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PROSITE entry PS00374


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00374
Entry name [info] MGMT
Accession [info] PS00374
Entry type [info] PATTERN
Date [info] 01-NOV-1990 CREATED;
01-NOV-1990 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00320
Associated ProRule [info] PRU10017

Name and characterization of the entry

Description [info] Methylated-DNA--protein-cysteine methyltransferase active site.
Pattern [info] 
[LIVMF]-P-C-H-R-[LIVMF](2).

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 67 in 67 different sequences
Number of true positive hits 53 in 53 different sequences
Number of 'unknown' hits 0
Number of false positive hits 14 in 14 different sequences
Number of false negative sequences 2
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 79.10 %
Recall (true positives / (true positives + false negatives)) 96.36 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 3
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 53 sequences 

ADAB_BACSU  (P19220), ADA_ECOLI   (P06134), ADA_SALTY   (P26189), 

MGMT_CANAL  (Q5A0Y8), MGMT_CANGA  (Q6FNR0), MGMT_CANLF  (Q6TDU1), 
MGMT_CRIGR  (P26186), MGMT_HUMAN  (P16455), MGMT_KLULA  (Q6CPW2), 
MGMT_LODEL  (A5E7M8), MGMT_MIMIV  (Q5UNU9), MGMT_MOUSE  (P26187), 
MGMT_PICST  (A3LZM4), MGMT_RAT(P24528), MGMT_YEAS7  (A6ZXD3), 
MGMT_YEAST  (P26188), OGT_ARCFU   (O27970), OGT_BACSU   (P11742), 
OGT_ECOLI   (P0AFH0), OGT_HAEIN   (P44687), OGT_METAC   (Q8TI34), 
OGT_METBF   (Q46EW4), OGT_METJA   (Q58924), OGT_METMA   (Q8PY44), 
OGT_METS5   (A4YH39), OGT_METTH   (O26715), OGT_METVM   (C9RE37), 
OGT_MYCBO   (P0A697), OGT_MYCLE   (P52982), OGT_MYCPA   (Q9ZET8), 
OGT_MYCTO   (P9WJW4), OGT_MYCTU   (P9WJW5), OGT_PYRAB   (Q9V1N7), 
OGT_PYRAE   (O93728), OGT_PYRFU   (Q8TZV2), OGT_PYRHO   (O59499), 
OGT_PYRSN   (F4HK38), OGT_SACS2   (Q97VW7), OGT_SALTI   (P0A2U1), 
OGT_SALTY   (P0A2U0), OGT_SHIFL   (P0AFH1), OGT_SULAC   (Q4J9C6), 
OGT_SULIA   (C3N1B4), OGT_SULIK   (C4KKV8), OGT_SULIL   (C3MKT6), 
OGT_SULIM   (C3MUC6), OGT_SULIN   (C3NMY2), OGT_SULIY   (C3N9B4), 
OGT_SULTO   (Q973C7), OGT_THEBM   (F0LIT8), OGT_THEGJ   (C5A3L5), 
OGT_THEKO   (O74023), OGT_THESM   (C6A382)
» more

UniProtKB/Swiss-Prot
False negative sequences		 2 sequences 

ATL1_SCHPO  (Q9UTN9), OGT_METKA   (Q8TZ11)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			1 sequence
			


			
MGMT_BOVIN  (P29177)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			14 sequences
			


			
CFA65_HUMAN (Q6ZU64), KBTBC_HUMAN (Q3ZCT8), KBTBC_MOUSE (Q9D618), 

			
KL40A_DANRE (B3DIV9), KL40B_DANRE (E9QJ30), KL41A_DANRE (E9QIN8), 
KL41B_DANRE (F1QEG2), KLH40_HUMAN (Q2TBA0), KLH40_MOUSE (Q9D783), 
KLH40_XENLA (Q5U504), KLH40_XENTR (Q5EB39), KLH41_HUMAN (O60662), 
KLH41_MOUSE (A2AUC9), KLH41_RAT   (Q9ER30)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			26 PDB
			


			1EH6; 1EH7; 1EH8; 1MGT; 1QNT; 1SFE; 1T39; 1WRJ; 1YFH; 2G7H; 4BHB; 4BHC; 
			
				4WX9; 4WXC; 4WXD; 4ZYE; 4ZYG; 6GA0; 7DKN; 7DQR; 7DQT; 8AES; 8RGG; 8RGH; 
				8RTY; 8RU2
			
			

			» more