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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS01327


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PURL: https://purl.expasy.org/prosite/signature/PS01327

Direct ScanProsite submission
General information about the entry

Entry name [info] MSCL
Accession [info] PS01327
Entry type [info] PATTERN
Date [info] 01-JUL-1999 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC01030

Name and characterization of the entry

Description [info] Large-conductance mechanosensitive channels mscL family signature.
Pattern [info]
[KR]-G-N-[LIVM](2)-D-[LIVM]-A-[LIVM]-[GA]-[LIVM](3)-G.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 362 in 362 different sequences
Number of true positive hits 362 in 362 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 22
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 94.27 %

Comments [info]

Taxonomic range [info] Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
362 sequences

MSCL1_RHILO (Q98DH7), MSCL2_RHILO (Q98DG5), MSCL3_RHILO (Q98B79), 
MSCL_ACIAD  (Q6FE93), MSCL_ACIB3  (B7GWU1), MSCL_ACIB5  (B7I868), 
MSCL_ACIBC  (B2HYF5), MSCL_ACIBS  (B0VRV0), MSCL_ACIBT  (A3M8J6), 
MSCL_ACIBY  (B0V4Z4), MSCL_ACIET  (B9MDX6), MSCL_ACISJ  (A1W457), 
MSCL_ACTP2  (A3N2P0), MSCL_ACTP7  (B3H2I9), MSCL_ACTPJ  (B0BRR8), 
MSCL_ACTSZ  (A6VKX7), MSCL_AERHH  (A0KNB2), MSCL_AERS4  (A4SJT9), 
MSCL_AFIC5  (B6JGA5), MSCL_AGRFC  (Q8UHY0), MSCL_ALKOO  (A8MGZ0), 
MSCL_ANAD2  (B8J6V0), MSCL_ANASK  (B4UD86), MSCL_ANOFW  (B7GLN3), 
MSCL_AROAE  (Q5P4W4), MSCL_AZOSB  (A1KC82), MSCL_AZOVD  (C1DER3), 
MSCL_BACAA  (C3PBD7), MSCL_BACAC  (C3L9Y0), MSCL_BACAH  (A0RJR6), 
MSCL_BACAN  (Q81KR6), MSCL_BACC0  (B7JS48), MSCL_BACC1  (Q72Z61), 
MSCL_BACC2  (B7IKT7), MSCL_BACC3  (C1EV23), MSCL_BACC4  (B7H732), 
MSCL_BACC7  (B7HSK8), MSCL_BACCN  (A7GTU7), MSCL_BACCQ  (B9J176), 
MSCL_BACCR  (Q816Z0), MSCL_BACCZ  (Q633B8), MSCL_BACFN  (Q5LGV7), 
