ProRule PRU10017
General rule information
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| Accession | PRU10017 |
| Dates | 16-OCT-2006 (Created)
3-SEP-2024 (Last updated, Version 7) |
| Data class | Domain; |
| Predictors |
PROSITE; PS00374; MGMT |
Name | Methylated-DNA--protein-cysteine methyltransferase active site |
| Function | Undefined |
| Scope(s) |
Eukaryota Bacteria Archaea Viruses |
| Example(s) | Q4J9C6 (OGT_SULAC); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + AltName: Full=Methylated-DNA--[protein]-cysteine S-methyltransferase; EC=2.1.1.63; |
Comments
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| CATALYTIC ACTIVITY | Reaction=a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA; Xref=Rhea:RHEA:24000, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:10132, Rhea:RHEA-COMP:11367, Rhea:RHEA-COMP:11368, ChEBI:CHEBI:29950, ChEBI:CHEBI:82612, ChEBI:CHEBI:85445, ChEBI:CHEBI:85448; EC=2.1.1.63; |
| CATALYTIC ACTIVITY | Reaction=a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:53428, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:10132, Rhea:RHEA-COMP:13555, Rhea:RHEA-COMP:13556, ChEBI:CHEBI:29950, ChEBI:CHEBI:82612, ChEBI:CHEBI:137386, ChEBI:CHEBI:137387; EC=2.1.1.63; |
Features
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| From: PS00374 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 3 | 3 | /note="Nucleophile; methyl group acceptor" | |||||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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