PROSITE logo

PROSITE entry PS00640


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] THIOL_PROTEASE_ASN
Accession [info] PS00640
Entry type [info] PATTERN
Date [info] 01-JUN-1992 CREATED;
01-NOV-1995 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00126
Associated ProRule [info] PRU10090

Name and characterization of the entry

Description [info] Eukaryotic thiol (cysteine) proteases asparagine active site.
Pattern [info]
[FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-x(2)-G-[LFYW]-
[LIVMFYG]-x-[LIVMF].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.


Total number of hits 200 in 200 different sequences
Number of true positive hits 200 in 200 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 130
Number of 'partial' sequences 24
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 60.61 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 6
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
200 sequences

4HBS_VANPL  (P0DO76), ACTN_ACTCC  (P00785), ACTN_ACTDE  (A5HII1), 
ALEUL_ARATH (Q8RWQ9), ALEU_ARATH  (Q8H166), ALEU_HORVU  (P05167), 
ANAN_ANACO  (P80884), BHPC1_PLABA (A0A509APV9), BROM1_ANACO (O23791), 
CATB1_GIAIN (P92131), CATB2_GIAIN (P92132), CATB3_GIAIN (P92133), 
CATB_BOVIN  (P07688), CATB_CHICK  (P43233), CATB_HUMAN  (P07858), 
CATB_MACFA  (Q4R5M2), CATB_MEDTR  (A0A072UTP9), CATB_MOUSE  (P10605), 
CATB_PIG(A1E295), CATB_PONAB  (Q5R6D1), CATB_RAT(P00787), 
CATB_SHEEP  (P83205), CATC_BOVIN  (Q3ZCJ8), CATC_CANLF  (O97578), 
CATC_HUMAN  (P53634), CATC_MACFA  (Q60HG6), CATC_MOUSE  (P97821), 
CATC_PONAB  (Q5RB02), CATC_RAT(P80067), CATF_DROME  (Q9VN93), 
CATH_BOVIN  (Q3T0I2), CATH_HUMAN  (P09668), CATH_MOUSE  (P49935), 
CATH_PIG(O46427), CATH_RAT(P00786), CATJ_MOUSE  (Q9R014), 
CATJ_RAT(Q63088), CATK_BOVIN  (Q5E968), CATK_CANLF  (Q3ZKN1), 
CATK_CHICK  (Q90686), CATK_HUMAN  (P43235), CATK_MACFA  (P61276), 
CATK_MACMU  (P61277), CATK_PIG(Q9GLE3), CATK_RABIT  (P43236), 
CATK_RAT(O35186), CATL1_BOVIN (P25975), CATL1_CANLF (Q9GL24), 
CATL1_CHICK (P09648), CATL1_CHLAE (Q9GKL8), CATL1_DROME (Q95029), 
CATL1_FELCA (P25773), CATL1_HUMAN (P07711), CATL1_MOUSE (P06797), 
CATL1_PIG   (Q28944), CATL1_RAT   (P07154), CATL1_SHEEP (Q10991), 
CATL2_BOVIN (Q5E998), CATL2_HUMAN (O60911), CATLL_FASHE (Q24940), 
CATLL_PHACE (O97397), CATL_AEDAE  (A0A1S4F2V5), CATL_BRUPA  (O17473), 
CATL_SARPE  (Q26636), CATL_SCHMA  (Q26534), CATQ_RAT(Q9QZE3), 
CATR_MOUSE  (Q9JIA9), CATS_BOVIN  (P25326), CATS_CANLF  (Q8HY81), 
CATS_HUMAN  (P25774), CATS_MOUSE  (O70370), CATS_RAT(Q02765), 
CATS_SAIBB  (Q8HY82), CATV_GVCPM  (O91466), CATV_GVXN   (Q9PYY5), 
CATV_NPVAC  (P25783), CATV_NPVAH  (Q80LP4), CATV_NPVAP  (Q91CL9), 
