We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE entry PS00509
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PURL: https://purl.expasy.org/prosite/signature/PS00509
Direct ScanProsite submission
General information about the entry
| Entry name [info] | RAS_GTPASE_ACTIV_1 |
| Accession [info] | PS00509 |
| Entry type [info] | PATTERN |
| Date [info] |
01-MAY-1991 CREATED;
01-DEC-2004 DATA UPDATE; 18-JUN-2025 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00438 |
Name and characterization of the entry
| Description [info] | Ras GTPase-activating proteins (rasGAP) domain signature. |
| Pattern [info] |
[GSNA]-x-[LIVMF]-[FYCI]-[LIVMFY]-R-[LIVMFY](2)-[GACNS]-[PAV]-[AV]-[LIV]- [LIVM]-[SGANT]-P. |
Numerical results [info]
| Total number of hits | 43 in 43 different sequences |
| Number of true positive hits | 43 in 43 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 13 |
| Number of 'partial' sequences | 1 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 76.79 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
43 sequences
BUD2_CANAL (Q5A506), BUD2_YEAST (P33314), DAB2P_HUMAN (Q5VWQ8), DAB2P_MOUSE (Q3UHC7), DAB2P_RAT (Q6P730), GAP1_CAEEL (Q22720), GAP1_DROME (P48423), GAP1_SCHPO (P33277), GAP2_CAEEL (Q8MLZ5), GAP2_DROME (Q8T498), IQGA1_HUMAN (P46940), IQGA1_MOUSE (Q9JKF1), IQGA2_HUMAN (Q13576), IQGA2_MOUSE (Q3UQ44), IQGA3_HUMAN (Q86VI3), IRA1_YEAST (P18963), IRA2_YEAST (P19158), NF1_HUMAN (P21359), NF1_MOUSE (Q04690), NF1_RAT (P97526), NGAP_DICDI (Q54Y08), NGAP_HUMAN (Q9UJF2), RAS4B_HUMAN (C9J798), RASA1_BOVIN (P09851), RASA1_HUMAN (P20936), RASA1_RAT (P50904), RASA2_HUMAN (Q15283), RASA2_MOUSE (P58069), RASA2_RAT (Q63713), RASA3_BOVIN (Q28013), RASA3_HUMAN (Q14644), RASA3_MOUSE (Q60790), RASA3_RAT (Q9QYJ2), RASL1_HUMAN (O95294), RASL1_MOUSE (Q9Z268), RASL2_HUMAN (O43374), RASL2_MOUSE (Q6PFQ7), RASL3_BOVIN (A6QQ91), RASL3_HUMAN (Q86YV0), RASL3_MOUSE (Q8C2K5), SYGP1_HUMAN (Q96PV0), SYGP1_MOUSE (F6SEU4), SYGP1_RAT (Q9QUH6)» more
|
| UniProtKB/Swiss-Prot False negative sequences |
13 sequences
GAPA_DICDI (O00899), GAPD1_BOVIN (A5D794), GAPD1_HUMAN (Q14C86), GAPD1_MOUSE (Q6PAR5), GAPD1_XENLA (A2RV61), IQG1_CANAL (Q5AH02), IQG1_YEAST (Q12280), NFAA_DICDI (Q55AR6), RGAA_DICDI (Q54K32), RME6_CAEBR (A8WVM4), RME6_CAEEL (Q9GYH7), RME6_DROME (Q9VZ08), RME6_DROPS (Q29HW3)» more |
| UniProtKB/Swiss-Prot 'Partial' sequences |
1 sequence
NF1_CHICK (P35608) |
| PDB [Detailed view] |
28 PDB
pdb_00001nf1; pdb_00001wer; pdb_00001wq1; pdb_00003bxj; pdb_00003fay; pdb_00005cjp; pdb_00006ob2; pdb_00006ob3; pdb_00006v65; pdb_00006v6f; pdb_00007moc; pdb_00007mp5; pdb_00007mp6; pdb_00007pgp; pdb_00007pgq; pdb_00007pgr; pdb_00007pgs; pdb_00007pgt; pdb_00007pgu; pdb_00007r03; pdb_00007r04; pdb_00008bos; pdb_00008e20; pdb_00008edl; pdb_00008edm; pdb_00008edn; pdb_00008edo; pdb_00009bz4 » more |