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PROSITE entry PS50050


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PURL: https://purl.expasy.org/prosite/signature/PS50050

Direct ScanProsite submission
General information about the entry

Entry name [info] TNFR_NGFR_2
Accession [info] PS50050
Entry type [info] MATRIX
Date [info] 01-NOV-1997 CREATED;
26-FEB-2020 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00561
Associated ProRule [info] PRU00206

Name and characterization of the entry

Description [info] TNFR/NGFR family cysteine-rich region domain profile.
Matrix / Profile [info] 
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=41;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=37;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-4.9359999; R2=0.0214000; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=538.8750000; R2=4.1875000; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=628; H_SCORE=3169; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=535; H_SCORE=2779; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=*; E1=0; MI=-105; MD=-105; IM=-105; DM=-105; MM=1; M0=-1;

...
 
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='P';  M= -4, -2,-25, -1,  3,-23,-13,-11,-19, -2,-21,-15, -1, 13, -2, -4,  3,  4,-17,-30,-19, -1;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='P';  M= -4, -7,-25, -5,  4,-24,-12, -3,-21,  1,-20,-11, -5,  5,  3,  0, -2, -7,-18,-24,-14,  2;
/M: SY='E';  M= -3,  0,-27,  4, 11,-23,-12, -7,-21, -2,-20,-15, -4, 11, -1, -9, -1, -6,-20,-27,-17,  4;
/M: SY='G';  M= -3,  3,-27,  1, -9,-28, 39,-11,-34, -9,-29,-19, 10,-17,-10,-10,  4,-12,-27,-26,-25, -9;
/I:         II=-7; MI=-8; IM=-8; MD=-15; DM=-15; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0;
/M: SY='Y';  M=-11, -7,-23, -9,  1,  0,-21,  2,-12, -8, -7, -3, -6,-16, -1, -6, -4,  1,-12,-14,  4,  0;
/M: SY='Y';  M=-19,-22,-25,-26,-22, 44,-29,  7, -2,-17,  2,  0,-18,-29,-20,-13,-18,-10, -7, 16, 52,-22;
/M: SY='C';  M= -6, -8,  5,-12, -8,-14,-19,-11,-13,-12,-10, -8, -4,-18, -5,-10,  1,  3, -9,-27,-11, -7;
/M: SY='D';  M= -5, 10,-21, 11,  3,-21,-12, -1,-21, -3,-18,-15,  7,-11, -1, -4,  3, -1,-17,-29,-11,  0;
/M: SY='S';  M= -4, -3,-23, -3,  1,-18, -8, -4,-17, -4,-14,-10, -2,-12,  0, -5,  2,  0,-13,-24, -9, -1;
/I:         MD=-22;
/M: SY='W';  M= -2, -5,-20, -6, -3,-13, -6, -8,-15, -2,-15,-11, -3,-10, -3, -5, -1, -3,-13,  1, -6, -3; D=-4;
/I:         MD=-22;
/M: SY='N';  M=  0,  6,-14,  2, -1,-15,  1,  3,-15, -4,-17,-11, 13, -8, -2, -4,  7,  0,-14,-23,-11, -2; D=-4;
/I:         MD=-22;
/M: SY='H';  M= -3, -4,-13, -5,  0, -5, -9,  6, -8, -3, -6, -2, -2, -7,  3, -1, -2, -3, -8, -7,  2,  1; D=-4;
/I:         II=-4; MI=0; IM=0; MD=-15; DM=-15; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0;
/M: SY='C';  M=  0,-10,  9,-12, -9, -4,-14, -9, -6,-12, -3, -4, -8,-15,-10,-10, -1,  1,  0,-19, -7, -9; D=-4;
/I:         DM=-22;
/M: SY='D';  M= -9,  5,-27,  7,  7,-23, -4, -5,-26,  2,-24,-16,  6, -5,  2,  2,  2, -5,-23,-27,-16,  3;
/M: SY='Q';  M= -5, -7,-24, -9,  1,-15,-19,  0,-10, -1,-10, -4, -4,-11,  2,  0, -3, -4,-10,-24, -7,  0;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/I:         MD=-15;
