PROSITE entry PS50001

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General information about the entry

Entry name [info]	SH2
Accession [info]	PS50001
Entry type [info]	MATRIX
Date [info]	01-NOV-1995 CREATED; 01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50001
Associated ProRule [info]	PRU00191

Name and characterization of the entry

Description [info]

Src homology 2 (SH2) domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=92;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=87;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.3941; R2=0.01483; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=547; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=412; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='W';  M=-16,-34,-40,-35,-25,  9,-21,-24,-17,-19,-16,-17,-34,-25,-18,-19,-33,-25,-25,111, 26,-18;
/M: SY='Y';  M=-17,-24,-26,-29,-24, 41,-30, -2,  7,-20,  6,  2,-19,-28,-22,-16,-19,-10, -1, 14, 48,-24;
/M: SY='H';  M=-14,-14,-23,-18,-14,  7,-23, 31, -9,-15, -3,  4, -8,-24, -9,-10,-15,-14,-11, -8, 18,-12;
/M: SY='G';  M= -3, -9,-30, -8,-14,-26, 45,-17,-36, -9,-28,-18, -1,-14,-14, -8, -3,-17,-27,-20,-24,-14;
/M: SY='K';  M= -8, -1,-25, -2,  0,-10,-16, -5,-19,  6,-18,-11,  1, -7, -3,  1, -4, -6,-16,-21, -6, -2;
/M: SY='I';  M= -8,-28,-24,-35,-27,  4,-34,-25, 36,-26, 23, 21,-23,-23,-20,-24,-19, -8, 26,-21, -1,-26;
/I:         I=-4; MI=0; IM=0;
/M: SY='S';  M=  1,  3,-18,  1,  0,-21, -4, -9,-20, -6,-25,-17, 10, -3,  0, -8, 20, 14,-16,-34,-19,  0;
/M: SY='R';  M=-16, -9,-30, -9, -1,-23, -8, -5,-31, 26,-23,-11,  0,-18,  6, 51, -9,-11,-21,-18,-12, -1;
/M: SY='E';  M= -2,  2,-25,  1, 12,-25,-12, -3,-21,  6,-20,-12,  2,-11, 10,  3,  2, -4,-18,-23,-14, 11;
/M: SY='E';  M=-10, 10,-29, 16, 26,-30,-15,  0,-26, 10,-21,-14,  3, -9, 19,  5, -2, -9,-25,-26,-13, 22;
/M: SY='A';  M= 36,-11,-11,-17, -7,-18, -6,-20, -6,-10, -9, -8,-11,-12,-10,-18,  8,  1,  4,-23,-18, -9;
/M: SY='E';  M=-10,  4,-28,  9, 36,-22,-20,  2,-23,  5,-16,-14, -1, -7, 12,  2, -2, -8,-22,-26,-12, 23;
/M: SY='R';  M= -6,  4,-25,  5, 10,-24,-14, -1,-23, 10,-19,-11,  3,-13,  9, 11,  0, -5,-19,-25,-11,  8;
/M: SY='L';  M=-10,-23,-23,-25,-15,  1,-27,-12, 13,-19, 28, 17,-22,-25, -8,-12,-22, -9,  4,-18,  2,-12;
/M: SY='L';  M=-10,-30,-20,-30,-20, 10,-30,-20, 20,-30, 49, 20,-30,-30,-20,-20,-30,-10, 11,-20,  0,-20;
/M: SY='R';  M= -8, -9,-23,-12, -6,-13,-19, -9, -6,  1, -1,  4, -6,-18,  1,  5, -8, -4, -6,-23, -7, -4;
/M: SY='N';  M= -4,  9,-22,  7,  5,-23, -9, -2,-21,  0,-21,-13, 11,-10,  5, -2,  5, -1,-19,-30,-15,  4;
/M: SY='K';  M= -8, -5,-27, -4,  3,-22,-12, -9,-19,  7,-20,-11, -2, -1,  2,  5, -3, -5,-16,-24,-13,  1;
/I:         I=-4; MI=-19; MD=-19; IM=-19;
/M: SY='G';  M= -4, -6,-21, -5, -1,-21, 10,-11,-22, -9,-20,-12, -4,  2, -6,-10, -1, -9,-19,-23,-19, -4; D=-4;
/I:         I=-4; MI=-19; MD=-19; IM=-19; DM=-19;
/M: SY='B';  M=-11, 10,-24, 10,  4,-20,-14, -1,-18,  5,-18,-10,  9, -4,  1,  3, -3, -6,-17,-26,-12,  1; D=-4;
/I:         I=-4; MI=-19; MD=-19; IM=-19; DM=-19;
/M: SY='E';  M= -4,  3,-14,  6,  9,-14, -8, -2,-12,  0,-12, -8,  1,  4,  4, -2,  1, -2,-12,-16, -9,  6; D=-4;
/I:         I=-4; MI=0; IM=0; DM=-19;
/M: SY='G';  M= -1,-11,-27,-11,-20,-29, 66,-20,-39,-20,-30,-20, -1,-21,-20,-20, -1,-20,-30,-17,-29,-20;
/M: SY='T';  M=  5,  3,-13,  0, -3,-18,-10,-13,-16, -9,-14,-13,  1,-12, -6,-12, 14, 18, -8,-31,-15, -5;
/M: SY='F';  M=-20,-29,-21,-38,-29, 74,-30,-15,  0,-28,  9,  0,-20,-30,-37,-19,-20,-10, -1, 12, 36,-29;
/M: SY='L';  M= -9,-30,-20,-31,-22,  8,-30,-21, 23,-28, 43, 21,-29,-29,-20,-20,-27, -9, 15,-21, -1,-21;
/M: SY='V';  M= -3,-29,-17,-32,-28,  1,-32,-28, 32,-24, 19, 14,-26,-26,-25,-23,-15, -4, 36,-25, -6,-28;
