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PROSITE entry PS00888


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General information about the entry

Entry name [info] CNMP_BINDING_1
Accession [info] PS00888
Entry type [info] PATTERN
Date [info] 01-OCT-1993 CREATED;
01-DEC-2004 DATA UPDATE;
08-NOV-2023 INFO UPDATE.
PROSITE Doc. [info] PDOC00691

Name and characterization of the entry

Description [info] Cyclic nucleotide-binding domain signature 1.
Pattern [info] 
[LIVM]-[VIC]-x-{H}-G-[DENQTA]-x-[GAC]-{L}-x-[LIVMFY](4)-x(2)-G.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_05 which contains 570'420 sequence entries.


Total number of hits 182 in 125 different sequences
Number of true positive hits 172 in 115 different sequences
Number of 'unknown' hits 0
Number of false positive hits 10 in 10 different sequences
Number of false negative sequences 188
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 94.51 %
Recall (true positives / (true positives + false negatives)) 47.78 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 3
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 115 sequences 

CNBD2_HUMAN (Q96M20), CNBD2_MACFA (Q95JR6), CNBD2_MOUSE (Q9D5U8), 

CNG1_CHICK  (Q90805), CNG3_CHICK  (Q90980), CNGA1_BOVIN (Q00194), 
CNGA1_CANLF (Q28279), CNGA1_HUMAN (P29973), CNGA1_MOUSE (P29974), 
CNGA1_RAT   (Q62927), CNGA2_BOVIN (Q03041), CNGA2_HUMAN (Q16280), 
CNGA2_MOUSE (Q62398), CNGA2_RABIT (Q28718), CNGA2_RAT   (Q00195), 
CNGA3_BOVIN (Q29441), CNGA3_HUMAN (Q16281), CNGA3_MOUSE (Q9JJZ8), 
CNGA4_HUMAN (Q8IV77), CNGA4_MOUSE (Q3UW12), CNGA4_RAT   (Q64359), 
CNGA_DROME  (Q24278), CNGB1_BOVIN (Q28181), CNGB1_HUMAN (Q14028), 
CNGB3_CANLF (Q8MJD7), CNGB3_HUMAN (Q9NQW8), CNGB3_MOUSE (Q9JJZ9), 
CNGK1_RHIEC (Q2K5E1), CNGK1_RHILO (Q98GN8), CNG_CAEEL   (Q03611), 
CNG_ICTPU   (P55934), CRP_ECO57   (P0ACK0), CRP_ECOL6   (P0ACJ9), 
CRP_ECOLI   (P0ACJ8), CRP_HAEIN   (P29281), CRP_KLEAE   (P0A2T7), 
CRP_PASMU   (O05689), CRP_SALTY   (P0A2T6), CRP_SHIFL   (P0ACK1), 
EGL4_CAEBR  (A8X6H1), EGL4_CAEEL  (O76360), GLSA2_BRADU (Q89KV2), 
HCN1_HUMAN  (O60741), HCN1_MOUSE  (O88704), HCN1_RABIT  (Q9MZS1), 
HCN1_RAT(Q9JKB0), HCN2_HUMAN  (Q9UL51), HCN2_MOUSE  (O88703), 
HCN2_RAT(Q9JKA9), HCN4_HUMAN  (Q9Y3Q4), HCN4_MOUSE  (O70507), 
HCN4_RABIT  (Q9TV66), HCN4_RAT(Q9JKA7), KAP0_BOVIN  (P00514), 
KAP0_CHICK  (Q5ZM91), KAP0_HUMAN  (P10644), KAP0_MESAU  (P86244), 
KAP0_MOUSE  (Q9DBC7), KAP0_PIG(P07802), KAP0_PONAB  (Q5REL1), 
KAP0_RAT(P09456), KAP1_HUMAN  (P31321), KAP1_MOUSE  (P12849), 
KAP1_RAT(P81377), KAP2_BOVIN  (P00515), KAP2_HUMAN  (P13861), 
KAP2_MOUSE  (P12367), KAP2_RAT(P12368), KAP3_BOVIN  (P31322), 
KAP3_HUMAN  (P31323), KAP3_MOUSE  (P31324), KAP3_RAT(P12369), 
KAPR1_DROME (P16905), KAPR2_DROME (P81900), KAPR_APLCA  (P31319), 
KAPR_ASPFU  (Q96UX3), KAPR_ASPNG  (Q9C196), KAPR_BLAEM  (P31320), 
KAPR_BLUGR  (Q9HEP7), KAPR_CAEEL  (P30625), KAPR_CANAL  (Q9HEW1), 
KAPR_CANGA  (Q6FQL6), KAPR_COLOR  (Q9C1C2), KAPR_COLTR  (O42794), 
KAPR_DEBHA  (Q6BZG7), KAPR_DICDI  (P05987), KAPR_EMENI  (O59922), 
KAPR_EREGS  (Q75AM2), KAPR_HYPAT  (Q86ZN7), KAPR_KLULA  (Q6CPK7), 
KAPR_MAGO7  (O14448), KAPR_MUCCL  (Q8TF77), KAPR_NEUCR  (Q01386), 
KAPR_SCHPO  (P36600), KAPR_STRPU  (Q26619), KAPR_USTMA  (P49605), 
KAPR_YARLI  (Q6C2X0), KAPR_YEAST  (P07278), KGP1_BOVIN  (P00516), 
KGP1_DROME  (Q03042), KGP1_HUMAN  (Q13976), KGP1_MOUSE  (P0C605), 
KGP24_DROME (Q03043), KGP25_DROME (P32023), KGP2_HUMAN  (Q13237), 
KGP2_MOUSE  (Q61410), KGP2_RAT(Q64595), KGP_EIMTE   (Q8MMZ8), 
KGP_PLABA   (A0A509AKL0), KGP_PLAF7   (Q8I719), KGP_PLAFO   (W7JX98), 
KGP_PLAVS   (A5K0N4), KGP_TOXGO   (Q8MMZ7), NTE1_SCHPO  (Q9USJ4), 
VFR_PSEAE   (P55222)
» more

