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PROSITE entry PS00433


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General information about the entry

Entry name [info] PHOSPHOFRUCTOKINASE
Accession [info] PS00433
Entry type [info] PATTERN
Date [info] 01-NOV-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00336

Name and characterization of the entry

Description [info] Phosphofructokinase signature.
Pattern [info]
[RK]-x(4)-[GAS]-H-x-[QL]-[QR]-[GS]-[GF]-x(5)-[DE]-[RL].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_03 which contains 571'609 sequence entries.


Total number of hits 340 in 303 different sequences
Number of true positive hits 340 in 303 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 17
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 95.24 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 2
Site [info] substrate_binding at position 1
Site [info] substrate_binding at position 4
Site [info] substrate_binding at position 7
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
303 sequences

PFKA1_ASPOR (Q9HGZ1), PFKA1_BACTN (Q8A8R5), PFKA1_CAEEL (Q9TZL8), 
PFKA1_CANAX (O94201), PFKA1_KLULA (Q03215), PFKA1_KOMPG (Q92448), 
PFKA1_LACLL (P0DOB6), PFKA1_NOSS1 (Q8YKG3), PFKA1_PICPA (Q8NJU8), 
PFKA1_SYNY3 (P72830), PFKA1_THET8 (P21777), PFKA1_YEAST (P16861), 
PFKA2_ASPOR (Q9HGZ0), PFKA2_BACTN (Q8A624), PFKA2_CAEEL (Q27483), 
PFKA2_CANAX (O94200), PFKA2_CLOPE (Q8XL57), PFKA2_KLULA (Q03216), 
PFKA2_KOMPG (C4QXA5), PFKA2_LACLL (P0DOB7), PFKA2_NOSS1 (Q8YVR1), 
PFKA2_PICPA (Q8TGA0), PFKA2_STRCO (Q9L1L8), PFKA2_SYNY3 (Q55988), 
PFKA2_YEAST (P16862), PFKA3_STRCO (Q9FC99), PFKAL_BOVIN (A1A4J1), 
PFKAL_HUMAN (P17858), PFKAL_MOUSE (P12382), PFKAL_PONAB (Q5R7V5), 
PFKAL_RAT   (P30835), PFKAM_BOVIN (Q0IIG5), PFKAM_CANLF (P52784), 
PFKAM_HORSE (Q867C9), PFKAM_HUMAN (P08237), PFKAM_MACFA (Q60HD9), 
PFKAM_MOUSE (P47857), PFKAM_PIG   (Q2HYU2), PFKAM_PONAB (Q5RAG9), 
PFKAM_RABIT (P00511), PFKAM_RAT   (P47858), PFKAP_HUMAN (Q01813), 
PFKAP_MOUSE (Q9WUA3), PFKAP_PONAB (Q5R636), PFKAP_RABIT (P47859), 
PFKAP_RAT   (P47860), PFKA_ACTP2  (A3N1C8), PFKA_ACTP7  (B3GY11), 
PFKA_ACTPJ  (B0BQ64), PFKA_ACTSZ  (A6VM63), PFKA_ALIF1  (Q5E2B1), 
PFKA_ALIFM  (B5FBT1), PFKA_ALISL  (B6EMS4), PFKA_ALKMQ  (A6TVD3), 
PFKA_ALKOO  (A8MLY0), PFKA_ANOFW  (B7GGT1), PFKA_AQUAE  (O67605), 
PFKA_ASPFU  (Q4W9B8), PFKA_ASPNG  (P78985), PFKA_BACAA  (C3PAI8), 
PFKA_BACAC  (C3L8X8), PFKA_BACAH  (A0RJJ6), PFKA_BACAN  (Q81KZ0), 
PFKA_BACC0  (B7JRX2), PFKA_BACC1  (Q72ZD8), PFKA_BACC2  (B7IJZ8), 
PFKA_BACC3  (C1EUU3), PFKA_BACC4  (B7HFB3), PFKA_BACC7  (B7HRN9), 
