PROSITE entry PS50114
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General information about the entry
| Entry name [info] | GATA_ZN_FINGER_2 |
| Accession [info] | PS50114 |
| Entry type [info] | MATRIX |
| Date [info] |
01-DEC-2001 CREATED;
10-MAY-2017 DATA UPDATE; 03-MAY-2023 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00300 |
| Associated ProRule [info] | PRU00094 |
Name and characterization of the entry
| Description [info] | GATA-type zinc finger domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=54; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=49; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.6125000; R2=0.0131851; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=4579.0708008; R2=3.0117648; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=599; H_SCORE=6383; N_SCORE=8.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=447; H_SCORE=5925; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='R'; M=-10,-10,-19,-10, -4,-12,-19, -2,-19, 6,-17, -9, -5, -7, -2, 9, -3, -4,-14,-24, -7, -4; /M: SY='R'; M= -9, -2,-15, -6, -5,-19,-11, 0,-23, 5,-20,-12, 4,-18, -1, 18, 3, 4,-15,-29,-12, -5; /M: SY='E'; M= 6, -1,-24, 1, 18,-25,-10,-10,-20, -2,-17,-13, -6, 5, 4,-10, 1, -4,-17,-27,-20, 10; /M: SY='G'; M= 2, -5,-28, -3,-13,-28, 45,-18,-33,-17,-25,-19, 0,-14,-16,-19, 1,-15,-25,-23,-26,-15; /M: SY='R'; M=-12,-14,-24,-18, -9,-11,-24,-10, -4, 1, 2, 5, -9,-19, 1, 18,-10, 0, -4,-22, -6, -6; /M: SY='E'; M= -7, -1,-15, 2, 22,-24,-18, -6,-21, 5,-18,-12, -2,-11, 10, 5, 4, -2,-16,-30,-17, 15; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='T'; M= 4,-12,-12,-15,-12,-10,-17,-18, 0,-11, -9, -5, -9,-18, -9,-12, 11, 13, 12,-30,-12,-11; /M: SY='N'; M=-10, 40,-20, 20, 0,-20, 0, 10,-20, 0,-30,-20, 60,-20, 0, 0, 10, 0,-30,-40,-20, 0; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='G'; M= -5, -6,-27, -9, -8,-19, 17, 5,-27,-10,-20,-10, 1,-18, -1, -7, -3,-12,-23,-20,-11, -5; /M: SY='T'; M= 13, -6,-12,-13,-10,-14,-12,-20, -9, -7,-11, -9, -5,-12,-10,-11, 12, 24, 2,-27,-14,-10; /M: SY='T'; M= -3, -6,-16,-13,-10, -9,-20,-12, -4,-10, -8, -3, -2,-14, -6, -8, 10, 25, 0,-28, -8, -9; /M: SY='T'; M= 3, 3,-15, -4, -4,-17,-12, -4,-15, -4,-18,-11, 8,-12, -2, -6, 16, 21, -9,-31,-12, -4; /M: SY='T'; M= 0, 0,-10,-10,-10,-10,-20,-20,-10,-10,-10,-10, 0,-10,-10,-10, 20, 50, 0,-30,-10,-10; /M: SY='P'; M= -5,-13,-30, -9, -2,-25,-18,-19,-18,-10,-26,-18,-12, 57, -9,-17, 2, 6,-21,-31,-25, -9; /M: SY='L'; M=-10,-29,-20,-29,-19, 8,-30,-20, 18,-26, 46, 19,-29,-29,-19,-18,-29,-10, 9,-20, 0,-19; /M: SY='W'; M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20; /M: SY='R'; M=-20, -9,-30, -9, 0,-20,-20, 5,-30, 28,-20, -9, 1,-20, 10, 66,-10,-11,-21,-21, -8, 0; /M: SY='R'; M=-19, -9,-30, -9, 1,-21,-20, -1,-30, 31,-21,-10, 0,-19, 10, 67,-10,-10,-20,-20,-10, 1; /M: SY='D'; M= -9, 35,-24, 38, 8,-31, 0, -1,-31, -3,-29,-24, 27,-14, -2, -9, 7, -5,-26,-37,-21, 3; /M: SY='P'; M= 2,-11,-29, -8, -1,-27, 11,-16,-24,-10,-23,-16, -8, 