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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00338


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PURL: https://purl.expasy.org/prosite/signature/PS00338

Direct ScanProsite submission
General information about the entry

Entry name [info] SOMATOTROPIN_2
Accession [info] PS00338
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00239

Name and characterization of the entry

Description [info] Somatotropin, prolactin and related hormones signature 2.
Pattern [info] 
C-[LIVMFY]-{PT}-x-D-[LIVMFYSTA]-x-{S}-{RK}-{A}-x-[LIVMFY]-x(2)-[LIVMFYT]-
x(2)-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 213 in 213 different sequences
Number of true positive hits 195 in 195 different sequences
Number of 'unknown' hits 0
Number of false positive hits 18 in 18 different sequences
Number of false negative sequences 22
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 91.55 %
Recall (true positives / (true positives + false negatives)) 89.86 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 1
Site [info] disulfide at position 16
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 195 sequences 

CSH1_BOVIN  (P09611), CSH1_HUMAN  (P0DML2), CSH2_BOVIN  (P19159), 

CSH2_HUMAN  (P0DML3), CSHL_HUMAN  (Q14406), CSH_SHEEP   (P16038), 
PLRP1_BOVIN (P05402), PLRP2_BOVIN (P12401), PLRP3_BOVIN (P12402), 
PLRP4_BOVIN (P18917), PR2C2_MOUSE (P04095), PR2C3_MOUSE (P04768), 
PR2C5_MOUSE (Q9JLV9), PR3B1_MESAU (P14059), PR3B1_MOUSE (P09586), 
PR3B1_RAT   (P09321), PR3D1_MOUSE (P18121), PR3D1_RAT   (P21702), 
PR3D4_RAT   (P34207), PR4A1_MOUSE (O35256), PR4A1_RAT   (P09320), 
PR7A1_MOUSE (O54830), PR7A2_MOUSE (O54831), PR7A2_RAT   (Q9R006), 
PR7C1_MOUSE (Q9CRB5), PR7D1_MOUSE (P04769), PR8A5_RAT   (P33579), 
PRL1_ONCKE  (P69130), PRL1_ONCTS  (P69131), PRL1_OREMO  (P09319), 
PRL2_ONCKE  (P09584), PRL2_ONCTS  (Q91364), PRL2_OREMO  (P09318), 
PRL_AILME   (Q8HXS1), PRL_ALEMO   (Q9QZL1), PRL_ANGAN   (P33096), 
PRL_ANGJA   (Q7ZZV3), PRL_BALBO   (P33089), PRL_BOVIN   (P01239), 
PRL_BUFJA   (P43001), PRL_CAMDR   (P22393), PRL_CAPHI   (Q28318), 
PRL_CARAU   (P87495), PRL_CEREL   (Q6UC74), PRL_CHEMY   (P33090), 
PRL_CHICK   (P14676), PRL_CORAU   (P34181), PRL_CYPCA   (P09585), 
PRL_DICLA   (P48249), PRL_FELCA   (P46403), PRL_HORSE   (P12420), 
PRL_HUMAN   (P01236), PRL_HYPMO   (P35395), PRL_HYPNO   (P29235), 
PRL_ICTPU   (P51904), PRL_ISOMA   (Q3Y4G6), PRL_LOXAF   (P10765), 
PRL_MACMU   (P55151), PRL_MELGA   (P17572), PRL_MESAU   (P37884), 
PRL_MONDO   (O62819), PRL_MOUSE   (P06879), PRL_NEOVI   (P29234), 
PRL_ONCMY   (P21993), PRL_PAROL   (Q9YGV6), PRL_PIG (P01238), 
PRL_PROAT   (P33091), PRL_RABIT   (Q28632), PRL_RAT (P01237), 
PRL_SALSA   (P48096), PRL_SHEEP   (P01240), PRL_SPAAU   (O93337), 