/M: SY='R';  M=-20,-10,-30,-10,  0,-20,-20,  0,-30, 30,-20,-10,  0,-20, 10, 70,-10,-10,-20,-20,-10,  0;
/M: SY='E';  M=-12,  4,-29, 10, 23,-15,-20, -6,-22,  1,-15,-14, -3, -2,  6, -5, -6,-10,-22,-23,-11, 15;
/M: SY='S';  M=  8, -1,-10, -2, -1,-20, -2,-10,-20, -7,-28,-19,  8,-11,  0, -4, 34, 17,-10,-37,-19, -1;
/M: SY='E';  M= -8,  9,-25, 15, 23,-26,-16, -1,-24,  4,-20,-16,  4, -9, 10,  2,  4, -3,-20,-31,-16, 16;
/M: SY='S';  M= -2,  1,-18, -2, -1,-21, -6, -6,-22,  1,-24,-15,  8,-10,  1,  2, 16, 13,-15,-31,-15, -1;
/I:         I=-5; MI=-27; MD=-27; IM=-27;
/M: SY='S';  M= -4,  0,-22, -2,  3,-15,-12, -2,-19,  1,-18,-11,  3, -8,  1, -2,  4,  3,-16,-25, -8,  1; D=-5;
/I:         I=-5; MI=-27; MD=-27; IM=-27; DM=-27;
/M: SY='P';  M= -6,-11,-22,-10, -3,-14,-16,-12, -5,  0, -9, -4,-10, 19, -4, -3, -8, -5, -8,-17,-11, -6; D=-5;
/I:         I=-5; MI=0; IM=0; DM=-27;
/M: SY='G';  M= -1, -2,-29, -3,-12,-30, 50,-15,-36,-15,-29,-19,  5,-15,-13,-16,  1,-16,-29,-23,-27,-13;
/M: SY='D';  M=  0, 10,-20, 15,  8,-28,  4, -9,-28, -6,-22,-19,  5,-12, -1,-11,  6, -5,-21,-31,-21,  4;
/M: SY='Y';  M=-17,-22,-26,-26,-20, 33,-30,  3,  4,-17,  3,  2,-18,-27,-18,-13,-17, -9, -2, 11, 46,-21;
/M: SY='T';  M=  9, -8, -9,-13,-10,-14,-12,-18, -7,-12,-12, -9, -5,-11,-10,-14, 15, 21,  3,-31,-15,-10;
/M: SY='L';  M=-10,-29,-18,-32,-24, 10,-32,-23, 24,-27, 33, 16,-26,-28,-22,-20,-24, -9, 16,-20,  0,-24;
/M: SY='S';  M= 10, -4, -7, -7, -6,-17, -5,-13,-15,-12,-22,-15,  3,-13, -5,-13, 28, 18, -6,-34,-16, -6;
/M: SY='V';  M= -8,-29,-20,-31,-26, 11,-27,-22, 16,-22, 11,  7,-26,-28,-25,-19,-18, -6, 21,  0,  4,-25;
/M: SY='R';  M=-11,-16,-25,-17,-10, -7,-22,-10,-10,  7, -7, -3,-11,-21, -5, 18,-11, -8, -5,-10, -2, -9;
/M:         M= -8, -1,-20,  0, -4, -7,-19, -7,-14, -6,-11, -9, -5,-18, -8, -6, -5, -2, -9,-15,  0, -6;
/M: SY='D';  M=-10,  5,-25,  7,  3,-19, -6, -7,-25,  0,-20,-15,  3,-15,  0, -1, -3, -9,-22,-16,-11,  1;
/M: SY='G';  M= -4,  7,-25, 11, -3,-25, 13,-11,-27, -9,-23,-18,  4,-16, -8,-10,  3, -7,-18,-25,-19, -5;
/I:         I=-2; MI=0; IM=0;
/M: SY='Q';  M= -8,  2,-23,  1,  4,-22,-13,  0,-17,  4,-16, -9,  4,-15,  5,  4, -2, -6,-15,-28,-12,  4;
/M: SY='V';  M= -4,-19,-17,-21,-21, -3,-23,-20, 14,-16,  0,  2,-16,-19,-21,-14, -8, -3, 23,-27, -9,-22;
/M: SY='K';  M=-10, -2,-28, -4,  3,-23,-11, -4,-23, 20,-21, -8,  1,-14,  9, 18, -5, -6,-19,-21, -9,  5;
/M: SY='H';  M=-18, -2,-29, -2,  2,-18,-20, 78,-26, -8,-16, -1,  6,-19,  8,  1, -9,-17,-26,-29, 14,  1;
/M: SY='Y';  M=-15,-24,-14,-29,-24, 26,-30, -9,  3,-20,  2, -1,-21,-23,-22,-18,-18, -8, -1,  8, 31,-24;
/M: SY='R';  M=-13, -4,-27, -5,  0,-21,-21, -2,-16, 16,-15, -4, -1,-17,  7, 22, -9, -8,-11,-24, -8,  1;
/M: SY='I';  M= -9,-30,-25,-37,-29,  4,-37,-29, 41,-27, 19, 17,-22,-23,-22,-26,-19, -8, 30,-20,  0,-29;
/M: SY='Q';  M=-12, -3,-21, -5,  4,-19,-20,  3,-16,  8,-13, -2,  1,-17, 12, 12, -8, -9,-17,-23, -7,  7;
/M: SY='K';  M= -4, -1,-19, -3,  3,-20,-15, -3,-21,  5,-21,-12,  2, -6,  2,  5,  4,  2,-16,-26,-12,  1;
/M: SY='T';  M= -6, -7,-19, -8, -6, -7,-21,-13, -3,-11,  1, -2, -7,-17, -9, -8, -4,  4, -1,-26, -8, -8;
/M: SY='D';  M= -5, 11,-24, 17, 14,-29, -3, -7,-27, -3,-21,-17,  3, -4,  3, -9,  1, -6,-23,-29,-19,  8;
/I:         I=-2; MI=-12; MD=-12; IM=-12;
/M: SY='N';  M= -6, 13,-20, 10,  3,-22,  0, -4,-22,  0,-21,-15, 16,-12,  1, -1,  7,  3,-19,-28,-16,  2; D=-2;
/I:         I=-2; MI=-12; MD=-12; IM=-12; DM=-12;
/M: SY='G';  M= -1, -2,-14, -3, -4,-16, 22, -8,-20, -6,-16,-11,  2,-10, -6, -5,  2, -7,-15,-14,-15, -5; D=-2;
/I:         I=-2; MI=0; IM=0; DM=-12;
/M: SY='K';  M= -8, -6,-27, -5, -2,-20, -6, -7,-20,  4,-17, -9, -4, -6, -2,  0, -6, -7,-16,-24,-12, -3;
/M: SY='Y';  M=-17,-24,-26,-26,-23, 35,-27,  2,  2,-18,  7,  2,-21,-30,-19,-14,-20,-10, -4, 18, 51,-23;
