PROSITE entry PS00396
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General information about the entry
| Entry name [info] | TOPOISOMERASE_I_PROK |
| Accession [info] | PS00396 |
| Entry type [info] | PATTERN |
| Date [info] |
01-NOV-1990 CREATED;
01-DEC-2004 DATA UPDATE; 08-NOV-2023 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00333 |
| Associated ProRule [info] | PRU10131 |
Name and characterization of the entry
| Description [info] | Prokaryotic DNA topoisomerase I active site. |
| Pattern [info] |
[EQ]-x-L-Y-[DEQSTLM]-x(3,12)-[LIVST]-[ST]-Y-x-R-[ST]-[DEQSN]. |
Numerical results [info]
| Total number of hits | 109 in 109 different sequences |
| Number of true positive hits | 108 in 108 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 1 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 1 |
| Precision (true positives / (true positives + false positives)) | 99.08 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses |
| Maximum number of repetitions [info] | 1 |
| Site [info] | active_site at position 9 |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
108 sequences
TOP1P_MIMIV (Q5UQB5), TOP1P_XYLFA (Q9PHK2), TOP1_AERPE (Q9YB01), TOP1_ALKPO (P34184), TOP1_AQUAE (O66893), TOP1_ARCFU (O28469), TOP1_BACAN (P40114), TOP1_BACSU (P39814), TOP1_BORBU (O51768), TOP1_BUCAI (P57371), TOP1_BUCAP (Q8K9P7), TOP1_CAMJE (Q9PLZ2), TOP1_ECOLI (P06612), TOP1_FERIS (O34204), TOP1_HAEIN (P43012), TOP1_HALH5 (Q9KA23), TOP1_HELPJ (Q9ZMV7), TOP1_HELPY (P55991), TOP1_LACLA (Q9CG80), TOP1_METJA (Q59046), TOP1_METTH (O27661), TOP1_MYCBO (P0A621), TOP1_MYCGA (Q9JN65), TOP1_MYCGE (P47368), TOP1_MYCLE (O69548), TOP1_MYCPN (P78032), TOP1_MYCS2 (A0R5D9), TOP1_MYCTA (A5U8X0), TOP1_MYCTO (P9WG48), TOP1_MYCTU (P9WG49), TOP1_PASMU (Q9CN30), TOP1_PSEAE (Q9HZJ5), TOP1_PYRAB (Q9UYS8), TOP1_PYRHO (O58356), TOP1_RICBR (Q1RIM1), TOP1_RICCN (Q92IH1), TOP1_RICFE (Q4UM42), TOP1_RICPR (Q9ZDK2), TOP1_RICTY (Q68X45), TOP1_SALTI (P0A2I2), TOP1_SALTY (P0A2I1), TOP1_STAA3 (Q2FHI8), TOP1_STAA8 (Q2FZ32), TOP1_STAAB (Q2YXL8), TOP1_STAAC (Q5HGI2), TOP1_STAAM (Q99UM1), TOP1_STAAN (Q7A5Y5), TOP1_STAAR (Q6GHI5), TOP1_STAAS (Q6G9W3), TOP1_STAAU (Q06AK7), TOP1_STAAW (Q8NWZ9), TOP1_STAEQ (Q5HPU2), TOP1_STAES (Q8CSU3), TOP1_STAHJ (Q4L5V2), TOP1_STAS1 (Q49X35), TOP1_STRCO (Q9X909), TOP1_SYNE7 (P34185), TOP1_SYNY3 (P73810), TOP1_THEAC (Q9HM08), TOP1_THEMA (P46799), TOP1_TREPA (O83409), TOP1_VIBCH (Q9KRB2), TOP1_XYLFA (Q9PEV8), TOP1_XYLFT (Q87AQ6), TOP1_ZYMMO (Q9X3X7), TOP3A_ARATH (Q9LVP1), TOP3A_DROME (Q9NG98), TOP3A_HUMAN (Q13472), TOP3A_MOUSE (O70157), TOP3A_ORYSJ (C7J0A2), TOP3B_ARATH (F4ISQ7), TOP3B_DROME (O96651), TOP3B_HUMAN (O95985), TOP3B_MOUSE (Q9Z321), TOP3B_ORYSJ (Q0J0S6), TOP3_ALKCK (Q5WAX6), TOP3_BACAH (A0R979), TOP3_BACAN (Q81Z97), TOP3_BACC1 (Q73E74), TOP3_BACCR (Q81IH1), TOP3_BACCZ (Q63GK5), TOP3_BACHK (Q6HP19), TOP3_BACLD (Q65N90), TOP3_BACSU (P96583), TOP3_CAEEL (O61660), TOP3_CANAR (A0A0L0P6P7), TOP3_DICDI (Q8T2T7), TOP3_ECOLI (P14294), TOP3_HAEIN (P43704), TOP3_PASMU (Q9CP53), TOP3_SALTI (Q8Z6F5), TOP3_SALTY (P40687), TOP3_SCHPO (O60126), TOP3_STAA3 (Q2FEN5), TOP3_STAA8 (Q2FW03), TOP3_STAAB (P0C2W6), TOP3_STAAC (Q5HDV4), TOP3_STAAM (Q99S17), TOP3_STAAN (Q7A455), TOP3_STAAR (Q6GEH9), TOP3_STAAS (Q6G767), TOP3_STAAW (Q7A075), TOP3_STAEQ (Q5HLZ4), TOP3_STAES (Q8CRF7), TOP3_STAHJ (Q4L8B8), TOP3_STAS1 (Q49ZH2), TOP3_VIBCH (Q9KQF5), TOP3_YEAST (P13099)» more
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| UniProtKB/Swiss-Prot 'Partial' sequences |
1 sequence
TOP1_KLEAE (P46155) |
| UniProtKB/Swiss-Prot False positive sequences |
1 sequence
SYSM_SCHPO (Q9UTB2) |
| PDB [Detailed view] |
33 PDB
1CY0; 1CY1; 1CY2; 1CY4; 1CY6; 1CY7; 1CY8; 1CY9; 1CYY; 1D6M; 1ECL; 1MW8; 1MW9; 2GAI; 2GAJ; 2O19; 2O54; 2O59; 2O5C; 2O5E; 3PWT; 3PX7; 4CGY; 4CHT; 4RUL; 5D5H; 5GVC; 5GVE; 5UJ1; 5UJY; 6CQ2; 6CQI; 6PCM » more |