pdb_00002fhw; pdb_00002g4m; pdb_00002gf1; pdb_00002h67; pdb_00002h8b; pdb_00002hh4; pdb_00002hho; pdb_00002hiu; pdb_00002ins; pdb_00002jmn; pdb_00002jum; pdb_00002juu; pdb_00002juv; pdb_00002jv1; pdb_00002jzq; pdb_00002k1v; pdb_00002k6t; pdb_00002k6u; pdb_00002k91; pdb_00002k9r; pdb_00002kbc; pdb_00002kji; pdb_00002kjj; pdb_00002kju; pdb_00002kqp; pdb_00002kqq; pdb_00002kxk; pdb_00002l1y; pdb_00002l1z; pdb_00002l29; pdb_00002lgb; pdb_00002lwz; pdb_00002m1d; pdb_00002m1e; pdb_00002m2m; pdb_00002m2n; pdb_00002m2o; pdb_00002m2p; pdb_00002mli; pdb_00002mpg; pdb_00002mpi; pdb_00002mv1; pdb_00002mvc; pdb_00002mvd; pdb_00002n2v; pdb_00002n2w; pdb_00002n2x; pdb_00002oly; pdb_00002olz; pdb_00002om0; pdb_00002om1; pdb_00002omg; pdb_00002omh; pdb_00002omi; pdb_00002qiu; pdb_00002r34; pdb_00002r35; pdb_00002r36; pdb_00002rn5; pdb_00002tci; pdb_00002v5p; pdb_00002vjz; pdb_00002vk0; pdb_00002w44; pdb_00002wby; pdb_00002wc0; pdb_00002wfu; pdb_00002wfv; pdb_00002wru; pdb_00002wrv; pdb_00002wrw; pdb_00002wrx; pdb_00002ws0; pdb_00002ws1; pdb_00002ws4; pdb_00002ws6; pdb_00002ws7; pdb_00002zp6; pdb_00002zpp; pdb_00003aiy; pdb_00003bxq; pdb_00003e4z; pdb_00003e7y; pdb_00003e7z; pdb_00003exx; pdb_00003fhp; pdb_00003fq9; pdb_00003gf1; pdb_00003gky; pdb_00003i3z; pdb_00003i40; pdb_00003ilg; pdb_00003inc; pdb_00003ins; pdb_00003ir0; pdb_00003jsd; pdb_00003kq6; pdb_00003kr3; pdb_00003lri; pdb_00003mth; pdb_00003p2x; pdb_00003p33; pdb_00003q6e; pdb_00003rov; pdb_00003rto; pdb_00003t2a; pdb_00003tt8; pdb_00003u4n; pdb_00003v19; pdb_00003v1g; pdb_00003w11; pdb_00003w12; pdb_00003w13; pdb_00003w7y; pdb_00003w7z; pdb_00003w80; pdb_00003zi3; pdb_00003zqr; pdb_00003zs2; pdb_00003zu1; pdb_00004a7e; pdb_00004aiy; pdb_00004ajx; pdb_00004ajz; pdb_00004ak0; pdb_00004akj; pdb_00004bs3; pdb_00004cxl; pdb_00004cxn; pdb_00004cy7; pdb_00004e7t; pdb_00004e7u; pdb_00004e7v; pdb_00004efx; pdb_00004eww; pdb_00004ewx; pdb_00004ewz; pdb_00004ex0; pdb_00004ex1; pdb_00004exx; pdb_00004ey1; pdb_00004ey9; pdb_00004eyd; pdb_00004eyn; pdb_00004eyp; pdb_00004f0n; pdb_00004f0o; pdb_00004f1a; pdb_00004f1b; pdb_00004f1c; pdb_00004f1d; pdb_00004f1f; pdb_00004f1g; pdb_00004f4t; pdb_00004f4v; pdb_00004f51; pdb_00004f8f; pdb_00004fg3; pdb_00004fka; pdb_00004gbc; pdb_00004gbi; pdb_00004gbk; pdb_00004gbl; pdb_00004gbn; pdb_00004i5y; pdb_00004i5z; pdb_00004idw; pdb_00004ihn; pdb_00004ins; pdb_00004iuz; pdb_00004iyd; pdb_00004iyf; pdb_00004m4f; pdb_00004m4h; pdb_00004m4i; pdb_00004m4j; pdb_00004m4l; pdb_00004m4m; pdb_00004nib; pdb_00004oga; pdb_00004p65; pdb_00004rxw; pdb_00004une; pdb_00004ung; pdb_00004unh; pdb_00004xc4; pdb_00004xss; pdb_00005aiy; pdb_00005boq; pdb_00005bpo; pdb_00005bqq; pdb_00005bts; pdb_00005cjo; pdb_00005cny; pdb_00005co2; pdb_00