20, -9,-15, -2,-11,-23,-25,-26, -7; /M: SY='D'; M= -6, 14,-21, 16, 13,-24,-13, -1,-24, -1,-21,-16, 7, -9, 3, -6, 10, 10,-18,-33,-14, 8; /M: SY='G'; M= -1, -6,-29, -8,-19,-29, 65,-18,-39,-19,-30,-20, 4,-20,-19,-19, 1,-19,-30,-21,-29,-19; /M: SY='H'; M= -9, 12,-24, 12, 9,-24,-13, 29,-24, -4,-21,-12, 15,-14, 8, -3, 4, -5,-24,-33, -6, 7; /M: SY='P'; M=-12,-17,-30,-15,-11, -3,-24, -6, -7,-11, -9, -6,-16, 20,-11,-15,-11, -2,-13,-10, 12,-14; /M: SY='L'; M= -7,-30,-19,-31,-24, 6,-31,-24, 27,-27, 35, 17,-29,-29,-23,-21,-23, -7, 23,-23, -3,-24; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='N'; M=-10, 38,-20, 19, 0,-20, -1, 10,-20, 1,-30,-20, 58,-20, 0, 2, 9, 0,-30,-39,-20, 0; /M: SY='A'; M= 48,-10,-11,-20,-10,-20, -1,-19,-11, -9,-10,-10,-10,-10, -9,-17, 9, 0, -1,-20,-20,-10; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='G'; M= 0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20, 0,-20,-20,-20, 0,-20,-30,-20,-30,-20; /M: SY='L'; M=-10,-30,-20,-30,-20, 12,-30,-20, 19,-30, 49, 19,-30,-30,-21,-20,-30,-10, 10,-19, 1,-20; /M: SY='Y'; M=-20,-22,-28,-24,-22, 40,-30, 12, 0,-14, 2, 0,-20,-30,-16,-12,-20,-10, -8, 26, 70,-22; /M: SY='H'; M=-15,-13,-25,-17,-11, 6,-24, 20, -3,-14, 2, 7, -7,-23, -2, -9,-14,-10, -9,-12, 18, -8; /M: SY='K'; M=-10, 0,-30, 0, 10,-30,-20,-10,-30, 49,-30,-10, 0,-10, 10, 31,-10,-10,-20,-20,-10, 10; /M: SY='L'; M= -9,-23,-21,-27,-18, 2,-25, -5, 16,-21, 29, 28,-21,-24,-11,-16,-20, -9, 7,-22, 0,-15; /M: SY='H'; M=-17, 12,-27, 6, 0,-20,-14, 61,-27, -2,-23, -7, 25,-20, 7, 6, -4,-13,-29,-32, 4, 0; /M: SY='G'; M= -3, -4,-28, -5,-11,-28, 41, -7,-34, -9,-29,-17, 6,-18, -9,-10, 3,-14,-27,-24,-22,-10; /M: SY='V'; M= -6,-16,-19,-19,-13,-10,-26, -6, 9,-11, 1, 8,-14,-20, -5,-11, -7, 0, 14,-26, -5,-10; /M: SY='N'; M= -3, 8,-23, 1, -3,-19,-10, 9,-15, -6,-21,-11, 17, 0, -3, -8, 2, -2,-18,-33,-14, -5; /M: SY='R'; M=-20,-10,-30,-10, 0,-20,-20, 0,-30, 30,-20,-10, 0,-20, 10, 70,-10,-10,-20,-20,-10, 0; /M: SY='P'; M= -9,-19,-38, -9, 0,-29,-19,-19,-20,-10,-30,-20,-18, 83, -9,-19, -7, -8,-29,-31,-29, -9; /M: SY='L'; M= -4,-28,-19,-30,-21, 5,-29,-22, 21,-27, 36, 16,-26,-27,-20,-21,-22, -6, 16,-22, -3,-21; /I: I=-6; MI=-32; MD=-32; IM=-32; /M: SY='T'; M= 4, -9,-17,-14,-10,-13,-14,-18, -2,-10,-12, -6, -3,-13, -8,-12, 13, 14, 2,-29,-12,-10; /I: DM=-32; /M: SY='M'; M=-10,-12,-22,-17, -9, -9,-20, -5, 1, 2, 8, 22,-10,-19, 2, 3,-16, -9, -3,-21, -5, -4; D=-6; /M: SY='K'; M=-12, -8,-33, -5, 5,-28,-20,-12,-27, 26,-28,-13, -7, 23, 3, 19,-10,-10,-23,-23,-17, 2; /M: SY='K'; M= -8, -3,-25, -5, 4,-23,-20,-10,-21, 25,-19, -7, -2,-12, 9, 17, -2, 3,-15,-23,-10, 6; /M: SY='D'; M=-10, 17,-27, 25, 17,-31,-13, -4,-32, 14,-26,-20, 8,-10, 6, 11, 1, -6,-23,-31,-17, 11; /I: I=-10; MI=0; IM=0; DM=-25; MD=-25; /M: SY='V'; M= 0,-19,-18,-22,-19, -8, -8,-20, 6,-20, 6, 4,-16,-22,-16,-18, -5, -2, 10,-25,-11,-18; /M: SY='I'; M= -6,-18,-26,-22,-17, -8,-28,-22, 23,-21, 6, 7,-12,-14,-12,-20, -9, -5, 13,-25, -7,-18; /M: SY='Q'; M= 4, -3,-23, -5, 5,-28,-14, -7,-17, 14,-20, -7, -1,-12, 18, 6, 2, -4,-14,-23,-13, 11; /M: SY='T'; M= 5, -2,-16, -6, -2,-20,-12,-13,-19, 7,-21,-13, 2,-11, -1, 6, 15, 16, -9,-29,-14, -2; /M: SY='R'; M=-20,-10,-30,-10, 0,-20,-20, 0,-30, 30,-20,-10, 0,-20, 10, 70,-10,-10,-20,-20,-10, 0; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 210 in 160 different sequences |
