PROSITE entry PS01192

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General information about the entry

Entry name [info]	HMG_COA_REDUCTASE_3
Accession [info]	PS01192
Entry type [info]	PATTERN
Date [info]	01-NOV-1997 CREATED; 01-NOV-1997 DATA UPDATE; 03-MAY-2023 INFO UPDATE.
PROSITE Doc. [info]	PDOC00064
Associated ProRule [info]	PRU10003

Name and characterization of the entry

Description [info]	Hydroxymethylglutaryl-coenzyme A reductases signature 3.
Pattern [info]	A-[LIVM]-x-[STAN]-x(2)-[LI]-x-[KRNQ]-[GSA]-H-[LM]-x-[FYLH].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_02 which contains 569'516 sequence entries.

Total number of hits	56 in 56 different sequences
Number of true positive hits	56 in 56 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	11
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	83.58 %

Comments [info]

Taxonomic range [info]	Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Site [info]	active_site at position 10
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

56 sequences

HMDH1_ARATH (P14891    ), HMDH1_ASPFU (Q4WHZ1    ), HMDH1_DICDI (P34135    ),

HMDH1_GIBZE (I1RXX1    ), HMDH1_GOSHI (O64966    ), HMDH1_HEVBR (P29057    ), 
HMDH1_ORYSI (A2X8W3    ), HMDH1_ORYSJ (Q0DY59    ), HMDH1_SOLTU (P48020    ), 
HMDH1_YEAST (P12683    ), HMDH2_ARATH (P43256    ), HMDH2_CAPAN (Q9XEL8    ), 
HMDH2_DICDI (P34136    ), HMDH2_GOSHI (O64967    ), HMDH2_HEVBR (P29058    ), 
HMDH2_SOLLC (P48022    ), HMDH2_SOLTU (Q41437    ), HMDH2_YEAST (P12684    ), 
HMDH3_HEVBR (Q00583    ), HMDH3_ORYSJ (Q9XHL5    ), HMDH3_SOLTU (Q41438    ), 
HMDH_AGRIP  (O76819    ), HMDH_ARCFU  (O28538    ), HMDH_ASPTE  (Q9Y7D2    ), 
HMDH_ASPTN  (Q0C8L9    ), HMDH_BLAGE  (P54960    ), HMDH_BOVIN  (A7Z064    ), 
HMDH_CAMAC  (P48021    ), HMDH_CANAL  (A0A1D8PD39), HMDH_CATRO  (Q03163    ), 
HMDH_CRIGR  (P00347    ), HMDH_CYBJA  (O74164    ), HMDH_DROME  (P14773    ), 
HMDH_GANLU  (B2KX91    ), HMDH_GIBF5  (S0DQM8    ), HMDH_GIBFU  (P0CT44    ), 
HMDH_HUMAN  (P04035    ), HMDH_MAIZE  (O24594    ), HMDH_MESAU  (P09610    ), 
HMDH_MOUSE  (Q01237    ), HMDH_NICSY  (Q01559    ), HMDH_PHYB8  (Q12649    ), 
HMDH_PIG    (Q1W675    ), HMDH_PONAB  (Q5R6N3    ), HMDH_RABIT  (Q29512    ), 
HMDH_RAT    (P51639    ), HMDH_SCHMA  (P16237    ), HMDH_STRPU  (P16393    ), 
HMDH_XENLA  (P20715    ), HMGR1_PANGI (A0A0A1C3I2), HMR2A_PANGI (A0A0A1C930), 
HMR2B_PANGI (U5JCC6    ), MLCD_PENCI  (Q8J0F4    ), MOKG_MONPI  (Q3S2U3    ), 
MVAA_PSEMV  (P13702    ), PBCC_EMENI  (C8VN86    )

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

11 sequences

HMDH2_ASPFU (Q4WSY2    ), HMDH_AERPE  (Q9YAS4    ), HMDH_BORBU  (O51628    ),

HMDH_HALS3  (B0R6J9    ), HMDH_HALVD  (Q59468    ), HMDH_METJA  (Q58116    ), 
HMDH_METTH  (O26662    ), HMDH_PYRAB  (Q9V1R3    ), HMDH_PYRHO  (O59469    ), 
HMDH_SACS2  (O08424    ), HMDH_SCHPO  (Q10283    )

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PDB
[Detailed view]

35 PDB

1DQ8; 1DQ9; 1DQA; 1HW8; 1HW9; 1HWI; 1HWJ; 1HWK; 1HWL; 1QAX; 1QAY; 1R31; 1R7I; 1T02; 2Q1L; 2Q6B; 2Q6C; 2R4F; 3BGL; 3CCT; 3CCW; 3CCZ; 3CD0; 3CD5; 3CD7; 3CDA; 3CDB; 4I4B; 4I56; 4I64; 4I6A; 4I6W; 4I6Y; 7ULI; 8ECG
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