PROSITE entry PS50001
View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry
| PURL [info] | https://purl.expasy.org/prosite/signature/PS50001 |
| Entry name [info] | SH2 |
| Accession [info] | PS50001 |
| Entry type [info] | MATRIX |
| Date [info] |
01-NOV-1995 CREATED;
01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC50001 |
| Associated ProRule [info] | PRU00191 |
Name and characterization of the entry
| Description [info] | Src homology 2 (SH2) domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=92; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=87; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.3941; R2=0.01483; TEXT='NScore'; /CUT_OFF: LEVEL=0; SCORE=547; N_SCORE=8.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=412; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: D=-20; I=-20; B1=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='W'; M=-16,-34,-40,-35,-25, 9,-21,-24,-17,-19,-16,-17,-34,-25,-18,-19,-33,-25,-25,111, 26,-18; /M: SY='Y'; M=-17,-24,-26,-29,-24, 41,-30, -2, 7,-20, 6, 2,-19,-28,-22,-16,-19,-10, -1, 14, 48,-24; /M: SY='H'; M=-14,-14,-23,-18,-14, 7,-23, 31, -9,-15, -3, 4, -8,-24, -9,-10,-15,-14,-11, -8, 18,-12; /M: SY='G'; M= -3, -9,-30, -8,-14,-26, 45,-17,-36, -9,-28,-18, -1,-14,-14, -8, -3,-17,-27,-20,-24,-14; /M: SY='K'; M= -8, -1,-25, -2, 0,-10,-16, -5,-19, 6,-18,-11, 1, -7, -3, 1, -4, -6,-16,-21, -6, -2; /M: SY='I'; M= -8,-28,-24,-35,-27, 4,-34,-25, 36,-26, 23, 21,-23,-23,-20,-24,-19, -8, 26,-21, -1,-26; /I: I=-4; MI=0; IM=0; /M: SY='S'; M= 1, 3,-18, 1, 0,-21, -4, -9,-20, -6,-25,-17, 10, -3, 0, -8, 20, 14,-16,-34,-19, 0; /M: SY='R'; M=-16, -9,-30, -9, -1,-23, -8, -5,-31, 26,-23,-11, 0,-18, 6, 51, -9,-11,-21,-18,-12, -1; /M: SY='E'; M= -2, 2,-25, 1, 12,-25,-12, -3,-21, 6,-20,-12, 2,-11, 10, 3, 2, -4,-18,-23,-14, 11; /M: SY='E'; M=-10, 10,-29, 16, 26,-30,-15, 0,-26, 10,-21,-14, 3, -9, 19, 5, -2, -9,-25,-26,-13, 22; /M: SY='A'; M= 36,-11,-11,-17, -7,-18, -6,-20, -6,-10, -9, -8,-11,-12,-10,-18, 8, 1, 4,-23,-18, -9; /M: SY='E'; M=-10, 4,-28, 9, 36,-22,-20, 2,-23, 5,-16,-14, -1, -7, 12, 2, -2, -8,-22,-26,-12, 23; /M: SY='R'; M= -6, 4,-25, 5, 10,-24,-14, -1,-23, 10,-19,-11, 3,-13, 9, 11, 0, -5,-19,-25,-11, 8; /M: SY='L'; M=-10,-23,-23,-25,-15, 1,-27,-12, 13,-19, 28, 17,-22,-25, -8,-12,-22, -9, 4,-18, 2,-12; /M: SY='L'; M=-10,-30,-20,-30,-20, 10,-30,-20, 20,-30, 49, 20,-30,-30,-20,-20,-30,-10, 11,-20, 0,-20; /M: SY='R'; M= -8, -9,-23,-12, -6,-13,-19, -9, -6, 1, -1, 4, -6,-18, 1, 5, -8, -4, -6,-23, -7, -4; /M: SY='N'; M= -4, 9,-22, 7, 5,-23, -9, -2,-21, 0,-21,-13, 11,-10, 5, -2, 5, -1,-19,-30,-15, 4; /M: SY='K'; M= -8, -5,-27, -4, 3,-22,-12, -9,-19, 7,-20,-11, -2, -1, 2, 5, -3, -5,-16,-24,-13, 1; /I: I=-4; MI=-19; MD=-19; IM=-19; /M: SY='G'; M= -4, -6,-21, -5, -1,-21, 10,-11,-22, -9,-20,-12, -4, 2, -6,-10, -1, -9,-19,-23,-19, -4; D=-4; /I: I=-4; MI=-19; MD=-19; IM=-19; DM=-19; /M: SY='B'; M=-11, 10,-24, 10, 4,-20,-14, -1,-18, 5,-18,-10, 9, -4, 1, 3, -3, -6,-17,-26,-12, 1; D=-4; /I: I=-4; MI=-19; MD=-19; IM=-19; DM=-19; /M: SY='E'; M= -4, 3,-14, 6, 9,-14, -8, -2,-12, 