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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00889


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PURL: https://purl.expasy.org/prosite/signature/PS00889

Direct ScanProsite submission
General information about the entry

Entry name [info] CNMP_BINDING_2
Accession [info] PS00889
Entry type [info] PATTERN
Date [info] 01-OCT-1993 CREATED;
01-OCT-1993 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00691

Name and characterization of the entry

Description [info] Cyclic nucleotide-binding domain signature 2.
Pattern [info] 
[LIVMF]-G-E-x-[GAS]-[LIVM]-x(5,11)-R-[STAQ]-A-x-[LIVMA]-x-[STACV].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 186 in 121 different sequences
Number of true positive hits 179 in 114 different sequences
Number of 'unknown' hits 0
Number of false positive hits 7 in 7 different sequences
Number of false negative sequences 197
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 96.24 %
Recall (true positives / (true positives + false negatives)) 47.61 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 3
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 114 sequences 

CNBD2_MOUSE (Q9D5U8), CNG1_CHICK  (Q90805), CNG3_CHICK  (Q90980), 

CNGA1_BOVIN (Q00194), CNGA1_CANLF (Q28279), CNGA1_HUMAN (P29973), 
CNGA1_MOUSE (P29974), CNGA1_RAT   (Q62927), CNGA2_BOVIN (Q03041), 
CNGA2_HUMAN (Q16280), CNGA2_MOUSE (Q62398), CNGA2_RABIT (Q28718), 
CNGA2_RAT   (Q00195), CNGA3_BOVIN (Q29441), CNGA3_HUMAN (Q16281), 
CNGA3_MOUSE (Q9JJZ8), CNGA3_RAT   (Q9ER33), CNGA4_HUMAN (Q8IV77), 
CNGA4_MOUSE (Q3UW12), CNGA4_RAT   (Q64359), CNGA_DROME  (Q24278), 
CNGB1_BOVIN (Q28181), CNGB1_HUMAN (Q14028), CNGB1_MOUSE (E1AZ71), 
CNGB1_RAT   (A0A8I5ZN27), CNGB3_CANLF (Q8MJD7), CNGB3_HUMAN (Q9NQW8), 
CNGB3_MOUSE (Q9JJZ9), CNGK1_RHIEC (Q2K5E1), CNGK1_RHILO (Q98GN8), 
