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PROSITE entry PS00778


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General information about the entry

Entry name [info] HIS_ACID_PHOSPHAT_2
Accession [info] PS00778
Entry type [info] PATTERN
Date [info] 01-DEC-1992 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00538

Name and characterization of the entry

Description [info] Histidine acid phosphatases active site signature.
Pattern [info] 
[LIVMF]-x-[LIVMFAG]-{T}-x-[STAGI]-H-D-[STANQ]-{V}-[LIVM]-x(2)-[LIVMFY]-
x(2)-[STA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_04 which contains 571'864 sequence entries.


Total number of hits 93 in 93 different sequences
Number of true positive hits 49 in 49 different sequences
Number of 'unknown' hits 0
Number of false positive hits 44 in 44 different sequences
Number of false negative sequences 31
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 52.69 %
Recall (true positives / (true positives + false negatives)) 61.25 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 7
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 49 sequences 

AGP_ECOLI   (P19926), AGP_PRORE   (Q52309), AGP_SALTY   (O33921), 

PHO10_CAEEL (Q09448), PHO11_CAEEL (Q09451), PHO5_CAEEL  (Q10944), 
PHYA1_ASPTE (O00085), PHYA2_ASPTE (O00100), PHYA_ARTBC  (D4ANW6), 
PHYA_ASPAW  (P34753), PHYA_ASPFU  (O00092), PHYA_ASPNG  (P34752), 
PHYA_ASPOR  (Q9C1T1), PHYA_ASPTN  (Q0CLV1), PHYA_CANAL  (A0A1D8PS71), 
PHYA_EMENI  (O00093), PHYA_NEUCR  (Q7S9V5), PHYA_PENOX  (Q6YNE9), 
PHYA_THETO  (O00107), PHYB_ASPAW  (P34755), PHYB_ASPNG  (P34754), 
PPA1_PICPA  (P52291), PPA1_SCHPO  (P08091), PPA2_SCHPO  (Q01682), 
PPA3_SCHPO  (O60172), PPA3_YEAST  (P24031), PPA5_KLULA  (P52289), 
PPA5_YEAST  (P00635), PPAB_YEAST  (P35842), PPAC_YEAST  (P38693), 
PPAD_YEAST  (P52290), PPAL_BOVIN  (Q0P5F0), PPAL_HUMAN  (P11117), 
PPAL_MACFA  (Q4R5N9), PPAL_MOUSE  (P24638), PPAL_PONAB  (Q5NVF6), 
PPAL_RAT(P20611), PPAL_XENLA  (B1H1P9), PPAP_BOVIN  (A6H730), 
PPAP_HUMAN  (P15309), PPAP_MOUSE  (Q8CE08), PPAP_RAT(P20646), 
PPAT_HUMAN  (Q9BZG2), PPAT_MOUSE  (D3YTS9), PPAT_XENLA  (Q3KQG9), 
PPAX_CAEEL  (Q09549), PPA_ECOLI   (P07102), STPA_SYNY3  (Q55034), 
Y4755_DICDI (Q54P71)
» more

UniProtKB/Swiss-Prot
False negative sequences		 31 sequences 

ACP1_CAEBR  (Q619N4), ACP1_CAEEL  (Q23534), ACPH1_APIME (Q5BLY5), 

CF60_DICDI  (Q54PR9), PEPP_ALLCE  (Q93WP4), PHO1_CAEEL  (Q19076), 
PPA4_SCHPO  (Q9USS6), PPA6_BOVIN  (A6H757), PPA6_HUMAN  (Q9NPH0), 
PPA6_MOUSE  (Q8BP40), PPA6_PONAB  (Q5R8C0), PXYP1_DANRE (Q6DH46), 
PXYP1_HUMAN (Q8TE99), PXYP1_MOUSE (Q8BHA9), PXYP1_RAT   (Q66H78), 
PXYP1_XENTR (Q0IHQ9), VIP1L_ARATH (F4J8C6), VIP1_BOVIN  (A7Z050), 
VIP1_CAEEL  (P91309), VIP1_DROME  (Q9VR59), VIP1_HUMAN  (Q6PFW1), 
VIP1_MOUSE  (A2ARP1), VIP1_PONAB  (Q5RDF1), VIP1_RAT(P0C644), 
VIP1_SCHPO  (O74429), VIP1_YEAST  (Q06685), VIP2_HUMAN  (O43314), 
VIP2_MOUSE  (Q6ZQB6), VIP2_PONAB  (Q5REW0), VIP2_XENLA  (Q5XHF8), 
Y4753_DICDI (Q54P72)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

PHYB_ASPFI  (P81440)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			44 sequences
			


			
ARGB_CHLPM  (A4SEI5), AT18C_ARATH (Q8GYD7), AT18D_ARATH (Q0WPK3), 

			
AT18E_ARATH (Q9FHK8), CDPKT_ORYSJ (Q2QVG8), CTX80_EUPOC (Q9N9X3), 
DBF4A_CRIGR (Q99MU0), DBP9_USTMA  (Q4P7M1), DPOL_SFAVA  (Q779J8), 
DTPA_CROTZ  (C9Y3M8), DTPA_ECO57  (Q8X651), DTPA_ECOL6  (Q8FH91), 
DTPA_ECOLI  (P77304), DTPA_ENT38  (A4W9W3), DTPA_KLEP3  (B5XWP3), 
DTPA_SALTI  (Q8Z6Q5), DTPA_SALTY  (Q8ZPM6), DTX18_ARATH (Q9LUH3), 
EMAL1_HUMAN (O00423), EMAL1_MOUSE (Q05BC3), EMAL1_RAT   (Q4V8C3), 
EMAL4_HUMAN (Q9HC35), EMAL4_XENLA (Q2TAF3), EMAL4_XENTR (Q6DIP5), 
EMAP_STRPU  (Q26613), GBB3_CANLF  (P79147), GBB3_HUMAN  (P16520), 
GBB3_MOUSE  (Q61011), GBB3_RAT(P52287), INT_BACSU   (P96629), 
LRC40_DANRE (Q7SXW3), LRC40_HUMAN (Q9H9A6), LRC40_MACFA (Q4R3P6), 
LRC40_MOUSE (Q9CRC8), LRC40_PONAB (Q5RFE9), LRC40_XENLA (Q6GPJ5), 
LRC40_XENTR (Q5M8G4), L_MABVO (Q6UY63), NBEL2_DANRE (E7FAW3), 
SURE1_BURL3 (Q390V3), TRKH_HALED  (E1V6C5), VIRB5_AGRFC (P17795), 
VIRB5_AGRT9 (P0A3W3), VIRB5_RHIRD (P0A3W2)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			27 PDB
			


			1CVI; 1DKL; 1DKM; 1DKN; 1DKO; 1DKP; 1DKQ; 1IHP; 1ND5; 1ND6; 1NT4; 1QFX; 
			
				1QWO; 1RPA; 1RPT; 1SK8; 1SK9; 1SKA; 1SKB; 2HPA; 3K4P; 3K4Q; 4TSR; 6RMR; 
				7Z1J; 7Z2S; 8XJ4
			
			

			» more