PROSITE logo
Due to maintenance work, this service will be unavailable from Mon Nov 11 17:30 until Tue Nov 12 09:00 CET. Apologies for the inconvenience.

ProRule PRU10003


General rule information [?]

Accession PRU10003
Dates 16-OCT-2006 (Created)
22-NOV-2019 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS01192; HMG_COA_REDUCTASE_3
Name Hydroxymethylglutaryl-coenzyme A reductases
Function Undefined
Scope(s) Eukaryota
Bacteria
Archaea
Example(s) P00347 (HMDH_CRIGR);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + AltName: Full=Hydroxymethylglutaryl-CoA reductase;
AltName: Full=NADPH;
                 EC=1.1.1.34;

Comments [?]

CATALYTIC ACTIVITY Reaction=(R)-mevalonate + CoA + 2 NADP(+) = (3S)-hydroxy-3- methylglutaryl-CoA + 2 H(+) + 2 NADPH; Xref=Rhea:RHEA:15989, ChEBI:CHEBI:15378, ChEBI:CHEBI:36464, ChEBI:CHEBI:43074, ChEBI:CHEBI:57287, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.34;

Features [?]

From: PS01192
Key From To Description Tag Condition FTGroup
ACT_SITE 7 7 /note="Proton donor"

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



View rule in raw text format (no links)

UniProtKB rule member sequences [?]