CNG_CAEEL   (Q03611), CNG_ICTPU   (P55934), CRP_ECO57   (P0ACK0), 
CRP_ECOL6   (P0ACJ9), CRP_ECOLI   (P0ACJ8), CRP_HAEIN   (P29281), 
CRP_KLEAE   (P0A2T7), CRP_PASMU   (O05689), CRP_SALTY   (P0A2T6), 
CRP_SHIFL   (P0ACK1), CRP_THET8   (Q5SID7), EGL4_CAEBR  (A8X6H1), 
EGL4_CAEEL  (O76360), KAP0_BOVIN  (P00514), KAP0_CHICK  (Q5ZM91), 
KAP0_DANRE  (Q5I0F6), KAP0_HUMAN  (P10644), KAP0_MOUSE  (Q9DBC7), 
KAP0_PIG(P07802), KAP0_PONAB  (Q5REL1), KAP0_RAT(P09456), 
KAP1_HUMAN  (P31321), KAP1_MOUSE  (P12849), KAP1_RAT(P81377), 
KAP2_BOVIN  (P00515), KAP2_HUMAN  (P13861), KAP2_MOUSE  (P12367), 
KAP2_RAT(P12368), KAP3_BOVIN  (P31322), KAP3_HUMAN  (P31323), 
KAP3_MOUSE  (P31324), KAP3_RAT(P12369), KAPR1_DROME (P16905), 
KAPR2_DROME (P81900), KAPR_APLCA  (P31319), KAPR_ASPFU  (Q96UX3), 
KAPR_ASPNG  (Q9C196), KAPR_BLAEM  (P31320), KAPR_BLUGR  (Q9HEP7), 
KAPR_CAEEL  (P30625), KAPR_CANAL  (Q9HEW1), KAPR_CANGA  (Q6FQL6), 
KAPR_COLOR  (Q9C1C2), KAPR_COLTR  (O42794), KAPR_DEBHA  (Q6BZG7), 
KAPR_DICDI  (P05987), KAPR_EMENI  (O59922), KAPR_EREGS  (Q75AM2), 
KAPR_HYPAT  (Q86ZN7), KAPR_KLULA  (Q6CPK7), KAPR_MUCCL  (Q8TF77), 
KAPR_MYCMD  (P49605), KAPR_NEUCR  (Q01386), KAPR_PYRO7  (O14448), 
KAPR_SCHPO  (P36600), KAPR_STRPU  (Q26619), KAPR_YARLI  (Q6C2X0), 
KAPR_YEAST  (P07278), KGP1_BOVIN  (P00516), KGP1_DROME  (Q03042), 
KGP1_HUMAN  (Q13976), KGP1_MOUSE  (P0C605), KGP1_RABIT  (O77676), 
KGP24_DROME (Q03043), KGP25_DROME (P32023), KGP2_HUMAN  (Q13237), 
KGP2_MOUSE  (Q61410), KGP2_RAT(Q64595), KGP_EIMTE   (Q8MMZ8), 
KGP_PLABA   (A0A509AKL0), KGP_PLAF7   (Q8I719), KGP_PLAFO   (W7JX98), 
KGP_PLAVS   (A5K0N4), KGP_TOXGO   (Q8MMZ7), PAT_MYCS2   (A0R3F9), 
PAT_MYCTU   (O05581), PDE5_DICDI  (Q8MLZ3), VFR_PSEAE   (P55222), 
Y073_MYCTO  (P9WQK4), Y073_MYCTU  (P9WQK5), Y2564_MYCTO (P9WQI4), 
Y2564_MYCTU (P9WQI5), Y2593_MYCBO (P63402), Y4233_RHOPA (Q02006)
» more

