PROSITE entry PS00501

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS00501
Entry name [info]	SPASE_I_1
Accession [info]	PS00501
Entry type [info]	PATTERN
Date [info]	01-MAY-1991 CREATED; 01-DEC-2004 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00418
Associated ProRule [info]	PRU10097

Name and characterization of the entry

Description [info]	Signal peptidases I serine active site.
Pattern [info]	[GS]-{PR}-S-M-{RS}-[PS]-[AT]-[LF].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	185 in 185 different sequences
Number of true positive hits	121 in 121 different sequences
Number of 'unknown' hits	1
Number of false positive hits	63 in 63 different sequences
Number of false negative sequences	21
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	65.76 %
Recall (true positives / (true positives + false negatives))	85.21 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info]	1
Site [info]	active_site at position 3
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	121 sequences IMP1_YEAST (P28627), IMP2_YEAST (P46972), LEP1_BACAM (P41026), LEP1_SYNY3 (P72660), LEP2_BACAM (P41025), LEP2_SYNY3 (P73157), LEPP_BACNA (P37943), LEPQ_BACNA (Q57350), LEPS_BACSU (P28628), LEPT_BACSU (P71013), LEPU_BACSU (P42959), LEPV_BACSU (O07560), LEP_AQUAE (O67088), LEP_BACCL (P41027), LEP_BACLI (P42668), LEP_BUCAI (P57347), LEP_BUCAP (Q8K9R0), LEP_BUCBP (Q89AM6), LEP_ECOLI (P00803), LEP_HAEIN (P44454), LEP_LEPLM (Q51876), LEP_MYCLE (O33021), LEP_MYCTO (P9WKA0), LEP_MYCTU (P9WKA1), LEP_PSEAE (Q9I5G7), LEP_PSEFL (P26844), LEP_SALTI (P0A1W3), LEP_SALTY (P0A1W2), LEP_STAAC (Q5HHB9), LEP_STAAM (P0A067), LEP_STAAN (P0A068), LEP_STAAR (Q6GIC3), LEP_STAAS (Q6GAW1), LEP_STAAU (P0A070), LEP_STAAW (P0A069), LEP_STRPN (O07344), LEP_STRR6 (P59662), PLSP1_ARATH (Q8H0W1), SC11A_BOVIN (P67810), SC11A_CANLF (P67811), SC11A_HUMAN (P67812), SC11A_MOUSE (Q9R0P6), SC11A_PONAB (Q5R9C7), SC11A_RAT (P42667), SC11B_HUMAN (P0C7V7), SC11C_CANLF (P13679), SC11C_HUMAN (Q9BY50), SC11C_MOUSE (Q9D8V7), SC11C_PONAB (Q5RC30), SC11C_RAT (Q9WTR7), SEC11_AJEC8 (F0UDD2), SEC11_AJECG (C0NKT8), SEC11_AJECH (C6HB29), SEC11_AJECN (A6QX24), SEC11_AJEDR (C5G8L5), SEC11_ARTBC (D4ALL0), SEC11_ARTGP (E4V4X0), SEC11_ARTOC (C5FQ45), SEC11_ASPCL (A1CL29), SEC11_ASPFC (B0XWT3), SEC11_ASPFU (Q4WYF4), SEC11_ASPOR (Q2UBW3), SEC11_ASPTN (Q0CQC5), SEC11_BLAGS (C5JJG5), SEC11_CANAL (Q5A869), SEC11_CANAW (C4YNJ0), SEC11_CANDC (B9WKT4), SEC11_CANTT (C5M4J6), SEC11_CHAGB (Q2H1P3), SEC11_CLAL4 (C4Y3D4), SEC11_COCP7 (C5PA33), SEC11_COCPS (E9CXH2), SEC11_COLGM (E3QXY4), SEC11_DEBHA (Q6BP15), SEC11_DICDI (Q86JD4), SEC11_EMENI (Q5B8K4), SEC11_EREGS (Q759W4), SEC11_FUSV7 (C7ZHK5), SEC11_GROCL (F0XJH4), SEC11_KLULA (Q6CMR5), SEC11_KOMPG (C4QXP7), SEC11_LACBS (B0D4L0), SEC11_LACTC (C5DDH1), SEC11_LEPMJ (E5A8D2), SEC11_LODEL (A5DS09), SEC11_METAQ (E9E796), SEC11_METRA (E9F8V9), SEC11_NEOFI (A1D6D8), SEC11_NEUCR (Q7RY44), SEC11_OGAPD (E7R7C4), SEC11_PARBA (C1GU90), SEC11_PARBD (C1FYD2), SEC11_PARBP (C0S3S0), SEC11_PENRW (B6HC89), SEC11_PICGU (A5DIZ8), SEC11_PICST (A3LXS1), SEC11_PODAN (B2B3T2), SEC11_PYRO7 (A4RGA1), SEC11_PYRTR (B2WEL2), SEC11_PYRTT (E3RR70), SEC11_SCHCM (D8Q7Q5), SEC11_SCLS1 (A7E716), SEC11_TALMQ (B6Q5G0), SEC11_TALSN (B8M5K5), SEC11_TRIVH (D4D5I1), SEC11_TUBMM (D5GNC3), SEC11_UNCRE (C4JYM4), SEC11_VERA1 (C9S8G0), SEC11_YEAS1 (B3LTI7), SEC11_YEAS2 (C7GLT4), SEC11_YEAS7 (A6ZVU2), SEC11_YEAS8 (C8ZAS4), SEC11_YEASA (E7KDY6), SEC11_YEASB (E7Q587), SEC11_YEASL (E7KQ01), SEC11_YEAST (P15367), SEC11_YEASV (E7LVX4), SEC11_YEASZ (E7QG89), SEC11_ZYGRC (C5E3W1), TPP1_ARATH (O04348), TPP2_ARATH (Q9M9Z2) » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	21 sequences IMP1L_HUMAN (Q96LU5), IMP1L_MOUSE (Q9CQU8), IMP1L_XENTR (Q28I39), IMP2L_BOVIN (Q2KI92), IMP2L_DANRE (Q6AZD4), IMP2L_HUMAN (Q96T52), IMP2L_MOUSE (Q8BPT6), IMP2L_SCHPO (Q9UST2), IMP2L_XENLA (Q5PQ63), LEPH_STAAC (Q5HHC0), LEPH_STAAM (P0A063), LEPH_STAAN (P0A064), LEPH_STAAR (Q6GIC4), LEPH_STAAS (Q6GAW2), LEPH_STAAU (P0A066), LEPH_STAAW (P0A065), LEP_HELPJ (Q9ZLQ5), LEP_HELPY (O25300), LEP_RICCN (Q92JB1), LEP_RICPR (Q9ZE32), SEC11_YARLI (Q6CAG9) » more
UniProtKB/Swiss-Prot 'Unknown' sequences	1 sequence L_CHAVB (B2C4J3)
UniProtKB/Swiss-Prot False positive sequences	63 sequences ACKL_DROME (Q9I7F7), ALDO1_ARATH (Q7G193), AQPZ_ECO57 (Q8X6K6), AQPZ_ECOL6 (P60845), AQPZ_ECOLI (P60844), AQPZ_SHIFL (O68874), ATG12_ASPCL (A1CTJ1), ATG12_ASPFU (A4D9P4), ATG12_ASPOR (Q2UMW6), ATG12_COCIM (Q1E8C2), ATG12_NEOFI (A1DMW6), ATG12_PYRO7 (Q51P78), DDL_SYNPW (A5GML7), EG1_ORYSI (A2WY00), EG1_ORYSJ (Q8S1D9), ERF1_CAEEL (O16520), FREM1_HUMAN (Q5H8C1), GNL3L_BOVIN (Q3T0J9), GNL3L_HUMAN (Q9NVN8), LVSD_DICDI (Q55AV3), NAGA_HUMAN (Q9Y303), NFAA_DICDI (Q55AR6), O51S1_HUMAN (Q8NGJ8), PEPF1_LACLC (P54124), PEPF_LACLA (Q9CEV7), PHLC_ARATH (Q8VYI2), PLSX_PARDP (A1B363), PLSX_RUEST (Q1GI68), POC1A_MOUSE (Q8JZX3), PPE19_MYCTO (P9WI24), PPE19_MYCTU (P9WI25), RIMB2_MOUSE (Q80U40), RIMB2_RAT (Q9JIR1), RS9_STRCO (Q53875), SNL4_ARATH (O04539), SNT2_YEAST (P53127), STU1_SCHPO (O42874), TBB1_AVESA (P25862), TBB1_ORYSJ (Q43594), TBB1_WHEAT (Q9ZRB2), TBB2_ELEIN (Q9ZPN9), TBB2_WHEAT (Q9ZRB1), TBB3_GOSHI (Q6VAF8), TBB3_PEA(P29502), TBB4_ELEIN (Q9ZPN7), TBB4_ORYSJ (P45960), TBB5_MAIZE (Q43697), TBB5_WHEAT (Q9ZRA8), TBB6_ARATH (P29514), TBB6_MAIZE (Q41783), TBB6_ORYSJ (Q76FS3), TBB8_MAIZE (Q41785), TBB8_ORYSJ (Q76FS2), TBB_HORVU (P93176), TDA7_CANGA (Q6FNJ6), TPIS_GRAGA (P48492), TPO5_YEAST (P36029), TRM51_VITVI (F6H2F8), UPP3_SCHPO (Q9US43), VPS10_FUSV7 (C7YGZ0), Y017_OSHVF (Q6R7K6), ZF69B_HUMAN (Q9UJL9), ZN598_DANRE (Q6PFK1) » more
PDB [Detailed view]	11 PDB 1B12; 1KN9; 1T7D; 3IIQ; 3S04; 4WVH; 4WVI; 4WVJ; 6B88; 7P2P; 7P2Q