PROSITE entry PS50035
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General information about the entry
| Entry name [info] | PLD |
| Accession [info] | PS50035 |
| Entry type [info] | MATRIX |
| Date [info] |
01-APR-2002 CREATED;
10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC50035 |
| Associated ProRule [info] | PRU00153 |
Name and characterization of the entry
| Description [info] | Phospholipase D phosphodiesterase active site profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=28; /DISJOINT: DEFINITION=PROTECT; N1=3; N2=26; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-1.4560000; R2=0.0316000; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=975.8386230; R2=0.5719298; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=316; H_SCORE=1157; N_SCORE=8.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=252; H_SCORE=1120; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MM=1; MI=-105; MD=-105; IM=-105; DM=-105; M0=-10; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='Y'; M= -8, -8,-23, -8,-10, -4, -9, -9,-10, -9, -8, -6, -7,-17,-10, -9, -5, -3, -8,-16, 2,-11; /M: M= -8, 0,-24, -1, -5, -9, -9, -7,-14, -6, -9, -6, 0,-16, -6, -4, -5, -5,-13,-22, -7, -6; /M: M= -8,-10,-28,-11,-12, -9, -2,-10,-16, -6,-13, -9, -6,-16,-10, -2, -9,-11,-14, -6, -2,-12; /M: SY='V'; M= -3,-19,-21,-22,-15, -3,-22,-17, 3, -7, 1, 1,-15,-20,-12, -3, -9, -2, 6,-14, -2,-15; /M: SY='H'; M=-12, -1,-23, -8, -7, -7,-19, 9, -1,-11, 1, 6, 5,-22, -2, -8,-10, -8, -8,-24, 1, -6; /M: SY='H'; M=-19, 5,-29, 3, 0,-20,-17, 89,-29, -9,-21, -3, 16,-20, 9, 0, -7,-17,-30,-31, 15, 0; /M: SY='S'; M= 0, 2,-19, -1, 1,-18,-12, -3,-17, -4,-15,-10, 3,-12, 2, -2, 6, 5,-13,-28,-12, 1; /M: SY='K'; M=-10, 0,-30, 0, 10,-30,-20,-10,-30, 49,-30,-10, 0,-10, 10, 32,-10,-10,-20,-20,-10, 10; /M: SY='L'; M= -7,-23,-21,-28,-22, 10,-20,-18, 13,-23, 15, 9,-18,-24,-20,-19,-14, -4, 9,-15, 4,-22; /M: SY='M'; M= -7,-26,-20,-31,-24, 15,-27,-15, 17,-21, 18, 19,-24,-26,-19,-18,-19, -8, 14, -8, 9,-21; /M: SY='I'; M= -4,-28,-21,-32,-27, -1,-29,-27, 30,-24, 15, 13,-23,-24,-22,-23,-15, -5, 29,-19, -5,-26; /M: SY='V'; M= -4,-25,-17,-29,-24, 7,-29,-25, 23,-22, 9, 8,-20,-23,-23,-21, -8, 1, 27,-22, -3,-25; /M: SY='D'; M=-18, 45,-29, 64, 23,-39,-11, 0,-39, 1,-29,-29, 18, -9, 2, -9, 1, -9,-29,-39,-20, 13; /M: SY='D'; M=-10, 23,-27, 28, 8,-31, 3, -1,-31, -1,-27,-21, 17,-14, 2, -4, 3, -8,-27,-33,-19, 4; /M: SY='E'; M= -3, 0,-23, 1, 11,-20,-16, -6,-20, 8,-17,-11, -1,-11, 3, 5, 0, -1,-14,-25,-12, 6; /I: I=-6; MI=0; MD=-21; IM=0; DM=-21; /M: SY='Y'; M= -7,-14,-19,-18,-13, 4,-22, -4, 5,-13, 3, 2,-12,-19, -9,-11, -8, 0, 3, -7, 11,-13; D=-4; /I: DM=-21; /M: SY='A'; M= 15,-16,-12,-21,-17, -8,-12,-21, 3,-16, -2, -2,-13,-18,-16,-18, 4, 4, 12,-25,-12,-17; /M: SY='Y'; M=-15,-21,-23,-25,-19, 21,-29, 6, 4,-20, 7, 4,-16,-26,-16,-15,-17,-10, -2, -2, 27,-19; /M: SY='I'; M= -6,-27,-20,-31,-26, 2,-32,-25, 31,-24, 18, 13,-23,-25,-22,-22,-15, -3, 29,-22, -1,-26; /M: SY='G'; M= 2, -8,-24,-10,-16,-25, 46,-18,-31,-17,-26,-16, 0,-17,-15,-17, 7, -6,-22,-24,-25,-16; /M: SY='S'; M= 5, -3,-17, -6, -9,-21, 17,-15,-24,-12,-26,-17, 5,-12, -9,-12, 20, 10,-14,-31,-21, -9; /M: SY='A'; M= 16,-12,-12,-19,-13, -7,-11,-13, -5,-13, -5, -4, -8,-17,-12,-15, 2, -1, 0,-22,-10,-13; /M: SY='N'; M=-11, 40,-22, 29, 4,-24, -2, 7,-24, 0,-30,-22, 50,-18, 0, -2, 9, -1,-29,-40,-20, 2; /M: SY='L'; M=-12,-30,-26,-34,-25, 17,-27,-19, 14,-25, 21, 13,-26,-27,-21,-20,-26,-13, 5, 12, 12,-22; /M: SY='B'; M= -6, 14, -9, 14, -2,-20, -6, -8,-22, -9,-20,-16, 10,-17, -7,-12, 4, -1,-17,-31,-15, -5; /M: SY='D'; M=-10, -1,-29, 2, -1,-16, -3, -9,-23, -5,-20,-13, -3, -2, -6,-10, -6, -9,-22,-13,-10, -4; /M: SY='R'; M= -3, -1,-23, -1, 1,-22, -3,-10,-23, 5,-20,-14, 1,-13, -2, 10, 2, -1,-15,-26,-17, -2; /M: SY='H'; M= -5, -4,-22, -6, -7, -8,-12, 13,-17, -5,-16,-10, 2,-19, -2, 1, 3, -1,-15,-15, 10, -7; /I: E1=0;» more |
Numerical results [info]
| Total number of hits | 415 in 230 different sequences |
| Number of true positive hits | 413 in 228 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 2 in 2 different sequences |
| Number of false negative sequences | 10 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 99.52 % |
| Recall (true positives / (true positives + false negatives)) | 97.64 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses |
| Maximum number of repetitions [info] | 2 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | K_Hofmann |
| Feature key [info] | DOMAIN |
| Feature description [info] | PLD phosphodiesterase |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
228 sequences
CLS1_BACAN (Q81V75), CLS1_BACCR (Q81I00), CLS1_BACSU (P45860), CLS1_STAAC (Q5HGA3), CLS1_STAAR (Q6GH88), CLS1_STAEQ (Q5HPM5), CLS1_STAES (Q8CPD8), CLS2_BACAN (Q81TR2), CLS2_BACCR (Q81GK4), CLS2_STAAC (Q5HEB2), CLS2_STAAR (Q6GEY7), CLS2_STAEQ (Q5HMD3), CLS2_STAES (Q8CNK3), CLSA_BACSU (P71040), CLSA_BUCA5 (B8D966), CLSA_BUCAI (P57361), CLSA_BUCAP (Q8K9P9), CLSA_BUCAT (B8D7H0), CLSA_BUCBP (Q89AL5), CLSA_CITK8 (A8AG50), CLSA_CROS8 (A7MNA4), CLSA_ECO24 (A7ZL20), CLSA_ECO27 (B7UQD9), CLSA_ECO45 (B7ML01), CLSA_ECO55 (B7LHJ4), CLSA_ECO57 (Q8XCC6), CLSA_ECO5E (B5YYF4), CLSA_ECO7I (B7NVL8), CLSA_ECO81 (B7MU36), CLSA_ECO8A (B7LY04), CLSA_ECOBW (C4ZTU1), CLSA_ECODH (B1XAT9), CLSA_ECOHS (A7ZZI5), CLSA_ECOK1 (A1AAH3), CLSA_ECOL5 (Q0TIC2), CLSA_ECOL6 (P0A6H9), CLSA_ECOLC (B1ITK7), CLSA_ECOLI (P0A6H8), CLSA_ECOLU (B7N460), CLSA_ECOSE (B6I9W2), CLSA_ECOSM (B1LH51), CLSA_ECOUT (Q1RCI7), CLSA_EDWI9 (C5BDA3), CLSA_ENT38 (A4WB84), CLSA_ERWT9 (B2VKV4), CLSA_ESCF3 (B7LS29), CLSA_KLEP3 (B5XQA9), CLSA_KLEP7 (A6TAJ7), CLSA_PECAS (Q6D4S2), CLSA_PECCP (C6DGY3), CLSA_PROMH (B4EWI7), CLSA_PSEA8 (B7V5T6), CLSA_PSEAB (Q02DW8), CLSA_PSEAE (Q9HTH0), CLSA_PSEE4 (Q1I2L0), CLSA_PSEF5 (Q4K3D9), CLSA_PSEFS (C3K1C4), CLSA_PSEP1 (A5WB80), CLSA_PSEPG (B0KR91), CLSA_PSEPK (Q88C19), CLSA_PSEPU (P31048), CLSA_PSEPW (B1JFN5), CLSA_PSESM (Q87TY7), CLSA_PSEU2 (Q4ZL66), CLSA_SALA4 (B5F4L0), CLSA_SALAR (A9MPD5), CLSA_SALCH (Q57NS0), CLSA_SALDC (B5FU52), CLSA_SALEP (B5R3N1), CLSA_SALG2 (B5R6L2), CLSA_SALHS (B4TJM2), CLSA_SALNS (B4SUC9), CLSA_SALPA (Q5PCS9), CLSA_SALPB (A9MWP9), CLSA_SALPC (C0Q393), CLSA_SALPK (B5BIA8), CLSA_SALSV (B4TX53), CLSA_SALTI (P63799), CLSA_SALTY (P63798), CLSA_SERP5 (A8GFA0), CLSA_SHIB3 (B2TZZ4), CLSA_SHIBS (Q31ZU1), CLSA_SHIDS (Q32GV1), CLSA_SHIFL (Q83RM8), CLSA_SHISS (Q3Z0W3), CLSA_SODGM (Q2NT72), CLSA_WIGBR (Q8D2I8), CLSA_YERE8 (A1JQ40), CLSA_YERP3 (A7FI50), CLSA_YERPA (Q1C7R0), CLSA_YERPB (B2K3U5), CLSA_YERPE (Q8ZEI2), CLSA_YERPG (A9R8K8), CLSA_YERPN (Q1CJ46), CLSA_YERPP (A4TJ85), CLSA_YERPS (Q66AL9), CLSA_YERPY (B1JKT9), CLSB_BACSU (P45865), CLSB_ECO57 (P0AA85), CLSB_ECOL6 (Q8FJN9), CLSB_ECOLI (P0AA84), CLSB_SALTI (Q8Z883), CLSB_SALTY (Q8ZQP4), CLSB_SHIFL (P59715), CLSC_ECOLI (P75919), CLS_ALKPO (O66043), CLS_CLOP1 (Q0TQG9), CLS_CLOPE (P0C2E2), CLS_CLOPS (Q0ST20), CLS_GEOKA (Q5L1S5), CLS_GEOSW (C5D794), CLS_GEOTN (A4IL76), CLS_HALH5 (Q9K8Z4), CLS_LISIN (Q927Z0), CLS_LISMC (C1KYS0), CLS_LISMF (Q71WS5), CLS_LISMH (B8DBK8), CLS_LISMO (Q8Y4E3), CLS_LISW6 (A0ALI7), CLS_OCEIH (Q8EM16), CLS_STAAM (P63800), CLS_STAAN (P63801), CLS_STAAS (Q6G7M2), CLS_STAAW (P63802), DRMC_BACP9 (P0DW07), F13_FOWPN (P36316), F13_MCV1(P26579), F13_MCV2(P25392), PG042_MONPV (A0A7H0DN15), PG042_VACCC (P20537), PG042_VACCW (P18377), PG057_MONPV (A0A7H0DN30), PG057_VACCA (O57179), PG057_VACCC (P20638), PG057_VACCI (P26653), PG057_VACCP (P29885), PG057_VACCW (P04021), PG057_VAR67 (P33815), PGPS1_BOVIN (Q2KJ28), PGPS1_CHICK (Q5ZHN9), PGPS1_CRIGR (Q9Z2Z7), PGPS1_DICDI (Q7KWX2), PGPS1_HUMAN (Q32NB8), PGPS1_MOUSE (Q8BHF7), PGPS1_PONAB (Q5R8K7), PGPS1_SACPS (P79001), PGPS1_YEAST (P25578), PLD1_CRIGR (O08684), PLD1_HUMAN (Q13393), PLD1_MOUSE (Q9Z280), PLD1_RAT(P70496), PLD1_SCHPO (Q09706), PLD2_BOVIN (Q0V8L6), PLD2_HUMAN (O14939), PLD2_MOUSE (P97813), PLD2_RAT(P70498), PLD3_BOVIN (Q2KJJ8), PLD3_HUMAN (Q8IV08), PLD3_MACFA (Q4R583), PLD3_MOUSE (O35405), PLD3_PONAB (Q5R4Y7), PLD3_RAT(Q5FVH2), PLD3_XENLA (Q6PB03), PLD3_XENTR (Q640B3), PLD4_HUMAN (Q96BZ4), PLD4_MOUSE (Q8BG07), PLD5_MOUSE (Q3UNN8), PLD6_BOVIN (E1BE10), PLD6_CANLF (E2RD63), PLD6_CHLRE (A8IW99), PLD6_HUMAN (Q8N2A8), PLD6_MOUSE (Q5SWZ9), PLD6_XENLA (A1L1C2), PLD6_XENTR (Q28DT3), PLDA1_ARATH (Q38882), PLDA1_BRAOC (O82549), PLDA1_CARPA (P86387), PLDA1_CYNCA (Q70EW5), PLDA1_MAIZE (Q43270), PLDA1_ORYSJ (Q43007), PLDA1_RICCO (Q41142), PLDA1_SPUBR (O04883), PLDA1_TOBAC (P93400), PLDA1_VIGUN (O04865), PLDA2_ARATH (Q9SSQ9), PLDA2_BRAOC (P55939), PLDA2_ORYSJ (P93844), PLDA3_ARATH (P58766), PLDA4_ARATH (Q9C888), PLDA_DICDI (Q54UK0), PLDB1_ARATH (P93733), PLDB2_ARATH (O23078), PLDB_DICDI (Q54WR4), PLDC_DICDI (Q54Z25), PLDD1_ARATH (Q9C5Y0), PLDG1_ARATH (Q9T053), PLDG2_ARATH (Q9T051), PLDG3_ARATH (Q9T052), PLDL_CAEEL (O17405), PLDY_DICDI (Q54K50), PLDZ1_ARATH (Q9LRZ5), PLDZ2_ARATH (Q9M9W8), PLDZ_DICDI (Q54SA1), PLD_PHYIN (Q5BMR2), PLD_RICBR (Q1RK58), PLD_RICCN (Q92G53), PLD_RICFE (Q4UJZ1), PLD_RICPR (Q9ZCD8), PLD_RICTY (Q68VT0), PLD_STRAT (Q53728), PPK1_ECO57 (P0A7B2), PPK1_ECOL6 (Q8FF70), PPK1_ECOLI (P0A7B1), PPK1_KLEPN (Q07411), PPK1_SALTI (Q8Z4R0), PPK1_SALTY (O86090), PPK1_VIBCH (Q9KU07), PPK1_VIBPA (Q87S51), PPK1_VIBVU (Q8DEW2), PPK1_VIBVY (Q7MNJ0), PPK1_YERPE (Q8ZCX2), PSS_ECOLI (P23830), PSS_HAEIN (P44704), SPO14_YEAST (P36126), Y190_HELPJ (Q9ZMP2), Y190_HELPY (P56117), Y988_STRMU (P34001), YJHR_ECOLI (P39369)» more
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| UniProtKB/Swiss-Prot False negative sequences |
10 sequences
PGPS1_SCHPO (Q9HDW1), PLD5_HUMAN (Q8N7P1), PLD6_DANRE (A3KNW0), PPK1_PSEPK (Q88CG4), PPK1_PSESM (Q87UP6), PPK1_STAEQ (Q5HLE0), PPK1_STAES (Q8CR71), PPK1_STAHJ (Q4L8X9), PPK1_STAS1 (Q4A040), ZUC_DROME (Q9VKD7)» more |
| UniProtKB/Swiss-Prot False positive sequences |
2 sequences
DYHA_CHLRE (Q39610), TYDP1_CAEEL (Q9TXV7) |
| PDB [Detailed view] |
29 PDB
1XDO; 1XDP; 2ZE4; 2ZE9; 3HSI; 4GGJ; 4GGK; 6KZ8; 6KZ9; 6OHM; 6OHO; 6OHP; 6OHQ; 6OHS; 6U8Z; 7JRB; 7JRC; 7JRU; 7JRV; 7JRW; 7JS5; 7JS7; 7SVP; 8Q1K; 8Q1X; 8V05; 8V06; 8V07; 8V08 » more |