We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE entry PS00790
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PURL: https://purl.expasy.org/prosite/signature/PS00790
Direct ScanProsite submission
General information about the entry
| Entry name [info] | RECEPTOR_TYR_KIN_V_1 |
| Accession [info] | PS00790 |
| Entry type [info] | PATTERN |
| Date [info] |
01-DEC-1992 CREATED;
01-APR-2006 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00629 |
Name and characterization of the entry
| Description [info] | Receptor tyrosine kinase class V signature 1. |
| Pattern [info] |
F-x-[DN]-x-[GAW]-[GAS]-C-[LIVM]-[SA]-[LIVM](2)-[SA]-[LV]-[KRHQ]-[LIVA]- x(3)-[KREQT]-C-[PSAWR]. |
Numerical results [info]
| Total number of hits | 49 in 49 different sequences |
| Number of true positive hits | 49 in 49 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 1 |
| Number of 'partial' sequences | 2 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 98.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Site [info] | disulfide(?) at position 7 |
| Site [info] | disulfide(?) at position 17 |
| Version [info] | 2 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
49 sequences
EPA4A_XENLA (Q91845), EPA4B_XENLA (Q91694), EPB1B_XENLA (Q91736), EPHA1_HUMAN (P21709), EPHA1_MOUSE (Q60750), EPHA2_HUMAN (P29317), EPHA2_MACFA (Q1KL86), EPHA2_MOUSE (Q03145), EPHA3_CHICK (P29318), EPHA3_DANRE (O13146), EPHA3_HUMAN (P29320), EPHA3_MOUSE (P29319), EPHA3_RAT (O08680), EPHA4_CHICK (Q07496), EPHA4_HUMAN (P54764), EPHA4_MOUSE (Q03137), EPHA5_CHICK (P54755), EPHA5_HUMAN (P54756), EPHA5_MOUSE (Q60629), EPHA5_RAT (P54757), EPHA6_HUMAN (Q9UF33), EPHA6_MOUSE (Q62413), EPHA6_RAT (P54758), EPHA7_CHICK (O42422), EPHA7_HUMAN (Q15375), EPHA7_MOUSE (Q61772), EPHA7_RAT (P54759), EPHA8_HUMAN (P29322), EPHA8_MOUSE (O09127), EPHAA_HUMAN (Q5JZY3), EPHAA_MOUSE (Q8BYG9), EPHB1_HUMAN (P54762), EPHB1_MOUSE (Q8CBF3), EPHB1_RAT (P09759), EPHB2_CHICK (P28693), EPHB2_COTJA (Q90344), EPHB2_HUMAN (P29323), EPHB2_MOUSE (P54763), EPHB3_CHICK (Q07498), EPHB3_HUMAN (P54753), EPHB3_MOUSE (P54754), EPHB3_XENLA (Q91735), EPHB4_HUMAN (P54760), EPHB4_MOUSE (P54761), EPHB5_CHICK (Q07497), EPHB6_HUMAN (O15197), EPHB6_MOUSE (O08644), EPHB6_PANTR (P0C0K6), EPHB6_RAT (P0C0K7)» more
|
| UniProtKB/Swiss-Prot False negative sequences |
1 sequence
EPB1A_XENLA (Q91571) |
| UniProtKB/Swiss-Prot 'Partial' sequences |
2 sequences
EPHA8_RAT (P29321), EPHB1_CHICK (Q07494) |
| PDB [Detailed view] |
25 PDB
pdb_00001kgy; pdb_00001nuk; pdb_00001shw; pdb_00002x10; pdb_00002x11; pdb_00003c8x; pdb_00003czu; pdb_00003etp; pdb_00003fl7; pdb_00003mbw; pdb_00003mx0; pdb_00003skj; pdb_00004bk4; pdb_00004bk5; pdb_00004bka; pdb_00004bkf; pdb_00004m4p; pdb_00004m4r; pdb_00007b7n; pdb_00007czf; pdb_00007k7j; pdb_00007s7k; pdb_00008trv; pdb_00008tv1; pdb_00008tv5 » more |