UniProtKB/Swiss-Prot
False negative sequences		 197 sequences 

ACH1_ARATH  (Q5FYU1), AKT1_ARATH  (Q38998), AKT1_ORYSI  (P0C550), 

AKT1_ORYSJ  (Q0JKV1), AKT2_ARATH  (Q38898), AKT2_ORYSJ  (Q75HP9), 
AKT3_ORYSJ  (Q8H569), AKT5_ARATH  (Q9SCX5), AKT6_ARATH  (Q8GXE6), 
ANR_PSEPH   (O85222), ARCR_STAA1  (A7X715), ARCR_STAA2  (A6U515), 
ARCR_STAA3  (Q2FDM8), ARCR_STAA8  (Q2FUY1), ARCR_STAA9  (A5IW58), 
ARCR_STAAB  (Q2YWH5), ARCR_STAAC  (Q5HCR6), ARCR_STAAE  (A6QKC0), 
ARCR_STAAM  (Q99R06), ARCR_STAAN  (Q7A381), ARCR_STAAR  (Q6GDH1), 
ARCR_STAAS  (Q6G643), ARCR_STAAT  (A8Z5D0), ARCR_STAAW  (Q8NUK9), 
ARCR_STAEQ  (Q5HKU6), ARCR_STAES  (Q8CML2), ARCR_STAHJ  (Q4L9J7), 
CLP_XANAC   (Q8PQ45), CLP_XANC8   (Q4UZF6), CLP_XANCB   (B0RN01), 
CLP_XANCP   (P22260), CLP_XANE5   (Q3BYB3), CLP_XANOM   (Q2NYD9), 
CLP_XANOP   (B2SL05), CLP_XANOR   (Q5GV61), CMR_MYCTO   (P9WMH4), 
CMR_MYCTU   (P9WMH5), CN15A_MEDTR (G7IBJ4), CN15B_MEDTR (G7JND3), 
CN15C_MEDTR (A0A072VMJ3), CNBD1_HUMAN (Q8NA66), CNBD2_HUMAN (Q96M20), 
CNBD2_MACFA (Q95JR6), CNG10_ARATH (Q9LNJ0), CNG11_ARATH (Q9SKD6), 
CNG12_ARATH (Q8GWD2), CNG13_ARATH (Q9LD40), CNG14_ARATH (Q9SJA4), 
CNG15_ARATH (Q9SL29), CNG16_ARATH (Q9SU64), CNG17_ARATH (Q8L7Z0), 
CNG18_ARATH (Q9LEQ3), CNG19_ARATH (Q9LDR2), CNG20_ARATH (Q9LD37), 
CNGC1_ARATH (O65717), CNGC2_ARATH (O65718), CNGC3_ARATH (Q9SKD7), 
CNGC4_ARATH (Q94AS9), CNGC5_ARATH (Q8RWS9), CNGC6_ARATH (O82226), 
CNGC7_ARATH (Q9S9N5), CNGC8_ARATH (Q9FXH6), CNGC9_ARATH (Q9M0A4), 
CRPL_CORGL  (Q79VI7), CRPL_MYCTO  (P9WMH2), CRPL_MYCTU  (P9WMH3), 
GBPC_DICDI  (Q8MVR1), GBPD_DICDI  (Q54S40), GORK_ARATH  (Q94A76), 
HCN1_HUMAN  (O60741), HCN1_MOUSE  (O88704), HCN1_RABIT  (Q9MZS1), 
HCN1_RAT(Q9JKB0), HCN2_HUMAN  (Q9UL51), HCN2_MOUSE  (O88703), 
HCN2_RAT(Q9JKA9), HCN3_HUMAN  (Q9P1Z3), HCN3_MOUSE  (O88705), 
HCN3_RAT(Q9JKA8), HCN4_HUMAN  (Q9Y3Q4), HCN4_MOUSE  (O70507), 
HCN4_RABIT  (Q9TV66), HCN4_RAT(Q9JKA7), KAT1_ARATH  (Q39128), 
KAT1_ORYSJ  (Q6K3T2), KAT2_ARATH  (Q38849), KAT2_ORYSJ  (Q5QNI1), 
KAT3_ARATH  (P92960), KAT3_ORYSJ  (Q5JM04), KAT4_ORYSJ  (Q652U9), 
KAT5_ORYSJ  (Q7XT08), KAT6_ORYSJ  (A2ZX97), KCNAE_DROME (Q02280), 
KCNH1_BOVIN (O18965), KCNH1_HUMAN (O95259), KCNH1_MOUSE (Q60603), 
KCNH1_RAT   (Q63472), KCNH2_CANLF (Q9TSZ3), KCNH2_CAVPO (O08703), 