MSCL_BACFR  (Q64XQ8), MSCL_BACHK  (Q6HCK7), MSCL_BACLD  (Q65E27), 
MSCL_BACMK  (A9VKI1), MSCL_BACP2  (A8FI71), MSCL_BACSU  (P94585), 
MSCL_BACTN  (Q89ZV7), MSCL_BACVZ  (A7Z9K9), MSCL_BARBK  (A1URL2), 
MSCL_BARHE  (Q6G4F8), MSCL_BARQU  (Q6G160), MSCL_BART1  (A9IQ78), 
MSCL_BDEBA  (Q6MRC6), MSCL_BEII9  (B2ID03), MSCL_BRADU  (Q89K46), 
MSCL_BRASO  (A4YWD8), MSCL_BREBN  (C0Z921), MSCL_BRUA1  (B2S9G8), 
MSCL_BRUA2  (Q2YPJ2), MSCL_BRUA4  (A6WVY7), MSCL_BRUAB  (Q57F40), 
MSCL_BRUC2  (A9M8A1), MSCL_BRUMB  (C0RH35), MSCL_BRUME  (Q8YFB7), 
MSCL_BRUO2  (A5VNQ9), MSCL_BRUSI  (B0CJU8), MSCL_BRUSU  (Q8G2K1), 
MSCL_BURA4  (B1YS18), MSCL_BURCH  (A0K875), MSCL_BURCJ  (B4EC31), 
MSCL_BURCM  (Q0BEC9), MSCL_BURL3  (Q39FB0), MSCL_BURM1  (A9AIS5), 
MSCL_BURM7  (A3MKN7), MSCL_BURM9  (A2SBC7), MSCL_BURMA  (Q62JH4), 
MSCL_BURMS  (A1V513), MSCL_BURO0  (B1JTX9), MSCL_BURO1  (Q1BHB3), 
MSCL_BURP0  (A3NWF4), MSCL_BURP1  (Q3JR90), MSCL_BURP6  (A3NAN4), 
MSCL_BURPS  (Q63T62), MSCL_BURTA  (Q2SWU6), MSCL_BURVG  (A4JF27), 
MSCL_CAMC1  (A7ZCB7), MSCL_CAMC5  (A7GXI2), MSCL_CAMHC  (A7I339), 
MSCL_CAUSK  (B0T274), MSCL_CAUVC  (Q9A2H6), MSCL_CAUVN  (B8H6A4), 
MSCL_CERS1  (A3PMB5), MSCL_CERS4  (Q3IZY4), MSCL_CERS5  (A4WVB7), 
MSCL_CHLAA  (A9WJI9), MSCL_CHLAD  (B8G6C2), MSCL_CHLCH  (Q3ANR9), 
MSCL_CHLL3  (Q3B3W2), MSCL_CHLP8  (B3QN57), MSCL_CHLPB  (B3EL80), 
MSCL_CHLPD  (A1BFW8), MSCL_CHLPM  (A4SEF1), MSCL_CHLTE  (Q8KD14), 
MSCL_CHRVO  (Q7NYB4), MSCL_CITK8  (A8AQI5), MSCL_CLOP1  (Q0TUQ9), 
MSCL_CLOPE  (P53380), MSCL_CLOPS  (Q0SWK0), MSCL_CROS8  (A7MPE5), 
MSCL_CUPMC  (Q1LIC3), MSCL_CUPNH  (Q0K6A4), MSCL_CUPPJ  (Q46WM9), 
MSCL_CYTH3  (Q11TN7), MSCL_DEHMB  (A5FPV4), MSCL_DEHMC  (Q3ZYR8), 
MSCL_DELAS  (A9BX57), MSCL_DESHD  (B8FTI4), MSCL_DESHY  (Q24Y14), 
MSCL_DINSH  (A8LLI0), MSCL_ECO24  (A7ZSH9), MSCL_ECO27  (B7UK14), 
MSCL_ECO45  (B7MCQ6), MSCL_ECO55  (B7LHZ2), MSCL_ECO57  (P0A743), 
MSCL_ECO5E  (B5YT10), MSCL_ECO7I  (B7NLL0), MSCL_ECO81  (B7N0T1), 
