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PROSITE entry PS00889


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PURL: https://purl.expasy.org/prosite/signature/PS00889

Direct ScanProsite submission
General information about the entry

Entry name [info] CNMP_BINDING_2
Accession [info] PS00889
Entry type [info] PATTERN
Date [info] 01-OCT-1993 CREATED;
01-OCT-1993 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00691

Name and characterization of the entry

Description [info] Cyclic nucleotide-binding domain signature 2.
Pattern [info] 
[LIVMF]-G-E-x-[GAS]-[LIVM]-x(5,11)-R-[STAQ]-A-x-[LIVMA]-x-[STACV].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 186 in 121 different sequences
Number of true positive hits 179 in 114 different sequences
Number of 'unknown' hits 0
Number of false positive hits 7 in 7 different sequences
Number of false negative sequences 197
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 96.24 %
Recall (true positives / (true positives + false negatives)) 47.61 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 3
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 114 sequences 

CNBD2_MOUSE (Q9D5U8), CNG1_CHICK  (Q90805), CNG3_CHICK  (Q90980), 

CNGA1_BOVIN (Q00194), CNGA1_CANLF (Q28279), CNGA1_HUMAN (P29973), 
CNGA1_MOUSE (P29974), CNGA1_RAT   (Q62927), CNGA2_BOVIN (Q03041), 
CNGA2_HUMAN (Q16280), CNGA2_MOUSE (Q62398), CNGA2_RABIT (Q28718), 
CNGA2_RAT   (Q00195), CNGA3_BOVIN (Q29441), CNGA3_HUMAN (Q16281), 
CNGA3_MOUSE (Q9JJZ8), CNGA3_RAT   (Q9ER33), CNGA4_HUMAN (Q8IV77), 
CNGA4_MOUSE (Q3UW12), CNGA4_RAT   (Q64359), CNGA_DROME  (Q24278), 
CNGB1_BOVIN (Q28181), CNGB1_HUMAN (Q14028), CNGB1_MOUSE (E1AZ71), 
CNGB1_RAT   (A0A8I5ZN27), CNGB3_CANLF (Q8MJD7), CNGB3_HUMAN (Q9NQW8), 
CNGB3_MOUSE (Q9JJZ9), CNGK1_RHIEC (Q2K5E1), CNGK1_RHILO (Q98GN8), 
