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PROSITE entry PS00338


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00338
Entry name [info] SOMATOTROPIN_2
Accession [info] PS00338
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00239

Name and characterization of the entry

Description [info] Somatotropin, prolactin and related hormones signature 2.
Pattern [info] 
C-[LIVMFY]-{PT}-x-D-[LIVMFYSTA]-x-{S}-{RK}-{A}-x-[LIVMFY]-x(2)-[LIVMFYT]-
x(2)-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 213 in 213 different sequences
Number of true positive hits 195 in 195 different sequences
Number of 'unknown' hits 0
Number of false positive hits 18 in 18 different sequences
Number of false negative sequences 22
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 91.55 %
Recall (true positives / (true positives + false negatives)) 89.86 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 1
Site [info] disulfide at position 16
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 195 sequences 

CSH1_BOVIN  (P09611), CSH1_HUMAN  (P0DML2), CSH2_BOVIN  (P19159), 

CSH2_HUMAN  (P0DML3), CSHL_HUMAN  (Q14406), CSH_SHEEP   (P16038), 
PLRP1_BOVIN (P05402), PLRP2_BOVIN (P12401), PLRP3_BOVIN (P12402), 
PLRP4_BOVIN (P18917), PR2C2_MOUSE (P04095), PR2C3_MOUSE (P04768), 
PR2C5_MOUSE (Q9JLV9), PR3B1_MESAU (P14059), PR3B1_MOUSE (P09586), 
PR3B1_RAT   (P09321), PR3D1_MOUSE (P18121), PR3D1_RAT   (P21702), 
PR3D4_RAT   (P34207), PR4A1_MOUSE (O35256), PR4A1_RAT   (P09320), 
PR7A1_MOUSE (O54830), PR7A2_MOUSE (O54831), PR7A2_RAT   (Q9R006), 
PR7C1_MOUSE (Q9CRB5), PR7D1_MOUSE (P04769), PR8A5_RAT   (P33579), 
PRL1_ONCKE  (P69130), PRL1_ONCTS  (P69131), PRL1_OREMO  (P09319), 
PRL2_ONCKE  (P09584), PRL2_ONCTS  (Q91364), PRL2_OREMO  (P09318), 
PRL_AILME   (Q8HXS1), PRL_ALEMO   (Q9QZL1), PRL_ANGAN   (P33096), 
PRL_ANGJA   (Q7ZZV3), PRL_BALBO   (P33089), PRL_BOVIN   (P01239), 
PRL_BUFJA   (P43001), PRL_CAMDR   (P22393), PRL_CAPHI   (Q28318), 
PRL_CARAU   (P87495), PRL_CEREL   (Q6UC74), PRL_CHEMY   (P33090), 
PRL_CHICK   (P14676), PRL_CORAU   (P34181), PRL_CYPCA   (P09585), 
PRL_DICLA   (P48249), PRL_FELCA   (P46403), PRL_HORSE   (P12420), 
PRL_HUMAN   (P01236), PRL_HYPMO   (P35395), PRL_HYPNO   (P29235), 
PRL_ICTPU   (P51904), PRL_ISOMA   (Q3Y4G6), PRL_LOXAF   (P10765), 
PRL_MACMU   (P55151), PRL_MELGA   (P17572), PRL_MESAU   (P37884), 
PRL_MONDO   (O62819), PRL_MOUSE   (P06879), PRL_NEOVI   (P29234), 
PRL_ONCMY   (P21993), PRL_PAROL   (Q9YGV6), PRL_PIG (P01238), 
PRL_PROAT   (P33091), PRL_RABIT   (Q28632), PRL_RAT (P01237), 
PRL_SALSA   (P48096), PRL_SHEEP   (P01240), PRL_SPAAU   (O93337), 
PRL_TRIVU   (O62781), SOM2_HUMAN  (P01242), SOM2_MACMU  (Q07370), 
SOM2_PANTR  (P58757), SOMA1_ACIGU (P26773), SOMA1_CARAU (O93359), 
SOMA1_ONCMY (P09538), SOMA1_ONCNE (Q91222), SOMA1_XENLA (P12855), 
SOMA2_ACIGU (P26774), SOMA2_CARAU (O93360), SOMA2_ONCMY (P20332), 
SOMA2_ONCNE (Q91221), SOMA2_XENLA (P12856), SOMA_ACABU  (Q01282), 
SOMA_ACALA  (P45654), SOMA_AILME  (Q8HYE5), SOMA_ANAPL  (P11228), 
SOMA_ANGJA  (P08899), SOMA_AQUCT  (P10813), SOMA_BALBO  (P33092), 
SOMA_BALPH  (Q659Q8), SOMA_BOSGF  (Q1HFN3), SOMA_BOSMU  (Q864S7), 
SOMA_BOVIN  (P01246), SOMA_BUBBU  (O18938), SOMA_CALJA  (Q9GMB3), 
SOMA_CAMDR  (Q7YRR6), SOMA_CANLF  (P33711), SOMA_CAPHI  (P67931), 
SOMA_CAVPO  (Q9JKM4), SOMA_CEREL  (P56437), SOMA_CHEMY  (P34005), 
SOMA_CHICK  (P08998), SOMA_CORAU  (P45655), SOMA_CORLV  (O13188), 
SOMA_CRONO  (P55755), SOMA_CTEID  (P69158), SOMA_CYPCA  (P10298), 
SOMA_DELDE  (Q8MI73), SOMA_DICLA  (Q05163), SOMA_ESOLU  (P34744), 
SOMA_FELCA  (P46404), SOMA_GALSE  (Q9GKA1), SOMA_GIRCA  (Q7YQD2), 
SOMA_HETFO  (Q9W6R8), SOMA_HIPAM  (Q7YQB8), SOMA_HORSE  (P01245), 
SOMA_HUMAN  (P01241), SOMA_HYPMO  (P69159), SOMA_HYPNO  (P69160), 
SOMA_ICTPU  (P34745), SOMA_KATPE  (P20391), SOMA_LABRO  (Q9W6J7), 
SOMA_LARCR  (Q9I9M4), SOMA_LATCA  (Q01283), SOMA_LEPOS  (P79885), 
SOMA_LOXAF  (P20392), SOMA_MACMU  (P33093), SOMA_MELGA  (P22077), 
SOMA_MESAU  (P37886), SOMA_MISMI  (Q9W6J5), SOMA_MONDO  (Q9GL60), 
SOMA_MORSA  (P48248), SOMA_MOUSE  (P06880), SOMA_NEOVI  (P19795), 
SOMA_ODOAR  (Q9I9L5), SOMA_ONCKE  (P07064), SOMA_ONCKI  (P10607), 
SOMA_ONCMA  (Q9DGG5), SOMA_ONCTS  (Q07221), SOMA_OREMO  (P34746), 
SOMA_ORENI  (P13391), SOMA_PAGMA  (P08591), SOMA_PANGG  (P69162), 
SOMA_PANPG  (P69161), SOMA_PANTR  (P58756), SOMA_PAROL  (P09537), 
SOMA_PERFV  (Q9DEV3), SOMA_PIG(P01248), SOMA_PRIGL  (P34006), 
SOMA_PROAN  (O73848), SOMA_PSEDN  (P24363), SOMA_RABIT  (P46407), 
SOMA_RAT(P01244), SOMA_RHIMB  (O73849), SOMA_SAIBB  (P58343), 
SOMA_SALSA  (P10814), SOMA_SCIOC  (Q9IB11), SOMA_SEBSC  (P87391), 
SOMA_SERQU  (P09539), SOMA_SHEEP  (P67930), SOMA_SIGGU  (Q9IBE5), 
SOMA_SOLSE  (P45643), SOMA_SPAAU  (P29971), SOMA_SPAEH  (O70615), 
SOMA_STRCA  (Q9PWG3), SOMA_TAKRU  (O12980), SOMA_THUAL  (P34747), 
SOMA_THUTH  (P09113), SOMA_TRITC  (Q98UF6), SOMA_TRIVU  (O62754), 
SOMA_VERVA  (O93566), SOMA_VICPA  (P37885), SOMA_VULVU  (P10766), 
SOMA_XANPY  (Q9GMB2), SOML1_SPAAU (P54863), SOML2_SPAAU (P79894), 
SOML_ACITR  (O93262), SOML_ANGAN  (Q90216), SOML_CARAU  (P79697), 
SOML_CYCLU  (P45640), SOML_GADMO  (P21919), SOML_HIPHI  (P45641), 
SOML_ICTPU  (Q9I8J9), SOML_ONCKE  (P24405), SOML_ORYLA  (Q6E211), 
SOML_PAROL  (P20362), SOML_PROAN  (O73847), SOML_SCIOC  (Q9YGK7), 
SOML_SIGGU  (Q9PWG4), SOML_SOLSE  (P45642), SOML_TETMU  (Q9I9H4)
» more

