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PROSITE entry PS01226


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General information about the entry

Entry name [info] HMG_COA_SYNTHASE
Accession [info] PS01226
Entry type [info] PATTERN
Date [info] 01-NOV-1997 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00942
Associated ProRule [info] PRU10116

Name and characterization of the entry

Description [info] Hydroxymethylglutaryl-coenzyme A synthase active site.
Pattern [info]
N-x-[DN]-[IV]-E-G-[IV]-D-x(2)-N-A-C-[FY]-x-G.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_03 which contains 571'609 sequence entries.


Total number of hits 24 in 24 different sequences
Number of true positive hits 24 in 24 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 1
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 96.00 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] active_site at position 12
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
24 sequences

AKT41_ALTAL (V5XYR2), ER13A_ASPFU (Q4WBQ3), ER13B_ASPFU (Q4WXT8), 
ERG13_CANAL (A0A1D8PTW6), ERG13_GIBZE (I1RY35), ERG13_SCHPO (P54874), 
ERG13_YEAST (P54839), HCS1_USTMA  (Q4P3F1), HCS1_ZYMTI  (F9X3D9), 
HMCS1_BLAGE (P54961), HMCS1_CHICK (P23228), HMCS1_CRIGR (P13704), 
HMCS1_HUMAN (Q01581), HMCS1_MOUSE (Q8JZK9), HMCS1_PONAB (Q5R7Z9), 
HMCS1_RAT   (P17425), HMCS2_BLAGE (P54870), HMCS2_BOVIN (Q2KIE6), 
HMCS2_HUMAN (P54868), HMCS2_MOUSE (P54869), HMCS2_PIG   (O02734), 
HMCS2_RAT   (P22791), HMCS_ARATH  (P54873), HMCS_CAEEL  (P54871)
» more

UniProtKB/Swiss-Prot
False negative sequences
1 sequence

HMCSA_DICDI (P54872)

		
PDB
[Detailed view]
2 PDB

2P8U; 2WYA