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PROSITE entry PS00708


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00708
Entry name [info] PRO_ENDOPEP_SER
Accession [info] PS00708
Entry type [info] PATTERN
Date [info] 01-DEC-1992 CREATED;
01-DEC-1992 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00587
Associated ProRule [info] PRU10084

Name and characterization of the entry

Description [info] Prolyl endopeptidase family serine active site.
Pattern [info] 
D-x(3)-A-x(3)-[LIVMFYW]-x(14)-G-x-S-x-G-G-[LIVMFYW](2).

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 57 in 57 different sequences
Number of true positive hits 50 in 50 different sequences
Number of 'unknown' hits 1
Number of false positive hits 6 in 6 different sequences
Number of false negative sequences 71
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 89.29 %
Recall (true positives / (true positives + false negatives)) 41.32 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 9
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 50 sequences 

AARE1_ORYSJ (Q0IXP9), AARE2_ORYSJ (Q338C0), ACPH_BOVIN  (P80227), 

ACPH_HUMAN  (P13798), ACPH_MOUSE  (Q8R146), ACPH_PIG(P19205), 
ACPH_RABIT  (P25154), ACPH_RAT(P13676), DAP2_YEAST  (P18962), 
DAPB_ARTBC  (D4AQT0), DAPB_ASPTN  (Q0CXB1), DAPB_NEUCR  (Q7SHU8), 
DAPB_PARBA  (C1GT79), DAPB_PARBD  (C1FZL3), DAPB_PARBP  (C0S7H1), 
DAPB_SORMK  (D1Z9B4), DAPB_TRIVH  (D4DCG0), DBIP_DENBC  (A0A4S8L6U5), 
DPP4_ARTBC  (D4APE2), DPP4_ARTOC  (C5FJE3), DPP4_ARTOT  (A0S5V9), 
DPP4_BOVIN  (P81425), DPP4_FELCA  (Q9N2I7), DPP4_HUMAN  (P27487), 
DPP4_MOUSE  (P28843), DPP4_PIG(P22411), DPP4_RAT(P14740), 
DPP4_TRIEQ  (A7UKV8), DPP4_TRIRU  (Q5J6J3), DPP4_TRITO  (B6V868), 
DPP4_TRIVH  (D4CZ59), LEDP_LENED  (A0A1Q3EPF5), OPHP_OMPOL  (P9WEN5), 
POPA_AMABI  (E2JFG1), POPA_GALM3  (H2E7Q7), POPB_AMABI  (E2JFG2), 
POPB_GALM3  (H2E7Q8), PPCE_AERHY  (Q06903), PPCE_BOVIN  (Q9XTA2), 
PPCE_DICDI  (Q86AS5), PPCE_ELIME  (P27028), PPCE_HUMAN  (P48147), 
PPCE_MOUSE  (Q9QUR6), PPCE_PIG(P23687), PPCE_RAT(O70196), 
PPCF_ELIMR  (P27195), PTRB_ECOLI  (P24555), PTRB_MORLA  (Q59536), 
YEA8_SCHPO  (O14073), YTMA_BACSU  (O34493)
» more