/M: SY='Y';  M= -9,-10,-17,-13,-13,  6,-18, -4, -9, -9, -8, -5, -7,-22,-10, -4, -3,  0, -7,-10, 15,-13;
/M: SY='I';  M= -7,-25,-22,-29,-20,  2,-31,-23, 23,-19, 17, 12,-21,-20,-19,-19,-17, -7, 19,-21, -3,-21;
/M: SY='S';  M= -2,  1,-23, -1, -1,-20,  0,-11,-23, -3,-22,-16,  3, -9, -3, -5,  6,  4,-18,-20,-13, -3;
/M: SY='E';  M= -6,  4,-26,  6,  9,-25,  3, -7,-25, -4,-22,-16,  5, -8,  1, -5,  3, -4,-21,-27,-18,  4;
/I:         I=-6; MI=-29; MD=-29; IM=-29;
/M: SY='R';  M= -5, -2,-16, -3,  0,-13, -1, -5,-14,  6,-11, -7,  2, -7,  0, 10, -3, -5,-12,-14, -9, -1; D=-6;
/I:         I=-6; MI=0; IM=0; DM=-29;
/M:         M= -6, -6,-23, -5, -1,-15,-19, -1, -9, -4, -5, -3, -6,-13, -2, -1, -6, -5, -7,-26, -8, -2;
/M: SY='R';  M= -4, -4,-18, -8, -4,-16,-12, -9,-17,  3,-16,-10,  0,-13,  0,  4,  2,  3,-12,-24, -9, -3;
/M: SY='F';  M=-15,-26,-19,-34,-26, 59,-28,-14,  0,-26,  8,  0,-17,-28,-32,-19,-18, -9, -1,  5, 27,-26;
/M: SY='N';  M= -4,  6,-19,  5,  1,-24, -1, -7,-23, -5,-22,-15,  9, -6, -3, -5,  3, -5,-20,-31,-20, -1;
/M: SY='S';  M=  3,  5, -9,  2, -3,-19, -5,-12,-19, -9,-24,-18,  9,-12, -5,-10, 25, 20,-11,-36,-18, -4;
/M: SY='L';  M=-10,-30,-22,-33,-23, 11,-32,-23, 26,-28, 35, 18,-26,-25,-21,-22,-25, -9, 16,-19,  1,-23;
/M: SY='P';  M= -1, -5,-24, -7, -3,-20,-10, -7,-14, -6,-16, -8, -3,  2,  2, -9,  0, -2,-14,-22,-12, -2;
/M: SY='E';  M=-10, 13,-28, 21, 30,-28,-18,  1,-25,  3,-17,-15,  2, -8, 15, -4, -2, -8,-24,-27,-12, 22;
/M: SY='L';  M=-10,-29,-22,-31,-21,  8,-31,-20, 23,-27, 41, 22,-27,-28,-18,-18,-27,-10, 12,-20,  0,-20;
/M: SY='I';  M= -5,-30,-17,-35,-29,  0,-35,-29, 38,-25, 16, 15,-25,-25,-25,-25,-16, -5, 37,-25, -5,-29;
/M: SY='E';  M= -8,  3,-25,  5, 11,-20,-15,  4,-19,  2,-16, -8,  2,-13,  9,  2, -1, -5,-18,-23, -6,  9;
/M: SY='H';  M=-17, -5,-28, -5, -6, -2,-20, 49,-17,-10,-12, -3, -1,-22, -1, -6,-11,-14,-19,-11, 30, -7;
/M: SY='Y';  M=-19,-16,-29,-17,-15, 19,-28, 32, -6,-12, -1,  1,-14,-27, -7, -9,-18,-12,-13, 11, 56,-15;
/M: SY='Q';  M= -6, -6,-23, -6,  4,-20,-17, -6,-17,  8,-15, -5, -3, -9, 10,  9,  2,  1,-14,-24,-10,  6;
/M: SY='Q';  M=-11,  0,-26,  1,  7,-23,-20,  9,-18, 10,-18, -6,  1,-14, 12,  6, -4, -6,-15,-24, -4,  8;
/M: SY='N';  M= -5,  6,-21,  1,  1,-18,-12,  4,-14, -3,-15, -6, 11,-15,  1, -2,  3,  0,-13,-31,-12,  0;
/M: SY='S';  M=  6, -5,-22, -5,  0,-24, -5, -6,-20, -2,-21,-11, -2,  1,  2, -6,  7, -2,-16,-27,-17,  0;
/M:         M= -2, -2,-20, -1, -6,-16,-12,-14, -6,-11, -1, -3, -7,-18, -8,-13, -8, -7, -4,-26,-13, -8;
/M: SY='G';  M= -2, -9,-26, -7, -6,-20, 12,-15,-21, -9,-17,-12, -7, -8,-10,-10, -3, -9,-15,-22,-17, -9;
/M: SY='L';  M=-11,-12,-19,-13, -5, -7,-25,-11,  3,-13, 15,  4,-10,-22, -6, -7,-16, -8, -3,-25, -7, -6;
/I:         I=-4; MI=-19; MD=-19; IM=-19;
/M: SY='C';  M= -4,-14, 11,-20,-17,-11,-22,-17, -3,-15, -4, -3,-12,-21,-15,-16, -6,  0,  3,-29,-11,-17; D=-4;
/I:         I=-4; MI=-19; MD=-19; IM=-19; DM=-19;
/M:         M= -9, -4, -6, -7, -3,-10,-17, -1,-16, -6,-15, -8, -1,-13, -4, -5, -1, -1,-13,-25, -6, -4; D=-4;
/I:         I=-4; MI=0; IM=0; DM=-19;
/M: SY='R';  M=-11, -9,-24,-10, -2,-14,-22, -7,-14, 14,-13, -5, -6,-15,  0, 17, -9, -5, -9,-20, -4, -3;
/M: SY='L';  M=-11,-29,-21,-29,-20, 11,-30,-16, 19,-27, 43, 19,-28,-29,-18,-19,-28,-10,  9,-15,  8,-20;
/M: SY='R';  M= -7,-11,-22,-13, -7,-11,-20, -9, -8,  2, -4, -2, -8,-18, -3,  8, -5,  2, -4,-22, -4, -6;
/M: SY='Y';  M=-12, -4,-25, -5, -4, -4,-20,  5,-12, -1,-12, -7, -4,-19, -1,  1, -5, -3,-12,-10, 16, -4;
/M: SY='P';  M= -5,-18,-34,-12, -3,-26,-19,-18,-15,-11,-24,-15,-17, 65,-10,-19, -6, -6,-21,-29,-26,-10;
/M: SY='V';  M= -5,-22,  7,-24,-20, -2,-28,-22,  7,-18,  4,  2,-22,-26,-22,-18,-12, -6, 17,-27, -8,-21;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.