KCNH2_HUMAN (Q12809), KCNH2_MOUSE (O35219), KCNH2_PIG   (Q9TUI4), 
KCNH2_RABIT (Q8WNY2), KCNH2_RAT   (O08962), KCNH3_HUMAN (Q9ULD8), 
KCNH3_MOUSE (Q9WVJ0), KCNH3_RAT   (O89047), KCNH4_HUMAN (Q9UQ05), 
KCNH4_RAT   (Q9R1T9), KCNH5_HUMAN (Q8NCM2), KCNH5_MOUSE (Q920E3), 
KCNH5_RAT   (Q9EPI9), KCNH6_CHICK (Q9PT84), KCNH6_HUMAN (Q9H252), 
KCNH6_RAT   (O54853), KCNH7_HUMAN (Q9NS40), KCNH7_MOUSE (Q9ER47), 
KCNH7_RAT   (O54852), KCNH8_HUMAN (Q96L42), KCNH8_MOUSE (P59111), 
KCNH8_RAT   (Q9QWS8), KOR1_ORYSJ  (Q653P0), KOR2_ORYSJ  (Q7XUW4), 
LDRP_THET2  (Q746J8), LDRP_THET8  (Q53W63), NTE1_ASPCL  (A1C9L6), 
NTE1_ASPFU  (Q4WA15), NTE1_ASPNC  (A2R350), NTE1_ASPOR  (Q2UDH2), 
NTE1_ASPTN  (Q0CNC7), NTE1_CANAL  (Q5A368), NTE1_CANGA  (Q6FKJ1), 
NTE1_CHAGB  (Q2H0D3), NTE1_COCIM  (Q1DLC7), NTE1_CRYNB  (P0CP37), 
NTE1_CRYNJ  (P0CP36), NTE1_DEBHA  (Q6BQK9), NTE1_EMENI  (Q5BAE9), 
NTE1_EREGS  (Q756Z0), NTE1_KLULA  (Q6CWC2), NTE1_LODEL  (A5E708), 
NTE1_MYCMD  (Q4PF83), NTE1_NEOFI  (A1D9Y2), NTE1_NEUCR  (Q7S8J1), 
NTE1_PHANO  (Q0UJ42), NTE1_PICGU  (A5DHA3), NTE1_PICST  (A3LYZ4), 
NTE1_PYRO7  (A4QVZ8), NTE1_SCHPO  (Q9USJ4), NTE1_YARLI  (Q6CF18), 
NTE1_YEAST  (Q04958), P2C19_ARATH (Q9SL76), PCTIR_BURCE (A0A0J5WTU0), 
PCTIR_PSEAI (P0DV41), PCTIR_RHOS2 (A0A1V0HUU2), PCTIR_XANPE (P0DV29), 
PDE6_DICDI  (Q8MM62), PLPL6_CAEEL (Q21534), PLPL6_HUMAN (Q8IY17), 
PLPL6_MOUSE (Q3TRM4), PLPL6_PONAB (Q5RDS0), PLPL7_CAEEL (Q02331), 
PLPL7_HUMAN (Q6ZV29), PLPL7_MOUSE (A2AJ88), PLPL7_RAT   (Q5BK26), 
RPGF1_CAEEL (P34578), RPGF2_BOVIN (F1MSG6), RPGF2_CANLF (F1PBJ0), 
RPGF2_HUMAN (Q9Y4G8), RPGF2_MOUSE (Q8CHG7), RPGF2_RAT   (F1M386), 
RPGF3_HUMAN (O95398), RPGF3_MOUSE (Q8VCC8), RPGF3_RAT   (Q9Z1C8), 
RPGF4_HUMAN (Q8WZA2), RPGF4_MOUSE (Q9EQZ6), RPGF_CAEEL  (G5EDB9), 
SDRP_THET8  (Q5SIL0), SKOR_ARATH  (Q9M8S6), SL9C1_HUMAN (Q4G0N8), 
SL9C1_MOUSE (Q6UJY2), SL9C2_HUMAN (Q5TAH2), SWS_DROAN   (B3MRI9), 
SWS_DROER   (B3NY03), SWS_DROGR   (B4JLX2), SWS_DROME   (Q9U969), 
SWS_DROMO   (B4L535), SWS_DROPE   (B4H3U8), SWS_DROPS   (B5DKS8), 
SWS_DROSE   (B4IL64), SWS_DROVI   (B4M709), SWS_DROWI   (B4N1W9), 
SWS_DROYA   (B4Q0P3), UEX_DROME   (A0A0B7P9G0), Y2565_MYCTO (P9WIY6), 
Y2565_MYCTU (P9WIY7), Y2594_MYCBO (P0A643)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

