We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE entry PS01334
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PURL: https://purl.expasy.org/prosite/signature/PS01334
Direct ScanProsite submission
General information about the entry
| Entry name [info] | PYRASE_CYS |
| Accession [info] | PS01334 |
| Entry type [info] | PATTERN |
| Date [info] |
01-JUL-1999 CREATED;
01-DEC-2004 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC01036 |
| Associated ProRule [info] | PRU10077 |
Name and characterization of the entry
| Description [info] | Pyrrolidone-carboxylate peptidase cysteine active site. |
| Pattern [info] |
[LIVF]-x-[GSAVC]-x-[LIVM]-S-x-[STAD]-A-G-x-[FY]-[LIVN]-C-[DNS]. |
Numerical results [info]
| Total number of hits | 146 in 146 different sequences |
| Number of true positive hits | 146 in 146 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 5 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 96.69 % |
Comments [info]
| Taxonomic range [info] | Archaea, Eukaryotes, Prokaryotes (Bacteria) |
| Maximum number of repetitions [info] | 1 |
| Site [info] | active_site at position 14 |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
146 sequences
PCP1_CALS4 (Q8RBX8), PCP1_PHOLL (Q7MAZ1), PCP1_RALN1 (Q8XXE9), PCP1_SACS2 (P58201), PCP1_STRPN (P65678), PCP1_STRR6 (P65679), PCP2_CALS4 (Q8R9J6), PCP2_PHOLL (Q7MZ76), PCP2_RALN1 (Q8XT56), PCP2_SACS2 (P58202), PCP2_STRPN (Q97NG9), PCP_ALIF1 (Q5E531), PCP_ALIFM (B5FEA5), PCP_ALKOO (A8MJA9), PCP_BACAA (C3P0R7), PCP_BACAC (C3LDV2), PCP_BACAH (A0RFP3), PCP_BACAM (P46107), PCP_BACAN (Q81NT5), PCP_BACC0 (B7JDC3), PCP_BACC1 (Q735N6), PCP_BACC2 (B7IMH6), PCP_BACC3 (C1F026), PCP_BACC4 (B7H8H3), PCP_BACC7 (B7HVU3), PCP_BACCN (A7GQB6), PCP_BACCQ (B9J587), PCP_BACCR (Q81BT3), PCP_BACCZ (Q639M5), PCP_BACHK (Q6HH08), PCP_BACLD (Q65FR5), PCP_BACMK (A9VKA7), PCP_BACSU (P28618), PCP_BACVZ (A7Z119), PCP_BRAHW (C0QXM0), PCP_BREBN (C0ZCX0), PCP_CHRVO (Q7NT84), PCP_CITK8 (A8AJA6), PCP_CLOBA (B2UZU4), PCP_CLOBB (B2TK93), PCP_CLOD6 (Q186N3), PCP_CLOP1 (Q0TQH4), PCP_CLOPE (Q8XKH1), PCP_CLOPS (Q0ST25), PCP_CUPNH (Q0KFE0), PCP_CUPPJ (Q477F9), PCP_CUPTR (B2AG45), PCP_DEIRA (Q9RX25), PCP_ENT38 (A4W870), PCP_ENTFA (Q838N8), PCP_ERWT9 (B2VBP1), PCP_ESCF3 (B7LKQ5), PCP_FINM2 (B0S415), PCP_FUSNN (Q8RI83), PCP_GLOVI (Q7NHX6), PCP_HALH5 (Q9K6U4), PCP_KLEP3 (B5XZE0), PCP_LACAC (Q5FMJ2), PCP_LACCB (B3W7M8), PCP_LACGA (Q040L6), PCP_LACH4 (A8YX24), PCP_LACJO (Q74HE9), PCP_LACLM (O87765), PCP_LACP3 (Q03CK3), PCP_LEVBA (Q03P20), PCP_MYCBO (P0A5R5), PCP_MYCBP (A1KFE2), PCP_MYCBT (C1AJZ7), PCP_MYCMM (B2HP18), PCP_MYCTA (A5TZ46), PCP_MYCTO (P9WIJ4), PCP_MYCTU (P9WIJ5), PCP_OCEIH (Q8ENE4), PCP_PECAS (Q6D7H1), PCP_PECCP (C6DCC7), PCP_PSEFL (P42673), PCP_PSEFS (C3JZR3), PCP_PYRAB (Q9UYQ9), PCP_PYRFU (O73944), PCP_PYRHO (O58321), PCP_SACI1 (C3NL04), PCP_SACI2 (C3MP49), PCP_SACI3 (C3N2L8), PCP_SACI6 (C4KEG7), PCP_SACI7 (C3NAL6), PCP_STAA1 (A7X782), PCP_STAA2 (A6U575), PCP_STAA3 (Q2FDH1), PCP_STAA8 (Q2FUS6), PCP_STAA9 (A5IWB7), PCP_STAAB (Q2YZA2), PCP_STAAC (Q5HCK7), PCP_STAAE (A6QKH8), PCP_STAAM (P65676), PCP_STAAN (P65677), PCP_STAAR (Q6GDB4), PCP_STAAS (Q6G5Y4), PCP_STAAT (A8Z5J1), PCP_STAAU (Q53596), PCP_STAAW (Q8NUH2), PCP_STACT (B9DND6), PCP_STAHJ (Q4L9S3), PCP_STAS1 (Q4A002), PCP_STRCO (Q9RL48), PCP_STRP1 (P68896), PCP_STRP2 (Q04L55), PCP_STRP3 (P0DC94), PCP_STRP6 (Q5XDD4), PCP_STRP7 (C1C6J3), PCP_STRP8 (Q8P243), PCP_STRPB (Q1JD20), PCP_STRPC (Q1JMZ5), PCP_STRPD (Q1JI40), PCP_STRPF (Q1J7Y1), PCP_STRPG (A2RFZ5), PCP_STRPI (B1IB28), PCP_STRPM (Q48UT7), PCP_STRPQ (P0DC95), PCP_STRPZ (B5XK96), PCP_STRS2 (A4W0R4), PCP_STRSY (A4VUH1), PCP_THEAB (B7IEE2), PCP_THEKO (Q5JEL5), PCP_THELN (O07883), PCP_THEM4 (A6LL24), PCP_THEON (B6YUJ5), PCP_THEP3 (B0K8Z7), PCP_THEPX (B0K0D9), PCP_TREDE (Q73RB6), PCP_VIBC1 (A7N3R7), PCP_VIBPA (Q87IL9), PCP_VIBVU (Q8D4N5), PCP_VIBVY (Q7MG84), PCP_YERE8 (A1JR34), PCP_YERP3 (A7FFS3), PCP_YERPA (Q1C571), PCP_YERPB (B2KA64), PCP_YERPE (Q8ZD86), PCP_YERPG (A9R3Y5), PCP_YERPN (Q1CKF9), PCP_YERPP (A4TKZ3), PCP_YERPS (Q667T6), PCP_YERPY (B1JRB0), PGPI_HUMAN (Q9NXJ5), PGPI_MOUSE (Q9ESW8), PGPI_RAT(Q76IC5)» more
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| UniProtKB/Swiss-Prot False negative sequences |
5 sequences
PCP_CLAM3 (A5CM68), PCP_COPPD (B5Y5X6), PCP_LYSSC (B1HUY7), PGPIL_HUMAN (A6NFU8), PGPIL_MOUSE (Q9CWB5)» more |
| PDB [Detailed view] |
12 PDB
pdb_00001a2z; pdb_00001aug; pdb_00001iof; pdb_00001iu8; pdb_00002df5; pdb_00003giu; pdb_00003lac; pdb_00003rnz; pdb_00003ro0; pdb_00005z40; pdb_00005z47; pdb_00005z48 |