Total number of hits	475 in 432 different sequences
Number of true positive hits	475 in 432 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	23
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	95.38 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info]	2
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	P_Bucher
Feature key [info]	DOMAIN
Feature description [info]	SH2
Version [info]	3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

432 sequences

3BP2_HUMAN  (P78314), 3BP2_MOUSE  (Q06649), ABL1_CAEEL  (P03949),

ABL1_HUMAN  (P00519), ABL1_MOUSE  (P00520), ABL2_HUMAN  (P42684), 
ABL2_MOUSE  (Q4JIM5), ABL_DROME   (P00522), ABL_FSVHY   (P10447), 
ABL_MLVAB   (P00521), BCAR3_BOVIN (Q58DL5), BCAR3_HUMAN (O75815), 
BCAR3_MACFA (Q4R8R1), BCAR3_MOUSE (Q9QZK2), BCAR3_RAT   (D3ZAZ5), 
BCAR3_XENLA (Q6INP9), BLK_HUMAN   (P51451), BLK_MOUSE   (P16277), 
BLNK_CHICK  (Q9YGC1), BLNK_HUMAN  (Q8WV28), BLNK_MOUSE  (Q9QUN3), 
BLNK_RAT(Q4KM52), BMX_HUMAN   (P51813), BMX_MOUSE   (P97504), 
BTKL_DROME  (P08630), BTK_CHICK   (Q8JH64), BTK_HUMAN   (Q06187), 
BTK_MOUSE   (P35991), CED2_CAEBR  (A8XI74), CED2_CAEEL  (Q9NHC3), 
CHIN_HUMAN  (P15882), CHIN_MOUSE  (Q91V57), CHIO_HUMAN  (P52757), 
CISH_BOVIN  (Q2HJ53), CISH_CHICK  (Q9PW70), CISH_HUMAN  (Q9NSE2), 
CISH_MOUSE  (Q62225), CISH_RAT(O70512), CLNK_HUMAN  (Q7Z7G1), 
CLNK_MOUSE  (Q9QZE2), CRKL_HUMAN  (P46109), CRKL_MOUSE  (P47941), 
CRKL_RAT(Q5U2U2), CRK_CHICK   (Q04929), CRK_DROME   (Q9XYM0), 
CRK_HUMAN   (P46108), CRK_MOUSE   (Q64010), CRK_RAT (Q63768), 
CRK_XENLA   (P87378), CSK1_CAEEL  (G5ECJ6), CSK_BOVIN   (Q0VBZ0), 
CSK_CHICK   (P41239), CSK_HUMAN   (P41240), CSK_MOUSE   (P41241), 
CSK_RAT (P32577), CSW_DROME   (P29349), CSW_DROVI   (Q24708), 
DAPP1_HUMAN (Q9UN19), DAPP1_MOUSE (Q9QXT1), DRK_DROSI   (Q6YKA8), 
EGRAP_DROME (Q6NR09), FER_CANLF   (Q9TTY2), FER_DROME   (P18106), 
FER_HUMAN   (P16591), FER_MOUSE   (P70451), FER_RAT (P09760), 
FES_FELCA   (P14238), FES_FSVGA   (P00542), FES_FSVST   (P00543), 
FES_HUMAN   (P07332), FES_MOUSE   (P16879), FGR_FSVGR   (P00544), 
FGR_HUMAN   (P09769), FGR_MOUSE   (P14234), FGR_RAT (Q6P6U0), 
FPS_AVISP   (P00541), FPS_FUJSV   (P00530), FRK1_CAEEL  (Q22146), 
FRK_HUMAN   (P42685), FRK_MOUSE   (Q922K9), FRK_RAT (Q62662), 
FYNA_DANRE  (Q6EWH2), FYNB_DANRE  (F1RDG9), FYN_BOVIN   (A0JNB0), 
FYN_CHICK   (Q05876), FYN_HUMAN   (P06241), FYN_MOUSE   (P39688), 
FYN_PIG (A1Y2K1), FYN_RAT (Q62844), FYN_XENLA   (P13406), 
FYN_XIPHE   (P27446), GAGC_AVISC  (P05433), GRAP2_HUMAN (O75791), 
GRAP2_MOUSE (O89100), GRAPL_HUMAN (Q8TC17), GRAP_BOVIN  (A6QLK6), 
GRAP_DROME  (Q08012), GRAP_HUMAN  (Q13588), GRAP_MOUSE  (Q9CX99), 
GRB10_HUMAN (Q13322), GRB10_MOUSE (Q60760), GRB10_PIG   (B5KFD7), 
GRB10_RAT   (P0CE43), GRB14_BOVIN (Q5ICW4), GRB14_HUMAN (Q14449), 
GRB14_MOUSE (Q9JLM9), GRB14_RAT   (O88900), GRB2A_XENLA (P87379), 
GRB2B_XENLA (Q6GPJ9), GRB2_CHICK  (Q07883), GRB2_HUMAN  (P62993), 
GRB2_MOUSE  (Q60631), GRB2_PONAB  (Q5R4J7), GRB2_RAT(P62994), 
GRB2_XENTR  (Q66II3), GRB7_BOVIN  (Q1RMW5), GRB7_HUMAN  (Q14451), 
GRB7_MOUSE  (Q03160), GRB7_RAT(Q9QZC5), HCK_HUMAN   (P08631), 
HCK_MACFA   (Q95M30), HCK_MOUSE   (P08103), HCK_RAT (P50545), 
HSH2D_DANRE (Q56A36), HSH2D_HUMAN (Q96JZ2), HSH2D_MOUSE (Q6VYH9), 
HTK16_HYDVU (P53356), ITK_HUMAN   (Q08881), ITK_MOUSE   (Q03526), 
JAK1_HUMAN  (P23458), JAK1_MOUSE  (P52332), JAK2_CHICK  (Q75R65), 