0,-12, -8, 1, 4, 4, -2, 1, -2,-12,-16, -9, 6; D=-4; /I: I=-4; MI=0; IM=0; DM=-19; /M: SY='G'; M= -1,-11,-27,-11,-20,-29, 66,-20,-39,-20,-30,-20, -1,-21,-20,-20, -1,-20,-30,-17,-29,-20; /M: SY='T'; M= 5, 3,-13, 0, -3,-18,-10,-13,-16, -9,-14,-13, 1,-12, -6,-12, 14, 18, -8,-31,-15, -5; /M: SY='F'; M=-20,-29,-21,-38,-29, 74,-30,-15, 0,-28, 9, 0,-20,-30,-37,-19,-20,-10, -1, 12, 36,-29; /M: SY='L'; M= -9,-30,-20,-31,-22, 8,-30,-21, 23,-28, 43, 21,-29,-29,-20,-20,-27, -9, 15,-21, -1,-21; /M: SY='V'; M= -3,-29,-17,-32,-28, 1,-32,-28, 32,-24, 19, 14,-26,-26,-25,-23,-15, -4, 36,-25, -6,-28; /M: SY='R'; M=-20,-10,-30,-10, 0,-20,-20, 0,-30, 30,-20,-10, 0,-20, 10, 70,-10,-10,-20,-20,-10, 0; /M: SY='E'; M=-12, 4,-29, 10, 23,-15,-20, -6,-22, 1,-15,-14, -3, -2, 6, -5, -6,-10,-22,-23,-11, 15; /M: SY='S'; M= 8, -1,-10, -2, -1,-20, -2,-10,-20, -7,-28,-19, 8,-11, 0, -4, 34, 17,-10,-37,-19, -1; /M: SY='E'; M= -8, 9,-25, 15, 23,-26,-16, -1,-24, 4,-20,-16, 4, -9, 10, 2, 4, -3,-20,-31,-16, 16; /M: SY='S'; M= -2, 1,-18, -2, -1,-21, -6, -6,-22, 1,-24,-15, 8,-10, 1, 2, 16, 13,-15,-31,-15, -1; /I: I=-5; MI=-27; MD=-27; IM=-27; /M: SY='S'; M= -4, 0,-22, -2, 3,-15,-12, -2,-19, 1,-18,-11, 3, -8, 1, -2, 4, 3,-16,-25, -8, 1; D=-5; /I: I=-5; MI=-27; MD=-27; IM=-27; DM=-27; /M: SY='P'; M= -6,-11,-22,-10, -3,-14,-16,-12, -5, 0, -9, -4,-10, 19, -4, -3, -8, -5, -8,-17,-11, -6; D=-5; /I: I=-5; MI=0; IM=0; DM=-27; /M: SY='G'; M= -1, -2,-29, -3,-12,-30, 50,-15,-36,-15,-29,-19, 5,-15,-13,-16, 1,-16,-29,-23,-27,-13; /M: SY='D'; M= 0, 10,-20, 15, 8,-28, 4, -9,-28, -6,-22,-19, 5,-12, -1,-11, 6, -5,-21,-31,-21, 4; /M: SY='Y'; M=-17,-22,-26,-26,-20, 33,-30, 3, 4,-17, 3, 2,-18,-27,-18,-13,-17, -9, -2, 11, 46,-21; /M: SY='T'; M= 9, -8, -9,-13,-10,-14,-12,-18, -7,-12,-12, -9, -5,-11,-10,-14, 15, 21, 3,-31,-15,-10; /M: SY='L'; M=-10,-29,-18,-32,-24, 10,-32,-23, 24,-27, 33, 16,-26,-28,-22,-20,-24, -9, 16,-20, 0,-24; /M: SY='S'; M= 10, -4, -7, -7, -6,-17, -5,-13,-15,-12,-22,-15, 3,-13, -5,-13, 28, 18, -6,-34,-16, -6; /M: SY='V'; M= -8,-29,-20,-31,-26, 11,-27,-22, 16,-22, 11, 7,-26,-28,-25,-19,-18, -6, 21, 0, 4,-25; /M: SY='R'; M=-11,-16,-25,-17,-10, -7,-22,-10,-10, 7, -7, -3,-11,-21, -5, 18,-11, -8, -5,-10, -2, -9; /M: M= -8, -1,-20, 0, -4, -7,-19, -7,-14, -6,-11, -9, -5,-18, -8, -6, -5, -2, -9,-15, 0, -6; /M: SY='D'; M=-10, 5,-25, 7, 3,-19, -6, -7,-25, 0,-20,-15, 3,-15, 0, -1, -3, -9,-22,-16,-11, 1; /M: SY='G'; M= -4, 7,-25, 11, -3,-25, 13,-11,-27, -9,-23,-18, 4,-16, -8,-10, 3, -7,-18,-25,-19, -5; /I: I=-2; MI=0; IM=0; /M: SY='Q'; M= -8, 2,-23, 1, 4,-22,-13, 0,-17, 4,-16, -9, 4,-15, 5, 4, -2, -6,-15,-28,-12, 4; /M: SY='V'; M= -4,-19,-17,-21,-21, -3,-23,-20, 14,-16, 0, 2,-16,-19,-21,-14, -8, -3, 23,-27, -9,-22; /M: SY='K'; M=-10, -2,-28, -4, 3,-23,-11, -4,-23, 20,-21, -8, 1,-14, 9, 18, -5, -6,-19,-21, -9, 5; /M: SY='H'; M=-18, -2,-29, -2, 2,-18,-20, 78,-26, -8,-16, -1, 6,-19, 8, 1, -9,-17,-26,-29, 14, 1; /M: SY='Y'; M=-15,-24,-14,-29,-24, 26,-30, -9, 3,-20, 2, -1,-21,-23,-22,-18,-18, -8, -1, 8, 31,-24; /M: SY='R'; M=-13, -4,-27, -5, 0,-21,-21, -2,-16, 