MSCL_ECO8A  (B7M0Z6), MSCL_ECOBW  (C4ZUE5), MSCL_ECODH  (B1X6E2), 
MSCL_ECOHS  (A8A595), MSCL_ECOK1  (A1AGI2), MSCL_ECOL5  (Q0TCH1), 
MSCL_ECOL6  (Q8FD11), MSCL_ECOLC  (B1IQ09), MSCL_ECOLI  (P0A742), 
MSCL_ECOLU  (B7NDR2), MSCL_ECOSE  (B6I204), MSCL_ECOSM  (B1LGP7), 
MSCL_ECOUT  (Q1R642), MSCL_ENT38  (A4WF99), MSCL_ERWT9  (B2VK97), 
MSCL_ESCF3  (B7LRQ7), MSCL_EXIS2  (B1YKK2), MSCL_EXISA  (C4KYQ8), 
MSCL_FLAJ1  (A5FKC3), MSCL_FUSNN  (Q8RFE0), MSCL_GEOKA  (Q5L081), 
MSCL_GEOMG  (Q39SN1), MSCL_GEOSL  (Q749E9), MSCL_GEOSW  (C5DA22), 
MSCL_GEOTN  (A4IMP7), MSCL_GLUOX  (Q5FNB7), MSCL_HAEDU  (Q7VKA0), 
MSCL_HAEI8  (Q4QMW0), MSCL_HAEIE  (A5UEB0), MSCL_HAEIG  (A5UH89), 
MSCL_HAEIN  (P44789), MSCL_HATHI  (Q9X722), MSCL_HERA2  (A9B815), 
MSCL_HERAR  (A4G9H5), MSCL_HISS1  (Q0I185), MSCL_HISS2  (B0UWZ1), 
MSCL_JANMA  (A6T365), MSCL_KLEP3  (B5XNC0), MSCL_KLEP7  (A6TEU4), 
MSCL_LACAC  (Q5FLW0), MSCL_LACCB  (B3WAS8), MSCL_LACGA  (Q041C3), 
MSCL_LACH4  (A8YTR2), MSCL_LACJO  (Q74HV9), MSCL_LACLA  (Q9CDW0), 
MSCL_LACLM  (A2RNQ7), MSCL_LACLS  (Q02W23), MSCL_LACP3  (Q034S0), 
MSCL_LACPL  (Q88X97), MSCL_LARHH  (C1DBZ0), MSCL_LATSS  (Q38V39), 
MSCL_LEGPA  (Q5X1Y7), MSCL_LEGPC  (A5IEQ9), MSCL_LEGPH  (Q5ZSH7), 
MSCL_LEGPL  (Q5WTR2), MSCL_LEPCP  (B1Y2I5), MSCL_LEUCK  (B1MZU9), 
MSCL_LEUMM  (Q03YJ0), MSCL_LEVBA  (Q03SF6), MSCL_LIGS1  (Q1WVR1), 
MSCL_LIMF3  (B2GEU1), MSCL_LIMRD  (A5VIB3), MSCL_LIMRJ  (B2G5U0), 
MSCL_LISIN  (Q929V3), MSCL_LISMC  (C1KX17), MSCL_LISMF  (Q71XV0), 
MSCL_LISMH  (B8DH65), MSCL_LISMO  (Q8Y5J6), MSCL_LISW6  (A0AKH0), 
MSCL_LYSSC  (B1HRA8), MSCL_MACCJ  (B9EBV2), MSCL_MANSM  (Q65QF7), 
MSCL_METC4  (B7KPQ5), MSCL_METEP  (A9W5W6), MSCL_METFK  (Q1H3M0), 
MSCL_METPB  (B1ZC68), MSCL_METPP  (A2SE21), MSCL_METRJ  (B1M0R9), 
MSCL_MYCBO  (P0A5K9), MSCL_MYCBP  (A1KHC1), MSCL_MYCBT  (C1ALX4), 
MSCL_MYCLB  (B8ZU13), MSCL_MYCLE  (Q9Z5G4), MSCL_MYCMM  (B2HEA6), 
MSCL_MYCTA  (A5U127), MSCL_MYCTO  (P9WJN4), MSCL_MYCTU  (P9WJN5), 