JAK2_HUMAN  (O60674), JAK2_MOUSE  (Q62120), JAK2_PIG(O19064), 
JAK2_PONAB  (Q5RB23), JAK2_RAT(Q62689), KSYK_CHICK  (F1N9Y5), 
KSYK_HUMAN  (P43405), KSYK_MOUSE  (P48025), KSYK_PIG(Q00655), 
KSYK_RAT(Q64725), LCK_AOTNA   (Q5PXS1), LCK_CHICK   (P42683), 
LCK_HUMAN   (P06239), LCK_MOUSE   (P06240), LCK_RAT (Q01621), 
LCK_SAISC   (Q95KR7), LCP2_HUMAN  (Q13094), LCP2_MOUSE  (Q60787), 
LYN_HUMAN   (P07948), LYN_MOUSE   (P25911), LYN_RAT (Q07014), 
MATK_HUMAN  (P42679), MATK_MOUSE  (P41242), MATK_RAT(P41243), 
NCK1_HUMAN  (P16333), NCK1_MOUSE  (Q99M51), NCK2_HUMAN  (O43639), 
NCK2_MOUSE  (O55033), NCK_DROME   (Q8IPW2), P55G_BOVIN  (O46404), 
P55G_HUMAN  (Q92569), P55G_MOUSE  (Q64143), P55G_RAT(Q63789), 
P85AA_XENLA (Q8UUU2), P85A_BOVIN  (P23727), P85A_HUMAN  (P27986), 
P85A_MOUSE  (P26450), P85A_PONAB  (Q5R685), P85A_RAT(Q63787), 
P85B_BOVIN  (P23726), P85B_HUMAN  (O00459), P85B_MOUSE  (O08908), 
P85B_RAT(Q63788), PLCG1_BOVIN (P08487), PLCG1_HUMAN (P19174), 
PLCG1_MOUSE (Q62077), PLCG1_RAT   (P10686), PLCG2_HUMAN (P16885), 
PLCG2_MOUSE (Q8CIH5), PLCG2_RAT   (P24135), PLCG_CAEEL  (Q22070), 
PTK6_HUMAN  (Q13882), PTK6_MOUSE  (Q64434), PTN11_CHICK (Q90687), 
PTN11_HUMAN (Q06124), PTN11_MOUSE (P35235), PTN11_RAT   (P41499), 
PTN6_HUMAN  (P29350), PTN6_MOUSE  (P29351), PTN6_RAT(P81718), 
PTP2_CAEEL  (G5EC24), RASA1_BOVIN (P09851), RASA1_HUMAN (P20936), 
RASA1_RAT   (P50904), RIN1_HUMAN  (Q13671), RIN1_RAT(P97680), 
RIN2_HUMAN  (Q8WYP3), RIN2_MOUSE  (Q9D684), RIN3_HUMAN  (Q8TB24), 
SEM5_CAEEL  (P29355), SH21A_BOVIN (Q3ZBB1), SH21A_HUMAN (O60880), 
SH21A_MACMU (Q71S10), SH21A_MOUSE (O88890), SH21A_PIG   (Q06AA1), 
SH21A_RAT   (B2RZ59), SH21A_SAGOE (Q9BG88), SH21B_HUMAN (O14796), 
SH21B_MOUSE (O35324), SH21C_MOUSE (Q45HK4), SH22A_HUMAN (Q9NP31), 
SH22A_MOUSE (Q9QXK9), SH23A_HUMAN (Q9BRG2), SH24A_HUMAN (Q9H788), 
SH24A_MOUSE (Q9D7V1), SH24A_RAT   (Q6AYC8), SH24A_XENTR (Q08CX2), 
SH24B_HUMAN (Q5SQS7), SH24B_MOUSE (A6X942), SH2B1_HUMAN (Q9NRF2), 
SH2B1_MOUSE (Q91ZM2), SH2B1_RAT   (Q62985), SH2B2_HUMAN (O14492), 
SH2B2_MOUSE (Q9JID9), SH2B2_RAT   (Q9Z200), SH2B3_HUMAN (Q9UQQ2), 
SH2B3_MOUSE (O09039), SH2B3_RAT   (P50745), SH2D3_HUMAN (Q8N5H7), 
SH2D3_MOUSE (Q9QZS8), SH2D5_HUMAN (Q6ZV89), SH2D5_MOUSE (Q8JZW5), 
SH2D5_PONAB (Q5R732), SH2D6_HUMAN (Q7Z4S9), SH2D6_MOUSE (Q9D413), 
SH2D7_HUMAN (A6NKC9), SH2D7_MOUSE (Q8BI17), SHARK_DROME (Q24145), 
SHA_ARATH   (B5X561), SHB_ARATH   (Q56XZ1), SHB_HUMAN   (Q15464), 
SHB_MOUSE   (Q6PD21), SHC1_BOVIN  (Q0IIE2), SHC1_HUMAN  (P29353), 
SHC1_MOUSE  (P98083), SHC1_PONAB  (Q5R7W7), SHC1_RAT(Q5M824), 
SHC1_XENLA  (Q8AY68), SHC2_HUMAN  (P98077), SHC2_MOUSE  (Q8BMC3), 
SHC2_RAT(O70142), SHC3_HUMAN  (Q92529), SHC3_MOUSE  (Q61120), 
SHC3_RAT(O70143), SHC4_HUMAN  (Q6S5L8), SHC4_MOUSE  (Q6S5L9), 
SHCH1_CAEEL (Q9TYT3), SHD_HUMAN   (Q96IW2), SHD_MOUSE   (O88834), 
SHE_HUMAN   (Q5VZ18), SHE_MOUSE   (Q8BSD5), SHF_HUMAN   (Q7M4L6), 
SHF_MOUSE   (Q8CG80), SHIP1_HUMAN (Q92835), SHIP1_MOUSE (Q9ES52), 
SHIP1_RAT   (P97573), SHIP1_XENLA (Q6P4S2), SHIP2_CANLF (A0A8I3NFE2), 
SHIP2_HUMAN (O15357), SHIP2_MOUSE (Q6P549), SHIP2_PIG   (D7PF45), 
SHIP2_RAT   (Q9WVR3), SHKA_DICDI  (Q54RB7), SHKB_DICDI  (Q54IP4), 
SHKC_DICDI  (Q54Y55), SHKD_DICDI  (Q54U31), SHKE_DICDI  (Q54G43), 
SHP2A_DANRE (Q2I6J1), SHP2B_DANRE (Q2I6J0), SLAP1_HUMAN (Q13239), 
SLAP1_MOUSE (Q60898), SLAP1_RAT   (P59622), SLAP2_HUMAN (Q9H6Q3), 