/M: SY='R';  M= -4, -7,-16, -8, -3, -8,-16, -2, -6, -1, -4, -2, -5,-14, -2,  3, -5, -2, -3,-17, -3, -4; D=-6;
/I:         I=-6; MI=-20; MD=-20; IM=-20; DM=-20;
/M: SY='P';  M= -4, -6,-21, -4,  1,-17,-12, -7,-12, -3,-14, -9, -4, 14,  1, -1,  0, -3,-14,-21,-14, -1; D=-6;
/I:         DM=-15;
/M: SY='C';  M=-12,-19, 78,-26,-25,-17,-28,-14,-27,-25,-18,-16,-18,-36,-22,-24,-13,-13,-14,-28,-17,-24;
/M: SY='T';  M= -4, -4,-19, -7, -4,-15,-15, -9,-16,  2,-16, -9,  0,-13,  0,  8,  9, 14, -9,-26, -9, -3;
/I:         II=-6; MI=-8; IM=-8; MD=-15; DM=-15; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0;
/M: SY='R';  M= -8, -6,-25, -8, -3,-16,-18, -2,-11,  0,-12, -5, -2, -6,  0,  1, -4, -3,-11,-24, -8, -3;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='E';  M= -7,  3,-27,  5,  9,-24,-10, -6,-22,  0,-21,-15,  3,  5,  2, -4,  1, -3,-21,-29,-18,  4;
/I:         MD=-15;
/M: SY='P';  M= -6, -7,-28, -5, -1,-21,-11,-10,-16, -5,-17,-11, -5, 19, -6, -9, -4, -6,-17,-27,-18, -5; D=-4;
/I:         MD=-15;
/M: SY='G';  M= -3,  0,-26, -1, -7,-24, 31,-11,-29,-10,-24,-16,  5,-17,-10,-11,  1,-11,-23,-23,-21, -9; D=-4;
/I:         MD=-15;
/M: SY='Q';  M= -9, -5,-22, -6,  0, -7,-12,  0,-13, -8, -6, -2, -4,-16,  1, -7, -4, -2,-13,-20, -2,  0; D=-4;
/I:         II=-7; MI=0; IM=0; MD=-15; DM=-15; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0;
/M:         M= -6, -9,-20, -9, -3, -8, -7, -7,-10, -4,-10, -6, -7,-16, -6,  0, -4, -6, -5,-17, -4, -5; D=-4;
/I:         DM=-15;
/M: SY='V';  M= -4,-18,-11,-18, -8, -8,-23,-19,  5,-13,  3,  3,-18,-18,-14,-14, -9, -4, 11,-27,-11,-11;
/M: SY='V';  M= -2,-12,-20,-15, -8,-11,-21,-14,  0, -3, -2,  2,-10,-18, -5, -5, -5,  1,  4,-24, -8, -7;
/M: SY='Q';  M= -2, -4,-23, -7,  3,-20,-15, -5,-16,  7,-16, -6, -1,-13, 10,  7,  2, -3,-13,-24,-11,  6;
/M: SY='P';  M= -8, -2,-28,  1,  2,-20,-14, -9,-16, -5,-16,-12, -3, 12, -5, -9, -4, -6,-17,-28,-16, -3;
/M: SY='C';  M= -4,-16, 73,-23,-23,-22,-10,-22,-29,-24,-21,-18,-14,-32,-24,-24, -6,-11,-13,-41,-27,-24;
/M: SY='T';  M= -1,  0,-17, -4, -5,-17,-12,-15,-14, -7,-15,-12,  2, -6, -6, -9, 12, 23, -8,-30,-14, -6;
/M: SY='R';  M=  1, -3,-24, -3,  2,-22, -7, -9,-20,  1,-18,-12, -2, -6,  0,  3,  2, -3,-15,-24,-16,  0;
/I:         MD=-20;
/M: SY='T';  M= -5,  4,-19,  1,  1,-17,-14, -8,-15, -1,-17,-11,  6, -9,  0, -4,  7, 12,-12,-26,-11,  1; D=-6;
/I:         II=-7; MI=-8; IM=-8; MD=-15; DM=-15; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0;
/M: SY='S';  M= -2,  0,-21, -2,  1,-23, -4, -5,-22,  1,-21,-12,  4,-13,  7,  5,  9,  5,-17,-28,-14,  3;
/M: SY='D';  M=-12, 34,-26, 37, 11,-30, -8,  3,-29,  1,-28,-23, 26, -8,  1, -5,  4, -5,-27,-37,-19,  6;
/M: SY='T';  M=  7, -7,-13,-14,-11,-12,-17,-19, -7, -8, -9, -8, -5,-11,-11, -7, 11, 25,  4,-28,-13,-12;
/M: SY='V';  M= -6,-16,-20,-16,-10,-11,-27,-15, 10, -9,  1,  3,-16,-18,-10,-11, -9, -3, 16,-27, -9,-11;
/M: SY='C';  M= -9,-19,115,-29,-29,-20,-29,-29,-29,-29,-20,-20,-18,-39,-29,-29, -9,-10,-10,-49,-30,-29;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2026_04 which contains 576'073 sequence entries.