PFKA_BACCE  (Q4MVY3), PFKA_BACCN  (A7GTP4), PFKA_BACCQ  (B9J099), 
PFKA_BACCR  (Q817F3), PFKA_BACCZ  (Q633J8), PFKA_BACHK  (Q6HCT3), 
PFKA_BACLD  (Q65G82), PFKA_BACMK  (A9VJR1), PFKA_BACP2  (A8FG55), 
PFKA_BACSU  (O34529), PFKA_BACVZ  (A7Z7K6), PFKA_BAUCH  (Q1LTT2), 
PFKA_BLOFL  (Q7VRK9), PFKA_BREBN  (C0Z7W7), PFKA_BUCA5  (B8D996), 
PFKA_BUCAI  (P57391), PFKA_BUCAP  (Q8K9N0), PFKA_BUCAT  (B8D7J8), 
PFKA_BUCBP  (P59563), PFKA_BUCCC  (Q057P0), PFKA_CALS4  (Q8R914), 
PFKA_CHLAA  (A9WCU2), PFKA_CHLAD  (B8GAA4), PFKA_CHLSY  (B9LHK4), 
PFKA_CITK8  (A8AL13), PFKA_CLOAB  (O08308), PFKA_CLOB1  (A7FYW7), 
PFKA_CLOB6  (C3KV06), PFKA_CLOBA  (B2UZX8), PFKA_CLOBB  (B2TQR6), 
PFKA_CLOBH  (A5I798), PFKA_CLOBJ  (C1FM55), PFKA_CLOBK  (B1IFV9), 
PFKA_CLOBL  (A7GIW9), PFKA_CLOBM  (B1L266), PFKA_CLOD6  (Q180P4), 
PFKA_CLONN  (A0PYC8), PFKA_CLOTE  (Q890Z2), PFKA_COREF  (Q8RQN5), 
PFKA_CORGL  (Q8NR14), PFKA_COXBU  (Q83EH9), PFKA_CROS8  (A7MQ83), 
PFKA_CYTH3  (Q11RE2), PFKA_DEIRA  (Q9RWN1), PFKA_DICDI  (P90521), 
PFKA_DROME  (P52034), PFKA_ECO24  (A7ZUC9), PFKA_ECO27  (B7UNN6), 
PFKA_ECO45  (B7MI48), PFKA_ECO55  (B7LA13), PFKA_ECO57  (P0A797), 
PFKA_ECO5E  (B5YZ53), PFKA_ECO7I  (B7NU91), PFKA_ECO81  (B7N2Q7), 
PFKA_ECO8A  (B7M6W7), PFKA_ECOBW  (C5A083), PFKA_ECODH  (B1XB82), 
PFKA_ECOHS  (A8A720), PFKA_ECOL5  (Q0TAE8), PFKA_ECOL6  (Q8FBD0), 
PFKA_ECOLC  (B1IVG3), PFKA_ECOLI  (P0A796), PFKA_ECOLU  (B7NFL3), 
PFKA_ECOSE  (B6I4Q8), PFKA_ECOSM  (B1LNL9), PFKA_EDWI9  (C5BC26), 
PFKA_ENT38  (A4WG81), PFKA_ENTCL  (Q9Z6C3), PFKA_ERWT9  (B2VF62), 
PFKA_ESCF3  (B7LVC9), PFKA_FINM2  (B0S230), PFKA_FUSNN  (Q8RG98), 
PFKA_GEOKA  (Q5KWB1), PFKA_GEOSE  (P00512), PFKA_GEOSW  (C5D663), 
PFKA_GLAP5  (B8F8G9), PFKA_HAECO  (Q27665), PFKA_HAEDU  (Q8GNC1), 
PFKA_HAEI8  (Q4QLS8), PFKA_HAEIE  (A5UD89), PFKA_HAEIN  (P43863), 
PFKA_HALH5  (Q9K843), PFKA_HALOH  (B8D1K5), PFKA_HAMD5  (C4K7E1), 
PFKA_HISS1  (Q0I267), PFKA_HISS2  (B0UW05), PFKA_KLEP3  (B5XZ40), 
PFKA_KLEP7  (A6TGB8), PFKA_LACAC  (Q5FKG6), PFKA_LACDE  (P80019), 
PFKA_LACGA  (Q043V2), PFKA_LACH4  (A8YV22), PFKA_LACJO  (Q74JM8), 
PFKA_LACLA  (P0DOB5), PFKA_LACLM  (A2RKA2), PFKA_LACLS  (Q02YK5), 
PFKA_LACPL  (Q88VY1), PFKA_LIGS1  (Q1WTT3), PFKA_LISIN  (Q92BE4), 
PFKA_LISMC  (C1KVL8), PFKA_LISMF  (Q71Z96), PFKA_LISMH  (B8DHH7), 
PFKA_LISMO  (Q8Y6W0), PFKA_LISW6  (A0AJ20), PFKA_LYSSH  (Q93LR4), 
PFKA_MACCJ  (B9E7A4), PFKA_MANSM  (Q65VM6), PFKA_MESH2  (Q601D3), 
PFKA_MESH7  (Q4A8Q3), PFKA_MESHJ  (Q4AAM2), PFKA_MYCBO  (P65691), 
PFKA_MYCCT  (Q2SSQ6), PFKA_MYCLE  (O33106), PFKA_MYCM1  (Q6KHX0), 
PFKA_MYCPU  (Q98PW8), PFKA_MYCTO  (P9WID6), PFKA_MYCTU  (P9WID7), 