UniProtKB/Swiss-Prot
False negative sequences		 188 sequences 

ACH1_ARATH  (Q5FYU1), AKT1_ARATH  (Q38998), AKT1_ORYSI  (P0C550), 

AKT1_ORYSJ  (Q0JKV1), AKT2_ARATH  (Q38898), AKT2_ORYSJ  (Q75HP9), 
AKT3_ORYSJ  (Q8H569), AKT5_ARATH  (Q9SCX5), AKT6_ARATH  (Q8GXE6), 
ANR_PSEPH   (O85222), ARCR_STAA1  (A7X715), ARCR_STAA2  (A6U515), 
ARCR_STAA3  (Q2FDM8), ARCR_STAA8  (Q2FUY1), ARCR_STAA9  (A5IW58), 
ARCR_STAAB  (Q2YWH5), ARCR_STAAC  (Q5HCR6), ARCR_STAAE  (A6QKC0), 
ARCR_STAAM  (Q99R06), ARCR_STAAN  (Q7A381), ARCR_STAAR  (Q6GDH1), 
ARCR_STAAS  (Q6G643), ARCR_STAAT  (A8Z5D0), ARCR_STAAW  (Q8NUK9), 
ARCR_STAEQ  (Q5HKU6), ARCR_STAES  (Q8CML2), ARCR_STAHJ  (Q4L9J7), 
CLP_XANAC   (Q8PQ45), CLP_XANC5   (Q3BYB3), CLP_XANC8   (Q4UZF6), 
CLP_XANCB   (B0RN01), CLP_XANCP   (P22260), CLP_XANOM   (Q2NYD9), 
CLP_XANOP   (B2SL05), CLP_XANOR   (Q5GV61), CMR_MYCTO   (P9WMH4), 
CMR_MYCTU   (P9WMH5), CN15A_MEDTR (G7IBJ4), CN15B_MEDTR (G7JND3), 
CN15C_MEDTR (A0A072VMJ3), CNBD1_HUMAN (Q8NA66), CNG10_ARATH (Q9LNJ0), 
CNG11_ARATH (Q9SKD6), CNG12_ARATH (Q8GWD2), CNG13_ARATH (Q9LD40), 
CNG14_ARATH (Q9SJA4), CNG15_ARATH (Q9SL29), CNG16_ARATH (Q9SU64), 
CNG17_ARATH (Q8L7Z0), CNG18_ARATH (Q9LEQ3), CNG19_ARATH (Q9LDR2), 
CNG20_ARATH (Q9LD37), CNGC1_ARATH (O65717), CNGC2_ARATH (O65718), 
CNGC3_ARATH (Q9SKD7), CNGC4_ARATH (Q94AS9), CNGC5_ARATH (Q8RWS9), 
CNGC6_ARATH (O82226), CNGC7_ARATH (Q9S9N5), CNGC8_ARATH (Q9FXH6), 
CNGC9_ARATH (Q9M0A4), CRPL_CORGL  (Q79VI7), CRPL_MYCTO  (P9WMH2), 
CRPL_MYCTU  (P9WMH3), GBPC_DICDI  (Q8MVR1), GBPD_DICDI  (Q54S40), 
GORK_ARATH  (Q94A76), HCN3_HUMAN  (Q9P1Z3), HCN3_MOUSE  (O88705), 
HCN3_RAT(Q9JKA8), KAT1_ARATH  (Q39128), KAT1_ORYSJ  (Q6K3T2), 
KAT2_ARATH  (Q38849), KAT2_ORYSJ  (Q5QNI1), KAT3_ARATH  (P92960), 
KAT3_ORYSJ  (Q5JM04), KAT4_ORYSJ  (Q652U9), KAT5_ORYSJ  (Q7XT08), 
KAT6_ORYSJ  (A2ZX97), KCNAE_DROME (Q02280), KCNH1_BOVIN (O18965), 
KCNH1_HUMAN (O95259), KCNH1_MOUSE (Q60603), KCNH1_RAT   (Q63472), 
KCNH2_CANLF (Q9TSZ3), KCNH2_HUMAN (Q12809), KCNH2_MOUSE (O35219), 
KCNH2_RABIT (Q8WNY2), KCNH2_RAT   (O08962), KCNH3_HUMAN (Q9ULD8), 
KCNH3_MOUSE (Q9WVJ0), KCNH3_RAT   (O89047), KCNH4_HUMAN (Q9UQ05), 
