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PROSITE documentation PDOC00239 |
The hormone somatotropin (growth hormone, GH) which plays an important role in growth control, choriomammotropin (lactogen), a placental analog of GH; and prolactin which acts primarily on the mammary gland by promoting lactation, have been shown [1] to be homologous. This family of proteins also includes other hormones listed below (references are only provided for recently determined sequences).
The schematic representation of the structure of proteins belonging to this family is shown below.
<----------------180-to-210-residues-------------> *** ***** xxxxxxxxxxxxxCxxxxxxxxxxxxxxxxxxxxxxxxxxxxCxxxCxxC | | | | +----------------------------+ +--+
'C': conserved cysteine involved in a disulfide bond. '*': position of the patterns.
We developed two signature patterns for this family of proteins, both patterns include cysteines involved in conserved disulfide bonds.
Last update:April 2006 / Pattern revised.
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PROSITE methods (with tools and information) covered by this documentation:
1 | Authors | Wallis M. |
Title | Episodic evolution of protein hormones in mammals. | |
Source | J. Mol. Evol. 53:10-18(2001). | |
PubMed ID | 11683318 |
2 | Authors | Connor A.M. Waterhouse P. Khokha R. Denhardt D.T. |
Title | Characterization of a mouse mitogen-regulated protein/proliferin gene and its promoter: a member of the growth hormone/prolactin gene superfamily. | |
Source | Biochim. Biophys. Acta 1009:75-82(1989). | |
PubMed ID | 2790033 |
3 | Authors | Kessler M.A. Milosavljevic M. Zieler C.G. Schuler L.A. |
Title | A subfamily of bovine prolactin-related transcripts distinct from placental lactogen in the fetal placenta. | |
Source | Biochemistry 28:5154-5161(1989). | |
PubMed ID | 2765528 |
4 | Authors | Rand-Weaver M. Noso T. Muramoto K. Kawauchi H. |
Source | Biochemistry 30:1509-1515(1991). |