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annotation rule: PRU10017

General rule information [?]

Accession PRU10017
Dates 16-OCT-2006 (Created)
27-OCT-2018 (Last updated, Version 5)
Data class Domain
Predictors PROSITE; PS00374; MGMT
Name Methylated-DNA--protein-cysteine methyltransferase active site
Function Undefined.

Propagated annotation [?]


Description [?]

+ AltName: Full=Methylated-DNA--[protein]-cysteine S-methyltransferase; EC=2.1.1.63;

Comments [?]

Catalytic activity Reaction=a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl- [protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl- [protein]; Xref=Rhea:RHEA:24000, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:10132, Rhea:RHEA-COMP:11367, Rhea:RHEA- COMP:11368, ChEBI:CHEBI:29950, ChEBI:CHEBI:82612, ChEBI:CHEBI:85445, ChEBI:CHEBI:85448; EC=2.1.1.63;.
Reaction=a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:53428, Rhea:RHEA-COMP:10131, Rhea:RHEA- COMP:10132, Rhea:RHEA-COMP:13555, Rhea:RHEA-COMP:13556, ChEBI:CHEBI:29950, ChEBI:CHEBI:82612, ChEBI:CHEBI:137386, ChEBI:CHEBI:137387; EC=2.1.1.63;.

Features [?]

From: PS00374
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     3     3       Nucleophile; methyl group acceptor        

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q4J9C6 (OGT_SULAC)
Scope
Eukaryota
Bacteria
Archaea
Viruses

Copyright

PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: prosite_license.html.



UniProtKB rule member sequences [?]