PROSITE documentation PDOC01030
Large-conductance mechanosensitive channels mscL family signature


Mechanosensitive ion channels play a critical role in transducing physical stresses at the cell membrane into an electrochemical response. Prokaryotes harbor a large-conductance mechanosensitive channel (gene mscL) [1] which is opened by membrane stretch force and may participate in the regulation of osmotic pressure changes within the cell.

MscL is a protein of about 15 kD. It forms a channel organized as a homopentamer [2], with each subunit containing two transmembrane regions.

As a signature pattern, we selected the best conserved region. It is located in the N-terminal region. It starts three residues before the beginning of the first transmembrane domain and ends in the middle of that domain.

Last update:

April 2006 / Pattern revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

MSCL, PS01327; Large-conductance mechanosensitive channels mscL family signature  (PATTERN)


1AuthorsMoe P.C. Blount P. Kung C.
TitleFunctional and structural conservation in the mechanosensitive channel MscL implicates elements crucial for mechanosensation.
SourceMol. Microbiol. 28:583-592(1998).
PubMed ID9632260

2AuthorsChang G. Spencer R.H. Lee A.T. Barclay M.T. Rees D.C.
TitleStructure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel.
SourceScience 282:2220-2226(1998).
PubMed ID9856938

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