PRL_TRIVU   (O62781), SOM2_HUMAN  (P01242), SOM2_MACMU  (Q07370), 
SOM2_PANTR  (P58757), SOMA1_ACIGU (P26773), SOMA1_CARAU (O93359), 
SOMA1_ONCMY (P09538), SOMA1_ONCNE (Q91222), SOMA1_XENLA (P12855), 
SOMA2_ACIGU (P26774), SOMA2_CARAU (O93360), SOMA2_ONCMY (P20332), 
SOMA2_ONCNE (Q91221), SOMA2_XENLA (P12856), SOMA_ACABU  (Q01282), 
SOMA_ACALA  (P45654), SOMA_AILME  (Q8HYE5), SOMA_ANAPL  (P11228), 
SOMA_ANGJA  (P08899), SOMA_AQUCT  (P10813), SOMA_BALBO  (P33092), 
SOMA_BALPH  (Q659Q8), SOMA_BOSGF  (Q1HFN3), SOMA_BOSMU  (Q864S7), 
SOMA_BOVIN  (P01246), SOMA_BUBBU  (O18938), SOMA_CALJA  (Q9GMB3), 
SOMA_CAMDR  (Q7YRR6), SOMA_CANLF  (P33711), SOMA_CAPHI  (P67931), 
SOMA_CAVPO  (Q9JKM4), SOMA_CEREL  (P56437), SOMA_CHEMY  (P34005), 
SOMA_CHICK  (P08998), SOMA_CORAU  (P45655), SOMA_CORLV  (O13188), 
SOMA_CRONO  (P55755), SOMA_CTEID  (P69158), SOMA_CYPCA  (P10298), 
SOMA_DELDE  (Q8MI73), SOMA_DICLA  (Q05163), SOMA_ESOLU  (P34744), 
SOMA_FELCA  (P46404), SOMA_GALSE  (Q9GKA1), SOMA_GIRCA  (Q7YQD2), 
SOMA_HETFO  (Q9W6R8), SOMA_HIPAM  (Q7YQB8), SOMA_HORSE  (P01245), 
SOMA_HUMAN  (P01241), SOMA_HYPMO  (P69159), SOMA_HYPNO  (P69160), 
SOMA_ICTPU  (P34745), SOMA_KATPE  (P20391), SOMA_LABRO  (Q9W6J7), 
SOMA_LARCR  (Q9I9M4), SOMA_LATCA  (Q01283), SOMA_LEPOS  (P79885), 
SOMA_LOXAF  (P20392), SOMA_MACMU  (P33093), SOMA_MELGA  (P22077), 
SOMA_MESAU  (P37886), SOMA_MISMI  (Q9W6J5), SOMA_MONDO  (Q9GL60), 
SOMA_MORSA  (P48248), SOMA_MOUSE  (P06880), SOMA_NEOVI  (P19795), 
SOMA_ODOAR  (Q9I9L5), SOMA_ONCKE  (P07064), SOMA_ONCKI  (P10607), 
SOMA_ONCMA  (Q9DGG5), SOMA_ONCTS  (Q07221), SOMA_OREMO  (P34746), 
SOMA_ORENI  (P13391), SOMA_PAGMA  (P08591), SOMA_PANGG  (P69162), 
SOMA_PANPG  (P69161), SOMA_PANTR  (P58756), SOMA_PAROL  (P09537), 
SOMA_PERFV  (Q9DEV3), SOMA_PIG(P01248), SOMA_PRIGL  (P34006), 
SOMA_PROAN  (O73848), SOMA_PSEDN  (P24363), SOMA_RABIT  (P46407), 
SOMA_RAT(P01244), SOMA_RHIMB  (O73849), SOMA_SAIBB  (P58343), 
SOMA_SALSA  (P10814), SOMA_SCIOC  (Q9IB11), SOMA_SEBSC  (P87391), 
SOMA_SERQU  (P09539), SOMA_SHEEP  (P67930), SOMA_SIGGU  (Q9IBE5), 
SOMA_SOLSE  (P45643), SOMA_SPAAU  (P29971), SOMA_SPAEH  (O70615), 
SOMA_STRCA  (Q9PWG3), SOMA_TAKRU  (O12980), SOMA_THUAL  (P34747), 
SOMA_THUTH  (P09113), SOMA_TRITC  (Q98UF6), SOMA_TRIVU  (O62754), 
SOMA_VERVA  (O93566), SOMA_VICPA  (P37885), SOMA_VULVU  (P10766), 
SOMA_XANPY  (Q9GMB2), SOML1_SPAAU (P54863), SOML2_SPAAU (P79894), 
SOML_ACITR  (O93262), SOML_ANGAN  (Q90216), SOML_CARAU  (P79697), 
SOML_CYCLU  (P45640), SOML_GADMO  (P21919), SOML_HIPHI  (P45641), 
SOML_ICTPU  (Q9I8J9), SOML_ONCKE  (P24405), SOML_ORYLA  (Q6E211), 
SOML_PAROL  (P20362), SOML_PROAN  (O73847), SOML_SCIOC  (Q9YGK7), 
SOML_SIGGU  (Q9PWG4), SOML_SOLSE  (P45642), SOML_TETMU  (Q9I9H4)
» more