KCNH4_RAT   (Q9R1T9), KCNH5_HUMAN (Q8NCM2), KCNH5_MOUSE (Q920E3), 
KCNH5_RAT   (Q9EPI9), KCNH6_CHICK (Q9PT84), KCNH6_HUMAN (Q9H252), 
KCNH6_RAT   (O54853), KCNH7_HUMAN (Q9NS40), KCNH7_MOUSE (Q9ER47), 
KCNH7_RAT   (O54852), KCNH8_HUMAN (Q96L42), KCNH8_MOUSE (P59111), 
KCNH8_RAT   (Q9QWS8), KGP1_RABIT  (O77676), KOR1_ORYSJ  (Q653P0), 
KOR2_ORYSJ  (Q7XUW4), LDRP_THET2  (Q746J8), LDRP_THET8  (Q53W63), 
NTE1_ASPCL  (A1C9L6), NTE1_ASPFU  (Q4WA15), NTE1_ASPNC  (A2R350), 
NTE1_ASPOR  (Q2UDH2), NTE1_ASPTN  (Q0CNC7), NTE1_CANAL  (Q5A368), 
NTE1_CANGA  (Q6FKJ1), NTE1_CHAGB  (Q2H0D3), NTE1_COCIM  (Q1DLC7), 
NTE1_CRYNB  (P0CP37), NTE1_CRYNJ  (P0CP36), NTE1_DEBHA  (Q6BQK9), 
NTE1_EMENI  (Q5BAE9), NTE1_EREGS  (Q756Z0), NTE1_KLULA  (Q6CWC2), 
NTE1_LODEL  (A5E708), NTE1_MAGO7  (A4QVZ8), NTE1_NEOFI  (A1D9Y2), 
NTE1_NEUCR  (Q7S8J1), NTE1_PHANO  (Q0UJ42), NTE1_PICGU  (A5DHA3), 
NTE1_PICST  (A3LYZ4), NTE1_USTMA  (Q4PF83), NTE1_YARLI  (Q6CF18), 
NTE1_YEAST  (Q04958), P2C19_ARATH (Q9SL76), PAT_MYCS2   (A0R3F9), 
PAT_MYCTU   (O05581), PCTIR_BURCE (A0A0J5WTU0), PCTIR_PSEAI (P0DV41), 
PCTIR_RHOS2 (A0A1V0HUU2), PCTIR_XANPE (P0DV29), PDE5_DICDI  (Q8MLZ3), 
PDE6_DICDI  (Q8MM62), PLPL6_CAEEL (Q21534), PLPL6_HUMAN (Q8IY17), 
PLPL6_MOUSE (Q3TRM4), PLPL6_PONAB (Q5RDS0), PLPL7_CAEEL (Q02331), 
PLPL7_HUMAN (Q6ZV29), PLPL7_MOUSE (A2AJ88), PLPL7_RAT   (Q5BK26), 
RPGF1_CAEEL (P34578), RPGF2_BOVIN (F1MSG6), RPGF2_CANLF (F1PBJ0), 
RPGF2_HUMAN (Q9Y4G8), RPGF2_MOUSE (Q8CHG7), RPGF2_RAT   (F1M386), 
RPGF3_HUMAN (O95398), RPGF3_MOUSE (Q8VCC8), RPGF3_RAT   (Q9Z1C8), 
RPGF4_HUMAN (Q8WZA2), RPGF4_MOUSE (Q9EQZ6), RPGF_CAEEL  (G5EDB9), 
SDRP_THET8  (Q5SIL0), SKOR_ARATH  (Q9M8S6), SL9C1_HUMAN (Q4G0N8), 
SL9C1_MOUSE (Q6UJY2), SL9C2_HUMAN (Q5TAH2), SWS_DROAN   (B3MRI9), 
SWS_DROER   (B3NY03), SWS_DROGR   (B4JLX2), SWS_DROME   (Q9U969), 
SWS_DROMO   (B4L535), SWS_DROPE   (B4H3U8), SWS_DROPS   (B5DKS8), 
SWS_DROSE   (B4IL64), SWS_DROVI   (B4M709), SWS_DROWI   (B4N1W9), 
SWS_DROYA   (B4Q0P3), UEX_DROME   (A0A0B7P9G0), Y073_MYCTO  (P9WQK4), 
Y073_MYCTU  (P9WQK5), Y2565_MYCTO (P9WIY6), Y2565_MYCTU (P9WIY7), 
Y2594_MYCBO (P0A643), Y4233_RHOPA (Q02006)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