PFKA_NATTJ  (B2A6Y0), PFKA_OCEIH  (Q8EPD6), PFKA_PAEMC  (Q59214), 
PFKA_PASMU  (Q9CPH2), PFKA_PECAS  (Q6CZ46), PFKA_PECCP  (C6DHK2), 
PFKA_PEDPA  (Q03F74), PFKA_PHOPR  (Q6LVK2), PFKA_SALA4  (B5F0P6), 
PFKA_SALAR  (A9MI50), PFKA_SALCH  (Q57HF3), PFKA_SALDC  (B5FPR2), 
PFKA_SALEP  (B5QWZ5), PFKA_SALG2  (B5RFA9), PFKA_SALHS  (B4TCK0), 
PFKA_SALNS  (B4T049), PFKA_SALPA  (Q5PIR6), PFKA_SALPB  (A9MZE7), 
PFKA_SALPC  (C0Q414), PFKA_SALPK  (B5BJI2), PFKA_SALSV  (B4TPS6), 
PFKA_SALTI  (P65693), PFKA_SALTY  (P65692), PFKA_SCHMA  (Q27778), 
PFKA_SCHPO  (O42938), PFKA_SERP5  (A8GLB0), PFKA_SHIB3  (B2TVQ8), 
PFKA_SHIBS  (Q31U74), PFKA_SHIDS  (Q32A80), PFKA_SHIFL  (P0A798), 
PFKA_SHISS  (Q3YV62), PFKA_SHOC1  (Q5WEF6), PFKA_SODGM  (Q2NQX2), 
PFKA_SPICI  (P20275), PFKA_STAA2  (A6U2G5), PFKA_STAA8  (Q2FXM8), 
PFKA_STAA9  (A5ITM2), PFKA_STAAB  (Q2YTE2), PFKA_STAAC  (Q5HF75), 
PFKA_STAAE  (A6QHN3), PFKA_STAAM  (P65694), PFKA_STAAN  (P99165), 
PFKA_STAAR  (Q6GG08), PFKA_STAAS  (Q6G8M8), PFKA_STAAT  (A8Z2L4), 
PFKA_STAAW  (P65695), PFKA_STACT  (B9DN94), PFKA_STAEQ  (Q5HNK6), 
PFKA_STAES  (Q8CS68), PFKA_STRA1  (Q3K1E6), PFKA_STRA3  (P65696), 
PFKA_STRA5  (P65697), PFKA_STRE4  (C0M8V6), PFKA_STREM  (B4U2M2), 
PFKA_STRGC  (A8AXW1), PFKA_STRMU  (Q8DTX6), PFKA_STRP1  (Q99ZD0), 
PFKA_STRP2  (Q04L24), PFKA_STRP3  (P0DD02), PFKA_STRP4  (B5E3Z8), 
PFKA_STRP6  (Q5XBV2), PFKA_STRP7  (C1C6M8), PFKA_STRP8  (Q8P0S6), 
PFKA_STRPB  (Q1JBF7), PFKA_STRPC  (Q1JLD9), PFKA_STRPD  (Q1JGH6), 
PFKA_STRPF  (Q1J694), PFKA_STRPG  (A2RE65), PFKA_STRPI  (B1IB66), 
PFKA_STRPJ  (B8ZNU0), PFKA_STRPM  (Q48T86), PFKA_STRPN  (Q97RC6), 
PFKA_STRPQ  (P0DD03), PFKA_STRPS  (B2IP53), PFKA_STRPZ  (B5XLV6), 
PFKA_STRR6  (Q8DQ85), PFKA_STRS7  (C0MGJ9), PFKA_STRSV  (A3CM69), 
PFKA_STRSY  (A4VTS0), PFKA_STRU0  (B9DSA4), PFKA_STRZJ  (C1CDP4), 
PFKA_STRZP  (C1CJY4), PFKA_STRZT  (C1CRZ7), PFKA_SULDN  (Q30T53), 
PFKA_SULNB  (A6QAB4), PFKA_TERTT  (C5BNR1), PFKA_THEMA  (Q9WY52), 
PFKA_THENN  (B9K6R9), PFKA_THEP1  (A5IKL2), PFKA_THEP3  (B0K7U7), 
PFKA_THEPX  (B0K6L2), PFKA_THESQ  (B1L9U3), PFKA_THET2  (Q72H98), 
PFKA_THEVB  (Q8DJB1), PFKA_TOLAT  (C4LEQ5), PFKA_TRIV2  (Q3M8N2), 
PFKA_VIBC1  (A7MX59), PFKA_VIBCH  (Q9KNP2), PFKA_VIBPA  (Q87KX0), 
PFKA_VIBVU  (Q8DCY1), PFKA_VIBVY  (Q7MGW6), PFKA_WOLSU  (Q7M9C2), 
PFKA_YARLI  (P59680), PFKA_YERE8  (A1JHZ3), PFKA_YERP3  (A7FCW1), 
PFKA_YERPA  (Q1C297), PFKA_YERPB  (B2JZA3), PFKA_YERPE  (Q8ZJL6), 
PFKA_YERPG  (A9R6A3), PFKA_YERPN  (Q1CD33), PFKA_YERPP  (A4TSA7), 
PFKA_YERPS  (Q66GA8), PFKA_YERPY  (B1JQU4), PFP_AMYME   (Q59126), 
PFP_AMYMS   (Q9AGC0), PFP_DICTH   (Q9KH71), PFP_STRCO   (O08333)
» more