CNG_CAEEL   (Q03611), CNG_ICTPU   (P55934), CRP_ECO57   (P0ACK0), 
CRP_ECOL6   (P0ACJ9), CRP_ECOLI   (P0ACJ8), CRP_HAEIN   (P29281), 
CRP_KLEAE   (P0A2T7), CRP_PASMU   (O05689), CRP_SALTY   (P0A2T6), 
CRP_SHIFL   (P0ACK1), CRP_THET8   (Q5SID7), EGL4_CAEBR  (A8X6H1), 
EGL4_CAEEL  (O76360), KAP0_BOVIN  (P00514), KAP0_CHICK  (Q5ZM91), 
KAP0_DANRE  (Q5I0F6), KAP0_HUMAN  (P10644), KAP0_MOUSE  (Q9DBC7), 
KAP0_PIG(P07802), KAP0_PONAB  (Q5REL1), KAP0_RAT(P09456), 
KAP1_HUMAN  (P31321), KAP1_MOUSE  (P12849), KAP1_RAT(P81377), 
KAP2_BOVIN  (P00515), KAP2_HUMAN  (P13861), KAP2_MOUSE  (P12367), 
KAP2_RAT(P12368), KAP3_BOVIN  (P31322), KAP3_HUMAN  (P31323), 
KAP3_MOUSE  (P31324), KAP3_RAT(P12369), KAPR1_DROME (P16905), 
KAPR2_DROME (P81900), KAPR_APLCA  (P31319), KAPR_ASPFU  (Q96UX3), 
KAPR_ASPNG  (Q9C196), KAPR_BLAEM  (P31320), KAPR_BLUGR  (Q9HEP7), 
KAPR_CAEEL  (P30625), KAPR_CANAL  (Q9HEW1), KAPR_CANGA  (Q6FQL6), 
KAPR_COLOR  (Q9C1C2), KAPR_COLTR  (O42794), KAPR_DEBHA  (Q6BZG7), 
KAPR_DICDI  (P05987), KAPR_EMENI  (O59922), KAPR_EREGS  (Q75AM2), 
KAPR_HYPAT  (Q86ZN7), KAPR_KLULA  (Q6CPK7), KAPR_MUCCL  (Q8TF77), 
KAPR_MYCMD  (P49605), KAPR_NEUCR  (Q01386), KAPR_PYRO7  (O14448), 
KAPR_SCHPO  (P36600), KAPR_STRPU  (Q26619), KAPR_YARLI  (Q6C2X0), 
KAPR_YEAST  (P07278), KGP1_BOVIN  (P00516), KGP1_DROME  (Q03042), 
KGP1_HUMAN  (Q13976), KGP1_MOUSE  (P0C605), KGP1_RABIT  (O77676), 
KGP24_DROME (Q03043), KGP25_DROME (P32023), KGP2_HUMAN  (Q13237), 
KGP2_MOUSE  (Q61410), KGP2_RAT(Q64595), KGP_EIMTE   (Q8MMZ8), 
KGP_PLABA   (A0A509AKL0), KGP_PLAF7   (Q8I719), KGP_PLAFO   (W7JX98), 
KGP_PLAVS   (A5K0N4), KGP_TOXGO   (Q8MMZ7), PAT_MYCS2   (A0R3F9), 
PAT_MYCTU   (O05581), PDE5_DICDI  (Q8MLZ3), VFR_PSEAE   (P55222), 
Y073_MYCTO  (P9WQK4), Y073_MYCTU  (P9WQK5), Y2564_MYCTO (P9WQI4), 
Y2564_MYCTU (P9WQI5), Y2593_MYCBO (P63402), Y4233_RHOPA (Q02006)
» more

