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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00191


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00191
General rule information [?]

Accession PRU00191
Dates 12-DEC-2003 (Created)
20-NOV-2019 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS50001; SH2
Name SH2 domain
Function SH2 domains function as regulatory modules of intracellular signalling cascades by interacting with high affinity to phosphotyrosine- containing target peptides in a sequence-specific and strictly phosphorylation-dependent manner.
Scope(s) Eukaryota
Viruses
Retroviridae
Example(s) Q13239;

Propagated annotation [?]

Keywords [?]

SH2 domain

Features [?]

From: PS50001
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="SH2 #"

Additional information [?]

Size range 65-129 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]