ProRule PRU00191

General rule information [?]

Accession PRU00191
Dates 12-DEC-2003 (Created)
20-NOV-2019 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS50001; SH2
Name SH2 domain
Function SH2 domains function as regulatory modules of intracellular signalling cascades by interacting with high affinity to phosphotyrosine- containing target peptides in a sequence-specific and strictly phosphorylation-dependent manner.
Scope(s) Eukaryota
Example(s) Q13239 (SLAP1_HUMAN);

Propagated annotation [?]

Keywords [?]

Features [?]

From: PS50001
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="SH2 #"

Additional information [?]

Size range 65-129 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined


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UniProtKB rule member sequences [?]