Home  |  Contact
Entry: PS00708

General information about the entry

Entry name [info] PRO_ENDOPEP_SER
Accession [info] PS00708
Entry type [info] PATTERN
Date [info] 01-DEC-1992 CREATED;
01-DEC-1992 DATA UPDATE;
23-FEB-2022 INFO UPDATE.
PROSITE Doc. [info] PDOC00587
Associated ProRule [info] PRU10084

Name and characterization of the entry

Description [info] Prolyl endopeptidase family serine active site.
Pattern [info] 
D-x(3)-A-x(3)-[LIVMFYW]-x(14)-G-x-S-x-G-G-[LIVMFYW](2).

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2022_01 which contains 566'996 sequence entries.


Total number of hits 52 in 52 different sequences
Number of true positive hits 46 in 46 different sequences
Number of 'unknown' hits 1
Number of false positive hits 5 in 5 different sequences
Number of false negative sequences 69
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 90.20 %
Recall (true positives / (true positives + false negatives)) 40.00 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 9
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 46 sequences 

AARE1_ORYSJ (Q0IXP9    ), AARE2_ORYSJ (Q338C0    ), ACPH_BOVIN  (P80227    ), 

ACPH_HUMAN  (P13798    ), ACPH_PIG    (P19205    ), ACPH_RAT    (P13676    ), 
APEH_MOUSE  (Q8R146    ), DAP2_YEAST  (P18962    ), DAPB_ARTBC  (D4AQT0    ), 
DAPB_ASPTN  (Q0CXB1    ), DAPB_NEUCR  (Q7SHU8    ), DAPB_PARBA  (C1GT79    ), 
DAPB_PARBD  (C1FZL3    ), DAPB_PARBP  (C0S7H1    ), DAPB_SORMK  (D1Z9B4    ), 
DAPB_TRIVH  (D4DCG0    ), DPP4_ARTBC  (D4APE2    ), DPP4_ARTOC  (C5FJE3    ), 
DPP4_ARTOT  (A0S5V9    ), DPP4_BOVIN  (P81425    ), DPP4_FELCA  (Q9N2I7    ), 
DPP4_HUMAN  (P27487    ), DPP4_MOUSE  (P28843    ), DPP4_PIG    (P22411    ), 
DPP4_RAT    (P14740    ), DPP4_TRIEQ  (A7UKV8    ), DPP4_TRIRU  (Q5J6J3    ), 
DPP4_TRITO  (B6V868    ), DPP4_TRIVH  (D4CZ59    ), POPA_AMABI  (E2JFG1    ), 
POPA_GALM3  (H2E7Q7    ), POPB_AMABI  (E2JFG2    ), POPB_GALM3  (H2E7Q8    ), 
PPCE_AERHY  (Q06903    ), PPCE_BOVIN  (Q9XTA2    ), PPCE_DICDI  (Q86AS5    ), 
PPCE_ELIME  (P27028    ), PPCE_HUMAN  (P48147    ), PPCE_MOUSE  (Q9QUR6    ), 
PPCE_PIG    (P23687    ), PPCE_RAT    (O70196    ), PPCF_ELIMR  (P27195    ), 
PTRB_ECOLI  (P24555    ), PTRB_MORLA  (Q59536    ), YEA8_SCHPO  (O14073    ), 
YTMA_BACSU  (O34493    )
» more