UniProtKB/Swiss-Prot
False negative sequences		 71 sequences 

AARE_ARATH  (Q84LM4), APEH_AERPE  (Q9YBQ2), CGEP_ARATH  (Q8VZF3), 

CGEP_ORYSJ  (Q10MJ1), DAP4_PSEMX  (Q6F3I7), DAPB1_PSEMX (O07834), 
DAPB3_PSEMX (V5YMB3), DAPB_AJEC8  (F0U7H7), DAPB_AJECG  (C0NUQ8), 
DAPB_AJECH  (C6HRC7), DAPB_AJECN  (A6RBI0), DAPB_AJEDR  (C5GVF3), 
DAPB_ARTGP  (E4UYL6), DAPB_ARTOC  (C5FYZ3), DAPB_ASPCL  (A1CJQ1), 
DAPB_ASPFC  (B0XYK8), DAPB_ASPFN  (B8N076), DAPB_ASPFU  (Q4WX13), 
DAPB_ASPNC  (A2QEK7), DAPB_ASPNG  (Q96VT7), DAPB_ASPOR  (Q2UPW4), 
DAPB_BLAGS  (C5JC30), DAPB_BOTFB  (A6SL49), DAPB_CHAGB  (Q2HF90), 
DAPB_COCP7  (C5P334), DAPB_COCPS  (E9CUF4), DAPB_COLGM  (E3QKD2), 
DAPB_EMENI  (Q5B934), DAPB_FUSV7  (C7YYG9), DAPB_GROCL  (F0XS04), 
DAPB_METAQ  (E9ED72), DAPB_METRA  (E9ETL5), DAPB_NEOFI  (A1D7R6), 
DAPB_PENRW  (B6HFS8), DAPB_PHANO  (Q0UVK7), DAPB_PODAN  (B2A951), 
DAPB_PYRO7  (A4QYQ5), DAPB_PYRTR  (B2WC36), DAPB_PYRTT  (E3S9K3), 
DAPB_SCLS1  (A7EQZ1), DAPB_TALMQ  (B6QVW4), DAPB_TALSN  (B8MTH6), 
DAPB_TUBMM  (D5GM60), DAPB_UNCRE  (C4JHY5), DAPB_VERA1  (C9SJ15), 
DPF1_CAEEL  (Q7JKY3), DPF2_CAEEL  (Q18253), DPF6_CAEEL  (P34422), 
DPP4_ASPCL  (A1CHP1), DPP4_ASPFC  (B0Y6C5), DPP4_ASPFN  (B8N970), 
DPP4_ASPFU  (Q4WPH9), DPP4_ASPOR  (Q2UH35), DPP4_EMENI  (Q5AZ42), 
DPP4_NEOFI  (A1CX29), DPP_GIAIN   (Q95WU5), OPH_PSESP   (Q9LCQ7), 
OPH_SPHS1   (Q588Z2), PPCEL_CHICK (Q5ZKL5), PPCEL_HUMAN (Q4J6C6), 
PPCEL_MACFA (A5LFV8), PPCEL_MOUSE (Q8C167), PPCEL_PONAB (Q5RAK4), 
PPCEL_RAT   (Q5HZA6), PPCEL_XENLA (Q32N48), PTP_PORG3   (B2RJX3), 
PTP_PORGI   (Q7MUW6), STE13_YEAST (P33894), VDDP4_VESVE (P0DRB8), 
VDDP4_VESVU (B1A4F7), VDPP4_APIME (B2D0J4)
» more

UniProtKB/Swiss-Prot
'Unknown' sequences		 1 sequence 

YTAP_BACSU  (O34973)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			6 sequences
			


			
AR1AA_XENLA (Q8AVT9), AR1AB_XENLA (A0A1L8EXB5), NAR1_MYCMD  (Q4PAR1), 

			
SEPR_BOVIN  (A5D7B7), SEPR_HUMAN  (Q12884), SEPR_MOUSE  (P97321)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			154 PDB
			


			1E5T; 1H2W; 1H2X; 1H2Y; 1J2E; 1N1M; 1NU6; 1NU8; 1O6F; 1O6G; 1ORV; 1ORW; 
			
				1PFQ; 1QFM; 1QFS; 1R9M; 1R9N; 1RWQ; 1TK3; 1TKR; 1U8E; 1VZ2; 1VZ3; 1W1I; 
				1WCY; 1X70; 2AJ8; 2AJB; 2AJC; 2AJD; 2AJL; 2BGN; 2BGR; 2BUA; 2BUB; 2BUC; 
				2FJP; 2G5P; 2G5T; 2G63; 2GBC; 2GBF; 2GBG; 2GBI; 2HHA; 2I03; 2I3Z; 2I78; 
				2IIT; 2IIV; 2JID; 2OAE; 2OAG; 2OGZ; 2OLE; 2ONC; 2OPH; 2OQI; 2OQV; 2P8S; 
				2QJR; 2QKY; 2QOE; 2QT9; 2QTB; 2RGU; 2RIP; 2XDW; 3BJM; 3C43; 3C45; 3CCB; 
				3CCC; 3D4L; 3DDU; 3EIO; 3EQ7; 3EQ8; 3EQ9; 3F8S; 3G0B; 3G0C; 3G0D; 3G0G; 
				3H0C; 3HAB; 3HAC; 3KWF; 3KWJ; 3NOX; 3O95; 3O9V; 3OC0; 3OPM; 3Q0T; 3Q8W; 
				3QBJ; 3SWW; 3SX4; 3VJK; 3VJL; 3VJM; 3W2T; 3WQH; 4A5S; 4AMY; 4AMZ; 4AN0; 
				4AN1; 4AX4; 4BCB; 4BCC; 4BCD; 4DSA; 4DSZ; 4DTC; 4FFV; 4FFW; 4G1F; 4J3J; 
				4JH0; 4KR0; 4L72; 4LKO; 4N8D; 4N8E; 4PNZ; 4PV7; 4QZV; 5I7U; 5ISM; 5J3J; 
				5KBY; 5LLS; 5N4D; 5N4E; 5N4F; 5T4B; 5T4E; 5T4F; 5T4H; 5VTA; 5Y7H; 5Y7J; 
				5Y7K; 5ZID; 6B1E; 6B1O; 7PX8; 7QUN; 7XNM; 8WKU; 8ZDX; 8ZE6
			
			

			» more