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PROSITE entry PS00396


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00396
Entry name [info] TOPO_IA_1
Accession [info] PS00396
Entry type [info] PATTERN
Date [info] 01-NOV-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00333
Associated ProRule [info] PRU10131

Name and characterization of the entry

Description [info] Topoisomerase (Topo) IA-type active site signature.
Pattern [info] 
[EQ]-x-L-Y-[DEQSTLM]-x(3,12)-[LIVST]-[ST]-Y-x-R-[ST]-[DEQSN].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 109 in 109 different sequences
Number of true positive hits 108 in 108 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 0
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 99.08 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 9
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 108 sequences 

TOP1P_MIMIV (Q5UQB5), TOP1P_XYLFA (Q9PHK2), TOP1_AERPE  (Q9YB01), 

TOP1_ALKPO  (P34184), TOP1_AQUAE  (O66893), TOP1_ARCFU  (O28469), 
TOP1_BACAN  (P40114), TOP1_BACSU  (P39814), TOP1_BORBU  (O51768), 
TOP1_BUCAI  (P57371), TOP1_BUCAP  (Q8K9P7), TOP1_CAMJE  (Q9PLZ2), 
TOP1_ECOLI  (P06612), TOP1_FERIS  (O34204), TOP1_HAEIN  (P43012), 
TOP1_HALH5  (Q9KA23), TOP1_HELPJ  (Q9ZMV7), TOP1_HELPY  (P55991), 
TOP1_LACLA  (Q9CG80), TOP1_METJA  (Q59046), TOP1_METTH  (O27661), 
TOP1_MYCBO  (P0A621), TOP1_MYCGA  (Q9JN65), TOP1_MYCGE  (P47368), 
TOP1_MYCLE  (O69548), TOP1_MYCPN  (P78032), TOP1_MYCS2  (A0R5D9), 
TOP1_MYCTA  (A5U8X0), TOP1_MYCTO  (P9WG48), TOP1_MYCTU  (P9WG49), 
TOP1_PASMU  (Q9CN30), TOP1_PSEAE  (Q9HZJ5), TOP1_PYRAB  (Q9UYS8), 
TOP1_PYRHO  (O58356), TOP1_RICBR  (Q1RIM1), TOP1_RICCN  (Q92IH1), 
TOP1_RICFE  (Q4UM42), TOP1_RICPR  (Q9ZDK2), TOP1_RICTY  (Q68X45), 
TOP1_SALTI  (P0A2I2), TOP1_SALTY  (P0A2I1), TOP1_STAA3  (Q2FHI8), 
TOP1_STAA8  (Q2FZ32), TOP1_STAAB  (Q2YXL8), TOP1_STAAC  (Q5HGI2), 
TOP1_STAAM  (Q99UM1), TOP1_STAAN  (Q7A5Y5), TOP1_STAAR  (Q6GHI5), 
TOP1_STAAS  (Q6G9W3), TOP1_STAAU  (Q06AK7), TOP1_STAAW  (Q8NWZ9), 
TOP1_STAEQ  (Q5HPU2), TOP1_STAES  (Q8CSU3), TOP1_STAHJ  (Q4L5V2), 
TOP1_STAS1  (Q49X35), TOP1_STRCO  (Q9X909), TOP1_SYNE7  (P34185), 
TOP1_SYNY3  (P73810), TOP1_THEAC  (Q9HM08), TOP1_THEMA  (P46799), 
TOP1_TREPA  (O83409), TOP1_VIBCH  (Q9KRB2), TOP1_XYLFA  (Q9PEV8), 
TOP1_XYLFT  (Q87AQ6), TOP1_ZYMMO  (Q9X3X7), TOP3A_ARATH (Q9LVP1), 
TOP3A_DROME (Q9NG98), TOP3A_HUMAN (Q13472), TOP3A_MOUSE (O70157), 
TOP3A_ORYSJ (C7J0A2), TOP3B_ARATH (F4ISQ7), TOP3B_DROME (O96651), 
TOP3B_HUMAN (O95985), TOP3B_MOUSE (Q9Z321), TOP3B_ORYSJ (Q0J0S6), 
TOP3_BACAH  (A0R979), TOP3_BACAN  (Q81Z97), TOP3_BACC1  (Q73E74), 
TOP3_BACCR  (Q81IH1), TOP3_BACCZ  (Q63GK5), TOP3_BACHK  (Q6HP19), 
TOP3_BACLD  (Q65N90), TOP3_BACSU  (P96583), TOP3_CAEEL  (O61660), 
TOP3_CANAR  (A0A0L0P6P7), TOP3_DICDI  (Q8T2T7), TOP3_ECOLI  (P14294), 
TOP3_HAEIN  (P43704), TOP3_PASMU  (Q9CP53), TOP3_SALTI  (Q8Z6F5), 
TOP3_SALTY  (P40687), TOP3_SCHPO  (O60126), TOP3_SHOC1  (Q5WAX6), 
TOP3_STAA3  (Q2FEN5), TOP3_STAA8  (Q2FW03), TOP3_STAAB  (P0C2W6), 
TOP3_STAAC  (Q5HDV4), TOP3_STAAM  (Q99S17), TOP3_STAAN  (Q7A455), 
TOP3_STAAR  (Q6GEH9), TOP3_STAAS  (Q6G767), TOP3_STAAW  (Q7A075), 
TOP3_STAEQ  (Q5HLZ4), TOP3_STAES  (Q8CRF7), TOP3_STAHJ  (Q4L8B8), 
TOP3_STAS1  (Q49ZH2), TOP3_VIBCH  (Q9KQF5), TOP3_YEAST  (P13099)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

TOP1_KLEAE  (P46155)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			1 sequence
			


			
SYSM_SCHPO  (Q9UTB2)


				
	

	

		PDB
[Detailed view]		
		
			37 PDB
			


			1CY0; 1CY1; 1CY2; 1CY4; 1CY6; 1CY7; 1CY8; 1CY9; 1CYY; 1D6M; 1ECL; 1MW8; 
			
				1MW9; 2GAI; 2GAJ; 2O19; 2O54; 2O59; 2O5C; 2O5E; 3PWT; 3PX7; 4CGY; 4CHT; 
				4RUL; 5D5H; 5GVC; 5GVE; 5UJ1; 5UJY; 6CQ2; 6CQI; 6PCM; 8CZQ; 8TFG; 9CA0; 
				9CA1
			
			

			» more