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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00778


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PURL: https://purl.expasy.org/prosite/signature/PS00778

Direct ScanProsite submission
General information about the entry

Entry name [info] HIS_ACID_PHOSPHAT_2
Accession [info] PS00778
Entry type [info] PATTERN
Date [info] 01-DEC-1992 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00538

Name and characterization of the entry

Description [info] Histidine acid phosphatases active site signature.
Pattern [info] 
[LIVMF]-x-[LIVMFAG]-{T}-x-[STAGI]-H-D-[STANQ]-{V}-[LIVM]-x(2)-[LIVMFY]-
x(2)-[STA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 93 in 93 different sequences
Number of true positive hits 49 in 49 different sequences
Number of 'unknown' hits 0
Number of false positive hits 44 in 44 different sequences
Number of false negative sequences 31
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 52.69 %
Recall (true positives / (true positives + false negatives)) 61.25 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 7
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 49 sequences 

AGP_ECOLI   (P19926), AGP_PRORE   (Q52309), AGP_SALTY   (O33921), 

PHO10_CAEEL (Q09448), PHO11_CAEEL (Q09451), PHO5_CAEEL  (Q10944), 
PHYA1_ASPTE (O00085), PHYA2_ASPTE (O00100), PHYA_ARTBC  (D4ANW6), 
PHYA_ASPAW  (P34753), PHYA_ASPFU  (O00092), PHYA_ASPNG  (P34752), 
PHYA_ASPOR  (Q9C1T1), PHYA_ASPTN  (Q0CLV1), PHYA_CANAL  (A0A1D8PS71), 
PHYA_EMENI  (O00093), PHYA_NEUCR  (Q7S9V5), PHYA_PENOX  (Q6YNE9), 
PHYA_THETO  (O00107), PHYB_ASPAW  (P34755), PHYB_ASPNG  (P34754), 
PPA1_PICPA  (P52291), PPA1_SCHPO  (P08091), PPA2_SCHPO  (Q01682), 
PPA3_SCHPO  (O60172), PPA3_YEAST  (P24031), PPA5_KLULA  (P52289), 
PPA5_YEAST  (P00635), PPAB_YEAST  (P35842), PPAC_YEAST  (P38693), 
PPAD_YEAST  (P52290), PPAL_BOVIN  (Q0P5F0), PPAL_HUMAN  (P11117), 
PPAL_MACFA  (Q4R5N9), PPAL_MOUSE  (P24638), PPAL_PONAB  (Q5NVF6), 
PPAL_RAT(P20611), PPAL_XENLA  (B1H1P9), PPAP_BOVIN  (A6H730), 
PPAP_HUMAN  (P15309), PPAP_MOUSE  (Q8CE08), PPAP_RAT(P20646), 
PPAT_HUMAN  (Q9BZG2), PPAT_MOUSE  (D3YTS9), PPAT_XENLA  (Q3KQG9), 
PPAX_CAEEL  (Q09549), PPA_ECOLI   (P07102), STPA_SYNY3  (Q55034), 
Y4755_DICDI (Q54P71)
» more

UniProtKB/Swiss-Prot
False negative sequences		 31 sequences 

ACP1_CAEBR  (Q619N4), ACP1_CAEEL  (Q23534), ACPH1_APIME (Q5BLY5), 

CF60_DICDI  (Q54PR9), PEPP_ALLCE  (Q93WP4), PHO1_CAEEL  (Q19076), 
PPA4_SCHPO  (Q9USS6), PPA6_BOVIN  (A6H757), PPA6_HUMAN  (Q9NPH0), 
PPA6_MOUSE  (Q8BP40), PPA6_PONAB  (Q5R8C0), PXYP1_DANRE (Q6DH46), 
PXYP1_HUMAN (Q8TE99), PXYP1_MOUSE (Q8BHA9), PXYP1_RAT   (Q66H78), 
PXYP1_XENTR (Q0IHQ9), VIP1L_ARATH (F4J8C6), VIP1_BOVIN  (A7Z050), 
VIP1_CAEEL  (P91309), VIP1_DROME  (Q9VR59), VIP1_HUMAN  (Q6PFW1), 
VIP1_MOUSE  (A2ARP1), VIP1_PONAB  (Q5RDF1), VIP1_RAT(P0C644), 
VIP1_SCHPO  (O74429), VIP1_YEAST  (Q06685), VIP2_HUMAN  (O43314), 
VIP2_MOUSE  (Q6ZQB6), VIP2_PONAB  (Q5REW0), VIP2_XENLA  (Q5XHF8), 
Y4753_DICDI (Q54P72)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

PHYB_ASPFI  (P81440)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			44 sequences
			


			
ARGB_CHLPM  (A4SEI5), AT18C_ARATH (Q8GYD7), AT18D_ARATH (Q0WPK3), 

			
AT18E_ARATH (Q9FHK8), CDPKT_ORYSJ (Q2QVG8), CTX80_EUPOC (Q9N9X3), 
DBF4A_CRIGR (Q99MU0), DBP9_MYCMD  (Q4P7M1), DPOL_SFAVA  (Q779J8), 
DTPA_CROTZ  (C9Y3M8), DTPA_ECO57  (Q8X651), DTPA_ECOL6  (Q8FH91), 
DTPA_ECOLI  (P77304), DTPA_ENT38  (A4W9W3), DTPA_KLEP3  (B5XWP3), 
DTPA_SALTI  (Q8Z6Q5), DTPA_SALTY  (Q8ZPM6), DTX18_ARATH (Q9LUH3), 
EMAL1_HUMAN (O00423), EMAL1_MOUSE (Q05BC3), EMAL1_RAT   (Q4V8C3), 
EMAL4_HUMAN (Q9HC35), EMAL4_XENLA (Q2TAF3), EMAL4_XENTR (Q6DIP5), 
EMAP_STRPU  (Q26613), GBB3_CANLF  (P79147), GBB3_HUMAN  (P16520), 
GBB3_MOUSE  (Q61011), GBB3_RAT(P52287), INT_BACSU   (P96629), 
LRC40_DANRE (Q7SXW3), LRC40_HUMAN (Q9H9A6), LRC40_MACFA (Q4R3P6), 
LRC40_MOUSE (Q9CRC8), LRC40_PONAB (Q5RFE9), LRC40_XENLA (Q6GPJ5), 
LRC40_XENTR (Q5M8G4), L_MABVO (Q6UY63), NBEL2_DANRE (E7FAW3), 
SURE1_BURL3 (Q390V3), TRKH_HALED  (E1V6C5), VIRB5_AGRFC (P17795), 
VIRB5_AGRT9 (P0A3W3), VIRB5_RHIRD (P0A3W2)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			27 PDB
			


			pdb_00001cvi; pdb_00001dkl; pdb_00001dkm; pdb_00001dkn; pdb_00001dko; pdb_00001dkp; pdb_00001dkq; pdb_00001ihp; pdb_00001nd5; pdb_00001nd6; pdb_00001nt4; pdb_00001qfx; 
			
				pdb_00001qwo; pdb_00001rpa; pdb_00001rpt; pdb_00001sk8; pdb_00001sk9; pdb_00001ska; pdb_00001skb; pdb_00002hpa; pdb_00003k4p; pdb_00003k4q; pdb_00004tsr; pdb_00006rmr; 
				pdb_00007z1j; pdb_00007z2s; pdb_00008xj4
			
			

			» more