UniProtKB/Swiss-Prot
False negative sequences		 69 sequences 

AARE_ARATH  (Q84LM4    ), APEH_AERPE  (Q9YBQ2    ), CGEP_ARATH  (Q8VZF3    ), 

CGEP_ORYSJ  (Q10MJ1    ), DAP4_PSEMX  (Q6F3I7    ), DAPB1_PSEMX (O07834    ), 
DAPB3_PSEMX (V5YMB3    ), DAPB_AJEC8  (F0U7H7    ), DAPB_AJECG  (C0NUQ8    ), 
DAPB_AJECH  (C6HRC7    ), DAPB_AJECN  (A6RBI0    ), DAPB_AJEDR  (C5GVF3    ), 
DAPB_ARTGP  (E4UYL6    ), DAPB_ARTOC  (C5FYZ3    ), DAPB_ASPCL  (A1CJQ1    ), 
DAPB_ASPFC  (B0XYK8    ), DAPB_ASPFN  (B8N076    ), DAPB_ASPFU  (Q4WX13    ), 
DAPB_ASPNC  (A2QEK7    ), DAPB_ASPNG  (Q96VT7    ), DAPB_ASPOR  (Q2UPW4    ), 
DAPB_BLAGS  (C5JC30    ), DAPB_BOTFB  (A6SL49    ), DAPB_CHAGB  (Q2HF90    ), 
DAPB_COCP7  (C5P334    ), DAPB_COCPS  (E9CUF4    ), DAPB_COLGM  (E3QKD2    ), 
DAPB_EMENI  (Q5B934    ), DAPB_FUSV7  (C7YYG9    ), DAPB_GROCL  (F0XS04    ), 
DAPB_MAGO7  (A4QYQ5    ), DAPB_METAQ  (E9ED72    ), DAPB_METRA  (E9ETL5    ), 
DAPB_NEOFI  (A1D7R6    ), DAPB_PENRW  (B6HFS8    ), DAPB_PHANO  (Q0UVK7    ), 
DAPB_PODAN  (B2A951    ), DAPB_PYRTR  (B2WC36    ), DAPB_PYRTT  (E3S9K3    ), 
DAPB_SCLS1  (A7EQZ1    ), DAPB_TALMQ  (B6QVW4    ), DAPB_TALSN  (B8MTH6    ), 
DAPB_TUBMM  (D5GM60    ), DAPB_UNCRE  (C4JHY5    ), DAPB_VERA1  (C9SJ15    ), 
DPF1_CAEEL  (Q7JKY3    ), DPF2_CAEEL  (Q18253    ), DPF6_CAEEL  (P34422    ), 
DPP4_ASPCL  (A1CHP1    ), DPP4_ASPFC  (B0Y6C5    ), DPP4_ASPFN  (B8N970    ), 
DPP4_ASPFU  (Q4WPH9    ), DPP4_ASPOR  (Q2UH35    ), DPP4_EMENI  (Q5AZ42    ), 
DPP4_NEOFI  (A1CX29    ), DPP_GIAIN   (Q95WU5    ), OPH_PSESP   (Q9LCQ7    ), 
OPH_SPHS1   (Q588Z2    ), PPCEL_CHICK (Q5ZKL5    ), PPCEL_HUMAN (Q4J6C6    ), 
PPCEL_MACFA (A5LFV8    ), PPCEL_MOUSE (Q8C167    ), PPCEL_PONAB (Q5RAK4    ), 
PPCEL_RAT   (Q5HZA6    ), PPCEL_XENLA (Q32N48    ), PTP_PORG3   (B2RJX3    ), 
PTP_PORGI   (Q7MUW6    ), STE13_YEAST (P33894    ), VDPP4_APIME (B2D0J4    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

ACPH_RABIT  (P25154    )


				
	

	

		UniProtKB/Swiss-Prot
'Unknown' sequences		
		
			1 sequence
			


			
YTAP_BACSU  (O34973    )


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			5 sequences
			


			
AR1AB_XENLA (A0A1L8EXB5), NAR1_USTMA  (Q4PAR1    ), SEPR_BOVIN  (A5D7B7    ), 

			
SEPR_HUMAN  (Q12884    ), SEPR_MOUSE  (P97321    )


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			148 PDB
			


			1E5T; 1H2W; 1H2X; 1H2Y; 1J2E; 1N1M; 1NU6; 1NU8; 1O6F; 1O6G; 1ORV; 1ORW; 
			
				1PFQ; 1QFM; 1QFS; 1R9M; 1R9N; 1RWQ; 1TK3; 1TKR; 1U8E; 1VZ2; 1VZ3; 1W1I; 
				1WCY; 1X70; 2AJ8; 2AJB; 2AJC; 2AJD; 2AJL; 2BGN; 2BGR; 2BUA; 2BUB; 2BUC; 
				2FJP; 2G5P; 2G5T; 2G63; 2GBC; 2GBF; 2GBG; 2GBI; 2HHA; 2I03; 2I3Z; 2I78; 
				2IIT; 2IIV; 2JID; 2OAE; 2OAG; 2OGZ; 2OLE; 2ONC; 2OPH; 2OQI; 2OQV; 2P8S; 
				2QJR; 2QKY; 2QOE; 2QT9; 2QTB; 2RGU; 2RIP; 2XDW; 3BJM; 3C43; 3C45; 3CCB; 
				3CCC; 3D4L; 3DDU; 3EIO; 3EQ7; 3EQ8; 3EQ9; 3F8S; 3G0B; 3G0C; 3G0D; 3G0G; 
				3H0C; 3HAB; 3HAC; 3KWF; 3KWJ; 3NOX; 3O95; 3O9V; 3OC0; 3OPM; 3Q0T; 3Q8W; 
				3QBJ; 3SWW; 3SX4; 3VJK; 3VJL; 3VJM; 3W2T; 3WQH; 4A5S; 4AMY; 4AMZ; 4AN0; 
				4AN1; 4AX4; 4BCB; 4BCC; 4BCD; 4DSA; 4DSZ; 4DTC; 4FFV; 4FFW; 4G1F; 4J3J; 
				4JH0; 4KR0; 4L72; 4LKO; 4N8D; 4N8E; 4PNZ; 4PV7; 4QZV; 5I7U; 5ISM; 5J3J; 
				5KBY; 5LLS; 5N4D; 5N4E; 5N4F; 5T4B; 5T4E; 5T4F; 5T4H; 5VTA; 5Y7H; 5Y7J; 
				5Y7K; 5ZID; 6B1E; 6B1O
			
			

			» more

				
	





View entry in original PROSITE format


View entry in raw text format (no links)


Direct ScanProsite submission