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PROSITE entry PS00501


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General information about the entry

Entry name [info] SPASE_I_1
Accession [info] PS00501
Entry type [info] PATTERN
Date [info] 01-MAY-1991 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00418
Associated ProRule [info] PRU10097

Name and characterization of the entry

Description [info] Signal peptidases I serine active site.
Pattern [info]
[GS]-{PR}-S-M-{RS}-[PS]-[AT]-[LF].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_03 which contains 571'609 sequence entries.


Total number of hits 185 in 185 different sequences
Number of true positive hits 121 in 121 different sequences
Number of 'unknown' hits 1
Number of false positive hits 63 in 63 different sequences
Number of false negative sequences 21
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 65.76 %
Recall (true positives / (true positives + false negatives)) 85.21 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 3
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
121 sequences

IMP1_YEAST  (P28627), IMP2_YEAST  (P46972), LEP1_BACAM  (P41026), 
LEP1_SYNY3  (P72660), LEP2_BACAM  (P41025), LEP2_SYNY3  (P73157), 
LEPP_BACNA  (P37943), LEPQ_BACNA  (Q57350), LEPS_BACSU  (P28628), 
LEPT_BACSU  (P71013), LEPU_BACSU  (P42959), LEPV_BACSU  (O07560), 
LEP_AQUAE   (O67088), LEP_BACCL   (P41027), LEP_BACLI   (P42668), 
LEP_BUCAI   (P57347), LEP_BUCAP   (Q8K9R0), LEP_BUCBP   (Q89AM6), 
LEP_ECOLI   (P00803), LEP_HAEIN   (P44454), LEP_MYCLE   (O33021), 
LEP_MYCTO   (P9WKA0), LEP_MYCTU   (P9WKA1), LEP_PHOLA   (Q51876), 
LEP_PSEAE   (Q9I5G7), LEP_PSEFL   (P26844), LEP_SALTI   (P0A1W3), 
LEP_SALTY   (P0A1W2), LEP_STAAC   (Q5HHB9), LEP_STAAM   (P0A067), 
LEP_STAAN   (P0A068), LEP_STAAR   (Q6GIC3), LEP_STAAS   (Q6GAW1), 
LEP_STAAU   (P0A070), LEP_STAAW   (P0A069), LEP_STRPN   (O07344), 
LEP_STRR6   (P59662), PLSP1_ARATH (Q8H0W1), SC11A_BOVIN (P67810), 
SC11A_CANLF (P67811), SC11A_HUMAN (P67812), SC11A_MOUSE (Q9R0P6), 
SC11A_PONAB (Q5R9C7), SC11A_RAT   (P42667), SC11B_HUMAN (P0C7V7), 
SC11C_CANLF (P13679), SC11C_HUMAN (Q9BY50), SC11C_MOUSE (Q9D8V7), 
SC11C_PONAB (Q5RC30), SC11C_RAT   (Q9WTR7), SEC11_AJEC8 (F0UDD2), 
SEC11_AJECG (C0NKT8), SEC11_AJECH (C6HB29), SEC11_AJECN (A6QX24), 
SEC11_AJEDR (C5G8L5), SEC11_ARTBC (D4ALL0), SEC11_ARTGP (E4V4X0), 
SEC11_ARTOC (C5FQ45), SEC11_ASPCL (A1CL29), SEC11_ASPFC (B0XWT3), 
SEC11_ASPFU (Q4WYF4), SEC11_ASPOR (Q2UBW3), SEC11_ASPTN (Q0CQC5), 
SEC11_BLAGS (C5JJG5), SEC11_CANAL (Q5A869), SEC11_CANAW (C4YNJ0), 
SEC11_CANDC (B9WKT4), SEC11_CANTT (C5M4J6), SEC11_CHAGB (Q2H1P3), 
SEC11_CLAL4 (C4Y3D4), SEC11_COCP7 (C5PA33), SEC11_COCPS (E9CXH2), 
SEC11_COLGM (E3QXY4), SEC11_DEBHA (Q6BP15), SEC11_DICDI (Q86JD4), 
SEC11_EMENI (Q5B8K4), SEC11_EREGS (Q759W4), SEC11_FUSV7 (C7ZHK5), 
SEC11_GROCL (F0XJH4), SEC11_KLULA (Q6CMR5), SEC11_KOMPG (C4QXP7), 
SEC11_LACBS (B0D4L0), SEC11_LACTC (C5DDH1), SEC11_LEPMJ (E5A8D2), 
SEC11_LODEL (A5DS09), SEC11_METAQ (E9E796), SEC11_METRA (E9F8V9), 
SEC11_NEOFI (A1D6D8), SEC11_NEUCR (Q7RY44), SEC11_OGAPD (E7R7C4), 
SEC11_PARBA (C1GU90), SEC11_PARBD (C1FYD2), SEC11_PARBP (C0S3S0), 
SEC11_PENRW (B6HC89), SEC11_PICGU (A5DIZ8), SEC11_PICST (A3LXS1), 
SEC11_PODAN (B2B3T2), SEC11_PYRO7 (A4RGA1), SEC11_PYRTR (B2WEL2), 
SEC11_PYRTT (E3RR70), SEC11_SCHCM (D8Q7Q5), SEC11_SCLS1 (A7E716), 
SEC11_TALMQ (B6Q5G0), SEC11_TALSN (B8M5K5), SEC11_TRIVH (D4D5I1), 
SEC11_TUBMM (D5GNC3), SEC11_UNCRE (C4JYM4), SEC11_VERA1 (C9S8G0), 
SEC11_YEAS1 (B3LTI7), SEC11_YEAS2 (C7GLT4), SEC11_YEAS7 (A6ZVU2), 
SEC11_YEAS8 (C8ZAS4), SEC11_YEASA (E7KDY6), SEC11_YEASB (E7Q587), 
SEC11_YEASL (E7KQ01), SEC11_YEAST (P15367), SEC11_YEASV (E7LVX4), 
SEC11_YEASZ (E7QG89), SEC11_ZYGRC (C5E3W1), TPP1_ARATH  (O04348), 
TPP2_ARATH  (Q9M9Z2)
» more