UniProtKB/Swiss-Prot
False negative sequences		 197 sequences 

ACH1_ARATH  (Q5FYU1), AKT1_ARATH  (Q38998), AKT1_ORYSI  (P0C550), 

AKT1_ORYSJ  (Q0JKV1), AKT2_ARATH  (Q38898), AKT2_ORYSJ  (Q75HP9), 
AKT3_ORYSJ  (Q8H569), AKT5_ARATH  (Q9SCX5), AKT6_ARATH  (Q8GXE6), 
ANR_PSEPH   (O85222), ARCR_STAA1  (A7X715), ARCR_STAA2  (A6U515), 
ARCR_STAA3  (Q2FDM8), ARCR_STAA8  (Q2FUY1), ARCR_STAA9  (A5IW58), 
ARCR_STAAB  (Q2YWH5), ARCR_STAAC  (Q5HCR6), ARCR_STAAE  (A6QKC0), 
ARCR_STAAM  (Q99R06), ARCR_STAAN  (Q7A381), ARCR_STAAR  (Q6GDH1), 
ARCR_STAAS  (Q6G643), ARCR_STAAT  (A8Z5D0), ARCR_STAAW  (Q8NUK9), 
ARCR_STAEQ  (Q5HKU6), ARCR_STAES  (Q8CML2), ARCR_STAHJ  (Q4L9J7), 
CLP_XANAC   (Q8PQ45), CLP_XANC8   (Q4UZF6), CLP_XANCB   (B0RN01), 
CLP_XANCP   (P22260), CLP_XANE5   (Q3BYB3), CLP_XANOM   (Q2NYD9), 
CLP_XANOP   (B2SL05), CLP_XANOR   (Q5GV61), CMR_MYCTO   (P9WMH4), 
CMR_MYCTU   (P9WMH5), CN15A_MEDTR (G7IBJ4), CN15B_MEDTR (G7JND3), 
CN15C_MEDTR (A0A072VMJ3), CNBD1_HUMAN (Q8NA66), CNBD2_HUMAN (Q96M20), 
CNBD2_MACFA (Q95JR6), CNG10_ARATH (Q9LNJ0), CNG11_ARATH (Q9SKD6), 
CNG12_ARATH (Q8GWD2), CNG13_ARATH (Q9LD40), CNG14_ARATH (Q9SJA4), 
CNG15_ARATH (Q9SL29), CNG16_ARATH (Q9SU64), CNG17_ARATH (Q8L7Z0), 
CNG18_ARATH (Q9LEQ3), CNG19_ARATH (Q9LDR2), CNG20_ARATH (Q9LD37), 
CNGC1_ARATH (O65717), CNGC2_ARATH (O65718), CNGC3_ARATH (Q9SKD7), 
CNGC4_ARATH (Q94AS9), CNGC5_ARATH (Q8RWS9), CNGC6_ARATH (O82226), 
CNGC7_ARATH (Q9S9N5), CNGC8_ARATH (Q9FXH6), CNGC9_ARATH (Q9M0A4), 
CRPL_CORGL  (Q79VI7), CRPL_MYCTO  (P9WMH2), CRPL_MYCTU  (P9WMH3), 
GBPC_DICDI  (Q8MVR1), GBPD_DICDI  (Q54S40), GORK_ARATH  (Q94A76), 
HCN1_HUMAN  (O60741), HCN1_MOUSE  (O88704), HCN1_RABIT  (Q9MZS1), 
HCN1_RAT(Q9JKB0), HCN2_HUMAN  (Q9UL51), HCN2_MOUSE  (O88703), 
HCN2_RAT(Q9JKA9), HCN3_HUMAN  (Q9P1Z3), HCN3_MOUSE  (O88705), 
HCN3_RAT(Q9JKA8), HCN4_HUMAN  (Q9Y3Q4), HCN4_MOUSE  (O70507), 
HCN4_RABIT  (Q9TV66), HCN4_RAT(Q9JKA7), KAT1_ARATH  (Q39128), 
KAT1_ORYSJ  (Q6K3T2), KAT2_ARATH  (Q38849), KAT2_ORYSJ  (Q5QNI1), 
KAT3_ARATH  (P92960), KAT3_ORYSJ  (Q5JM04), KAT4_ORYSJ  (Q652U9), 
KAT5_ORYSJ  (Q7XT08), KAT6_ORYSJ  (A2ZX97), KCNAE_DROME (Q02280), 
KCNH1_BOVIN (O18965), KCNH1_HUMAN (O95259), KCNH1_MOUSE (Q60603), 
KCNH1_RAT   (Q63472), KCNH2_CANLF (Q9TSZ3), KCNH2_CAVPO (O08703), 