UniProtKB/Swiss-Prot
False negative sequences		 22 sequences 

PR2A1_MOUSE (Q9JHK0), PR2A1_RAT   (Q9JII3), PR2B1_MOUSE (Q9DAZ2), 

PR2B1_RAT   (Q9JKL9), PR3C1_MOUSE (Q9QUN5), PR3C1_RAT   (Q9QUL0), 
PR5A1_MOUSE (Q9JII2), PR5A1_RAT   (Q9JII4), PR6A1_MOUSE (O35257), 
PR6A1_RAT   (P24800), PR7B1_MOUSE (Q8CGZ9), PR7B1_RAT   (Q8CJ42), 
PR8A4_RAT   (P33580), PR8A6_MOUSE (Q9DAY2), PR8A7_RAT   (P33578), 
PR8A8_MOUSE (Q9DAS4), PR8A9_MOUSE (Q9CQ58), PR8A9_RAT   (Q920I0), 
PRL1_ALLMI  (P55751), PRL1_CRONO  (P55753), PRL2_ALLMI  (P55752), 
PRL2_CRONO  (P55754)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

GHR4_RAT(P33581)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			18 sequences
			


			
ALA2_ARATH  (P98205), CD3E_PIG(Q7YRN2), ENV_FFV (O56861), 

			
ENV_HV2EH   (Q89607), ENV_HV2UC   (Q76638), ENV_SFV1(P23073), 
ENV_SFV3L   (P27399), GRT1A_DANRE (Q6PBU5), GRTP1_HUMAN (Q5TC63), 
GRTP1_MOUSE (Q9D3N8), GRTP1_RAT   (Q4QQU7), GRTP1_XENLA (Q6GLZ0), 
GRTP1_XENTR (Q6GL87), ODB2_CAEEL  (Q23571), PP341_ARATH (Q9SUH6), 
ZFHX4_CHICK (O73590), ZFHX4_HUMAN (Q86UP3), ZFHX4_MOUSE (Q9JJN2)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			22 PDB
			


			pdb_00001a22; pdb_00001bp3; pdb_00001f6f; pdb_00001hgu; pdb_00001huw; pdb_00001hwg; pdb_00001hwh; pdb_00001kf9; pdb_00001rw5; pdb_00001z7c; pdb_00002q98; pdb_00003d48; 
			
				pdb_00003ew3; pdb_00003hhr; pdb_00003mzg; pdb_00003n06; pdb_00003n0p; pdb_00003ncb; pdb_00003ncc; pdb_00003nce; pdb_00003ncf; pdb_00003npz
			
			

			» more