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PROSITE entry PS00488


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00488
Entry name [info] PAL_HISTIDASE
Accession [info] PS00488
Entry type [info] PATTERN
Date [info] 01-MAY-1991 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00424
Associated ProRule [info] PRU10122

Name and characterization of the entry

Description [info] Phenylalanine and histidine ammonia-lyases signature.
Pattern [info] 
[GS]-[STG]-[LIVM]-[STG]-[SAC]-S-G-[DH]-L-x-[PN]-L-[SA]-x(2,3)-[SAGVTL].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 274 in 274 different sequences
Number of true positive hits 274 in 274 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 1
Number of 'partial' sequences 4
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 99.64 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 6
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 274 sequences 

CCTP1_TALIS (P9WEN6), CLZ10_COCLU (A0A345BJN1), HALL_DICDI  (Q556V9), 

HKM12_ASPHA (P0DUM0), HUTH1_CAEEL (Q20502), HUTH1_FUSNN (Q8RFC2), 
HUTH2_FUSNN (Q8RDU4), HUTH_ACICJ  (A5FZB9), HUTH_AGRFC  (Q8U8Z7), 
HUTH_ALIF1  (Q5E0C6), HUTH_ALIFM  (B5ETN1), HUTH_ALKMQ  (A6TSX0), 
HUTH_ALKOO  (A8MF64), HUTH_ALLAM  (B9K288), HUTH_ANAD2  (B8J950), 
HUTH_ANADE  (Q2IIV4), HUTH_ANASK  (B4UC43), HUTH_AROAE  (Q5NZX8), 
HUTH_BACAA  (C3P4M2), HUTH_BACAC  (C3L982), HUTH_BACAH  (A0RH39), 
HUTH_BACAN  (Q81Y45), HUTH_BACC0  (B7JI80), HUTH_BACC1  (Q733H8), 
HUTH_BACC2  (B7ISJ2), HUTH_BACC3  (C1EN93), HUTH_BACC4  (B7HCD0), 
HUTH_BACC7  (B7HKJ1), HUTH_BACCN  (A7GR00), HUTH_BACCQ  (B9IUH0), 
HUTH_BACCR  (Q81AC6), HUTH_BACCZ  (Q637H8), HUTH_BACHK  (Q6HFE9), 
HUTH_BACMK  (A9VPT8), HUTH_BACSU  (P10944), HUTH_BACVZ  (A7ZAE4), 
HUTH_BARHE  (Q6G3U8), HUTH_BARQU  (Q6FZP9), HUTH_BART1  (A9IVW5), 
HUTH_BOVIN  (A7YWP4), HUTH_BRADU  (Q89GV3), HUTH_BRASB  (A5EQB7), 
HUTH_BRASO  (A4YNK7), HUTH_BRUA1  (B2SD96), HUTH_BRUA2  (Q2YIL6), 
HUTH_BRUA4  (A6WYU8), HUTH_BRUAB  (Q579E8), HUTH_BRUC2  (A9MCL0), 
HUTH_BRUO2  (A5VVJ6), HUTH_BRUSI  (A9WVU3), HUTH_BRUSU  (Q8FVB4), 
HUTH_BURA4  (B1YT80), HUTH_BURCH  (A0K8U6), HUTH_BURCJ  (B4EDX5), 
HUTH_BURCM  (Q0BDK6), HUTH_BURL3  (Q39EP0), HUTH_BURM1  (A9AGP7), 
HUTH_BURM7  (A3MLT7), HUTH_BURM9  (A2SA96), HUTH_BURMA  (Q62LJ6), 
HUTH_BURO0  (B1JV50), HUTH_BURO1  (Q1BHY5), HUTH_BURP0  (A3NXA3), 
HUTH_BURP6  (A3NBH0), HUTH_BURPS  (Q63SH6), HUTH_BURVG  (A4JG46), 
HUTH_CALS4  (Q8RBH4), HUTH_CAUSK  (B0SYU6), HUTH_CAUVC  (P58082), 
HUTH_CAUVN  (B8H2S1), HUTH_CERS1  (A3PK23), HUTH_CERS4  (Q3J289), 