KCNH2_HUMAN (Q12809), KCNH2_MOUSE (O35219), KCNH2_PIG   (Q9TUI4), 
KCNH2_RABIT (Q8WNY2), KCNH2_RAT   (O08962), KCNH3_HUMAN (Q9ULD8), 
KCNH3_MOUSE (Q9WVJ0), KCNH3_RAT   (O89047), KCNH4_HUMAN (Q9UQ05), 
KCNH4_RAT   (Q9R1T9), KCNH5_HUMAN (Q8NCM2), KCNH5_MOUSE (Q920E3), 
KCNH5_RAT   (Q9EPI9), KCNH6_CHICK (Q9PT84), KCNH6_HUMAN (Q9H252), 
KCNH6_RAT   (O54853), KCNH7_HUMAN (Q9NS40), KCNH7_MOUSE (Q9ER47), 
KCNH7_RAT   (O54852), KCNH8_HUMAN (Q96L42), KCNH8_MOUSE (P59111), 
KCNH8_RAT   (Q9QWS8), KOR1_ORYSJ  (Q653P0), KOR2_ORYSJ  (Q7XUW4), 
LDRP_THET2  (Q746J8), LDRP_THET8  (Q53W63), NTE1_ASPCL  (A1C9L6), 
NTE1_ASPFU  (Q4WA15), NTE1_ASPNC  (A2R350), NTE1_ASPOR  (Q2UDH2), 
NTE1_ASPTN  (Q0CNC7), NTE1_CANAL  (Q5A368), NTE1_CANGA  (Q6FKJ1), 
NTE1_CHAGB  (Q2H0D3), NTE1_COCIM  (Q1DLC7), NTE1_CRYNB  (P0CP37), 
NTE1_CRYNJ  (P0CP36), NTE1_DEBHA  (Q6BQK9), NTE1_EMENI  (Q5BAE9), 
NTE1_EREGS  (Q756Z0), NTE1_KLULA  (Q6CWC2), NTE1_LODEL  (A5E708), 
NTE1_MYCMD  (Q4PF83), NTE1_NEOFI  (A1D9Y2), NTE1_NEUCR  (Q7S8J1), 
NTE1_PHANO  (Q0UJ42), NTE1_PICGU  (A5DHA3), NTE1_PICST  (A3LYZ4), 
NTE1_PYRO7  (A4QVZ8), NTE1_SCHPO  (Q9USJ4), NTE1_YARLI  (Q6CF18), 
NTE1_YEAST  (Q04958), P2C19_ARATH (Q9SL76), PCTIR_BURCE (A0A0J5WTU0), 
PCTIR_PSEAI (P0DV41), PCTIR_RHOS2 (A0A1V0HUU2), PCTIR_XANPE (P0DV29), 
PDE6_DICDI  (Q8MM62), PLPL6_CAEEL (Q21534), PLPL6_HUMAN (Q8IY17), 
PLPL6_MOUSE (Q3TRM4), PLPL6_PONAB (Q5RDS0), PLPL7_CAEEL (Q02331), 
PLPL7_HUMAN (Q6ZV29), PLPL7_MOUSE (A2AJ88), PLPL7_RAT   (Q5BK26), 
RPGF1_CAEEL (P34578), RPGF2_BOVIN (F1MSG6), RPGF2_CANLF (F1PBJ0), 
RPGF2_HUMAN (Q9Y4G8), RPGF2_MOUSE (Q8CHG7), RPGF2_RAT   (F1M386), 
RPGF3_HUMAN (O95398), RPGF3_MOUSE (Q8VCC8), RPGF3_RAT   (Q9Z1C8), 
RPGF4_HUMAN (Q8WZA2), RPGF4_MOUSE (Q9EQZ6), RPGF_CAEEL  (G5EDB9), 
SDRP_THET8  (Q5SIL0), SKOR_ARATH  (Q9M8S6), SL9C1_HUMAN (Q4G0N8), 
SL9C1_MOUSE (Q6UJY2), SL9C2_HUMAN (Q5TAH2), SWS_DROAN   (B3MRI9), 
SWS_DROER   (B3NY03), SWS_DROGR   (B4JLX2), SWS_DROME   (Q9U969), 
SWS_DROMO   (B4L535), SWS_DROPE   (B4H3U8), SWS_DROPS   (B5DKS8), 
SWS_DROSE   (B4IL64), SWS_DROVI   (B4M709), SWS_DROWI   (B4N1W9), 
SWS_DROYA   (B4Q0P3), UEX_DROME   (A0A0B7P9G0), Y2565_MYCTO (P9WIY6), 
Y2565_MYCTU (P9WIY7), Y2594_MYCBO (P0A643)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

