We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU10084
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU10084
General rule information
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| Accession | PRU10084 |
| Dates | 16-OCT-2006 (Created)
22-NOV-2019 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS00708; PRO_ENDOPEP_SER |
Name | Prolyl endopeptidase family serine active site |
| Function | Undefined |
| Scope(s) |
Eukaryota Bacteria Archaea |
| Example(s) | Q9XTA2; |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + AltName: Full=Dipeptidyl-peptidase IV; EC=3.4.14.5; |
Comments
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| CATALYTIC ACTIVITY | Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.; EC=3.4.14.5; |
Features
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| From: PS00708 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 5 | 5 | /note="Charge relay system" | |||||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [1] Bacteria [14] Eukaryota [107] All [ 122 ]
- Retrieve set of proteins with 3D structure for this domain