HUTH_CERSK  (B9KSW6), HUTH_CHESB  (Q11E18), HUTH_CHLAA  (A9WHT8), 
HUTH_CHLSY  (B9LLY0), HUTH_CHRVO  (Q7P188), HUTH_CITK8  (A8AJ15), 
HUTH_CLOTE  (Q891Q1), HUTH_DEIDV  (C1CWB4), HUTH_DEIRA  (Q9RZ06), 
HUTH_DESPS  (Q6AKP3), HUTH_DICDI  (Q54JI7), HUTH_ENT38  (A4W8B5), 
HUTH_GEOKA  (Q5L310), HUTH_GEOSW  (C5D4K1), HUTH_GEOTN  (A4IK90), 
HUTH_GLOVI  (Q7NCB3), HUTH_GLUDA  (A9H863), HUTH_GLUOX  (Q5FRR8), 
HUTH_HALH5  (Q9KBE6), HUTH_HALS3  (B0R544), HUTH_HALSA  (Q9HQD5), 
HUTH_HUMAN  (P42357), HUTH_HYPNA  (Q0BZK2), HUTH_IDILO  (Q5QV30), 
HUTH_KLEP3  (B5XZ79), HUTH_KLEP7  (A6T6L1), HUTH_KORVE  (Q1IRT8), 
HUTH_LEGPA  (Q5X5I5), HUTH_LEGPC  (A5IBM2), HUTH_LEGPH  (Q5ZVR0), 
HUTH_LEGPL  (Q5WWW8), HUTH_MACCJ  (B9E7E0), HUTH_MARMM  (Q0AP92), 
HUTH_METNO  (B8II08), HUTH_METS4  (B0UQ15), HUTH_MOUSE  (P35492), 
HUTH_MYXXD  (Q1D6R1), HUTH_NATTJ  (B2A3D9), HUTH_PARC0  (A1TRE4), 
HUTH_PARDP  (A1AZX9), HUTH_PARPJ  (B2T2Y2), HUTH_PHEZH  (B4RED8), 
HUTH_PHOLL  (Q7N296), HUTH_PHOPR  (Q6LQ56), HUTH_PSEA6  (Q15X40), 
HUTH_PSEA8  (B7V3J1), HUTH_PSEAB  (Q02ER8), HUTH_PSEAE  (Q9HU85), 
HUTH_PSEFS  (Q8VMR3), HUTH_PSEPF  (Q3KJE6), HUTH_PSEPK  (Q88CZ7), 
HUTH_PSEPU  (P21310), HUTH_PSESM  (Q87UM1), HUTH_PSYCK  (Q1Q9E4), 
HUTH_PSYIN  (A1STQ3), HUTH_PSYWF  (A5WDR1), HUTH_RALN1  (Q8XW29), 
HUTH_RAT(P21213), HUTH_RHILO  (Q983I0), HUTH_RHIME  (O31197), 
HUTH_RHIR8  (B9JDC0), HUTH_RHIRH  (Q9KWE4), HUTH_RHOCS  (B6IWC6), 
HUTH_ROSDO  (Q162E2), HUTH_RUEPO  (Q5LRD8), HUTH_SALA4  (B5F069), 
HUTH_SALAR  (A9MJE9), HUTH_SALCH  (Q57RG6), HUTH_SALDC  (B5FP58), 
HUTH_SALEP  (B5QX62), HUTH_SALG2  (B5R758), HUTH_SALHS  (B4TC45), 
HUTH_SALNS  (B4SZJ4), HUTH_SALPA  (Q5PG61), HUTH_SALPB  (A9MTJ1), 
HUTH_SALPC  (C0PWX9), HUTH_SALPK  (B5BC34), HUTH_SALSV  (B4TQT6), 
HUTH_SALTI  (Q8Z896), HUTH_SALTY  (Q8ZQQ9), HUTH_SHEON  (Q8EKJ4), 
HUTH_SHEPA  (A8HA91), HUTH_SHEPW  (B8CGY5), HUTH_SHESH  (A8G1S5), 
HUTH_SHEWM  (B1KP55), HUTH_SHOC1  (Q5WAZ6), HUTH_SORC5  (A9GFW6), 
HUTH_SPHAL  (Q1GSH0), HUTH_STAA2  (A6TXF8), HUTH_STAA3  (Q2FKP8), 
HUTH_STAA8  (Q2G2P7), HUTH_STAA9  (A5INP9), HUTH_STAAB  (Q2YUR3), 
HUTH_STAAC  (Q5HJY8), HUTH_STAAE  (A6QD47), HUTH_STAAM  (P64415), 
HUTH_STAAN  (P64416), HUTH_STAAR  (Q6GKT7), HUTH_STAAS  (Q6GD82), 
HUTH_STAAT  (A8YYT1), HUTH_STAAW  (Q8NYY3), HUTH_STAS1  (Q4A173), 
HUTH_STIAU  (Q93TX3), HUTH_STRAW  (Q82I33), HUTH_STRCO  (Q9EWW1), 
HUTH_STRGC  (A8AZ70), HUTH_STRGR  (P24221), HUTH_STRP1  (P58083), 
HUTH_STRP3  (P0DB74), HUTH_STRP6  (Q5X9K4), HUTH_STRP8  (Q8NZ46), 
HUTH_STRPG  (A2RGS5), HUTH_STRPQ  (P0DB75), HUTH_STRPZ  (B5XIY2), 
HUTH_STRSV  (A3CL24), HUTH_SYMTH  (Q67JH4), HUTH_THEAC  (Q9HLI6), 