UniProtKB/Swiss-Prot
False negative sequences
17 sequences

PFKA1_CLOPE (Q8XNH2), PFKA3_BACTN (Q8A2E9), PFKA_ENTFA  (Q836R3), 
PFKA_LACCB  (B3WE64), PFKA_LACP3  (Q039I0), PFKA_MALP2  (Q8EVH2), 
PFKA_MYCGE  (P47457), PFKA_MYCPN  (P75476), PFKA_PERMH  (C0QQX4), 
PFKA_PROFC  (D7GCU5), PFKA_SPITD  (E0RTD9), PFKA_STRTD  (Q03KB7), 
PFKA_STRTR  (Q9L9E3), PFKA_SULSY  (B2V7W7), PFKA_UREPA  (Q9PQV8), 
PFP_THETK   (G4RK16), SQIK_ALKUR  (A0A2P6MHT4)
» more

UniProtKB/Swiss-Prot
'Partial' sequences
2 sequences

PFKA2_THET8 (P21778), PFKA_CALFI  (Q27543)

		
PDB
[Detailed view]
31 PDB

1MTO; 1PFK; 1ZXX; 2PFK; 3O8L; 3O8N; 3O8O; 3OPY; 3PFK; 3U39; 4A3S; 4I36; 4I4I; 4I7E; 4OMT; 4PFK; 4RH3; 4U1R; 4WL0; 4XYJ; 4XYK; 4XZ2; 5XOE; 5XZ6; 5XZ7; 5XZ8; 5XZ9; 5XZA; 6PFK; 7LW1; 7TFF
» more