ProRule PRU10017

General rule information [?]

Accession PRU10017
Dates 16-OCT-2006 (Created)
22-NOV-2019 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS00374; MGMT
Name Methylated-DNA--protein-cysteine methyltransferase active site
Function Undefined
Scope(s) Eukaryota
Example(s) Q4J9C6 (OGT_SULAC);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + AltName: Full=Methylated-DNA--[protein]-cysteine S-methyltransferase;

Comments [?]

CATALYTIC ACTIVITY Reaction=a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:24000, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:10132, Rhea:RHEA-COMP:11367, Rhea:RHEA-COMP:11368, ChEBI:CHEBI:29950, ChEBI:CHEBI:82612, ChEBI:CHEBI:85445, ChEBI:CHEBI:85448; EC=;
CATALYTIC ACTIVITY Reaction=a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:53428, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:10132, Rhea:RHEA-COMP:13555, Rhea:RHEA-COMP:13556, ChEBI:CHEBI:29950, ChEBI:CHEBI:82612, ChEBI:CHEBI:137386, ChEBI:CHEBI:137387; EC=;

Features [?]

From: PS00374
Key From To Description Tag Condition FTGroup
ACT_SITE 3 3 /note="Nucleophile; methyl group acceptor"

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]