PROSITE entry PS01070

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS01070
Entry name [info]	NUCLEASE_NON_SPEC
Accession [info]	PS01070
Entry type [info]	PATTERN
Date [info]	01-NOV-1995 CREATED; 01-JUL-1999 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00821
Associated ProRule [info]	PRU10047

Name and characterization of the entry

Description [info]	DNA/RNA non-specific endonucleases active site.
Pattern [info]	D-R-G-H-[QLIM]-x(3)-[AG].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	17 in 17 different sequences
Number of true positive hits	12 in 12 different sequences
Number of 'unknown' hits	0
Number of false positive hits	5 in 5 different sequences
Number of false negative sequences	1
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	70.59 %
Recall (true positives / (true positives + false negatives))	92.31 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Site [info]	active_site at position 4
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	12 sequences NUC1_CUNEE (P81203), NUC1_SYNRA (P81204), NUC1_YEAST (P08466), NUCA_NOSS1 (P38446), NUCA_SERMA (P13717), NUCE_STRPN (P0A3S3), NUCE_STRR6 (P0A3S4), NUCG_BOVIN (P38447), NUCG_CAEEL (Q95NM6), NUCG_HUMAN (Q14249), NUCG_MOUSE (O08600), PNU1_SCHPO (Q10480) » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	1 sequence EXOG_HUMAN (Q9Y2C4)
UniProtKB/Swiss-Prot False positive sequences	5 sequences FFSA_ASPFV (A0A7L8UVC9), FHCA_METEA (C5B137), MURD_PSEPF (Q3K742), TGA6_ARATH (Q39140), Y4XK_SINFN (P55703) » more
PDB [Detailed view]	7 PDB 1G8T; 1QAE; 1QL0; 1SMN; 3S5B; 4E3Y; 4QN0