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| annotation rule: PRU00191 |
General rule information
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| Accession | PRU00191 |
| Dates | 12-DEC-2003 (Created) 20-NOV-2019 (Last updated, Version 7) |
| Data class | Domain |
| Predictors | PROSITE; PS50001; SH2 |
| Name | SH2 domain |
| Function | SH2 domains function as regulatory modules of intracellular signalling cascades by interacting with high affinity to phosphotyrosine- containing target peptides in a sequence-specific and strictly phosphorylation-dependent manner. |
Propagated annotation
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Keywords
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Features
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| From: PS50001 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | SH2 # | |||||||||
Additional information
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| Size range | 65-129 amino acids |
| Related rules | None |
| Repeats | 1-2 |
| Topology | Undefined |
| Example | Q13239 (SLAP1_HUMAN) |
| Scope | Eukaryota
Viruses; Retroviridae |
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UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Eukaryota [433] Viruses [18] All [ 451 ]
- Retrieve set of proteins with 3D structure for this domain