PROSITE documentation PDOC00783Coproporphyrinogen III oxidase signature
Coproporphyrinogen III oxidase (EC 1.3.3.3) (coproporphyrinogenase) [1,2] catalyzes the oxidative decarboxylation of coproporphyrinogen III into protoporphyrinogen IX, a common step in the pathway for the biosynthesis of porphyrins such as heme, chlorophyll or cobalamin.
Coproporphyrinogen III oxidase is an enzyme that requires iron for its activity. A cysteine seems to be important for the catalytic mechanism [3]. Sequences from a variety of eukaryotic and prokaryotic sources show that this enzyme has been evolutionarily conserved. As a signature pattern we selected a highly conserved region in the central part of the sequence; this region contains the only conserved cysteine and is rich in charged amino acids.
Note:Some bacteria possess an anaerobic form of coproporphyrinogen III oxidase [4] which does not belong to this family.
Last update:April 2006 / Pattern revised.
-------------------------------------------------------------------------------
PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Xu K. Elliott T. |
| Title | An oxygen-dependent coproporphyrinogen oxidase encoded by the hemF gene of Salmonella typhimurium. | |
| Source | J. Bacteriol. 175:4990-4999(1993). | |
| PubMed ID | 8349542 |
| 2 | Authors | Kohno H. Furukawa T. Yoshinaga T. Tokunaga R. Taketani S. |
| Title | Coproporphyrinogen oxidase. Purification, molecular cloning, and induction of mRNA during erythroid differentiation. | |
| Source | J. Biol. Chem. 268:21359-21363(1993). | |
| PubMed ID | 8407975 |
| 3 | Authors | Camadro J.M. Chambon H. Jolles J. Labbe P. |
| Title | Purification and properties of coproporphyrinogen oxidase from the yeast Saccharomyces cerevisiae. | |
| Source | Eur. J. Biochem. 156:579-587(1986). | |
| PubMed ID | 3516695 |
| 4 | Authors | Xu K. Elliott T. |
| Title | Cloning, DNA sequence, and complementation analysis of the Salmonella typhimurium hemN gene encoding a putative oxygen-independent coproporphyrinogen III oxidase. | |
| Source | J. Bacteriol. 176:3196-3203(1994). | |
| PubMed ID | 8195073 |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
View entry in original PROSITE document format
View entry in raw text format (no links)