General rule information
[?]
Accession |
PRU10073 |
Dates |
16-OCT-2006 (Created) 13-MAY-2020 (Last updated, Version 11) |
Predictors |
PROSITE; PS00869; RENAL_DIPEPTIDASE_1
|
Predictors |
PROSITE; PS51365; RENAL_DIPEPTIDASE_2
|
Names |
Renal dipeptidase family; microsomal dipeptidase; membrane dipeptidase |
Function |
Renal dipeptidase (rDP) (EC 3.4.13.19) and related enzymes are zinc-dependent metalloenzymes which hydrolyze a wide range of dipeptides. |
Propagated annotation
[?]
case <FTGroup:1> or <FTGroup:2> or not <AnyFeature:PS51365>
end case
case <Feature:PS51365:365=C> and <FTGroup:3> and <FTGroup:4>
Subunit |
Homodimer; disulfide-linked. |
end case
Similarity |
Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. |
case <FTGroup:1> or <FTGroup:2>
GO:0016805; Molecular function: dipeptidase activity.
GO:0016787; Molecular function: hydrolase activity.
GO:0046872; Molecular function: metal ion binding.
GO:0008237; Molecular function: metallopeptidase activity.
GO:0008233; Molecular function: peptidase activity.
GO:0008270; Molecular function: zinc ion binding.
end case
case <FTTag:disulf>
end case
From: PS51365 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
METAL
|
|
20
|
|
20
|
|
Zinc #1; catalytic
|
|
|
|
H
|
|
1
|
METAL
|
|
22
|
|
22
|
|
Zinc #1; catalytic
|
|
|
|
D
|
|
1
|
METAL
|
|
125
|
|
125
|
|
Zinc #1; catalytic
|
|
|
|
E
|
|
1
|
METAL
|
|
125
|
|
125
|
|
Zinc #2; catalytic
|
|
|
|
E
|
|
2
|
METAL
|
|
198
|
|
198
|
|
Zinc #2; catalytic
|
|
|
|
Y
|
|
2
|
METAL
|
|
219
|
|
219
|
|
Zinc #2; catalytic
|
|
|
|
H
|
|
2
|
BINDING
|
|
152
|
|
152
|
|
Substrate
|
|
|
|
H
|
|
|
BINDING
|
|
230
|
|
230
|
|
Substrate
|
|
|
|
R
|
|
|
BINDING
|
|
290
|
|
290
|
|
Substrate
|
|
|
|
D
|
|
|
DISULFID
|
|
71
|
|
154
|
|
|
|
disulf
|
|
C-x*-C
|
|
3
|
DISULFID
|
|
226
|
|
258
|
|
|
|
disulf
|
|
C-x*-C
|
|
4
|
DISULFID
|
|
365
|
|
365
|
|
Interchain
|
|
disulf
|
|
C-x*-C
|
|
|
case not <AnyFeature:PS51365>
From: PS00869 |
METAL
|
|
2
|
|
2
|
|
Zinc #1; catalytic
|
|
|
|
|
|
|
end case
Additional information
[?]
Size range |
260-380 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
Q3SZM7 (DPEP1_BOVIN) |
Scope |
Eukaryota
Bacteria
Archaea |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]