Total number of hits 166 in 82 different sequences
Number of true positive hits 165 in 81 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 19
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 99.40 %
Recall (true positives / (true positives + false negatives)) 89.67 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 4
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Feature key [info] REPEAT
Feature description [info] TNFR-Cys
Version [info] 6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 81 sequences 

A53R_VACCW  (P24756), A53_VACCC   (P21071), ACCR1_ARATH (Q9S7D9), 

ACR4L_ARATH (Q9LX29), CD27_HUMAN  (P26842), CD27_MOUSE  (P41272), 
CKI4_ORYSJ  (Q75J39), CRI4_MAIZE  (O24585), CRMB_CAMPM  (P68636), 
CRMB_CAMPS  (P68637), CRMB_CWPXG  (O73559), CRMB_MONPV  (P0DTN0), 
CRMB_VAR67  (P0DSV7), CRMB_VARV   (P0DSV8), TNF6B_HUMAN (O95407), 
TNR11_HUMAN (Q9Y6Q6), TNR11_MOUSE (O35305), TNR14_HUMAN (Q92956), 
TNR14_MOUSE (Q80WM9), TNR16_CHICK (P18519), TNR16_HUMAN (P08138), 
TNR16_MOUSE (Q9Z0W1), TNR16_RAT   (P07174), TNR19_HUMAN (Q9NS68), 
TNR19_MOUSE (Q9JLL3), TNR1A_BOVIN (O19131), TNR1A_HUMAN (P19438), 
TNR1A_MOUSE (P25118), TNR1A_PIG   (P50555), TNR1A_RAT   (P22934), 
TNR1B_HUMAN (P20333), TNR1B_MOUSE (P25119), TNR1B_RAT   (Q80WY6), 
TNR21_HUMAN (O75509), TNR21_MOUSE (Q9EPU5), TNR21_RAT   (D3ZF92), 
TNR22_MOUSE (Q9ER62), TNR23_MOUSE (Q9ER63), TNR25_HUMAN (Q93038), 
TNR26_MOUSE (P83626), TNR27_HUMAN (Q9HAV5), TNR27_MOUSE (Q8BX35), 
TNR3_HUMAN  (P36941), TNR3_MOUSE  (P50284), TNR4_HUMAN  (P43489), 
TNR4_MOUSE  (P47741), TNR4_RAT(P15725), TNR5_BOVIN  (Q28203), 
TNR5_CALJA  (Q3LRP1), TNR5_CANLF  (Q7YRL5), TNR5_HORSE  (Q3ZTK5), 
TNR5_HUMAN  (P25942), TNR5_MOUSE  (P27512), TNR5_PIG(Q8SQ34), 
TNR6_BOVIN  (P51867), TNR6_CERAT  (Q9BDN4), TNR6_HUMAN  (P25445), 
TNR6_MACFA  (Q9TSN4), TNR6_MACMU  (Q9BDP2), TNR6_MACNE  (Q9BDN0), 
TNR6_MOUSE  (P25446), TNR6_PIG(O77736), TNR6_RAT(Q63199), 
TNR8_HUMAN  (P28908), TNR8_MOUSE  (Q60846), TNR8_RAT(P97525), 
TNR9_HUMAN  (Q07011), TR10A_HUMAN (O00220), TR10B_HUMAN (O14763), 
TR10B_MOUSE (Q9QZM4), TR10C_HUMAN (O14798), TR10D_HUMAN (Q9UBN6), 
TR11B_BOVIN (A5D7R1), TR11B_HUMAN (O00300), TR11B_MOUSE (O08712), 
TR11B_RAT   (O08727), UL144_HCMVM (F5HAM0), UL144_HCMVO (Q68396), 
VT2_MYXVL   (P29825), VT2_RFVKA   (P25943), WGN_DROME   (Q9VWS4)
» more