SLAP2_MOUSE (Q8R4L0), SOCS1_HUMAN (O15524), SOCS1_MOUSE (O35716), 
SOCS1_RAT   (Q9QX78), SOCS2_BOVIN (Q861R0), SOCS2_HUMAN (O14508), 
SOCS2_MOUSE (O35717), SOCS2_PIG   (Q7YRV6), SOCS2_RAT   (O88582), 
SOCS3_BOVIN (Q9BEG9), SOCS3_CANLF (Q68AM8), SOCS3_CHICK (Q90X67), 
SOCS3_HUMAN (O14543), SOCS3_MOUSE (O35718), SOCS3_RAT   (O88583), 
SOCS4_BOVIN (Q0VC91), SOCS4_HUMAN (Q8WXH5), SOCS4_MOUSE (Q91ZA6), 
SOCS4_PONAB (Q5RDX2), SOCS5_BOVIN (Q29RN6), SOCS5_HUMAN (O75159), 
SOCS5_MOUSE (O54928), SOCS6_HUMAN (O14544), SOCS6_MOUSE (Q9JLY0), 
SOCS6_PONAB (Q5RCM6), SOCS7_HUMAN (O14512), SOCS7_MOUSE (Q8VHQ2), 
SOEM_CAEEL  (Q7YWN4), SPE8_CAEBR  (A8WZ92), SPE8_CAEEL  (O01798), 
SPK1_GIRTI  (P42687), SPRI_DROME  (Q8MQW8), SPT6H_DANRE (Q8UVK2), 
SPT6H_HUMAN (Q7KZ85), SPT6H_MOUSE (Q62383), SPT6_ASPFU  (Q4WWH6), 
SPT6_CANAL  (Q3MNT0), SPT6_CANGA  (Q6FLB1), SPT6_DEBHA  (Q6BVE1), 
SPT6_EREGS  (Q75EP8), SPT6_KLULA  (Q6CVK3), SPT6_YEAST  (P23615), 
SRC1_CAEEL  (G5EE56), SRC1_XENLA  (P13115), SRC2_CAEEL  (O45539), 
SRC2_XENLA  (P13116), SRC42_DROME (Q9V9J3), SRC64_DROME (P00528), 
SRC_AVIS2   (P15054), SRC_AVISR   (P00525), SRC_AVISS   (P14084), 
SRC_AVIST   (P14085), SRC_CHICK   (P00523), SRC_DANRE   (Q1JPZ3), 
SRC_HUMAN   (P12931), SRC_MOUSE   (P05480), SRC_RAT (Q9WUD9), 
SRC_RSVH1   (P25020), SRC_RSVP(P00526), SRC_RSVPA   (P31693), 
SRC_RSVSA   (P00524), SRC_RSVSE   (P63185), SRK1_SPOLA  (P42686), 
SRK2_SPOLA  (P42688), SRK3_SPOLA  (P42689), SRK4_SPOLA  (P42690), 
SRMS_HUMAN  (Q9H3Y6), SRMS_MOUSE  (Q62270), STA31_XENLA (Q9PVX8), 
STA32_XENLA (Q7ZXK3), STA5A_BOVIN (Q95115), STA5A_HUMAN (P42229), 
STA5A_MOUSE (P42230), STA5A_PIG   (Q9TUZ1), STA5A_RAT   (Q62771), 
STA5A_SHEEP (P42231), STA5B_BOVIN (Q9TUM3), STA5B_HUMAN (P51692), 
STA5B_MOUSE (P42232), STA5B_PIG   (Q9TUZ0), STA5B_RAT   (P52632), 
STAP1_HUMAN (Q9ULZ2), STAP1_MOUSE (Q9JM90), STAP2_HUMAN (Q9UGK3), 
STAP2_MOUSE (Q8R0L1), STAT1_HUMAN (P42224), STAT1_MOUSE (P42225), 
STAT1_PIG   (Q764M5), STAT2_HUMAN (P52630), STAT2_MOUSE (Q9WVL2), 
STAT2_PIG   (O02799), STAT3_BOVIN (P61635), STAT3_CHICK (Q6DV79), 
STAT3_HUMAN (P40763), STAT3_MOUSE (P42227), STAT3_PIG   (Q19S50), 
STAT3_RAT   (P52631), STAT4_HUMAN (Q14765), STAT4_MOUSE (P42228), 
STAT6_HUMAN (P42226), STAT6_MOUSE (P52633), STATA_DICDI (O00910), 
STATB_CAEEL (Q20977), STATB_DICDI (Q70GP4), STATC_DICDI (Q54BD4), 
STAT_ANOGA  (Q7QDU4), STAT_DROME  (Q24151), STK_HYDVU   (P17713), 
TEC_HUMAN   (P42680), TEC_MOUSE   (P24604), TENS1_BOVIN (Q9GLM4), 
TENS1_CHICK (Q04205), TENS1_HUMAN (Q9HBL0), TENS1_MOUSE (E9Q0S6), 
TENS2_HUMAN (Q63HR2), TENS2_MOUSE (Q8CGB6), TENS3_HUMAN (Q68CZ2), 
TENS3_MOUSE (Q5SSZ5), TENS4_BOVIN (Q32PJ7), TENS4_HUMAN (Q8IZW8), 
TENS4_MOUSE (Q8BZ33), TENS4_RAT   (Q4V8I3), TENSH_CAEEL (H2L045), 
TXK_HUMAN   (P42681), TXK_MOUSE   (P42682), VAV2_HUMAN  (P52735), 
VAV2_MOUSE  (Q60992), VAV3_HUMAN  (Q9UKW4), VAV3_MOUSE  (Q9R0C8), 
VAV_BOVIN   (Q08DN7), VAV_CAEEL   (Q45FX5), VAV_DROME   (Q9NHV9), 
VAV_HUMAN   (P15498), VAV_MOUSE   (P27870), VAV_RAT (P54100), 
YES_AVISY   (P00527), YES_CANLF   (Q28923), YES_CHICK   (P09324), 
YES_DANRE   (A1A5H8), YES_HUMAN   (P07947), YES_MOUSE   (Q04736), 
YES_RAT (F1LM93), YES_XENLA   (P10936), YES_XIPHE   (P27447), 
YRK_CHICK   (Q02977), ZAP70_HUMAN (P43403), ZAP70_MOUSE (P43404)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

