PRU10073

General rule information [?]

Accession	PRU10073
Dates	16-OCT-2006 (Created) 19-NOV-2022 (Last updated, Version 13)

Data class

Domain

Predictors

PROSITE; PS00869; RENAL_DIPEPTIDASE_1

Predictors

PROSITE; PS51365; RENAL_DIPEPTIDASE_2

Names

Renal dipeptidase family; microsomal dipeptidase; membrane dipeptidase

Function

Renal dipeptidase (rDP) (EC 3.4.13.19) and related enzymes are zinc-dependent metalloenzymes which hydrolyze a wide range of dipeptides.

Propagated annotation [?]

Description [?]

case <FTGroup:1> or <FTGroup:2> or not <AnyFeature:PS51365>

+ AltName: Full=dipeptidase; EC 3.4.13.19;

Comments [?]

Catalytic activity	RHEA:48940: an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid EC 3.4.13.19
Cofactor	Zn(2+)

end case

case <Feature:PS51365:365=C> and <FTGroup:3> and <FTGroup:4>

Subunit

Homodimer; disulfide-linked.

end case

Similarity

Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2>

GO:0016805; Molecular function: dipeptidase activity.
GO:0016787; Molecular function: hydrolase activity.
GO:0046872; Molecular function: metal ion binding.
GO:0008237; Molecular function: metallopeptidase activity.
GO:0008233; Molecular function: peptidase activity.
GO:0008270; Molecular function: zinc ion binding.

Keywords [?]

Dipeptidase
Hydrolase
Metal-binding
Metalloprotease
Protease
Zinc

end case

case <FTTag:disulf>

Disulfide bond

end case

Features [?]

From: PS51365

Key From To Description Tag Condition FTGroup

BINDING 20 20 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="catalytic H 1

BINDING 22 22 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="catalytic D 1

BINDING 125 125 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="catalytic E 1

BINDING 125 125 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" /ligand_note="catalytic E 2

BINDING 198 198 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" /ligand_note="catalytic Y 2

BINDING 219 219 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" /ligand_note="catalytic H 2

BINDING 152 152 /ligand="substrate H

BINDING 230 230 /ligand="substrate R

BINDING 290 290 /ligand="substrate D

DISULFID 71 154 disulf C-x*-C 3

DISULFID 226 258 disulf C-x*-C 4

DISULFID 365 365 Interchain disulf C-x*-C

case not <AnyFeature:PS51365>

From: PS00869

BINDING 2 2 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="catalytic

end case

Additional information [?]

Size range	260-380 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q3SZM7 (DPEP1_BOVIN)
Scope	Eukaryota Bacteria Archaea

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Bacteria [2]

Eukaryota [30]

All [ 32 ]
Retrieve set of proteins with 3D structure for this domain

Bacteria	[2]
Eukaryota	[30]
All	[ 32 ]