HUTH_THEVO  (Q978N8), HUTH_TREDE  (Q73Q56), HUTH_VIBCH  (Q9KSQ4), 
HUTH_VIBPA  (Q87Q77), HUTH_VIBVU  (Q8DA21), HUTH_VIBVY  (Q7MK58), 
HUTH_XANAC  (Q8PLZ8), HUTH_XANC8  (Q4UTB9), HUTH_XANCB  (B0RUX3), 
HUTH_XANCP  (Q8PAA7), HUTH_YERE8  (A1JSW6), HUTH_YERPE  (Q8ZA10), 
HUTH_YERPS  (Q664B8), HUTIH_BRUME (Q8YD09), LENB_ASPLE  (A0AAN4PAE6), 
MFM7_PHOSM  (A0A3G1DJK5), PAL1_ARATH  (P35510), PAL1_DAUCA  (O23865), 
PAL1_FRIUN  (P0DO55), PAL1_IPOBA  (P14166), PAL1_LITER  (O49835), 
PAL1_NARPS  (A0A2H5AIW0), PAL1_ORYSJ  (P14717), PAL1_PEA(Q01861), 
PAL1_PETCR  (P24481), PAL1_PETHY  (Q50EX7), PAL1_POPKI  (P45731), 
PAL1_PRUAV  (O64963), PAL1_RUBID  (Q9M568), PAL1_SOLLC  (P35511), 
PAL1_SOLTU  (P31425), PAL1_SOYBN  (P27991), PAL1_TOBAC  (P25872), 
PAL2_ARATH  (P45724), PAL2_CICAR  (Q9SMK9), PAL2_IPOBA  (Q42858), 
PAL2_LITER  (O49836), PAL2_NARPS  (A0A2H5AIY6), PAL2_ORYSI  (A2X7F7), 
PAL2_ORYSJ  (Q0DZE0), PAL2_PEA(Q04593), PAL2_PETCR  (P45728), 
PAL2_PHAVU  (P19142), PAL2_POPKI  (Q43052), PAL2_SOLTU  (P31426), 
PAL2_TOBAC  (P35513), PAL3_ARATH  (P45725), PAL3_PETCR  (P45729), 
PAL3_PHAVU  (P19143), PAL3_TOBAC  (P45733), PAL4_ARATH  (Q9SS45), 
PAL4_POPKI  (Q40910), PAL5_SOLLC  (P26600), PALY1_PLEOS (A0A4Y6HUI7), 
PALY2_PLEOS (A0A4Y6HUD7), PALY_AMAMU  (O93967), PALY_BROFI  (Q42609), 
PALY_CAMSI  (P45726), PALY_CITLI  (Q42667), PALY_DIGLA  (O23924), 
PALY_FLAVE  (A0A0A7AAW9), PALY_HELAN  (O04058), PALY_MAIZE  (Q8VXG7), 
PALY_MEDSA  (P27990), PALY_MYCMD  (Q96V77), PALY_PERAE  (P45727), 
PALY_PINTA  (P52777), PALY_POPTR  (P45730), PALY_RHOMI  (P10248), 
PALY_RHOTO  (P11544), PALY_STYHU  (P45732), PALY_TRIMT  (X2BTY5), 
PALY_TRISU  (P45734), PALY_WHEAT  (Q43210), PAL_NOSP7   (B2J528), 
PAL_TRIV2   (Q3M5Z3), PAM_TAXCA   (Q6GZ04), PAM_TAXCH   (Q68G84), 
STR11_STRTC (A0A384XHA3), TALY_CERS4  (Q3IWB0), TALY_CUPMC  (Q1LRV9), 
TAM_CHOCO   (Q0VZ68), TAM_MYXFU   (B8ZV93), TAM_MYXSM   (B8ZV94), 
TAM_STRGL   (Q8GMG0)
» more

UniProtKB/Swiss-Prot
False negative sequences		 1 sequence 

HUTH_RHORT  (Q2RUU3)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			4 sequences
			


			
PAL1_PHAVU  (P07218), PALY_AGABI  (Q92195), PALY_MALDO  (P35512), 

			
PALY_VITVI  (P45735)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			41 PDB
			


			1B8F; 1EB4; 1GK2; 1GKJ; 1GKM; 1T6J; 1T6P; 1W27; 1Y2M; 2NYF; 2NYN; 2O6Y; 
			
				2O78; 2O7B; 2O7D; 2O7E; 2O7F; 2OHY; 2QVE; 2RJR; 2RJS; 2YII; 3CZO; 3KDY; 
				3KDZ; 3NZ4; 4BAA; 4BAB; 4C5R; 4C5S; 4C5U; 4C6G; 4CQ5; 4V2Q; 4V2R; 5LTM; 
				6F6T; 6H2O; 6HQF; 6RGS; 7TQR
			
			

			» more