KAP0_MESAU  (P86244), KAP2_PIG(P05207)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			7 sequences
			


			
ERYH_BRUA2  (Q2YIQ6), ERYH_BRUAB  (P0C119), ERYH_BRUME  (Q8YCV3), 

			
ERYH_BRUSU  (Q8FVH2), LERI_RHIR8  (B9JN20), XANB_XANCB  (B0RVK6), 
XANB_XANCP  (P0C7J3)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			180 PDB
			


			pdb_00001cgp; pdb_00001cx4; pdb_00001g6n; pdb_00001hw5; pdb_00001i5z; pdb_00001i6x; pdb_00001j59; pdb_00001lb2; pdb_00001ne4; pdb_00001ne6; pdb_00001o3q; pdb_00001o3r; 
			
				pdb_00001o3s; pdb_00001o3t; pdb_00001rgs; pdb_00001rl3; pdb_00001run; pdb_00001ruo; pdb_00001u12; pdb_00001vp6; pdb_00001zrc; pdb_00001zrd; pdb_00001zre; pdb_00001zrf; 
				pdb_00002cgp; pdb_00002gzw; pdb_00002k0g; pdb_00002kxl; pdb_00002oz6; pdb_00002qcs; pdb_00002qvs; pdb_00002wc2; pdb_00002zd9; pdb_00003beh; pdb_00003cl1; pdb_00003etq; 
				pdb_00003fhi; pdb_00003fwe; pdb_00003hif; pdb_00003idb; pdb_00003idc; pdb_00003iia; pdb_00003iyd; pdb_00003j4q; pdb_00003j4r; pdb_00003kcc; pdb_00003n4m; pdb_00003ocp; 
				pdb_00003od0; pdb_00003of1; pdb_00003ogj; pdb_00003plq; pdb_00003pna; pdb_00003pvb; pdb_00003qop; pdb_00003rdi; pdb_00003rou; pdb_00003rpq; pdb_00003ryp; pdb_00003ryr; 
				pdb_00003shr; pdb_00003tnp; pdb_00003tnq; pdb_00004ava; pdb_00004avb; pdb_00004avc; pdb_00004bh9; pdb_00004bhp; pdb_00004chv; pdb_00004chw; pdb_00004din; pdb_00004ev0; 
				pdb_00004ft8; pdb_00004hzf; pdb_00004i01; pdb_00004i02; pdb_00004i09; pdb_00004i0a; pdb_00004i0b; pdb_00004jv4; pdb_00004jva; pdb_00004ku7; pdb_00004ku8; pdb_00004muv; 
				pdb_00004mx3; pdb_00004off; pdb_00004ofg; pdb_00004oll; pdb_00004onu; pdb_00004qx5; pdb_00004qxk; pdb_00004r8h; pdb_00004rz7; pdb_00004wbb; pdb_00004x6q; pdb_00004x6r; 
				pdb_00004z07; pdb_00005bv6; pdb_00005c6c; pdb_00005c8w; pdb_00005ciz; pdb_00005dyk; pdb_00005dyl; pdb_00005dzc; pdb_00005e16; pdb_00005ezr; pdb_00005f0a; pdb_00005fet; 
				pdb_00005h3o; pdb_00005j48; pdb_00005jax; pdb_00005jd7; pdb_00005jix; pdb_00005jiz; pdb_00005jr7; pdb_00005kjx; pdb_00005kjy; pdb_00005kjz; pdb_00005l0n; pdb_00006b6h; 
				pdb_00006bq8; pdb_00006byr; pdb_00006bys; pdb_00006eo1; pdb_00006i9d; pdb_00006iax; pdb_00006no7; pdb_00006pb4; pdb_00006pb5; pdb_00006pb6; pdb_00006qcy; pdb_00006qcz; 
				pdb_00006qd0; pdb_00006qd1; pdb_00006qd2; pdb_00006qd3; pdb_00006qd4; pdb_00006wej; pdb_00006wek; pdb_00006wel; pdb_00006wjf; pdb_00006wjg; pdb_00007few; pdb_00007ff0; 
				pdb_00007ff8; pdb_00007ff9; pdb_00007lft; pdb_00007lfw; pdb_00007lfx; pdb_00007lfy; pdb_00007lg1; pdb_00007lv3; pdb_00007lz4; pdb_00007n15; pdb_00007n16; pdb_00007n17; 
				pdb_00007o4h; pdb_00007rh9; pdb_00007rhg; pdb_00007rhh; pdb_00007rhi; pdb_00007rhj; pdb_00007rhk; pdb_00007rhl; pdb_00007rhs; pdb_00007ssb; pdb_00007t4t; pdb_00007t4u; 
				pdb_00007t4v; pdb_00007t4w; pdb_00008bx7; pdb_00008em8; pdb_00008etp; pdb_00008eu3; pdb_00008euc; pdb_00008ev8; pdb_00008ev9; pdb_00008eva; pdb_00008evb; pdb_00008evc
			
			

			» more