23 sequences

JAK1_CYPCA  (Q09178), JAK1_DANRE  (O12990), JAK3_HUMAN  (P52333),

JAK3_MOUSE  (Q62137), JAK3_RAT(Q63272), JAK_DROME   (Q24592), 
RIN1_MOUSE  (Q921Q7), RIN3_MOUSE  (P59729), SPT6H_CAEBR (Q93148), 
SPT6H_CAEEL (P34703), SPT6H_DROME (Q9W420), SPT6_ASPOR  (Q2U561), 
SPT6_CRYNB  (P0CR73), SPT6_CRYNJ  (P0CR72), SPT6_EMENI  (Q5B7Q7), 
SPT6_GIBZE  (Q4HYQ4), SPT6_NEUCR  (Q8NIV6), SPT6_SCHPO  (Q09915), 
SPT6_USTMA  (Q4PI89), STAT1_CAEBR (Q61AP6), STAT1_CAEEL (Q9NAD6), 
TYK2_HUMAN  (P29597), TYK2_MOUSE  (Q9R117)

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PDB
[Detailed view]

612 PDB

1A07; 1A08; 1A09; 1A1A; 1A1B; 1A1C; 1A1E; 1A81; 1AB2; 1AD5; 1AOT; 1AOU; 1AYA; 1AYB; 1AYC; 1AYD; 1BF5; 1BFI; 1BFJ; 1BG1; 1BHF; 1BHH; 1BKL; 1BKM; 1BLJ; 1BLK; 1BM2; 1BMB; 1CJ1; 1CSY; 1CSZ; 1CWD; 1CWE; 1D1Z; 1D4T; 1D4W; 1F1W; 1F2F; 1FBZ; 1FHS; 1FMK; 1FU5; 1FU6; 1FYR; 1G83; 1GHU; 1GRI; 1H9O; 1HCS; 1HCT; 1I3Z; 1IJR; 1IS0; 1JU5; 1JWO; 1JYQ; 1JYR; 1JYU; 1K9A; 1KA6; 1KA7; 1KC2; 1KSW; 1LCJ; 1LCK; 1LKK; 1LKL; 1LUI; 1LUK; 1LUM; 1LUN; 1M27; 1M61; 1MIL; 1MW4; 1NRV; 1NZL; 1NZV; 1O41; 1O42; 1O43; 1O44; 1O45; 1O46; 1O47; 1O48; 1O49; 1O4A; 1O4B; 1O4C; 1O4D; 1O4E; 1O4F; 1O4G; 1O4H; 1O4I; 1O4J; 1O4K; 1O4L; 1O4M; 1O4N; 1O4O; 1O4P; 1O4Q; 1O4R; 1OO3; 1OO4; 1OPK; 1OPL; 1P13; 1PIC; 1QAD; 1QCF; 1QG1; 1R1P; 1R1Q; 1R1S; 1RJA; 1RPY; 1RQQ; 1SHA; 1SHB; 1SHD; 1SKJ; 1SPR; 1SPS; 1TCE; 1TZE; 1UUR; 1UUS; 1WQU; 1X0N; 1X27; 1X6C; 1XA6; 1Y1U; 1Y57; 1YVL; 1Z3K; 1ZFP; 2ABL; 2AOA; 2AOB; 2AUG; 2B3O; 2BBU; 2C0I; 2C0O; 2C0T; 2C9W; 2CI8; 2CI9; 2CIA; 2CR4; 2CRH; 2CS0; 2DCR; 2DLY; 2DLZ; 2DM0; 2DVJ; 2DX0; 2ECD; 2EKX; 2EL8; 2EO3; 2EO6; 2EOB; 2ETZ; 2EU0; 2EYV; 2EYY; 2EYZ; 2FCI; 2FO0; 2GE9; 2GSB; 2H46; 2H5K; 2H8H; 2HCK; 2HDV; 2HDX; 2HMH; 2HUW; 2IUG; 2IUH; 2IUI; 2IZV; 2JYQ; 2K79; 2K7A; 2KK6; 2KNO; 2L3T; 2L4K; 2L6K; 2LCT; 2LNW; 2LNX; 2LQN; 2LQW; 2MC1; 2MK2; 2MQI; 2MRJ; 2MRK; 2OQ1; 2OZO; 2PLD; 2PLE; 2PNA; 2PNB; 2PTK; 2QMS; 2RD0; 2RMX; 2ROR; 2RSY; 2SHP; 2SRC; 2VIF; 2Y3A; 2YSX; 2YU7; 3BKB; 3C7I; 3CBL; 3CD3; 3CWG; 3CXL; 3EAC; 3EAZ; 3GQI; 3GXW; 3GXX; 3HCK; 3HHM; 3HIZ; 3IMD; 3IMJ; 3IN7; 3IN8; 3K2M; 3KFJ; 3M7F; 3MAZ; 3MXC; 3MXY; 3N7Y; 3N84; 3N8M; 3NHN; 3OV1; 3OVE; 3PJP; 3PQZ; 3PS5; 3PSI; 3PSJ; 