16,-15, -4, -1,-17, 7, 22, -9, -8,-11,-24, -8, 1; /M: SY='I'; M= -9,-30,-25,-37,-29, 4,-37,-29, 41,-27, 19, 17,-22,-23,-22,-26,-19, -8, 30,-20, 0,-29; /M: SY='Q'; M=-12, -3,-21, -5, 4,-19,-20, 3,-16, 8,-13, -2, 1,-17, 12, 12, -8, -9,-17,-23, -7, 7; /M: SY='K'; M= -4, -1,-19, -3, 3,-20,-15, -3,-21, 5,-21,-12, 2, -6, 2, 5, 4, 2,-16,-26,-12, 1; /M: SY='T'; M= -6, -7,-19, -8, -6, -7,-21,-13, -3,-11, 1, -2, -7,-17, -9, -8, -4, 4, -1,-26, -8, -8; /M: SY='D'; M= -5, 11,-24, 17, 14,-29, -3, -7,-27, -3,-21,-17, 3, -4, 3, -9, 1, -6,-23,-29,-19, 8; /I: I=-2; MI=-12; MD=-12; IM=-12; /M: SY='N'; M= -6, 13,-20, 10, 3,-22, 0, -4,-22, 0,-21,-15, 16,-12, 1, -1, 7, 3,-19,-28,-16, 2; D=-2; /I: I=-2; MI=-12; MD=-12; IM=-12; DM=-12; /M: SY='G'; M= -1, -2,-14, -3, -4,-16, 22, -8,-20, -6,-16,-11, 2,-10, -6, -5, 2, -7,-15,-14,-15, -5; D=-2; /I: I=-2; MI=0; IM=0; DM=-12; /M: SY='K'; M= -8, -6,-27, -5, -2,-20, -6, -7,-20, 4,-17, -9, -4, -6, -2, 0, -6, -7,-16,-24,-12, -3; /M: SY='Y'; M=-17,-24,-26,-26,-23, 35,-27, 2, 2,-18, 7, 2,-21,-30,-19,-14,-20,-10, -4, 18, 51,-23; /M: SY='Y'; M= -9,-10,-17,-13,-13, 6,-18, -4, -9, -9, -8, -5, -7,-22,-10, -4, -3, 0, -7,-10, 15,-13; /M: SY='I'; M= -7,-25,-22,-29,-20, 2,-31,-23, 23,-19, 17, 12,-21,-20,-19,-19,-17, -7, 19,-21, -3,-21; /M: SY='S'; M= -2, 1,-23, -1, -1,-20, 0,-11,-23, -3,-22,-16, 3, -9, -3, -5, 6, 4,-18,-20,-13, -3; /M: SY='E'; M= -6, 4,-26, 6, 9,-25, 3, -7,-25, -4,-22,-16, 5, -8, 1, -5, 3, -4,-21,-27,-18, 4; /I: I=-6; MI=-29; MD=-29; IM=-29; /M: SY='R'; M= -5, -2,-16, -3, 0,-13, -1, -5,-14, 6,-11, -7, 2, -7, 0, 10, -3, -5,-12,-14, -9, -1; D=-6; /I: I=-6; MI=0; IM=0; DM=-29; /M: M= -6, -6,-23, -5, -1,-15,-19, -1, -9, -4, -5, -3, -6,-13, -2, -1, -6, -5, -7,-26, -8, -2; /M: SY='R'; M= -4, -4,-18, -8, -4,-16,-12, -9,-17, 3,-16,-10, 0,-13, 0, 4, 2, 3,-12,-24, -9, -3; /M: SY='F'; M=-15,-26,-19,-34,-26, 59,-28,-14, 0,-26, 8, 0,-17,-28,-32,-19,-18, -9, -1, 5, 27,-26; /M: SY='N'; M= -4, 6,-19, 5, 1,-24, -1, -7,-23, -5,-22,-15, 9, -6, -3, -5, 3, -5,-20,-31,-20, -1; /M: SY='S'; M= 3, 5, -9, 2, -3,-19, -5,-12,-19, -9,-24,-18, 9,-12, -5,-10, 25, 20,-11,-36,-18, -4; /M: SY='L'; M=-10,-30,-22,-33,-23, 11,-32,-23, 26,-28, 35, 18,-26,-25,-21,-22,-25, -9, 16,-19, 1,-23; /M: SY='P'; M= -1, -5,-24, -7, -3,-20,-10, -7,-14, -6,-16, -8, -3, 2, 2, -9, 0, -2,-14,-22,-12, -2; /M: SY='E'; M=-10, 13,-28, 21, 30,-28,-18, 1,-25, 3,-17,-15, 2, -8, 15, -4, -2, -8,-24,-27,-12, 22; /M: SY='L'; M=-10,-29,-22,-31,-21, 8,-31,-20, 23,-27, 41, 22,-27,-28,-18,-18,-27,-10, 12,-20, 0,-20; /M: SY='I'; M= -5,-30,-17,-35,-29, 0,-35,-29, 38,-25, 16, 15,-25,-25,-25,-25,-16, -5, 37,-25, -5,-29; /M: SY='E'; M= -8, 3,-25, 5, 11,-20,-15, 4,-19, 2,-16, -8, 2,-13, 9, 2, -1, -5,-18,-23, -6, 9; /M: SY='H'; M=-17, -5,-28, -5, -6, -2,-20, 49,-17,-10,-12, -3, -1,-22, -1, -6,-11,-14,-19,-11, 30, -7; /M: SY='Y'; M=-19,-16,-29,-17,-15, 19,-28, 32, -6,-12, -1, 1,-14,-27, -7, -9,-18,-12,-13, 11, 56,-15; /M: SY='Q'; M= -6, -6,-23, -6, 4,-20,-17, -6,-17, 8,-15, -5, -3, -9, 10, 9, 2, 1,-14,-24,-10, 6; /M: SY='Q'; M=-11, 0,-26, 1, 7,-23,-20, 9,-18, 10,-18, -6, 