KAP0_MESAU  (P86244), KAP2_PIG(P05207)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			7 sequences
			


			
ERYH_BRUA2  (Q2YIQ6), ERYH_BRUAB  (P0C119), ERYH_BRUME  (Q8YCV3), 

			
ERYH_BRUSU  (Q8FVH2), LERI_RHIR8  (B9JN20), XANB_XANCB  (B0RVK6), 
XANB_XANCP  (P0C7J3)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			180 PDB
			


			pdb_00001cgp; pdb_00001cx4; pdb_00001g6n; pdb_00001hw5; pdb_00001i5z; pdb_00001i6x; pdb_00001j59; pdb_00001lb2; pdb_00001ne4; pdb_00001ne6; pdb_00001o3q; pdb_00001o3r; 
			
				pdb_00001o3s; pdb_00001o3t; pdb_00001rgs; pdb_00001rl3; pdb_00001run; pdb_00001ruo; pdb_00001u12; pdb_00001vp6; pdb_00001zrc; pdb_00001zrd; pdb_00001zre; pdb_00001zrf; 
				pdb_00002cgp; pdb_00002gzw; pdb_00002k0g; pdb_00002kxl; pdb_00002oz6; pdb_00002qcs; pdb_00002qvs; pdb_00002wc2; pdb_00002zd9; pdb_00003beh; pdb_00003cl1; pdb_00003etq; 
				pdb_00003fhi; pdb_00003fwe; pdb_00003hif; pdb_00003idb; pdb_00003idc; pdb_00003iia; pdb_00003iyd; pdb_00003j4q; pdb_00003j4r; pdb_00003kcc; pdb_00003n4m; pdb_00003ocp; 
				pdb_00003od0; pdb_00003of1; pdb_00003ogj; pdb_00003plq; pdb_00003pna; pdb_00003pvb; pdb_00003qop; pdb_00003rdi; pdb_00003rou; pdb_00003rpq; pdb_00003ryp; pdb_00003ryr; 
				pdb_00003shr; pdb_00003tnp; pdb_00003tnq; pdb_00004ava; pdb_00004avb; pdb_00004avc; pdb_00004bh9; pdb_00004bhp; pdb_00004chv; pdb_00004chw; pdb_00004din; pdb_00004ev0; 
				pdb_00004ft8; pdb_00004hzf; pdb_00004i01; pdb_00004i02; pdb_00004i09; pdb_00004i0a; pdb_00004i0b; pdb_00004jv4; pdb_00004jva; pdb_00004ku7; pdb_00004ku8; pdb_00004muv; 
				pdb_00004mx3; pdb_00004off; pdb_00004ofg; pdb_00004oll; pdb_00004onu; pdb_00004qx5; pdb_00004qxk; pdb_00004r8h; pdb_00004rz7; pdb_00004wbb; pdb_00004x6q; pdb_00004x6r; 
				pdb_00004z07; pdb_00005bv6; pdb_00005c6c; pdb_00005c8w; pdb_00005ciz; pdb_00005dyk; pdb_00005dyl; pdb_00005dzc; pdb_00005e16; pdb_00005ezr; pdb_00005f0a; pdb_00005fet; 
				pdb_00005h3o; pdb_00005j48; pdb_00005jax; pdb_00005jd7; pdb_00005jix; pdb_00005jiz; pdb_00005jr7; pdb_00005kjx; pdb_00005kjy; pdb_00005kjz; pdb_00005l0n; pdb_00006b6h; 
				pdb_00006bq8; pdb_00006byr; pdb_00006bys; pdb_00006eo1; pdb_00006i9d; pdb_00006iax; pdb_00006no7; pdb_00006pb4; pdb_00006pb5; pdb_00006pb6; pdb_00006qcy; pdb_00006qcz; 
				pdb_00006qd0; pdb_00006qd1; pdb_00006qd2; pdb_00006qd3; pdb_00006qd4; pdb_00006wej; pdb_00006wek; pdb_00006wel; pdb_00006wjf; pdb_00006wjg; pdb_00007few; pdb_00007ff0; 
				pdb_00007ff8; pdb_00007ff9; pdb_00007lft; pdb_00007lfw; pdb_00007lfx; pdb_00007lfy; pdb_00007lg1; pdb_00007lv3; pdb_00007lz4; pdb_00007n15; pdb_00007n16; pdb_00007n17; 
				pdb_00007o4h; pdb_00007rh9; pdb_00007rhg; pdb_00007rhh; pdb_00007rhi; pdb_00007rhj; pdb_00007rhk; pdb_00007rhl; pdb_00007rhs; pdb_00007ssb; pdb_00007t4t; pdb_00007t4u; 
				pdb_00007t4v; pdb_00007t4w; pdb_00008bx7; pdb_00008em8; pdb_00008etp; pdb_00008eu3; pdb_00008euc; pdb_00008ev8; pdb_00008ev9; pdb_00008eva; pdb_00008evb; pdb_00008evc
			
			

			» more