PROSITE entry PS00869

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS00869
Entry name [info]	RENAL_DIPEPTIDASE_1
Accession [info]	PS00869
Entry type [info]	PATTERN
Date [info]	01-OCT-1993 CREATED; 01-NOV-1995 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00678
Associated ProRule [info]	PRU10073

Name and characterization of the entry

Description [info]	Renal dipeptidase active site.
Pattern [info]	[LIVM]-E-G-[GA]-x(2)-[LIVMF]-x(6)-L-x(3)-Y-x(2)-G-[LIVM]-R.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	20 in 20 different sequences
Number of true positive hits	20 in 20 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	12
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	62.50 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Site [info]	active_site at position 2
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

20 sequences

DPEP1_BOVIN (Q3SZM7), DPEP1_COCP7 (C5PCZ0), DPEP1_COCPS (E9D269),

DPEP1_HUMAN (P16444), DPEP1_MOUSE (P31428), DPEP1_PIG   (P22412), 
DPEP1_RABIT (P31429), DPEP1_RAT   (P31430), DPEP1_SHEEP (P43477), 
DPEP2_COCP7 (C5PCN6), DPEP2_COCPS (E9CV02), DPEP2_HUMAN (Q9H4A9), 
DPEP2_MOUSE (Q8C255), DPEP2_RAT   (Q5M872), DPEP3_HUMAN (Q9H4B8), 
DPEP3_MACFA (Q4R7M2), DPEP3_MOUSE (Q9DA79), DPEP3_RAT   (Q5U2X4), 
YPQQ_KLEPN  (P27509), YPQR_ACICA  (P07783)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
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Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

12 sequences

DPEH1_SCHPO (O14124), DPEH2_SCHPO (O59832), DPEP1_ARTBC (D4B2N2),

DPEP1_ARTGP (E5R2Q7), DPEP1_ARTOC (C5FK77), DPEP1_TRIVH (D4DEJ7), 
DPEP2_FUSV7 (C7ZIE1), DPEP2_TALSN (B8LWT1), DPEP2_UNCRE (C4JQN7), 
GLIJ_ASPFU  (Q4WMJ8), SIRJ_LEPMC  (Q6Q886), TCPJ_CLAP2  (M1VV65)

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PDB
[Detailed view]

4 PDB

1ITQ; 1ITU; 6VGO; 6VGR