CATV_NPVBM  (P41721), CATV_NPVBS  (Q9YWK4), CATV_NPVCD  (Q6VTL7), 
CATV_NPVCF  (P41715), CATV_NPVEP  (Q91GE3), CATV_NPVHC  (Q9WGE0), 
CATV_NPVHZ  (Q8V5U0), CATV_NPVLD  (Q9YMP9), CATV_NPVMC  (Q8QLK1), 
CATV_NPVOP  (O10364), CATV_NPVR1  (Q8B9D5), CATV_NPVSE  (Q9J8B9), 
CATW_FELCA  (Q9TST1), CATW_HUMAN  (P56202), CATW_MOUSE  (P56203), 
CATZ1_CAEEL (G5EGP8), CATZ_BOVIN  (P05689), CATZ_HUMAN  (Q9UBR2), 
CATZ_MOUSE  (Q9WUU7), CATZ_ONCVO  (Q6PN98), CATZ_RAT(Q9R1T3), 
CEP01_AMBAR (V5LU01), CEP1_ARATH  (Q9FGR9), CEP2_ARATH  (Q9STL4), 
CEP3_ARATH  (Q9STL5), CPGP1_ZINOF (P82473), CPL1_CAEEL  (O45734), 
CPP1_ENTH1  (Q01957), CPP2_ENTH1  (Q01958), CPP3_ENTH1  (P36184), 
CPR1_CAEEL  (P25807), CPR3_CAEEL  (P43507), CPR4_CAEEL  (P43508), 
CPR5_CAEEL  (P43509), CPR6_CAEEL  (P43510), CRUST_PANBO (Q86GF7), 
CYSEP_PHAVU (P25803), CYSEP_RICCO (O65039), CYSEP_VIGMU (P12412), 
CYSP1_DICDI (P04988), CYSP1_HAECO (P19092), CYSP1_HOMAM (P13277), 
CYSP1_HORVU (P25249), CYSP1_LEIPI (P35591), CYSP1_MAIZE (Q10716), 
CYSP1_ORYSJ (Q7XR52), CYSP1_OSTOS (P25802), CYSP2_DICDI (P04989), 
CYSP2_HAECO (P25793), CYSP2_HOMAM (P25782), CYSP2_HORVU (P25250), 
CYSP2_LEIPI (Q05094), CYSP2_MAIZE (Q10717), CYSP3_HOMAM (P25784), 
CYSP3_OSTOS (Q06544), CYSP3_SOLLC (Q40143), CYSP4_BRANA (P25251), 
CYSP4_DICDI (P54639), CYSP5_DICDI (P54640), CYSP6_DICDI (Q94503), 
CYSP7_DICDI (Q94504), CYSP_BLOTA  (A1KXI0), CYSP_HEMSP  (P43156), 
CYSP_PEA(P25804), CYSP_SCHJA  (P43157), CYSP_SCHMA  (P25792), 
CYSP_THEAN  (P25781), CYSP_THEPA  (P22497), CYSP_TRYBB  (P14658), 
CYSP_TRYCR  (P25779), DPAP1_PLAF7 (Q8IIJ9), ERVB_TABDI  (P60994), 
ERVC1_TABDI (P83654), ERVC2_TABDI (A8DS38), FPC1_PLAF7  (P25805), 
LMCPA_LEIME (P25775), LMCPB_LEIME (P36400), MDO1_ANAMC  (P83443), 
MUCIN_MUCPR (B2LSD2), ORYA_ORYSJ  (P25776), ORYB_ORYSJ  (P25777), 
ORYC_ORYSJ  (P25778), P34_SOYBN   (P22895), PAPA1_CARPA (P00784), 
PAPA2_CARPA (P14080), PAPA3_CARPA (P10056), PAPA4_CARPA (P05994), 
PAPA5_CARPA (P05993), PEPT1_DERFA (P16311), PEPT1_DERPT (P08176), 
PEPT1_EURMA (P25780), PEPT1_PSOOV (Q1EIQ3), PVP1_PLAVN  (P46102), 
RD19A_ARATH (P43296), RD19B_ARATH (P43295), RD19C_ARATH (Q9SUL1), 
RD19D_ARATH (Q8VYS0), RD21A_ARATH (P43297), RD21B_ARATH (Q9FMH8), 
RD21C_ARATH (Q9LT78), RDL1_ARATH  (Q94B08), RDL2_ARATH  (Q9LT77), 
RDL3_ARATH  (Q9LXW3), RDL6_ARATH  (F4JNL3), REP1_ORYSJ  (Q7F3A8), 
REPA_ORYSJ  (Q7GDU7), SAG12_ARATH (Q9FJ47), SAG39_ORYSI (A2XQE8), 
SAG39_ORYSJ (Q7XWK5), SERA5_PLAF7 (Q9TY95), SERA5_PLAFD (P69193), 
SERA5_PLAFG (P69192), SILIC_PETFI (Q6YD92), TEST2_MOUSE (Q80UB0), 
TEST2_RAT   (P15242), TINAG_BOVIN (Q3SZI1), TINAG_HUMAN (Q9UJW2), 
VANSY_GLEHE (A0A068CNX1), VANSY_VANPL (A0A0F7G352), VX1_PLAVS   (P42666), 
XCP2_ARATH  (Q9LM66), YCF2E_CAEEL (P90850)
» more

