We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU10097
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU10097
General rule information
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| Accession | PRU10097 |
| Dates | 16-OCT-2006 (Created)
22-NOV-2019 (Last updated, Version 11) |
| Data class | Domain; |
| Predictors |
Metamotif; -; PS00501~(PS00760){,1}~PS00761 |
Name | Signal peptidases I serine active sites |
| Function | Signal peptidases (SPases) (also known as leader peptidases) remove the signal peptides from secretory proteins. |
| Scope(s) |
Eukaryota Bacteria |
| Example(s) | Q5HHB9; |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + AltName: Full=Signal peptidase I; EC=3.4.21.89; |
Comments
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| CATALYTIC ACTIVITY | Reaction=Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.; EC=3.4.21.89; |
Keywords
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Gene Ontology
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| GO:0016787; Molecular function:hydrolase activity |
| GO:0008233; Molecular function:peptidase activity |
Cross-references
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Features
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| From: PS00501 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 3 | 3 | ||||||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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