Home  |  Contact
annotation rule: PRU10073

General rule information [?]

Accession PRU10073
Dates 16-OCT-2006 (Created)
13-MAY-2020 (Last updated, Version 11)
Data class Domain
Names Renal dipeptidase family; microsomal dipeptidase; membrane dipeptidase
Function Renal dipeptidase (rDP) (EC and related enzymes are zinc-dependent metalloenzymes which hydrolyze a wide range of dipeptides.

Propagated annotation [?]

Description [?]

case <FTGroup:1> or <FTGroup:2> or not <AnyFeature:PS51365>
+ AltName: Full=dipeptidase; EC;

Comments [?]

Catalytic activity RHEA:48940: an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid
Cofactor Zn(2+)
end case

case <Feature:PS51365:365=C> and <FTGroup:3> and <FTGroup:4>
Subunit Homodimer; disulfide-linked.
end case

Similarity Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2>
GO:0016805; Molecular function: dipeptidase activity.
GO:0016787; Molecular function: hydrolase activity.
GO:0046872; Molecular function: metal ion binding.
GO:0008237; Molecular function: metallopeptidase activity.
GO:0008233; Molecular function: peptidase activity.
GO:0008270; Molecular function: zinc ion binding.

Keywords [?]

end case

case <FTTag:disulf>
end case

Features [?]

From: PS51365
Key     From     To       Description   Tag   Condition   FTGroup
METAL     20     20       Zinc #1; catalytic     H   1
METAL     22     22       Zinc #1; catalytic     D   1
METAL     125     125       Zinc #1; catalytic     E   1
METAL     125     125       Zinc #2; catalytic     E   2
METAL     198     198       Zinc #2; catalytic     Y   2
METAL     219     219       Zinc #2; catalytic     H   2
BINDING     152     152       Substrate     H  
BINDING     230     230       Substrate     R  
BINDING     290     290       Substrate     D  
DISULFID     71     154           disulf   C-x*-C   3
DISULFID     226     258           disulf   C-x*-C   4
DISULFID     365     365       Interchain   disulf   C-x*-C  
case not <AnyFeature:PS51365>
From: PS00869
METAL     2     2       Zinc #1; catalytic        
end case

Additional information [?]

Size range 260-380 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q3SZM7 (DPEP1_BOVIN)


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]