UniProtKB/Swiss-Prot
False negative sequences
130 sequences

361L_IIV6   (Q91FG3), BLH1_YEAST  (Q01532), BLMH_CHICK  (P87362), 
BLMH_HUMAN  (Q13867), BLMH_RAT(P70645), BROM2_ANACO (P14518), 
CAN10_HUMAN (Q9HC96), CAN10_MACFA (Q95LP4), CAN10_MOUSE (Q9ESK3), 
CAN10_RAT   (Q9ES66), CAN11_HUMAN (Q9UMQ6), CAN12_HUMAN (Q6ZSI9), 
CAN12_MOUSE (Q9ER56), CAN13_HUMAN (Q6MZZ7), CAN13_MOUSE (Q3UW68), 
CAN13_RAT   (Q5BK10), CAN14_HUMAN (A8MX76), CAN15_HUMAN (O75808), 
CAN15_MOUSE (Q9JLG8), CAN1_BOVIN  (Q27970), CAN1_CAEEL  (P34308), 
CAN1_HUMAN  (P07384), CAN1_MACFA  (Q9GLG2), CAN1_MOUSE  (O35350), 
CAN1_PIG(P35750), CAN1_PONAB  (Q5NVS7), CAN1_RAT(P97571), 
CAN2_BOVIN  (Q27971), CAN2_CHICK  (Q92178), CAN2_HUMAN  (P17655), 
CAN2_MACFA  (Q9GLG1), CAN2_MOUSE  (O08529), CAN2_RAT(Q07009), 
CAN3_BOVIN  (P51186), CAN3_CHICK  (Q92177), CAN3_HUMAN  (P20807), 
CAN3_MACFA  (Q9GLG7), CAN3_MOUSE  (Q64691), CAN3_PIG(P43368), 
CAN3_RAT(P16259), CAN3_SHEEP  (Q9TTH8), CAN5_CAEEL  (Q22036), 
CAN5_HUMAN  (O15484), CAN5_MOUSE  (O08688), CAN5_RAT(Q8R4C0), 
CAN6_HUMAN  (Q9Y6Q1), CAN6_MOUSE  (O35646), CAN6_RAT(O88501), 
CAN7_HUMAN  (Q9Y6W3), CAN7_MOUSE  (Q9R1S8), CAN7_PIG(A0FKG7), 
CAN8_HUMAN  (A6NHC0), CAN8_MOUSE  (Q91VA3), CAN8_RAT(Q78EJ9), 
CAN9_HUMAN  (O14815), CAN9_MOUSE  (Q9D805), CAN9_RAT(O35920), 
CANA_DROME  (Q11002), CANB_DROME  (Q9VT65), CANC_DROME  (Q9VXH6), 
CAND_DROME  (P27398), CANX_CHICK  (P00789), CAN_SCHMA   (P27730), 
CAT7_MOUSE  (Q91ZF2), CAT7_RAT(D3ZZ07), CATB1_ARATH (F4HVZ1), 
CATB2_ARATH (Q93VC9), CATB3_ARATH (Q94K85), CATC_SCHMA  (Q26563), 
CATF_HUMAN  (Q9UBX1), CATF_MOUSE  (Q9R013), CATK_MOUSE  (P55097), 
CATL1_PARTE (Q94714), CATL2_PARTE (A0E358), CATL3_PARTE (Q94715), 
CATM_MOUSE  (Q9JL96), CATO_HUMAN  (P43234), CATO_MOUSE  (Q8BM88), 
CATV_NPVST  (Q91BH1), CFAD_DICDI  (Q54TR1), CPGP2_ZINOF (P82474), 
CPLA_DICDI  (Q8MUF9), CTSB_DICDI  (Q54QD9), CYSP3_DICDI (Q23894), 
CYSPL_SOLLC (P20721), DEK1_ARATH  (Q8RVL2), DEK1_MAIZE  (Q8RVL1), 
DEK1_ORYSJ  (Q6ZFZ4), ECPA_STAEP  (P0C0P9), ECPA_STAEQ  (Q5HKF6), 
ECPA_STAES  (P0C0Q0), ERVA_TABDI  (A5YVK8), FPC2A_PLAF7 (Q8I6U4), 
FPC2B_PLAF7 (Q8I6U5), FPC3_PLAF7  (Q8IIL0), GMSA_DICDI  (Q54ME1), 
MEX1_JACME  (P84346), MEX2_JACME  (P84347), PEPC_LACDL  (Q48543), 
PEPC_LACHE  (Q10744), PEPC_LACLA  (Q9CEG3), PEPC_LACLC  (Q04723), 
PEPC_LISIN  (Q928V0), PEPC_LISMO  (O69192), PEPC_STRTR  (Q56115), 
PEPE_LACHE  (P94870), PEPG_LACDL  (P94869), PEPW_LACDL  (P94868), 
RDL4_ARATH  (Q9SUT0), RDL5_ARATH  (Q9SUS9), SSPB_STAA8  (Q2FZL3), 
SSPB_STAAC  (Q5HH36), SSPB_STAAM  (Q99V46), SSPB_STAAN  (Q7A6A7), 
SSPB_STAAR  (Q6GI35), SSPB_STAAS  (Q6GAG5), SSPB_STAAU  (P0C1S6), 
SSPB_STAAW  (Q8NX99), SSPP_STAA8  (Q2G2R8), SSPP_STAAC  (Q5HEL3), 
SSPP_STAAM  (P65825), SSPP_STAAN  (P65826), SSPP_STAAR  (Q6GFE8), 
SSPP_STAAS  (Q6G824), SSPP_STAAU  (P81297), SSPP_STAAW  (Q8NVS9), 
TPR_PORGI   (P25806), VF224_IIV3  (Q197D6), VF224_IIV6  (Q91FU7), 
XCP1_ARATH  (O65493)
» more