1,-14, 12, 6, -4, -6,-15,-24, -4, 8; /M: SY='N'; M= -5, 6,-21, 1, 1,-18,-12, 4,-14, -3,-15, -6, 11,-15, 1, -2, 3, 0,-13,-31,-12, 0; /M: SY='S'; M= 6, -5,-22, -5, 0,-24, -5, -6,-20, -2,-21,-11, -2, 1, 2, -6, 7, -2,-16,-27,-17, 0; /M: M= -2, -2,-20, -1, -6,-16,-12,-14, -6,-11, -1, -3, -7,-18, -8,-13, -8, -7, -4,-26,-13, -8; /M: SY='G'; M= -2, -9,-26, -7, -6,-20, 12,-15,-21, -9,-17,-12, -7, -8,-10,-10, -3, -9,-15,-22,-17, -9; /M: SY='L'; M=-11,-12,-19,-13, -5, -7,-25,-11, 3,-13, 15, 4,-10,-22, -6, -7,-16, -8, -3,-25, -7, -6; /I: I=-4; MI=-19; MD=-19; IM=-19; /M: SY='C'; M= -4,-14, 11,-20,-17,-11,-22,-17, -3,-15, -4, -3,-12,-21,-15,-16, -6, 0, 3,-29,-11,-17; D=-4; /I: I=-4; MI=-19; MD=-19; IM=-19; DM=-19; /M: M= -9, -4, -6, -7, -3,-10,-17, -1,-16, -6,-15, -8, -1,-13, -4, -5, -1, -1,-13,-25, -6, -4; D=-4; /I: I=-4; MI=0; IM=0; DM=-19; /M: SY='R'; M=-11, -9,-24,-10, -2,-14,-22, -7,-14, 14,-13, -5, -6,-15, 0, 17, -9, -5, -9,-20, -4, -3; /M: SY='L'; M=-11,-29,-21,-29,-20, 11,-30,-16, 19,-27, 43, 19,-28,-29,-18,-19,-28,-10, 9,-15, 8,-20; /M: SY='R'; M= -7,-11,-22,-13, -7,-11,-20, -9, -8, 2, -4, -2, -8,-18, -3, 8, -5, 2, -4,-22, -4, -6; /M: SY='Y'; M=-12, -4,-25, -5, -4, -4,-20, 5,-12, -1,-12, -7, -4,-19, -1, 1, -5, -3,-12,-10, 16, -4; /M: SY='P'; M= -5,-18,-34,-12, -3,-26,-19,-18,-15,-11,-24,-15,-17, 65,-10,-19, -6, -6,-21,-29,-26,-10; /M: SY='V'; M= -5,-22, 7,-24,-20, -2,-28,-22, 7,-18, 4, 2,-22,-26,-22,-18,-12, -6, 17,-27, -8,-21; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 475 in 432 different sequences |
| Number of true positive hits | 475 in 432 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 23 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 95.38 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes, Eukaryotic viruses |
| Maximum number of repetitions [info] | 2 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | P_Bucher |
| Feature key [info] | DOMAIN |
| Feature description [info] | SH2 |
| Version [info] | 3 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
432 sequences
3BP2_HUMAN (P78314), 3BP2_MOUSE (Q06649), ABL1_CAEEL (P03949), ABL1_HUMAN (P00519), ABL1_MOUSE (P00520), ABL2_HUMAN (P42684), ABL2_MOUSE (Q4JIM5), ABL_DROME (P00522), ABL_FSVHY (P10447), ABL_MLVAB (P00521), BCAR3_BOVIN (Q58DL5), BCAR3_HUMAN (O75815), BCAR3_MACFA (Q4R8R1), BCAR3_MOUSE (Q9QZK2), BCAR3_RAT (D3ZAZ5), BCAR3_XENLA (Q6INP9), BLK_HUMAN (P51451), BLK_MOUSE (P16277), BLNK_CHICK (Q9YGC1), BLNK_HUMAN (Q8WV28), BLNK_MOUSE (Q9QUN3), BLNK_RAT(Q4KM52), BMX_HUMAN (P51813), BMX_MOUSE (P97504), BTKL_DROME (P08630), BTK_CHICK (Q8JH64), BTK_HUMAN (Q06187), BTK_MOUSE (P35991), CED2_CAEBR (A8XI74), CED2_CAEEL (Q9NHC3), CHIN_HUMAN (P15882), CHIN_MOUSE (Q91V57), CHIO_HUMAN (P52757), CISH_BOVIN (Q2HJ53), CISH_CHICK (Q9PW70), CISH_HUMAN (Q9NSE2), CISH_MOUSE (Q62225), CISH_RAT(O70512), CLNK_HUMAN (Q7Z7G1), CLNK_MOUSE (Q9QZE2), CRKL_HUMAN (P46109), CRKL_MOUSE (P47941), CRKL_RAT(Q5U2U2), CRK_CHICK (Q04929), CRK_DROME (Q9XYM0), CRK_HUMAN (P46108), CRK_MOUSE (Q64010), CRK_RAT (Q63768), CRK_XENLA (P87378), CSK1_CAEEL (G5ECJ6), CSK_BOVIN (Q0VBZ0), CSK_CHICK (P41239), CSK_HUMAN (P41240), CSK_MOUSE (P41241), CSK_RAT (P32577), CSW_DROME (P29349), CSW_DROVI (Q24708), DAPP1_HUMAN (Q9UN19), DAPP1_MOUSE (Q9QXT1), DRK_DROSI (Q6YKA8), EGRAP_DROME (Q6NR09), FER_CANLF (Q9TTY2), FER_DROME (P18106), FER_HUMAN (P16591), FER_MOUSE (P70451), FER_RAT (P09760), FES_FELCA (P14238), FES_FSVGA (P00542), FES_FSVST (P00543), FES_HUMAN (P07332), FES_MOUSE (P16879), FGR_FSVGR (P00544), FGR_HUMAN (P09769), FGR_MOUSE (P14234), FGR_RAT (Q6P6U0), FPS_AVISP (P00541), FPS_FUJSV (P00530), FRK1_CAEEL (Q22146), FRK_HUMAN (P42685), FRK_MOUSE (Q922K9), FRK_RAT (Q62662), FYNA_DANRE (Q6EWH2), FYNB_DANRE (F1RDG9), FYN_BOVIN (A0JNB0), FYN_CHICK (Q05876), FYN_HUMAN (P06241), FYN_MOUSE (P39688), FYN_PIG (A1Y2K1), FYN_RAT (Q62844), FYN_XENLA (P13406), FYN_XIPHE (P27446), GAGC_AVISC (P05433), GRAP2_HUMAN (O75791), GRAP2_MOUSE (O89100), GRAPL_HUMAN (Q8TC17), GRAP_BOVIN (A6QLK6), GRAP_DROME (Q08012), GRAP_HUMAN (Q13588), GRAP_MOUSE (Q9CX99), GRB10_HUMAN (Q13322), GRB10_MOUSE (Q60760), GRB10_PIG (B5KFD7), GRB10_RAT (P0CE43), GRB14_BOVIN (Q5ICW4), GRB14_HUMAN (Q14449), GRB14_MOUSE (Q9JLM9), GRB14_RAT (O88900), GRB2A_XENLA (P87379), GRB2B_XENLA (Q6GPJ9), GRB2_CHICK (Q07883), GRB2_HUMAN (P62993), GRB2_MOUSE (Q60631), GRB2_PONAB (Q5R4J7), GRB2_RAT(P62994), GRB2_XENTR (Q66II3), GRB7_BOVIN (Q1RMW5), GRB7_HUMAN (Q14451), GRB7_MOUSE (Q03160), GRB7_RAT(Q9QZC5), HCK_HUMAN (P08631), HCK_MACFA (Q95M30), HCK_MOUSE (P08103), HCK_RAT (P50545), HSH2D_DANRE (Q56A36), HSH2D_HUMAN (Q96JZ2), HSH2D_MOUSE (Q6VYH9), HTK16_HYDVU (P53356), ITK_HUMAN (Q08881), ITK_MOUSE (Q03526), JAK1_HUMAN (P23458), JAK1_MOUSE (P52332), JAK2_CHICK (Q75R65), JAK2_HUMAN (O60674), JAK2_MOUSE (Q62120), JAK2_PIG(O19064), JAK2_PONAB (Q5RB23), JAK2_RAT(Q62689), KSYK_CHICK (F1N9Y5), KSYK_HUMAN (P43405), KSYK_MOUSE (P48025), KSYK_PIG(Q00655), KSYK_RAT(Q64725), LCK_AOTNA (Q5PXS1), LCK_CHICK (P42683), LCK_HUMAN (P06239), LCK_MOUSE (P06240), LCK_RAT (Q01621), LCK_SAISC (Q95KR7), LCP2_HUMAN (Q13094), LCP2_MOUSE (Q60787), LYN_HUMAN (P07948), LYN_MOUSE (P25911), LYN_RAT (Q07014), MATK_HUMAN (P42679), MATK_MOUSE (P41242), MATK_RAT(P41243), NCK1_HUMAN (P16333), NCK1_MOUSE (Q99M51), NCK2_HUMAN (O43639), NCK2_MOUSE (O55033), NCK_DROME (Q8IPW2), P55G_BOVIN (O46404), P55G_HUMAN (Q92569), P55G_MOUSE (Q64143), P55G_RAT(Q63789), P85AA_XENLA (Q8UUU2), P85A_BOVIN (P23727), P85A_HUMAN (P27986), P85A_MOUSE (P26450), P85A_PONAB (Q5R685), P85A_RAT(Q63787), P85B_BOVIN (P23726), P85B_HUMAN (O00459), P85B_MOUSE (O08908), P85B_RAT(Q63788), PLCG1_BOVIN (P08487), PLCG1_HUMAN (P19174), PLCG1_MOUSE (Q62077), PLCG1_RAT (P10686), PLCG2_HUMAN (P16885), PLCG2_MOUSE (Q8CIH5), PLCG2_RAT (P24135), PLCG_CAEEL (Q22070), PTK6_HUMAN (Q13882), PTK6_MOUSE (Q64434), PTN11_CHICK (Q90687), PTN11_HUMAN (Q06124), PTN11_MOUSE (P35235), PTN11_RAT (P41499), PTN6_HUMAN (P29350), PTN6_MOUSE (P29351), PTN6_RAT(P81718), PTP2_CAEEL (G5EC24), RASA1_BOVIN (P09851), RASA1_HUMAN (P20936), RASA1_RAT (P50904), RIN1_HUMAN (Q13671), RIN1_RAT(P97680), RIN2_HUMAN (Q8WYP3), RIN2_MOUSE (Q9D684), RIN3_HUMAN (Q8TB24), SEM5_CAEEL (P29355), SH21A_BOVIN (Q3ZBB1), SH21A_HUMAN (O60880), SH21A_MACMU (Q71S10), SH21A_MOUSE (O88890), SH21A_PIG (Q06AA1), SH21A_RAT (B2RZ59), SH21A_SAGOE (Q9BG88), SH21B_HUMAN (O14796), SH21B_MOUSE (O35324), SH21C_MOUSE (Q45HK4), SH22A_HUMAN (Q9NP31), SH22A_MOUSE (Q9QXK9), SH23A_HUMAN (Q9BRG2), SH24A_HUMAN (Q9H788), SH24A_MOUSE (Q9D7V1), SH24A_RAT (Q6AYC8), SH24A_XENTR (Q08CX2), SH24B_HUMAN (Q5SQS7), SH24B_MOUSE (A6X942), SH2B1_HUMAN (Q9NRF2), SH2B1_MOUSE (Q91ZM2), SH2B1_RAT (Q62985), SH2B2_HUMAN (O14492), SH2B2_MOUSE (Q9JID9), SH2B2_RAT (Q9Z200), SH2B3_HUMAN (Q9UQQ2), SH2B3_MOUSE (O09039), SH2B3_RAT (P50745), SH2D3_HUMAN (Q8N5H7), SH2D3_MOUSE (Q9QZS8), SH2D5_HUMAN (Q6ZV89), SH2D5_MOUSE (Q8JZW5), SH2D5_PONAB (Q5R732), SH2D6_HUMAN (Q7Z4S9), SH2D6_MOUSE (Q9D413), SH2D7_HUMAN (A6NKC9), SH2D7_MOUSE (Q8BI17), SHARK_DROME (Q24145), SHA_ARATH (B5X561), SHB_ARATH (Q56XZ1), SHB_HUMAN (Q15464), SHB_MOUSE (Q6PD21), SHC1_BOVIN (Q0IIE2), SHC1_HUMAN (P29353), SHC1_MOUSE (P98083), SHC1_PONAB (Q5R7W7), SHC1_RAT(Q5M824), SHC1_XENLA (Q8AY68), SHC2_HUMAN (P98077), SHC2_MOUSE (Q8BMC3), SHC2_RAT(O70142), SHC3_HUMAN (Q92529), SHC3_MOUSE (Q61120), SHC3_RAT(O70143), SHC4_HUMAN (Q6S5L8), SHC4_MOUSE (Q6S5L9), SHCH1_CAEEL (Q9TYT3), SHD_HUMAN (Q96IW2), SHD_MOUSE (O88834), SHE_HUMAN (Q5VZ18), SHE_MOUSE (Q8BSD5), SHF_HUMAN (Q7M4L6), SHF_MOUSE (Q8CG80), SHIP1_HUMAN (Q92835), SHIP1_MOUSE (Q9ES52), SHIP1_RAT (P97573), SHIP1_XENLA (Q6P4S2), SHIP2_CANLF (A0A8I3NFE2), SHIP2_HUMAN (O15357), SHIP2_MOUSE (Q6P549), SHIP2_PIG (D7PF45), SHIP2_RAT (Q9WVR3), SHKA_DICDI (Q54RB7), SHKB_DICDI (Q54IP4), SHKC_DICDI (Q54Y55), SHKD_DICDI (Q54U31), SHKE_DICDI (Q54G43), SHP2A_DANRE (Q2I6J1), SHP2B_DANRE (Q2I6J0), SLAP1_HUMAN (Q13239), SLAP1_MOUSE (Q60898), SLAP1_RAT (P59622), SLAP2_HUMAN (Q9H6Q3), SLAP2_MOUSE (Q8R4L0), SOCS1_HUMAN (O15524), SOCS1_MOUSE (O35716), SOCS1_RAT (Q9QX78), SOCS2_BOVIN (Q861R0), SOCS2_HUMAN (O14508), SOCS2_MOUSE (O35717), SOCS2_PIG (Q7YRV6), SOCS2_RAT (O88582), SOCS3_BOVIN (Q9BEG9), SOCS3_CANLF (Q68AM8), SOCS3_CHICK (Q90X67), SOCS3_HUMAN (O14543), SOCS3_MOUSE (O35718), SOCS3_RAT (O88583), SOCS4_BOVIN (Q0VC91), SOCS4_HUMAN (Q8WXH5), SOCS4_MOUSE (Q91ZA6), SOCS4_PONAB (Q5RDX2), SOCS5_BOVIN (Q29RN6), SOCS5_HUMAN (O75159), SOCS5_MOUSE (O54928), SOCS6_HUMAN (O14544), SOCS6_MOUSE (Q9JLY0), SOCS6_PONAB (Q5RCM6), SOCS7_HUMAN (O14512), SOCS7_MOUSE (Q8VHQ2), SOEM_CAEEL (Q7YWN4), SPE8_CAEBR (A8WZ92), SPE8_CAEEL (O01798), SPK1_GIRTI (P42687), SPRI_DROME (Q8MQW8), SPT6H_DANRE (Q8UVK2), SPT6H_HUMAN (Q7KZ85), SPT6H_MOUSE (Q62383), SPT6_ASPFU (Q4WWH6), SPT6_CANAL (Q3MNT0), SPT6_CANGA (Q6FLB1), SPT6_DEBHA (Q6BVE1), SPT6_EREGS (Q75EP8), SPT6_KLULA (Q6CVK3), SPT6_YEAST (P23615), SRC1_CAEEL (G5EE56), SRC1_XENLA (P13115), SRC2_CAEEL (O45539), SRC2_XENLA (P13116), SRC42_DROME (Q9V9J3), SRC64_DROME (P00528), SRC_AVIS2 (P15054), SRC_AVISR (P00525), SRC_AVISS (P14084), SRC_AVIST (P14085), SRC_CHICK (P00523), SRC_DANRE (Q1JPZ3), SRC_HUMAN (P12931), SRC_MOUSE (P05480), SRC_RAT (Q9WUD9), SRC_RSVH1 (P25020), SRC_RSVP(P00526), SRC_RSVPA (P31693), SRC_RSVSA (P00524), SRC_RSVSE (P63185), SRK1_SPOLA (P42686), SRK2_SPOLA (P42688), SRK3_SPOLA (P42689), SRK4_SPOLA (P42690), SRMS_HUMAN (Q9H3Y6), SRMS_MOUSE (Q62270), STA31_XENLA (Q9PVX8), STA32_XENLA (Q7ZXK3), STA5A_BOVIN (Q95115), STA5A_HUMAN (P42229), STA5A_MOUSE (P42230), STA5A_PIG (Q9TUZ1), STA5A_RAT (Q62771), STA5A_SHEEP (P42231), STA5B_BOVIN (Q9TUM3), STA5B_HUMAN (P51692), STA5B_MOUSE (P42232), STA5B_PIG (Q9TUZ0), STA5B_RAT (P52632), STAP1_HUMAN (Q9ULZ2), STAP1_MOUSE (Q9JM90), STAP2_HUMAN (Q9UGK3), STAP2_MOUSE (Q8R0L1), STAT1_HUMAN (P42224), STAT1_MOUSE (P42225), STAT1_PIG (Q764M5), STAT2_HUMAN (P52630), STAT2_MOUSE (Q9WVL2), STAT2_PIG (O02799), STAT3_BOVIN (P61635), STAT3_CHICK (Q6DV79), STAT3_HUMAN (P40763), STAT3_MOUSE (P42227), STAT3_PIG (Q19S50), STAT3_RAT (P52631), STAT4_HUMAN (Q14765), STAT4_MOUSE (P42228), STAT6_HUMAN (P42226), STAT6_MOUSE (P52633), STATA_DICDI (O00910), STATB_CAEEL (Q20977), STATB_DICDI (Q70GP4), STATC_DICDI (Q54BD4), STAT_ANOGA (Q7QDU4), STAT_DROME (Q24151), STK_HYDVU (P17713), TEC_HUMAN (P42680), TEC_MOUSE (P24604), TENS1_BOVIN (Q9GLM4), TENS1_CHICK (Q04205), TENS1_HUMAN (Q9HBL0), TENS1_MOUSE (E9Q0S6), TENS2_HUMAN (Q63HR2), TENS2_MOUSE (Q8CGB6), TENS3_HUMAN (Q68CZ2), TENS3_MOUSE (Q5SSZ5), TENS4_BOVIN (Q32PJ7), TENS4_HUMAN (Q8IZW8), TENS4_MOUSE (Q8BZ33), TENS4_RAT (Q4V8I3), TENSH_CAEEL (H2L045), TXK_HUMAN (P42681), TXK_MOUSE (P42682), VAV2_HUMAN (P52735), VAV2_MOUSE (Q60992), VAV3_HUMAN (Q9UKW4), VAV3_MOUSE (Q9R0C8), VAV_BOVIN (Q08DN7), VAV_CAEEL (Q45FX5), VAV_DROME (Q9NHV9), VAV_HUMAN (P15498), VAV_MOUSE (P27870), VAV_RAT (P54100), YES_AVISY (P00527), YES_CANLF (Q28923), YES_CHICK (P09324), YES_DANRE (A1A5H8), YES_HUMAN (P07947), YES_MOUSE (Q04736), YES_RAT (F1LM93), YES_XENLA (P10936), YES_XIPHE (P27447), YRK_CHICK (Q02977), ZAP70_HUMAN (P43403), ZAP70_MOUSE (P43404)» more
|
| UniProtKB/Swiss-Prot False negative sequences |
23 sequences
JAK1_CYPCA (Q09178), JAK1_DANRE (O12990), JAK3_HUMAN (P52333), JAK3_MOUSE (Q62137), JAK3_RAT(Q63272), JAK_DROME (Q24592), RIN1_MOUSE (Q921Q7), RIN3_MOUSE (P59729), SPT6H_CAEBR (Q93148), SPT6H_CAEEL (P34703), SPT6H_DROME (Q9W420), SPT6_ASPOR (Q2U561), SPT6_CRYNB (P0CR73), SPT6_CRYNJ (P0CR72), SPT6_EMENI (Q5B7Q7), SPT6_GIBZE (Q4HYQ4), SPT6_MYCMD (Q4PI89), SPT6_NEUCR (Q8NIV6), SPT6_SCHPO (Q09915), STAT1_CAEBR (Q61AP6), STAT1_CAEEL (Q9NAD6), TYK2_HUMAN (P29597), TYK2_MOUSE (Q9R117)» more |
| PDB [Detailed view] |
618 PDB
1A07; 1A08; 1A09; 1A1A; 1A1B; 1A1C; 1A1E; 1A81; 1AB2; 1AD5; 1AOT; 1AOU; 1AYA; 1AYB; 1AYC; 1AYD; 1BF5; 1BFI; 1BFJ; 1BG1; 1BHF; 1BHH; 1BKL; 1BKM; 1BLJ; 1BLK; 1BM2; 1BMB; 1CJ1; 1CSY; 1CSZ; 1CWD; 1CWE; 1D1Z; 1D4T; 1D4W; 1F1W; 1F2F; 1FBZ; 1FHS; 1FMK; 1FU5; 1FU6; 1FYR; 1G83; 1GHU; 1GRI; 1H9O; 1HCS; 1HCT; 1I3Z; 1IJR; 1IS0; 1JU5; 1JWO; 1JYQ; 1JYR; 1JYU; 1K9A; 1KA6; 1KA7; 1KC2; 1KSW; 1LCJ; 1LCK; 1LKK; 1LKL; 1LUI; 1LUK; 1LUM; 1LUN; 1M27; 1M61; 1MIL; 1MW4; 1NRV; 1NZL; 1NZV; 1O41; 1O42; 1O43; 1O44; 1O45; 1O46; 1O47; 1O48; 1O49; 1O4A; 1O4B; 1O4C; 1O4D; 1O4E; 1O4F; 1O4G; 1O4H; 1O4I; 1O4J; 1O4K; 1O4L; 1O4M; 1O4N; 1O4O; 1O4P; 1O4Q; 1O4R; 1OO3; 1OO4; 1OPK; 