UniProtKB/Swiss-Prot
False negative sequences
21 sequences

IMP1L_HUMAN (Q96LU5), IMP1L_MOUSE (Q9CQU8), IMP1L_XENTR (Q28I39), 
IMP2L_BOVIN (Q2KI92), IMP2L_DANRE (Q6AZD4), IMP2L_HUMAN (Q96T52), 
IMP2L_MOUSE (Q8BPT6), IMP2L_SCHPO (Q9UST2), IMP2L_XENLA (Q5PQ63), 
LEPH_STAAC  (Q5HHC0), LEPH_STAAM  (P0A063), LEPH_STAAN  (P0A064), 
LEPH_STAAR  (Q6GIC4), LEPH_STAAS  (Q6GAW2), LEPH_STAAU  (P0A066), 
LEPH_STAAW  (P0A065), LEP_HELPJ   (Q9ZLQ5), LEP_HELPY   (O25300), 
LEP_RICCN   (Q92JB1), LEP_RICPR   (Q9ZE32), SEC11_YARLI (Q6CAG9)
» more

UniProtKB/Swiss-Prot
'Unknown' sequences
1 sequence

L_CHAVB (B2C4J3)

		
UniProtKB/Swiss-Prot
False positive sequences
63 sequences

ACKL_DROME  (Q9I7F7), ALDO1_ARATH (Q7G193), AQPZ_ECO57  (Q8X6K6), 
AQPZ_ECOL6  (P60845), AQPZ_ECOLI  (P60844), AQPZ_SHIFL  (O68874), 
ATG12_ASPCL (A1CTJ1), ATG12_ASPFU (A4D9P4), ATG12_ASPOR (Q2UMW6), 
ATG12_COCIM (Q1E8C2), ATG12_NEOFI (A1DMW6), ATG12_PYRO7 (Q51P78), 
DDL_SYNPW   (A5GML7), EG1_ORYSI   (A2WY00), EG1_ORYSJ   (Q8S1D9), 
ERF1_CAEEL  (O16520), FREM1_HUMAN (Q5H8C1), GNL3L_BOVIN (Q3T0J9), 
GNL3L_HUMAN (Q9NVN8), LVSD_DICDI  (Q55AV3), NAGA_HUMAN  (Q9Y303), 
NFAA_DICDI  (Q55AR6), O51S1_HUMAN (Q8NGJ8), PEPF1_LACLC (P54124), 
PEPF_LACLA  (Q9CEV7), PHLC_ARATH  (Q8VYI2), PLSX_PARDP  (A1B363), 
PLSX_RUEST  (Q1GI68), POC1A_MOUSE (Q8JZX3), PPE19_MYCTO (P9WI24), 
PPE19_MYCTU (P9WI25), RIMB2_MOUSE (Q80U40), RIMB2_RAT   (Q9JIR1), 
RS9_STRCO   (Q53875), SNL4_ARATH  (O04539), SNT2_YEAST  (P53127), 
STU1_SCHPO  (O42874), TBB1_AVESA  (P25862), TBB1_ORYSJ  (Q43594), 
TBB1_WHEAT  (Q9ZRB2), TBB2_ELEIN  (Q9ZPN9), TBB2_WHEAT  (Q9ZRB1), 
TBB3_GOSHI  (Q6VAF8), TBB3_PEA(P29502), TBB4_ELEIN  (Q9ZPN7), 
TBB4_ORYSJ  (P45960), TBB5_MAIZE  (Q43697), TBB5_WHEAT  (Q9ZRA8), 
TBB6_ARATH  (P29514), TBB6_MAIZE  (Q41783), TBB6_ORYSJ  (Q76FS3), 
TBB8_MAIZE  (Q41785), TBB8_ORYSJ  (Q76FS2), TBB_HORVU   (P93176), 
TDA7_CANGA  (Q6FNJ6), TPIS_GRAGA  (P48492), TPO5_YEAST  (P36029), 
TRM51_VITVI (F6H2F8), UPP3_SCHPO  (Q9US43), VPS10_FUSV7 (C7YGZ0), 
Y017_OSHVF  (Q6R7K6), ZF69B_HUMAN (Q9UJL9), ZN598_DANRE (Q6PFK1)
» more

PDB
[Detailed view]
11 PDB

1B12; 1KN9; 1T7D; 3IIQ; 3S04; 4WVH; 4WVI; 4WVJ; 6B88; 7P2P; 7P2Q