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PROSITE entry PS00509


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00509
Entry name [info] RAS_GTPASE_ACTIV_1
Accession [info] PS00509
Entry type [info] PATTERN
Date [info] 01-MAY-1991 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00438

Name and characterization of the entry

Description [info] Ras GTPase-activating proteins domain signature.
Pattern [info] 
[GSNA]-x-[LIVMF]-[FYCI]-[LIVMFY]-R-[LIVMFY](2)-[GACNS]-[PAV]-[AV]-[LIV]-
[LIVM]-[SGANT]-P.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 43 in 43 different sequences
Number of true positive hits 43 in 43 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 13
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 76.79 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 43 sequences 

BUD2_CANAL  (Q5A506), BUD2_YEAST  (P33314), DAB2P_HUMAN (Q5VWQ8), 

DAB2P_MOUSE (Q3UHC7), DAB2P_RAT   (Q6P730), GAP1_CAEEL  (Q22720), 
GAP1_DROME  (P48423), GAP1_SCHPO  (P33277), GAP2_CAEEL  (Q8MLZ5), 
GAP2_DROME  (Q8T498), IQGA1_HUMAN (P46940), IQGA1_MOUSE (Q9JKF1), 
IQGA2_HUMAN (Q13576), IQGA2_MOUSE (Q3UQ44), IQGA3_HUMAN (Q86VI3), 
IRA1_YEAST  (P18963), IRA2_YEAST  (P19158), NF1_HUMAN   (P21359), 
NF1_MOUSE   (Q04690), NF1_RAT (P97526), NGAP_DICDI  (Q54Y08), 
NGAP_HUMAN  (Q9UJF2), RAS4B_HUMAN (C9J798), RASA1_BOVIN (P09851), 
RASA1_HUMAN (P20936), RASA1_RAT   (P50904), RASA2_HUMAN (Q15283), 
RASA2_MOUSE (P58069), RASA2_RAT   (Q63713), RASA3_BOVIN (Q28013), 
RASA3_HUMAN (Q14644), RASA3_MOUSE (Q60790), RASA3_RAT   (Q9QYJ2), 
RASL1_HUMAN (O95294), RASL1_MOUSE (Q9Z268), RASL2_HUMAN (O43374), 
RASL2_MOUSE (Q6PFQ7), RASL3_BOVIN (A6QQ91), RASL3_HUMAN (Q86YV0), 
RASL3_MOUSE (Q8C2K5), SYGP1_HUMAN (Q96PV0), SYGP1_MOUSE (F6SEU4), 
SYGP1_RAT   (Q9QUH6)
» more

UniProtKB/Swiss-Prot
False negative sequences		 13 sequences 

GAPA_DICDI  (O00899), GAPD1_BOVIN (A5D794), GAPD1_HUMAN (Q14C86), 

GAPD1_MOUSE (Q6PAR5), GAPD1_XENLA (A2RV61), IQG1_CANAL  (Q5AH02), 
IQG1_YEAST  (Q12280), NFAA_DICDI  (Q55AR6), RGAA_DICDI  (Q54K32), 
RME6_CAEBR  (A8WVM4), RME6_CAEEL  (Q9GYH7), RME6_DROME  (Q9VZ08), 
RME6_DROPS  (Q29HW3)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

NF1_CHICK   (P35608)


				
	

	

		PDB
[Detailed view]		
		
			27 PDB
			


			1NF1; 1WER; 1WQ1; 3BXJ; 3FAY; 5CJP; 6OB2; 6OB3; 6V65; 6V6F; 7MOC; 7MP5; 
			
				7MP6; 7PGP; 7PGQ; 7PGR; 7PGS; 7PGT; 7PGU; 7R03; 7R04; 8BOS; 8E20; 8EDL; 
				8EDM; 8EDN; 8EDO
			
			

			» more