UniProtKB/Swiss-Prot
'Partial' sequences
24 sequences

BLMH_RABIT  (P13019), CAL1_CALGI  (P20728), CAN1_RABIT  (P06815), 
CAN2_PIG(P43367), CAN2_RABIT  (P06814), CATB_COTJA  (P81494), 
CATL1_FASHE (Q09093), CATL2_FASHE (P80342), CATL3_FASHE (P80532), 
CATL4_FASHE (P80528), CATL9_FASHE (P80533), CYSB_FASHE  (P80529), 
CYSP1_VASCU (P32954), CYSP2_VASCU (P32955), CYSP3_VASCU (P32956), 
CYSP4_VASCU (P32957), CYSP_TRIFO  (P33403), CYSP_TRIVA  (P33404), 
HP29_SARPE  (P29184), KARA_BROPL  (P22442), MDO2_ANAMC  (P83447), 
PEPT1_DERMI (P16312), PHIG1_PHIGI (P84789), THPA_THADA  (P21381)
» more

PDB
[Detailed view]
377 PDB

1AEC; 1AIM; 1ATK; 1AU0; 1AU2; 1AU3; 1AU4; 1AYU; 1AYV; 1AYW; 1BGO; 1BP4; 1BQI; 1BY8; 1CJL; 1CPJ; 1CS8; 1CSB; 1CTE; 1CVZ; 1DEU; 1EF7; 1EWL; 1EWM; 1EWO; 1EWP; 1F29; 1F2A; 1F2B; 1F2C; 1FH0; 1GEC; 1GLO; 1GMY; 1HUC; 1ICF; 1ITO; 1IWD; 1JQP; 1K3B; 1KHP; 1KHQ; 1ME3; 1ME4; 1MEG; 1MEM; 1MHW; 1MIR; 1MS6; 1NB3; 1NB5; 1NL6; 1NLJ; 1NPZ; 1NQC; 1O0E; 1PAD; 1PBH; 1PCI; 1PE6; 1PIP; 1POP; 1PPD; 1PPN; 1PPO; 1PPP; 1Q6K; 1QDQ; 1S4V; 1SNK; 1SP4; 1STF; 1THE; 1TU6; 1U9Q; 1U9V; 1U9W; 1U9X; 1VSN; 1XKG; 1YAL; 1YK7; 1YK8; 1YT7; 2ACT; 2AIM; 2AS8; 2ATO; 2AUX; 2AUZ; 2BDL; 2C0Y; 2CIO; 2DC6; 2DC7; 2DC8; 2DC9; 2DCA; 2DCB; 2DCC; 2DCD; 2DJF; 2DJG; 2F1G; 2F7D; 2FO5; 2FQ9; 2FRA; 2FRQ; 2FT2; 2FTD; 2FUD; 2FYE; 2G6D; 2G7Y; 2H7J; 2HH5; 2HHN; 2HXZ; 2IPP; 2NQD; 2O6X; 2OP3; 2OZ2; 2PAD; 2PBH; 2PNS; 2PRE; 2R6N; 2R9M; 2R9N; 2R9O; 2VHS; 2WBF; 2XU1; 2XU3; 2XU4; 