KAP2_PIG(P05207)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			10 sequences
			


			
ALG11_HUMAN (Q2TAA5), ALG11_PONAB (Q5R7Z6), CARA_SULTO  (Q970U8), 

			
CBIMQ_METLZ (A2SSD6), DAPB_MAGO7  (A4QYQ5), EPHA_MYCTU  (I6YGS0), 
SFSA_GEOMG  (Q39WK9), SFSA_GEOSL  (P61664), SFSA_TRIEI  (Q111B4), 
SYT15_HUMAN (Q9BQS2)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			200 PDB
			


			1CGP; 1CX4; 1G6N; 1HW5; 1I5Z; 1I6X; 1J59; 1LB2; 1NE4; 1NE6; 1O3Q; 1O3R; 
			
				1O3S; 1O3T; 1Q3E; 1Q43; 1Q5O; 1RGS; 1RL3; 1RUN; 1RUO; 1U12; 1VP6; 1ZRC; 
				1ZRD; 1ZRE; 1ZRF; 2CGP; 2GZW; 2K0G; 2KXL; 2MNG; 2MPF; 2OZ6; 2Q0A; 2QCS; 
				2QVS; 2WC2; 2ZD9; 3BEH; 3BPZ; 3CL1; 3CLP; 3CO2; 3ETQ; 3FFQ; 3FHI; 3FWE; 
				3HIF; 3IDB; 3IDC; 3IIA; 3IYD; 3J4Q; 3J4R; 3KCC; 3N4M; 3OCP; 3OD0; 3OF1; 
				3OGJ; 3OTF; 3PLQ; 3PNA; 3PVB; 3QOP; 3RDI; 3ROU; 3RPQ; 3RYP; 3RYR; 3SHR; 
				3TNP; 3TNQ; 3U0Z; 3U10; 3U11; 4BH9; 4BHP; 4CHV; 4CHW; 4DIN; 4FT8; 4HBN; 
				4HZF; 4I01; 4I02; 4I09; 4I0A; 4I0B; 4JV4; 4JVA; 4KL1; 4KU7; 4KU8; 4MUV; 
				4MX3; 4NVP; 4OFF; 4OFG; 4QX5; 4QXK; 4R8H; 4RZ7; 4WBB; 4X6Q; 4X6R; 4Z07; 
				5BV6; 5C6C; 5C8W; 5CIZ; 5DYK; 5DYL; 5DZC; 5E16; 5EZR; 5F0A; 5FET; 5H3O; 
				5J48; 5JAX; 5JD7; 5JIX; 5JIZ; 5JON; 5JR7; 5KHG; 5KHH; 5KHI; 5KHJ; 5KHK; 
				5KJX; 5KJY; 5KJZ; 5L0N; 5U6O; 5U6P; 6B6H; 6BQ8; 6BYR; 6BYS; 6EO1; 6GYN; 
				6GYO; 6I9D; 6IAX; 6M63; 6NO7; 6PB4; 6PB5; 6PB6; 6QCY; 6QCZ; 6QD0; 6QD1; 
				6QD2; 6QD3; 6QD4; 6UQF; 6UQG; 6WEJ; 6WEK; 6WEL; 6WJF; 6WJG; 7FEW; 7FF0; 
				7FF8; 7FF9; 7LFT; 7LFW; 7LFX; 7LFY; 7LG1; 7LV3; 7LZ4; 7MBJ; 7N15; 7N16; 
				7N17; 7NMN; 7NP3; 7NP4; 7O4H; 7RH9; 7RHG; 7RHH; 7RHI; 7RHJ; 7RHK; 7RHL; 
				7RHS; 7SSB; 7T4T; 7T4U; 7T4V; 7T4W; 8BX7; 8EM8
			
			

			» more