ProRule PRU10003
General rule information
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| Accession | PRU10003 |
| Dates | 16-OCT-2006 (Created)
22-NOV-2019 (Last updated, Version 5) |
| Data class | Domain; |
| Predictors |
PROSITE; PS01192; HMG_COA_REDUCTASE_3 |
Name | Hydroxymethylglutaryl-coenzyme A reductases |
| Function | Undefined |
| Scope(s) |
Eukaryota Bacteria Archaea |
| Example(s) | P00347 (HMDH_CRIGR); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + AltName: Full=Hydroxymethylglutaryl-CoA reductase; AltName: Full=NADPH; EC=1.1.1.34; |
Comments
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| CATALYTIC ACTIVITY | Reaction=(R)-mevalonate + CoA + 2 NADP(+) = (3S)-hydroxy-3- methylglutaryl-CoA + 2 H(+) + 2 NADPH; Xref=Rhea:RHEA:15989, ChEBI:CHEBI:15378, ChEBI:CHEBI:36464, ChEBI:CHEBI:43074, ChEBI:CHEBI:57287, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.34; |
Features
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| From: PS01192 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 7 | 7 | /note="Proton donor" | |||||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [9] Bacteria [2] Eukaryota [56] All [ 67 ]
- Retrieve set of proteins with 3D structure for this domain