We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

PROSITE entry PS01021

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PURL: https://purl.expasy.org/prosite/signature/PS01021

Direct ScanProsite submission

General information about the entry

Entry name [info]	COPROGEN_OXIDASE
Accession [info]	PS01021
Entry type [info]	PATTERN
Date [info]	01-JUN-1994 CREATED; 01-APR-2006 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00783

Name and characterization of the entry

Description [info]	Coproporphyrinogen III oxidase signature.
Pattern [info]	K-x-[WQA]-[CA]-x(2)-[FYH](2)-x-[LIVM]-x-[HY]-R-x-E-x-R-G-[LIVMT]-G-G- [LIVM]-F-[FY]-D.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	235 in 235 different sequences
Number of true positive hits	235 in 235 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	4
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	98.33 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Version [info]	2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

235 sequences

HEM61_ARATH (Q9LR75), HEM61_NOSS1 (Q8YZ37), HEM62_NOSS1 (Q8YX58),

HEM6_AERHH  (A0KEX7), HEM6_AERS4  (A4ST50), HEM6_AGRFC  (Q8UD80), 
HEM6_ALCBS  (Q0VTD7), HEM6_ALLAM  (B9JZ61), HEM6_AROAE  (Q5P7I0), 
HEM6_BORBR  (Q7WL80), HEM6_BORPA  (Q7W7U0), HEM6_BORPD  (A9ITM7), 
HEM6_BORPE  (Q7VWE7), HEM6_BRADU  (Q89SC2), HEM6_BRUA1  (B2S710), 
HEM6_BRUA2  (Q2YS10), HEM6_BRUA4  (A6WZC8), HEM6_BRUAB  (Q57BW7), 
HEM6_BRUC2  (A9M6L4), HEM6_BRUMB  (C0REI6), HEM6_BRUME  (P63850), 
HEM6_BRUSU  (P63851), HEM6_BURA4  (B1YU52), HEM6_BURCJ  (B4E5R8), 
HEM6_BURCM  (Q0BD83), HEM6_BURL3  (Q39E99), HEM6_BURM1  (A9AJJ8), 
HEM6_BURM7  (A3MI45), HEM6_BURM9  (A2S4B5), HEM6_BURMA  (Q62II8), 
HEM6_BURMS  (A1V2G0), HEM6_BURO0  (B1JW43), HEM6_BURP0  (A3NT46), 
HEM6_BURP6  (A3N7F7), HEM6_BURPS  (Q63VT1), HEM6_CAUSK  (B0T8D1), 
HEM6_CAUVC  (Q9AAT8), HEM6_CAUVN  (B8GZX1), HEM6_CHESB  (Q11GB4), 
HEM6_CHRSD  (Q1QTJ9), HEM6_CHRVO  (Q7P012), HEM6_CITK8  (A8ADF0), 
HEM6_COXBN  (A9KC01), HEM6_COXBR  (A9NA93), HEM6_COXBU  (Q83AZ6), 
HEM6_CROS8  (A7MKX5), HEM6_DECAR  (Q479T3), HEM6_DROME  (Q9V3D2), 
HEM6_ECO24  (A7ZPN6), HEM6_ECO27  (B7UGD5), HEM6_ECO45  (B7MHT7), 