MSCL_MYCUA  (A0PWB0), MSCL_NITHX  (Q1QL44), MSCL_NITWN  (Q3SRA3), 
MSCL_NOVAD  (Q2G9Z8), MSCL_OCEIH  (Q8CUT6), MSCL_PARC0  (A1TTF7), 
MSCL_PARD8  (A6L898), MSCL_PARDP  (A1B4B3), MSCL_PARL1  (A7HR02), 
MSCL_PARP8  (B2JGJ7), MSCL_PARPJ  (B2T3W8), MSCL_PARXL  (Q13Z35), 
MSCL_PASMU  (P57950), MSCL_PECAS  (Q6CZZ8), MSCL_PECCA  (O68284), 
MSCL_PECCP  (C6DFR9), MSCL_PEDPA  (Q03D91), MSCL_PELPB  (B4SGK3), 
MSCL_PELPD  (A1APN2), MSCL_PHEZH  (B4RCK7), MSCL_PHOV8  (A6L685), 
MSCL_POLNA  (A1VK53), MSCL_PORG3  (B2RJU3), MSCL_PORGI  (Q7MUZ1), 
MSCL_PROA2  (B4S9H4), MSCL_PROMH  (B4F1L3), MSCL_PSE14  (Q48DU1), 
MSCL_PSEA8  (B7V0F9), MSCL_PSEAB  (Q02G63), MSCL_PSEAE  (Q9HVH7), 
MSCL_PSEE4  (Q1I4K7), MSCL_PSEF5  (Q4K5Q6), MSCL_PSEFL  (O68286), 
MSCL_PSEFS  (C3K2E3), MSCL_PSEP1  (A5W917), MSCL_PSEP7  (A6VC02), 
MSCL_PSEPF  (Q3K6I0), MSCL_PSEPG  (B0KHQ5), MSCL_PSEPK  (Q88E23), 
MSCL_PSEPW  (B1J2X0), MSCL_PSESM  (Q87WB2), MSCL_PSEU2  (Q4ZNG6), 
MSCL_PSYA2  (Q4FUU9), MSCL_PSYCK  (Q1QDU6), MSCL_PSYWF  (A5WCE5), 
MSCL_RALN1  (Q8XVA1), MSCL_RALPJ  (B2UDT8), MSCL_RENSM  (A9WMF7), 
MSCL_RHIE6  (B3PNR8), MSCL_RHIEC  (Q2KCQ1), MSCL_RHIJ3  (Q1MLQ8), 
MSCL_RHILW  (B5ZPK8), MSCL_RHIME  (Q92S72), MSCL_RHIR8  (B9J924), 
MSCL_RHIWR  (A5VBY5), MSCL_RHOP2  (Q2IWV4), MSCL_RHOPA  (Q6N6D0), 
MSCL_RHOPB  (Q214K6), MSCL_RHOPS  (Q136W9), MSCL_ROSDO  (Q16BG3), 
MSCL_ROSS1  (A5UVR8), MSCL_RUEPO  (Q5LMR7), MSCL_SALA4  (B5F7R7), 
MSCL_SALAR  (A9MN76), MSCL_SALCH  (Q57J60), MSCL_SALDC  (B5FJI6), 
MSCL_SALEP  (B5R1E7), MSCL_SALG2  (B5RH45), MSCL_SALHS  (B4TJY1), 
MSCL_SALNS  (B4SUR2), MSCL_SALPA  (Q5PIT4), MSCL_SALPB  (A9N8B5), 
MSCL_SALPC  (C0PZV3), MSCL_SALPK  (B5BGV7), MSCL_SALSV  (B4TXB4), 
MSCL_SALTI  (P0A1X9), MSCL_SALTY  (P0A1X8), MSCL_SERP5  (A8GKG9), 
MSCL_SHEB2  (B8ECI1), MSCL_SHEB5  (A3CZU7), MSCL_SHEB8  (A6WT30), 
MSCL_SHEB9  (A9L4L5), MSCL_SHEON  (Q8EJE5), MSCL_SHEPC  (A4YAR8), 
MSCL_SHESA  (A0KSJ1), MSCL_SHESM  (Q0HMW6), MSCL_SHESR  (Q0HQW4), 