2XU5; 2YJ2; 2YJ8; 2YJ9; 2YJB; 2YJC; 3AI8; 3BC3; 3C9E; 3CBJ; 3CBK; 3CH2; 3CH3; 3E1Z; 3H6S; 3H7D; 3H89; 3H8B; 3H8C; 3HD3; 3HHA; 3HWN; 3I06; 3IEJ; 3IMA; 3IUT; 3IV2; 3K24; 3K9M; 3KFQ; 3KKU; 3KSE; 3KW9; 3KWB; 3KWZ; 3KX1; 3LFY; 3LXS; 3N3G; 3N4C; 3O0U; 3O1G; 3OF8; 3OF9; 3OVX; 3OVZ; 3PBH; 3PDF; 3TNX; 3USV; 4AXL; 4AXM; 4BPV; 4BQV; 4BS5; 4BS6; 4BSQ; 4CDC; 4CDD; 4CDE; 4CDF; 4DMX; 4DMY; 4KLB; 4MZO; 4MZS; 4N79; 4N8W; 4OEL; 4OEM; 4P6E; 4P6G; 4PAD; 4PI3; 4QH6; 4QRG; 4QRV; 4QRX; 4W5B; 4W5C; 4X6H; 4X6I; 4X6J; 4XUI; 4YV8; 4YVA; 5EF4; 5EGW; 5F02; 5I4H; 5J94; 5JA7; 5JH3; 5JT8; 5MAE; 5MAJ; 5MBL; 5MBM; 5MQY; 5PAD; 5QBU; 5QBV; 5QBW; 5QBX; 5QBY; 5QBZ; 5QC0; 5QC1; 5QC2; 5QC3; 5QC4; 5QC5; 5QC6; 5QC7; 5QC8; 5QC9; 5QCA; 5QCB; 5QCC; 5QCD; 5QCE; 5QCF; 5QCG; 5QCH; 5QCI; 5QCJ; 5TDI; 5TUN; 5VCN; 5VCO; 5VPG; 5VPH; 5VPK; 5VPL; 5Z5O; 6ASH; 6AY2; 6CZK; 6CZS; 6EZP; 6EZX; 6F06; 6H8T; 6HGY; 6JD0; 6JD8; 6MIS; 6N3S; 6O2X; 6OKJ; 6P4E; 6PAD; 6PXF; 6QBS; 6QL8; 6QLM; 6QLW; 6QLX; 6QM0; 6TCX; 6UX6; 6X42; 6X44; 6Y6L; 6YCB; 6YCC; 6YCD; 6YYN; 6YYO; 6YYP; 6YYQ; 6YYR; 7JUJ; 7NXL; 7NXM; 7PCK; 7PK4; 7Q8D; 7Q8F; 7Q8G; 7Q8H; 7Q8I; 7Q8J; 7Q8K; 7Q8L; 7Q8M; 7Q8N; 7Q8O; 7Q8P; 7Q8Q; 7Q9H; 7QBL; 7QBM; 7QBN; 7QBO; 7QFF; 7QFH; 7QGW; 7QHJ; 7QHK; 7QKB; 7QKC; 7QKD; 7QNS; 7QO2; 7S18; 7S19; 7W33; 7W34; 7Z3T; 7Z58; 7ZS7; 7ZVF; 7ZXA; 8A4U; 8A4V; 8A4W; 8A4X; 8A5B; 8AHV; 8B4F; 8B4T; 8B5F; 8C3D; 8C77; 8GX2; 8HE9; 8HEI; 8HEN; 8HET; 8HFV; 8OFA; 8OZA; 8PCH; 8PI3; 8PRX; 8QKB; 8RND; 8UAC; 9PAP
» more