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annotation rule: PRU10073

General rule information [?]

Accession PRU10073
Dates 16-OCT-2006 (Created)
13-MAY-2020 (Last updated, Version 11)
Data class Domain
Predictors PROSITE; PS00869; RENAL_DIPEPTIDASE_1
Predictors PROSITE; PS51365; RENAL_DIPEPTIDASE_2
Names Renal dipeptidase family; microsomal dipeptidase; membrane dipeptidase
Function Renal dipeptidase (rDP) (EC 3.4.13.19) and related enzymes are zinc-dependent metalloenzymes which hydrolyze a wide range of dipeptides.

Propagated annotation [?]


Description [?]

case <FTGroup:1> or <FTGroup:2> or not <AnyFeature:PS51365>
+ AltName: Full=dipeptidase; EC 3.4.13.19;

Comments [?]

Catalytic activity RHEA:48940: an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid
EC 3.4.13.19
Cofactor Zn(2+)
end case

case <Feature:PS51365:365=C> and <FTGroup:3> and <FTGroup:4>
Subunit Homodimer; disulfide-linked.
end case

Similarity Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2>
GO:0016805; Molecular function: dipeptidase activity.
GO:0016787; Molecular function: hydrolase activity.
GO:0046872; Molecular function: metal ion binding.
GO:0008237; Molecular function: metallopeptidase activity.
GO:0008233; Molecular function: peptidase activity.
GO:0008270; Molecular function: zinc ion binding.

Keywords [?]

Dipeptidase
Hydrolase
Metal-binding
Metalloprotease
Protease
Zinc
end case

case <FTTag:disulf>
Disulfide bond
end case


Features [?]

From: PS51365
Key     From     To       Description   Tag   Condition   FTGroup
METAL     20     20       Zinc #1; catalytic     H   1
METAL     22     22       Zinc #1; catalytic     D   1
METAL     125     125       Zinc #1; catalytic     E   1
METAL     125     125       Zinc #2; catalytic     E   2
METAL     198     198       Zinc #2; catalytic     Y   2
METAL     219     219       Zinc #2; catalytic     H   2
BINDING     152     152       Substrate     H  
BINDING     230     230       Substrate     R  
BINDING     290     290       Substrate     D  
DISULFID     71     154           disulf   C-x*-C   3
DISULFID     226     258           disulf   C-x*-C   4
DISULFID     365     365       Interchain   disulf   C-x*-C  
case not <AnyFeature:PS51365>
From: PS00869
METAL     2     2       Zinc #1; catalytic        
end case


Additional information [?]

Size range 260-380 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q3SZM7 (DPEP1_BOVIN)
Scope
Eukaryota
Bacteria
Archaea

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]