PROSITE entry PS01192

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS01192
Entry name [info]	HMG_COA_REDUCTASE_3
Accession [info]	PS01192
Entry type [info]	PATTERN
Date [info]	01-NOV-1997 CREATED; 01-NOV-1997 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00064
Associated ProRule [info]	PRU10003

Name and characterization of the entry

Description [info]	Hydroxymethylglutaryl-coenzyme A reductases signature 3.
Pattern [info]	A-[LIVM]-x-[STAN]-x(2)-[LI]-x-[KRNQ]-[GSA]-H-[LM]-x-[FYLH].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	58 in 58 different sequences
Number of true positive hits	58 in 58 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	11
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	84.06 %

Comments [info]

Taxonomic range [info]	Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Site [info]	active_site at position 10
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

58 sequences

HMDH1_ARATH (P14891), HMDH1_ASPFU (Q4WHZ1), HMDH1_DICDI (P34135),

HMDH1_GIBZE (I1RXX1), HMDH1_GOSHI (O64966), HMDH1_HEVBR (P29057), 
HMDH1_ORYSI (A2X8W3), HMDH1_ORYSJ (Q0DY59), HMDH1_SOLTU (P48020), 
HMDH1_YEAST (P12683), HMDH2_ARATH (P43256), HMDH2_CAPAN (Q9XEL8), 
HMDH2_DICDI (P34136), HMDH2_GOSHI (O64967), HMDH2_HEVBR (P29058), 
HMDH2_SOLLC (P48022), HMDH2_SOLTU (Q41437), HMDH2_YEAST (P12684), 
HMDH3_HEVBR (Q00583), HMDH3_ORYSJ (Q9XHL5), HMDH3_SOLTU (Q41438), 
HMDH_AGRIP  (O76819), HMDH_ARCFU  (O28538), HMDH_ASPTE  (Q9Y7D2), 
HMDH_ASPTN  (Q0C8L9), HMDH_BLAGE  (P54960), HMDH_BOVIN  (A7Z064), 
HMDH_CAMAC  (P48021), HMDH_CANAL  (A0A1D8PD39), HMDH_CATRO  (Q03163), 
HMDH_CRIGR  (P00347), HMDH_CYBJA  (O74164), HMDH_DROME  (P14773), 
HMDH_GANLU  (B2KX91), HMDH_GIBF5  (S0DQM8), HMDH_GIBFU  (P0CT44), 
HMDH_HUMAN  (P04035), HMDH_MAIZE  (O24594), HMDH_MESAU  (P09610), 
HMDH_MOUSE  (Q01237), HMDH_NICSY  (Q01559), HMDH_PHYB8  (Q12649), 
HMDH_PIG(Q1W675), HMDH_PONAB  (Q5R6N3), HMDH_RABIT  (Q29512), 
HMDH_RAT(P51639), HMDH_SCHMA  (P16237), HMDH_STRPU  (P16393), 
HMDH_XENLA  (P20715), HMGR1_CANSA (A0A7J6H013), HMGR1_PANGI (A0A0A1C3I2), 
HMGR2_CANSA (A0A803NI27), HMR2A_PANGI (A0A0A1C930), HMR2B_PANGI (U5JCC6), 
MLCD_PENCI  (Q8J0F4), MOKG_MONPI  (Q3S2U3), MVAA_PSEMV  (P13702), 
PBCC_EMENI  (C8VN86)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

11 sequences

HMDH2_ASPFU (Q4WSY2), HMDH_AERPE  (Q9YAS4), HMDH_BORBU  (O51628),

HMDH_HALS3  (B0R6J9), HMDH_HALVD  (Q59468), HMDH_METJA  (Q58116), 
HMDH_METTH  (O26662), HMDH_PYRAB  (Q9V1R3), HMDH_PYRHO  (O59469), 
HMDH_SACS2  (O08424), HMDH_SCHPO  (Q10283)

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PDB
[Detailed view]

38 PDB

1DQ8; 1DQ9; 1DQA; 1HW8; 1HW9; 1HWI; 1HWJ; 1HWK; 1HWL; 1QAX; 1QAY; 1R31; 1R7I; 1T02; 2Q1L; 2Q6B; 2Q6C; 2R4F; 3BGL; 3CCT; 3CCW; 3CCZ; 3CD0; 3CD5; 3CD7; 3CDA; 3CDB; 4I4B; 4I56; 4I64; 4I6A; 4I6W; 4I6Y; 7ULI; 8ECG; 8GDN; 8SZ6; 8VLQ
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