ProRule PRU00191
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00191 |
| Accession | PRU00191 |
| Dates | 12-DEC-2003 (Created)
20-NOV-2019 (Last updated, Version 7) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50001; SH2 |
Name | SH2 domain |
| Function | SH2 domains function as regulatory modules of intracellular signalling cascades by interacting with high affinity to phosphotyrosine- containing target peptides in a sequence-specific and strictly phosphorylation-dependent manner. |
| Scope(s) |
Eukaryota Viruses Retroviridae |
| Example(s) | Q13239 (SLAP1_HUMAN); |
Propagated annotation
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Keywords
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Features
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| From: PS50001 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="SH2 #" | |||||||||
Additional information
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| Size range | 65-129 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-2 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [437] Viruses [18] All [ 455 ]
- Retrieve set of proteins with 3D structure for this domain