HEM6_ECO57  (Q8XBI4), HEM6_ECO5E  (B5YZY1), HEM6_ECO7I  (B7NPX2), 
HEM6_ECO81  (B7MY86), HEM6_ECO8A  (B7M6U5), HEM6_ECOBW  (C4ZX09), 
HEM6_ECODH  (B1XAA7), HEM6_ECOHS  (A8A2T4), HEM6_ECOK1  (A1ADV0), 
HEM6_ECOL5  (Q0TF33), HEM6_ECOL6  (Q8FFA3), HEM6_ECOLC  (B1IWM6), 
HEM6_ECOLI  (P36553), HEM6_ECOLU  (B7N626), HEM6_ECOSE  (B6I512), 
HEM6_ECOSM  (B1LMN0), HEM6_ECTM1  (A4XNB8), HEM6_ENT38  (A4WD41), 
HEM6_ERWT9  (B2VI13), HEM6_ESCF3  (B7LKJ9), HEM6_FRAT1  (Q14HF0), 
HEM6_FRATF  (A7NC51), HEM6_FRATH  (Q2A3H9), HEM6_FRATM  (B2SGG9), 
HEM6_FRATN  (A0Q6H6), HEM6_FRATO  (Q0BLZ2), HEM6_FRATT  (Q5NFZ8), 
HEM6_FRATW  (A4IY09), HEM6_GLOVI  (Q7NEK3), HEM6_HORVU  (Q42840), 
HEM6_HUMAN  (P36551), HEM6_IDILO  (Q5QXJ4), HEM6_KLEP3  (B5XVR1), 
HEM6_KLEP7  (A6TC68), HEM6_LEGPA  (Q5X5U7), HEM6_LEGPC  (A5IBB3), 
HEM6_LEGPH  (Q5ZW72), HEM6_LEGPL  (Q5WX75), HEM6_LEIMA  (P84155), 
HEM6_METCA  (Q603L4), HEM6_MOUSE  (P36552), HEM6_NITEC  (Q0AEP6), 
HEM6_NITEU  (Q82TL0), HEM6_ORYSJ  (Q7XPL2), HEM6_PARMW  (Q7U4M7), 
HEM6_PARPJ  (B2T2A3), HEM6_PARXL  (Q142L8), HEM6_PECAS  (Q6D8U8), 
HEM6_PECCP  (C6D9M5), HEM6_PHOLL  (Q7N6Z9), HEM6_PHOPR  (Q6LLK0), 
HEM6_POLNA  (A1VN15), HEM6_POLSJ  (Q12C42), HEM6_PROM0  (A3PF71), 
HEM6_PROM1  (A2C524), HEM6_PROM2  (A8G786), HEM6_PROM5  (A2BYW5), 
HEM6_PROM9  (Q318G0), HEM6_PROMA  (Q7V9T7), HEM6_PROMH  (B4EZS7), 
HEM6_PROMM  (Q7V568), HEM6_PROMP  (Q7UZS3), HEM6_PROMS  (A2BTG1), 
HEM6_PROMT  (Q46IN4), HEM6_PSE14  (Q48QH6), HEM6_PSEA8  (B7V0Q9), 
HEM6_PSEAB  (Q02V57), HEM6_PSEAE  (P43898), HEM6_PSEE4  (Q1I2G6), 
HEM6_PSEF5  (Q4KKQ4), HEM6_PSEFS  (C3K4I0), HEM6_PSEP1  (A5VWK4), 
HEM6_PSEP7  (A6UX86), HEM6_PSEPF  (Q3KKE0), HEM6_PSEPG  (B0KF35), 
HEM6_PSEPK  (Q88RQ6), HEM6_PSEPW  (B1J4A2), HEM6_PSESM  (Q88B49), 
HEM6_PSEU2  (Q500S4), HEM6_RALN1  (Q8XXC3), HEM6_RALPJ  (B2U8Z4), 
HEM6_RAT(Q3B7D0), HEM6_RHIE6  (B3PV29), HEM6_RHIEC  (Q2K5S3), 
HEM6_RHIJ3  (Q1MDJ5), HEM6_RHILW  (B5ZY73), HEM6_RHIME  (Q92PD8), 
HEM6_RHIR8  (B9J7B2), HEM6_RICAE  (C3PM25), HEM6_RICAH  (A8GQB7), 
HEM6_RICB8  (A8GY81), HEM6_RICBR  (Q1RGQ3), HEM6_RICCN  (Q92FV8), 
HEM6_RICFE  (Q4UJP2), HEM6_RICPR  (Q9ZC86), HEM6_RICPU  (C4K2Y8), 
HEM6_RICRO  (B0BVQ3), HEM6_RICRS  (A8GU63), HEM6_RICTY  (Q68VN1), 