UniProtKB/Swiss-Prot
False negative sequences		 22 sequences 

PR2A1_MOUSE (Q9JHK0), PR2A1_RAT   (Q9JII3), PR2B1_MOUSE (Q9DAZ2), 

PR2B1_RAT   (Q9JKL9), PR3C1_MOUSE (Q9QUN5), PR3C1_RAT   (Q9QUL0), 
PR5A1_MOUSE (Q9JII2), PR5A1_RAT   (Q9JII4), PR6A1_MOUSE (O35257), 
PR6A1_RAT   (P24800), PR7B1_MOUSE (Q8CGZ9), PR7B1_RAT   (Q8CJ42), 
PR8A4_RAT   (P33580), PR8A6_MOUSE (Q9DAY2), PR8A7_RAT   (P33578), 
PR8A8_MOUSE (Q9DAS4), PR8A9_MOUSE (Q9CQ58), PR8A9_RAT   (Q920I0), 
PRL1_ALLMI  (P55751), PRL1_CRONO  (P55753), PRL2_ALLMI  (P55752), 
PRL2_CRONO  (P55754)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

GHR4_RAT(P33581)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			18 sequences
			


			
ALA2_ARATH  (P98205), CD3E_PIG(Q7YRN2), ENV_FFV (O56861), 

			
ENV_HV2EH   (Q89607), ENV_HV2UC   (Q76638), ENV_SFV1(P23073), 
ENV_SFV3L   (P27399), GRT1A_DANRE (Q6PBU5), GRTP1_HUMAN (Q5TC63), 
GRTP1_MOUSE (Q9D3N8), GRTP1_RAT   (Q4QQU7), GRTP1_XENLA (Q6GLZ0), 
GRTP1_XENTR (Q6GL87), ODB2_CAEEL  (Q23571), PP341_ARATH (Q9SUH6), 
ZFHX4_CHICK (O73590), ZFHX4_HUMAN (Q86UP3), ZFHX4_MOUSE (Q9JJN2)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			22 PDB
			


			1A22; 1BP3; 1F6F; 1HGU; 1HUW; 1HWG; 1HWH; 1KF9; 1RW5; 1Z7C; 2Q98; 3D48; 
			
				3EW3; 3HHR; 3MZG; 3N06; 3N0P; 3NCB; 3NCC; 3NCE; 3NCF; 3NPZ
			
			

			» more