005co6; pdb_00005co9; pdb_00005d52; pdb_00005d53; pdb_00005d54; pdb_00005d5e; pdb_00005e7w; pdb_00005ems; pdb_00005en9; pdb_00005ena; pdb_00005fb6; pdb_00005hpr; pdb_00005hpu; pdb_00005hqi; pdb_00005hrq; pdb_00005jyq; pdb_00005kqv; pdb_00005l3l; pdb_00005l3m; pdb_00005l3n; pdb_00005lis; pdb_00005mam; pdb_00005mhd; pdb_00005miz; pdb_00005mt3; pdb_00005mt9; pdb_00005mwq; pdb_00005u8q; pdb_00005udp; pdb_00005uoz; pdb_00005uqa; pdb_00005urt; pdb_00005uru; pdb_00005usp; pdb_00005uss; pdb_00005usv; pdb_00005uu2; pdb_00005uu3; pdb_00005uu4; pdb_00005viz; pdb_00005wbt; pdb_00005wdm; pdb_00005wob; pdb_00006b3q; pdb_00006b70; pdb_00006bfc; pdb_00006ce7; pdb_00006ce9; pdb_00006ceb; pdb_00006ck2; pdb_00006fey; pdb_00006ff3; pdb_00006gnq; pdb_00006gv0; pdb_00006hn5; pdb_00006ins; pdb_00006jk8; pdb_00006jr3; pdb_00006k59; pdb_00006kh8; pdb_00006kh9; pdb_00006kha; pdb_00006nwv; pdb_00006o17; pdb_00006or0; pdb_00006p4z; pdb_00006pyh; pdb_00006q8q; pdb_00006qq7; pdb_00006qqg; pdb_00006qrh; pdb_00006qrk; pdb_00006rlx; pdb_00006rva; pdb_00006s34; pdb_00006s4i; pdb_00006s4j; pdb_00006sof; pdb_00006tc2; pdb_00006tyh; pdb_00006u46; pdb_00006um2; pdb_00006vep; pdb_00006veq; pdb_00006ver; pdb_00006ves; pdb_00006vet; pdb_00006vwg; pdb_00006vwi; pdb_00006x4x; pdb_00006z7w; pdb_00006z7y; pdb_00006z7z; pdb_00006zhb; pdb_00006zi8; pdb_00007ac4; pdb_00007bw7; pdb_00007bw8; pdb_00007bwa; pdb_00007elj; pdb_00007ins; pdb_00007jp3; pdb_00007kd6; pdb_00007md4; pdb_00007md5; pdb_00007mqo; pdb_00007mqr; pdb_00007mqs; pdb_00007nhu; pdb_00007pg0; pdb_00007pg2; pdb_00007pg3; pdb_00007pg4; pdb_00007qac; pdb_00007qgf; pdb_00007qid; pdb_00007rkd; pdb_00007rze; pdb_00007rzf; pdb_00007rzi; pdb_00007s0q; pdb_00007s4y; pdb_00007sl1; pdb_00007sl2; pdb_00007sl3; pdb_00007sl4; pdb_00007sl6; pdb_00007sl7; pdb_00007sth; pdb_00007sti; pdb_00007stj; pdb_00007stk; pdb_00007u6e; pdb_00007v3p; pdb_00007wrq; pdb_00007yj4; pdb_00007yq3; pdb_00007yq4; pdb_00007yq5; pdb_00007yrr; pdb_00007z5l; pdb_00007z5q; pdb_00008cls; pdb_00008eyr; pdb_00008eyx; pdb_00008eyy; pdb_00008ez0; pdb_00008gsg; pdb_00008guy; pdb_00008hgz; pdb_00008hsf; pdb_00008hsk; pdb_00008ipz; pdb_00008oky; pdb_00008oni; pdb_00008onk; pdb_00008onp; pdb_00008onr; pdb_00008pi4; pdb_00008pi5; pdb_00008pi6; pdb_00008pjc; pdb_00008pjh; pdb_00008rrp; pdb_00008rvt; pdb_00008sbd; pdb_00008tk9; pdb_00008tkt; pdb_00008tku; pdb_00008u4c; pdb_00008u4e; pdb_00008vjb; pdb_00008vjc; pdb_00008wu0; pdb_00008x06; pdb_00008x2m; pdb_00008xjs; pdb_00008xk1; pdb_00008xkm; pdb_00008xkr; pdb_00008z4b; pdb_00009ins; pdb_00009lvc; pdb_00009lvd; pdb_00009lve; pdb_00009lvx; pdb_00009lvy; pdb_00009m4x; pdb_00009m4y; pdb_00009m4z; pdb_00009m50; pdb_00009m51
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