HEM6_SACD2  (Q21PU0), HEM6_SALA4  (B5F0I0), HEM6_SALAR  (A9MID0), 
HEM6_SALCH  (Q57LQ6), HEM6_SALDC  (B5FQE4), HEM6_SALEP  (B5R4G0), 
HEM6_SALG2  (B5RCS3), HEM6_SALHS  (B4TCI1), HEM6_SALNS  (B4T0I0), 
HEM6_SALPA  (Q5PI28), HEM6_SALPB  (A9N336), HEM6_SALPC  (C0PZ88), 
HEM6_SALPK  (B5BB50), HEM6_SALSV  (B4TR28), HEM6_SALTI  (Q8Z4U8), 
HEM6_SALTY  (P33771), HEM6_SCHPO  (Q9UTE2), HEM6_SERP5  (A8GHH2), 
HEM6_SHEAM  (A1S1K6), HEM6_SHEB2  (B8E3K7), HEM6_SHEB5  (A3CYL1), 
HEM6_SHEB8  (A6WHB7), HEM6_SHEDO  (Q12T99), HEM6_SHEHH  (B0TLD7), 
HEM6_SHEON  (Q8EKQ2), HEM6_SHEPA  (A8GYI0), HEM6_SHEPC  (A4Y1D3), 
HEM6_SHEPW  (B8CHB9), HEM6_SHESA  (A0KR67), HEM6_SHESH  (A8FP82), 
HEM6_SHESM  (Q0HPA0), HEM6_SHESR  (Q0I0R6), HEM6_SHESW  (A1RDY8), 
HEM6_SHEWM  (B1KCX1), HEM6_SHIB3  (B2TX24), HEM6_SHIBS  (Q31Y44), 
HEM6_SHIDS  (Q32DB7), HEM6_SHIF8  (Q0T273), HEM6_SHIFL  (Q83QN1), 
HEM6_SHISS  (Q3YZA7), HEM6_SINMW  (A6U9R1), HEM6_SODGM  (Q2NS88), 
HEM6_SOYBN  (P35055), HEM6_STRM5  (B4SNL7), HEM6_STRMK  (B2FND0), 
HEM6_STUS1  (A4VFI3), HEM6_SYNP6  (Q5N3S5), HEM6_SYNS9  (Q3AWA8), 
HEM6_SYNSC  (Q3AMK3), HEM6_SYNY3  (P72848), HEM6_THEVB  (Q8DL15), 
HEM6_THISH  (B8GTF9), HEM6_TOBAC  (Q42946), HEM6_VARPS  (C5CLQ3), 
HEM6_VIBA3  (B7VMW3), HEM6_VIBC1  (A7N128), HEM6_VIBC3  (A5F4C4), 
HEM6_VIBCH  (Q9KVT4), HEM6_VIBCM  (C3LPC8), HEM6_VIBPA  (Q87KE3), 
HEM6_VIBVU  (Q8DDD5), HEM6_VIBVY  (Q7MGL4), HEM6_WIGBR  (Q8D1X2), 
HEM6_XANAC  (Q8PF76), HEM6_XANC8  (Q4UP76), HEM6_XANCB  (B0RYP5), 
HEM6_XANCP  (Q8P3Q0), HEM6_XANE5  (Q3BMT4), HEM6_XANOM  (Q2NY70), 
HEM6_XANOP  (B2SK75), HEM6_XANOR  (Q5GUY0), HEM6_XYLFA  (Q9PHC7), 
HEM6_XYLFM  (B0U1G5), HEM6_XYLFT  (Q87FB2), HEM6_YEAST  (P11353), 
HEM6_YERE8  (A1JL37), HEM6_YERP3  (A7FG82), HEM6_YERPA  (Q1C5T7), 
HEM6_YERPB  (B2K962), HEM6_YERPE  (Q8ZCF9), HEM6_YERPG  (A9QZK6), 
HEM6_YERPN  (Q1CJZ7), HEM6_YERPP  (A4TMK2), HEM6_YERPS  (Q668I6), 
HEM6_YERPY  (B1JSJ6)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

4 sequences

HEM6_DICDI  (Q54IA7), HEM6_ECO55  (B7LCI0), HEM6_FRAP2  (B0U151),

HEM6_METFK  (Q1H4H0)

» more

PDB
[Detailed view]

9 PDB

pdb_00001tk1; pdb_00001tkl; pdb_00001tlb; pdb_00001txn; pdb_00001vju; pdb_00002aex; pdb_00002qt8; pdb_00003dwr; pdb_00003dws