1OPL; 1P13; 1PIC; 1QAD; 1QCF; 1QG1; 1R1P; 1R1Q; 1R1S; 1RJA; 1RPY; 1RQQ; 1SHA; 1SHB; 1SHD; 1SKJ; 1SPR; 1SPS; 1TCE; 1TZE; 1UUR; 1UUS; 1WQU; 1X0N; 1X27; 1X6C; 1XA6; 1Y1U; 1Y57; 1YVL; 1Z3K; 1ZFP; 2ABL; 2AOA; 2AOB; 2AUG; 2B3O; 2BBU; 2C0I; 2C0O; 2C0T; 2C9W; 2CI8; 2CI9; 2CIA; 2CR4; 2CRH; 2CS0; 2DCR; 2DLY; 2DLZ; 2DM0; 2DVJ; 2DX0; 2ECD; 2EKX; 2EL8; 2EO3; 2EO6; 2EOB; 2ETZ; 2EU0; 2EYV; 2EYY; 2EYZ; 2FCI; 2FO0; 2GE9; 2GSB; 2H46; 2H5K; 2H8H; 2HCK; 2HDV; 2HDX; 2HMH; 2HUW; 2IUG; 2IUH; 2IUI; 2IZV; 2JYQ; 2K79; 2K7A; 2KK6; 2KNO; 2L3T; 2L4K; 2L6K; 2LCT; 2LNW; 2LNX; 2LQN; 2LQW; 2MC1; 2MK2; 2MQI; 2MRJ; 2MRK; 2OQ1; 2OZO; 2PLD; 2PLE; 2PNA; 2PNB; 2PTK; 2QMS; 2RD0; 2RMX; 2ROR; 2RSY; 2SHP; 2SRC; 2VIF; 2Y3A; 2YSX; 2YU7; 3BKB; 3C7I; 3CBL; 3CD3; 3CWG; 3CXL; 3EAC; 3EAZ; 3GQI; 3GXW; 3GXX; 3HCK; 3HHM; 3HIZ; 3IMD; 3IMJ; 3IN7; 3IN8; 3K2M; 3KFJ; 3M7F; 3MAZ; 3MXC; 3MXY; 3N7Y; 3N84; 3N8M; 3NHN; 3OV1; 3OVE; 3PJP; 3PQZ; 3PS5; 3PSI; 3PSJ; 3PSK; 3QWX; 3QWY; 3S8L; 3S8N; 3S8O; 3S9K; 3T04; 3TKZ; 3TL0; 3UF4; 3US4; 3UYO; 3VRO; 3VRY; 3VRZ; 3VS0; 3VS1; 3VS2; 3VS3; 3VS4; 3VS5; 3VS6; 3VS7; 3WA4; 4A55; 4D8K; 4DGP; 4DGX; 4E68; 4E93; 4EIH; 4EY0; 4F59; 4F5A; 4F5B; 4FBN; 4FL2; 4FL3; 4GL9; 4GWF; 4H1O; 4H34; 4JE4; 4JEG; 4JGH; 4JMG; 4JMH; 4JPS; 4K11; 4K2R; 4K44; 4K45; 4L1B; 4L23; 4L2Y; 4LUD; 4LUE; 4M4Z; 4NWF; 4NWG; 4OHD; 4OHE; 4OHH; 4OHI; 4OHL; 4OVU; 4OVV; 4P9V; 4P9Z; 4QSY; 4ROJ; 4TZI; 4U17; 4U1P; 4U5W; 4WAF; 4WWQ; 4X6S; 4XEY; 4XI2; 4XZ0; 4XZ1; 4Y5U; 4Y5W; 4YKN; 4Z32; 4ZOP; 5AUL; 5BK8; 5BO4; 5CDW; 5D0J; 5D39; 5DC0; 5DC4; 5DC9; 5DF6; 5EEL; 5EEQ; 5EG3; 5EHP; 5EHR; 5FI4; 5GJH; 5GJI; 5H09; 5H0B; 5H0E; 5H0G; 5H0H; 5I6V; 5IBM; 5IBS; 5ITD; 5IXD; 5IXI; 5JN0; 5KAZ; 5L04; 5M6U; 5MO4; 5MTJ; 5MTM; 5MTN; 5SW8; 5SWG; 5SWO; 5SWP; 5SWR; 5SWT; 5SX8; 5SX9; 5SXA; 5SXB; 5SXC; 5SXD; 5SXE; 5SXF; 5SXI; 5SXJ; 5SXK; 5TNW; 5TO4; 5TQ1; 5TQS; 5TYI; 5U06; 5U1Q; 5UK8; 5UKJ; 5UL1; 5VKL; 5VKO; 5W3R; 5X7B; 5X94; 5XGH; 5XGI; 5XGJ; 5XZR; 6AMV; 6AMW; 6ATD; 6BMR; 6BMU; 6BMV; 6BMW; 6BMX; 6BMY; 6BN5; 6C7Y; 6CMP; 6CMQ; 6CMR; 6CMS; 6CRF; 6CRG; 6E2P; 6E2Q; 6F3F; 6GME; 6GMH; 6HTF; 6I4X; 6I5J; 6I5N; 6ICG; 6ICH; 6JMF; 6KC4; 6MBW; 6MBZ; 6MD7; 6MD9; 6MDA; 6MDB; 6MDC; 6MDD; 6NCT; 6NJS; 6NUQ; 6PBC; 6PXB; 6PXC; 6QHD; 6QTC; 6R5G; 6SM5; 6TED; 6TLC; 6UX2; 6VK2; 6WAX; 6WAY; 6WCZ; 6WM1; 6WO2; 6WU8; 7CIO; 7EMN; 7JVM; 7JVN; 7M6T; 7MP3; 7MPH; 7MYN; 7MYO; 7NUF; 7NXE; 7O3D; 7O6B; 7OOP; 7OPC; 7OPD; 7PG5; 7PG6; 7Q5T; 7Q5U; 7Q5W; 7Q63; 7R75; 7R7D; 7R7I; 7R7L; 7R8W; 7R8X; 7RCT; 7RNS; 7RNU; 7RNV; 7SA7; 7T1K; 7T1L; 7T1U; 7T6F; 7T8T; 7TVA; 7TVB; 7TZ7; 7UBT; 7UC6; 7UC7; 7UNC; 7UND; 7UY0; 7UY3; 7VXG; 7WFY; 7XHQ; 7YQE; 7Z3J; 7ZLM; 7ZLN; 7ZLO; 7ZLP; 7ZLR; 7ZLS; 8AM0; 8ATK; 8B5Y; 8CBH; 8CZ9; 8D3F; 8DCP; 8DCX; 8DD4; 8DD8; 8DGO; 8DGQ; 8EWY; 8GMB; 8GUB; 8GWW; 8H36; 8H37; 8ILR; 8ILS; 8ILV; 8JN8; 8JN9; 8JQG; 8JQH; 8JQI; 8OEU; 8OEV; 8OF0; 8RZW; 8RZY; 8S01; 8S04; 8S06; 8S07; 8S0H; 8S0I; 8S0J; 8S0K; 8S0O; 8S0P; 8S0Q; 8S0S; 8SBC; 8SBJ; 8SSN; 8T12; 8T13; 8T6D; 8T6G; 8T7C; 8T7Q; 8T8Q; 8TDU; 8TGD; 8TS7; 8TS8; 8TS9; 8TSA; 8TSB; 8TSC; 8TSD; 8TU6; 8U7W; 8U7X; 8V8H; 8V8I; 8V8J; 8V8U; 8V8V; 8W9A; 8W9B; 8WFY; 8WX7; 8X2P; 8XN8; 9BIG; 9BLG; 9BT8; 9BYJ » more |