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PROSITE entry PS00546


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00546
Entry name [info] CYSTEINE_SWITCH
Accession [info] PS00546
Entry type [info] PATTERN
Date [info] 01-DEC-1991 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00472

Name and characterization of the entry

Description [info] Matrixins cysteine switch.
Pattern [info] 
P-R-C-[GN]-x-P-[DR]-[LIVSAPKQ].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 74 in 74 different sequences
Number of true positive hits 72 in 72 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 67
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 97.30 %
Recall (true positives / (true positives + false negatives)) 51.80 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] chelates_zinc at position 3
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 72 sequences 

095L_IIV3   (Q196W5), 2MMP_ARATH  (O04529), 3MMP_ARATH  (Q5XF51), 

5MMP_ARATH  (Q9ZUJ5), GLE_CHLRE   (P31178), HE_HEMPU(P91953), 
HE_PARLI(P22757), MEP1_SOYBN  (P29136), MMP10_HUMAN (P09238), 
MMP10_MOUSE (O55123), MMP10_RAT   (P07152), MMP11_HUMAN (P24347), 
MMP11_XENLA (Q11005), MMP12_HUMAN (P39900), MMP12_MOUSE (P34960), 
MMP12_RABIT (P79227), MMP13_BOVIN (O77656), MMP13_HORSE (O18927), 
MMP13_HUMAN (P45452), MMP13_MOUSE (P33435), MMP13_RABIT (O62806), 
MMP13_RAT   (P23097), MMP13_XENLA (Q10835), MMP14_BOVIN (Q9GLE4), 
MMP14_HUMAN (P50281), MMP14_MOUSE (P53690), MMP14_PIG   (Q9XT90), 
MMP14_PONAB (Q5RES1), MMP14_RABIT (Q95220), MMP14_RAT   (Q10739), 
MMP15_HUMAN (P51511), MMP15_MOUSE (O54732), MMP16_HUMAN (P51512), 
MMP16_MOUSE (Q9WTR0), MMP16_RAT   (O35548), MMP1A_MOUSE (Q9EPL5), 
MMP1B_MOUSE (Q9EPL6), MMP1_BOVIN  (P28053), MMP1_HORSE  (Q9XSZ5), 
MMP1_HUMAN  (P03956), MMP1_PIG(P21692), MMP1_RABIT  (P13943), 
MMP20_BOVIN (O18767), MMP20_HUMAN (O60882), MMP20_MOUSE (P57748), 
MMP20_PIG   (P79287), MMP27_HUMAN (Q9H306), MMP27_TUPBE (Q9GKE1), 
MMP2_BOVIN  (Q9GLE5), MMP2_CHICK  (Q90611), MMP2_HUMAN  (P08253), 
MMP2_MOUSE  (P33434), MMP2_RABIT  (P50757), MMP2_RAT(P33436), 
MMP3_CANLF  (Q6Y4Q5), MMP3_HUMAN  (P08254), MMP3_MOUSE  (P28862), 
MMP3_RABIT  (P28863), MMP3_RAT(P03957), MMP7_HUMAN  (P09237), 
MMP7_MOUSE  (Q10738), MMP7_RAT(P50280), MMP8_HUMAN  (P22894), 
MMP8_MOUSE  (O70138), MMP8_RAT(O88766), MMP9_BOVIN  (P52176), 
MMP9_CANLF  (O18733), MMP9_HUMAN  (P14780), MMP9_MOUSE  (P41245), 
MMP9_RABIT  (P41246), MMP9_RAT(P50282), MMPA_CAEEL  (G5EGM1)
» more

UniProtKB/Swiss-Prot
False negative sequences		 67 sequences 

1MMP_ARATH  (O23507), 4MMP_ARATH  (Q8GWW6), AD26A_MOUSE (Q9R158), 

ADA10_BOVIN (Q10741), ADA10_HUMAN (O14672), ADA10_MOUSE (O35598), 
ADA10_PIG   (O77633), ADA10_RAT   (Q10743), ADA10_XENLA (Q8JIY1), 
ADA12_MOUSE (Q61824), ADA15_HUMAN (Q13444), ADA15_MOUSE (O88839), 
ADA15_RAT   (Q9QYV0), ADA17_HUMAN (P78536), ADA17_MOUSE (Q9Z0F8), 
ADA17_RAT   (Q9Z1K9), ADA19_HUMAN (Q9H013), ADA19_MOUSE (O35674), 
ADA20_HUMAN (O43506), ADA21_HUMAN (Q9UKJ8), ADA21_MOUSE (Q9JI76), 
ADA24_MOUSE (Q9R160), ADA25_MOUSE (Q9R159), ADA28_HUMAN (Q9UKQ2), 
ADA28_MACFA (Q9XSL6), ADA28_MOUSE (Q9JLN6), ADA30_HUMAN (Q9UKF2), 
ADA33_HUMAN (Q9BZ11), ADA33_MOUSE (Q923W9), ADEC1_HUMAN (O15204), 
ATS12_HUMAN (P58397), ATS12_MOUSE (Q811B3), ATS14_HUMAN (Q8WXS8), 
ATS15_HUMAN (Q8TE58), ATS15_MOUSE (P59384), ATS16_HUMAN (Q8TE57), 
ATS16_MOUSE (Q69Z28), ATS17_HUMAN (Q8TE56), ATS18_HUMAN (Q8TE60), 
ATS18_MOUSE (Q4VC17), ATS19_HUMAN (Q8TE59), ATS19_MOUSE (P59509), 
ATS1_BOMMO  (Q5W7F4), ATS7_HUMAN  (Q9UKP4), ATS7_MOUSE  (Q68SA9), 
ATS7_RAT(Q1EHB3), ATS9_HUMAN  (Q9P2N4), MMP11_MOUSE (Q02853), 
MMP12_RAT   (Q63341), MMP17_HUMAN (Q9ULZ9), MMP17_MOUSE (Q9R0S3), 
MMP18_XENLA (O13065), MMP19_HUMAN (Q99542), MMP19_MOUSE (Q9JHI0), 
MMP1_AQUCT  (Q11133), MMP21_CYNPY (Q90YC2), MMP21_HUMAN (Q8N119), 
MMP21_MOUSE (Q8K3F2), MMP21_XENLA (O93470), MMP24_HUMAN (Q9Y5R2), 
MMP24_MOUSE (Q9R0S2), MMP25_HUMAN (Q9NPA2), MMP25_MOUSE (Q3U435), 
MMP26_HUMAN (Q9NRE1), MMP28_HUMAN (Q9H239), MMP3_HORSE  (Q28397), 
MMP7_FELCA  (P55032)
» more

UniProtKB/Swiss-Prot
False positive sequences		 2 sequences 

APCL_HUMAN  (O95996), RGYR2_AERPE (Q9YC75)


				
	

	

		PDB
[Detailed view]		
		
			19 PDB
			


			1CK7; 1EAK; 1GXD; 1L6J; 1SLM; 1SU3; 2MZE; 2MZH; 2MZI; 5TH6; 5TH9; 5UE2; 
			
				5UE3; 5UE4; 5UE5; 8K5V; 8K5W; 8K5X; 8K5Y
			
			

			» more