3PSK; 3QWX; 3QWY; 3S8L; 3S8N; 3S8O; 3S9K; 3T04; 3TKZ; 3TL0; 3UF4; 3US4; 3UYO; 3VRO; 3VRY; 3VRZ; 3VS0; 3VS1; 3VS2; 3VS3; 3VS4; 3VS5; 3VS6; 3VS7; 3WA4; 4A55; 4D8K; 4DGP; 4DGX; 4E68; 4E93; 4EIH; 4EY0; 4F59; 4F5A; 4F5B; 4FBN; 4FL2; 4FL3; 4GL9; 4GWF; 4H1O; 4H34; 4JE4; 4JEG; 4JGH; 4JMG; 4JMH; 4JPS; 4K11; 4K2R; 4K44; 4K45; 4L1B; 4L23; 4L2Y; 4LUD; 4LUE; 4M4Z; 4NWF; 4NWG; 4OHD; 4OHE; 4OHH; 4OHI; 4OHL; 4OVU; 4OVV; 4P9V; 4P9Z; 4QSY; 4ROJ; 4TZI; 4U17; 4U1P; 4U5W; 4WAF; 4WWQ; 4X6S; 4XEY; 4XI2; 4XZ0; 4XZ1; 4Y5U; 4Y5W; 4YKN; 4Z32; 4ZOP; 5AUL; 5BK8; 5BO4; 5CDW; 5D0J; 5D39; 5DC0; 5DC4; 5DC9; 5DF6; 5EEL; 5EEQ; 5EG3; 5EHP; 5EHR; 5FI4; 5GJH; 5GJI; 5H09; 5H0B; 5H0E; 5H0G; 5H0H; 5I6V; 5IBM; 5IBS; 5ITD; 5IXD; 5IXI; 5JN0; 5KAZ; 5L04; 5M6U; 5MO4; 5MTJ; 5MTM; 5MTN; 5SW8; 5SWG; 5SWO; 5SWP; 5SWR; 5SWT; 5SX8; 5SX9; 5SXA; 5SXB; 5SXC; 5SXD; 5SXE; 5SXF; 5SXI; 5SXJ; 5SXK; 5TNW; 5TO4; 5TQ1; 5TQS; 5TYI; 5U06; 5U1Q; 5UK8; 5UKJ; 5UL1; 5VKL; 5VKO; 5W3R; 5X7B; 5X94; 5XGH; 5XGI; 5XGJ; 5XZR; 6AMV; 6AMW; 6ATD; 6BMR; 6BMU; 6BMV; 6BMW; 6BMX; 6BMY; 6BN5; 6C7Y; 6CMP; 6CMQ; 6CMR; 6CMS; 6CRF; 6CRG; 6E2P; 6E2Q; 6F3F; 6GME; 6GMH; 6HTF; 6I4X; 6I5J; 6I5N; 6ICG; 6ICH; 6JMF; 6KC4; 6MBW; 6MBZ; 6MD7; 6MD9; 6MDA; 6MDB; 6MDC; 6MDD; 6NCT; 6NJS; 6NUQ; 6PBC; 6PXB; 6PXC; 6QHD; 6QTC; 6R5G; 6SM5; 6TED; 6TLC; 6UX2; 6VK2; 6WAX; 6WAY; 6WCZ; 6WM1; 6WO2; 6WU8; 7CIO; 7EMN; 7JVM; 7JVN; 7M6T; 7MP3; 7MPH; 7MYN; 7MYO; 7NUF; 7NXE; 7O3D; 7O6B; 7OOP; 7OPC; 7OPD; 7PG5; 7PG6; 7Q5T; 7Q5U; 7Q5W; 7Q63; 7R75; 7R7D; 7R7I; 7R7L; 7R8W; 7R8X; 7RCT; 7RNS; 7RNU; 7RNV; 7SA7; 7T1K; 7T1L; 7T1U; 7T6F; 7T8T; 7TVA; 7TVB; 7TZ7; 7UBT; 7UC6; 7UC7; 7UNC; 7UND; 7UY0; 7UY3; 7VXG; 7WFY; 7XHQ; 7YQE; 7Z3J; 7ZLM; 7ZLN; 7ZLO; 7ZLP; 7ZLR; 7ZLS; 8AM0; 8ATK; 8B5Y; 8CBH; 8CZ9; 8D3F; 8DCP; 8DCX; 8DD4; 8DD8; 8DGO; 8DGQ; 8EWY; 8GMB; 8GUB; 8GWW; 8H36; 8H37; 8ILR; 8ILS; 8ILV; 8JN8; 8JN9; 8OEU; 8OEV; 8OF0; 8RZW; 8RZY; 8S01; 8S04; 8S06; 8S07; 8S0H; 8S0I; 8S0J; 8S0K; 8S0O; 8S0P; 8S0Q; 8S0S; 8SBC; 8SBJ; 8SSN; 8T12; 8T13; 8T6D; 8T6G; 8T7C; 8T7Q; 8T8Q; 8TDU; 8TGD; 8TS7; 8TS8; 8TS9; 8TSA; 8TSB; 8TSC; 8TSD; 8TU6; 8U7W; 8U7X; 8V8H; 8V8I; 8V8J; 8V8U; 8V8V; 8W9A; 8W9B; 8WFY; 8WX7; 8X2P; 8XN8; 9BLG
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