UniProtKB/Swiss-Prot
False negative sequences		 19 sequences 

ACCR2_ARATH (O80963), C22L_VACCC  (P21106), EDAR_HUMAN  (Q9UNE0), 

EDAR_MOUSE  (Q9R187), EDAR_ORYLA  (Q90VY2), TNR12_HUMAN (Q9NP84), 
TNR12_MOUSE (Q9CR75), TNR17_HUMAN (Q02223), TNR17_MOUSE (O88472), 
TNR18_HUMAN (Q9Y5U5), TNR18_MOUSE (O35714), TNR9_MOUSE  (P20334), 
TR13B_HUMAN (O14836), TR13B_MOUSE (Q9ET35), TR13C_HUMAN (Q96RJ3), 
TR13C_MOUSE (Q9D8D0), TR19L_HUMAN (Q969Z4), TR19L_MACFA (Q9N092), 
TR19L_MOUSE (Q8BX43)
» more

UniProtKB/Swiss-Prot
False positive sequences		 1 sequence 

LAMA5_HUMAN (O15230)


				
	

	

		PDB
[Detailed view]		
		
			105 PDB
			


			pdb_00001d0g; pdb_00001d4v; pdb_00001du3; pdb_00001ext; pdb_00001ft4; 
			
				pdb_00001jma; pdb_00001ncf; pdb_00001sg1; pdb_00001tnr; pdb_00001za3; 
				pdb_00002aw2; pdb_00002h9g; pdb_00002hev; pdb_00002hey; pdb_00002kn1; 
				pdb_00003alq; pdb_00003buk; pdb_00003ij2; pdb_00003k51; pdb_00003me2; 
				pdb_00003me4; pdb_00003mhd; pdb_00003mi8; pdb_00003qbq; pdb_00003qd6; 
				pdb_00003qo4; pdb_00003thm; pdb_00003tje; pdb_00003u3p; pdb_00003u3q; 
				pdb_00003u3s; pdb_00003u3t; pdb_00003u3v; pdb_00003urf; pdb_00003x3f; 
				pdb_00004e4d; pdb_00004fhq; pdb_00004giq; pdb_00004i9x; pdb_00004j6g; 
				pdb_00004kgg; pdb_00004kgq; pdb_00004msv; pdb_00004mxw; pdb_00004n90; 
				pdb_00004od2; pdb_00004rsu; pdb_00004yn0; pdb_00005bnq; pdb_00005cir; 
				pdb_00005dmi; pdb_00005dmj; pdb_00005ihl; pdb_00005l36; pdb_00005t2q; 
				pdb_00005t2r; pdb_00005tl5; pdb_00005tlj; pdb_00005tlk; pdb_00005wi8; 
				pdb_00005wiw; pdb_00005wjf; pdb_00006a3v; pdb_00006a3w; pdb_00006bwv; 
				pdb_00006cpr; pdb_00006cu0; pdb_00006fax; pdb_00006mgp; pdb_00006mhr; 
				pdb_00006mi2; pdb_00006mkz; pdb_00006ng3; pdb_00006ogx; pdb_00006okm; 
				pdb_00006okn; pdb_00006pe8; pdb_00006pe9; pdb_00006t3j; pdb_00006y8k; 
				pdb_00007d4b; pdb_00007kp7; pdb_00007kp8; pdb_00007kpb; pdb_00007kx0; 
				pdb_00007msg; pdb_00007msj; pdb_00007p3i; pdb_00007x9g; pdb_00007yk4; 
				pdb_00007yxu; pdb_00008ag1; pdb_00008dpx; pdb_00008ds5; pdb_00008gye; 
				pdb_00008hlb; pdb_00008oz3; pdb_00008yx1; pdb_00008yx9; pdb_00008zui; 
				pdb_00009cu8; pdb_00009f7z; pdb_00009lfl; pdb_00009s3i; pdb_00009s3j
			
			

			» more