MSCL_SHESW  (A1RFK8), MSCL_SHIB3  (B2U2R0), MSCL_SHIBS  (Q31VY6), 
MSCL_SHISS  (Q3YWW9), MSCL_SINFN  (C3MFT5), MSCL_SINMW  (A6U5U5), 
MSCL_SODGM  (Q2NQQ0), MSCL_SPHAL  (Q1GUG3), MSCL_STAA1  (A7X204), 
MSCL_STAA2  (A6U1G8), MSCL_STAA3  (Q2FH87), MSCL_STAA8  (P68805), 
MSCL_STAA9  (A5ISN0), MSCL_STAAB  (Q2YXW9), MSCL_STAAC  (Q5HG71), 
MSCL_STAAE  (A6QGQ0), MSCL_STAAM  (P68803), MSCL_STAAN  (P68804), 
MSCL_STAAR  (Q6GH57), MSCL_STAAS  (Q6G9L1), MSCL_STAAW  (P68806), 
MSCL_STACT  (B9DP78), MSCL_STAEQ  (Q5HPJ2), MSCL_STAES  (Q8CPC4), 
MSCL_STAHJ  (Q4L656), MSCL_STAS1  (Q49XE2), MSCL_STRM5  (B4STT2), 
MSCL_STRMK  (B2FSD7), MSCL_SYMTH  (Q67PL7), MSCL_SYNAS  (Q2LUI9), 
MSCL_SYNWW  (Q0AWD5), MSCL_SYNY3  (P73553), MSCL_THISH  (B8GTM8), 
MSCL_TOLAT  (C4LE79), MSCL_TRIL1  (B3EA78), MSCL_VARPS  (C5CQL2), 
MSCL_VIBC3  (A5F037), MSCL_VIBCH  (Q9KLX9), MSCL_VIBCM  (C3LVM7), 
MSCL_XANAC  (Q8PHE9), MSCL_XANC8  (Q4UXZ0), MSCL_XANCB  (B0RPI5), 
MSCL_XANCP  (Q8P626), MSCL_XANE5  (Q3BQ08), MSCL_XANOM  (Q2P0I7), 
MSCL_XANOP  (B2SWL6), MSCL_XANOR  (Q5GXD6), MSCL_XYLF2  (B2I658), 
MSCL_XYLFA  (Q9PHA5), MSCL_XYLFM  (B0U1E0), MSCL_XYLFT  (Q87FA1), 
MSCL_YERE8  (A1JRZ6), MSCL_YERP3  (A7FNK6), MSCL_YERPA  (Q1C2X5), 
MSCL_YERPE  (Q8ZJ83), MSCL_YERPG  (A9R923), MSCL_YERPN  (Q1CCX2), 
MSCL_YERPP  (A4TH19), MSCL_YERPS  (Q664V0)
» more

UniProtKB/Swiss-Prot
False negative sequences
22 sequences

MSCL_BORBR  (Q7WDW9), MSCL_BORPA  (Q7W2W9), MSCL_BORPD  (A9HW97), 
MSCL_BORPE  (Q7W079), MSCL_BRAHW  (C0QYW6), MSCL_CHLL2  (B3ECJ4), 
MSCL_CLOB8  (A6M387), MSCL_CLOTE  (Q898L6), MSCL_DECAR  (Q47AR9), 
MSCL_ENTFA  (Q82ZB4), MSCL_FLAPJ  (A6GYI6), MSCL_GEODF  (B9M9E4), 
MSCL_HYPNA  (Q0C5R9), MSCL_METSB  (B8EJ45), MSCL_NITV9  (B8DR67), 
MSCL_OENOB  (Q04FK1), MSCL_SYNE7  (Q31LP8), MSCL_SYNJA  (Q2JSN8), 
MSCL_SYNJB  (Q2JLN5), MSCL_SYNP6  (Q5N075), MSCL_THIDA  (Q3SG48), 
MSCL_ZYMMO  (Q5NNP2)
» more

PDB
[Detailed view]
3 PDB

pdb_00002oar; pdb_00003hzq; pdb_00006ctd