| Number of true positive hits | 209 in 159 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 1 |
| Number of false negative sequences | 18 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 99.52 % |
| Recall (true positives / (true positives + false negatives)) | 92.07 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | K_Hofmann |
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 2 |
| Feature key [info] | ZN_FING |
| Feature description [info] | GATA-type |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
159 sequences
AMS2_SCHPO (Q9URT4 ), AREA_ASPNG (O13412 ), AREA_ASPOR (O13415 ), AREA_EMENI (P17429 ), AREA_GIBFU (P78688 ), AREA_PENCH (Q01582 ), AREA_PENRO (O13508 ), ASD4_NEUCR (Q9HEV5 ), ASH1_CANAL (Q5A5Q6 ), ASH1_YEAST (P34233 ), BRG1_CANAL (Q59LY1 ), CGA1_ORYSJ (Q6YW48 ), CGPB_FUSVN (Q00858 ), DAL80_YEAST (P26343 ), ECM23_YEAST (Q02710 ), EGL18_CAEEL (G5EGF4 ), EGL27_CAEEL (Q09228 ), ELT1_CAEEL (P28515 ), ELT2_CAEEL (Q10655 ), ELT3_CAEEL (B7WN96 ), ELT4_CAEEL (Q8MQA7 ), ELT6_CAEEL (G5EGN3 ), ELT7_CAEEL (O61924 ), FEP1_SCHPO (Q10134 ), FIL1_SCHPO (O94720 ), GAF1_SCHPO (Q10280 ), GAT10_ARATH (Q8VZP4 ), GAT11_ARATH (Q6DBP8 ), GAT12_ARATH (P69781 ), GAT13_ARATH (Q9SKN6 ), GAT14_ARATH (Q9M1U2 ), GAT15_ARATH (Q8LG10 ), GAT15_ORYSI (B8AX51 ), GAT15_ORYSJ (Q6L5E5 ), GAT16_ARATH (Q9FJ10 ), GAT17_ARATH (Q9LIB5 ), GAT17_ORYSJ (Q6Z433 ), GAT18_ARATH (Q8LC79 ), GAT18_ORYSI (A2XKR7 ), GAT18_ORYSJ (Q10F25 ), GAT19_ARATH (Q6QPM2 ), GAT1A_XENLA (P23767 ), GAT1B_XENLA (P23768 ), GAT1_CANAL (Q5A432 ), GAT1_YEAST (P43574 ), GAT20_ARATH (Q9ZPX0 ), GAT20_ORYSJ (Q5Z4U5 ), GAT21_ARATH (Q5HZ36 ), GAT22_ARATH (Q9SZI6 ), GAT23_ARATH (Q8LC59 ), GAT24_ARATH (Q8GXL7 ), GAT25_ARATH (Q9LRH6 ), GAT26_ARATH (Q8W4H1 ), GAT27_ARATH (Q5PP38 ), GAT28_ARATH (Q8H1G0 ), GAT29_ARATH (Q9LT45 ), GAT2_YEAST (P40209 ), GAT3_YEAST (Q07928 ), GAT4_YEAST (P40569 ), GAT5A_XENLA (P43695 ), GAT5B_XENLA (P43696 ), GAT6A_XENLA (Q91678 ), GAT6B_XENLA (P70005 ), GATA1_ARATH (Q8LAU9 ), GATA1_BOVIN (A2VDY6 ), GATA1_CHICK (P17678 ), GATA1_HUMAN (P15976 ), GATA1_MOUSE (P17679 ), GATA1_RAT (P43429 ), GATA2_ARATH (O49741 ), GATA2_CHICK (P23824 ), GATA2_HUMAN (P23769 ), GATA2_MOUSE (O09100 ), GATA2_RAT (Q924Y4 ), GATA2_XENLA (P23770 ), GATA3_ARATH (Q8L4M6 ), GATA3_BOVIN (Q08DV0 ), GATA3_CHICK (P23825 ), GATA3_DANRE (Q91428 ), GATA3_HUMAN (P23771 ), GATA3_MOUSE (P23772 ), GATA3_XENLA (P23773 ), GATA4_ARATH (O49743 ), GATA4_CANLF (Q0Q0E4 ), GATA4_CHICK (P43691 ), GATA4_HUMAN (P43694 ), GATA4_MOUSE (Q08369 ), GATA4_RAT (P46152 ), GATA4_XENLA (Q91677 ), GATA5_ARATH (Q9FH57 ), GATA5_BOVIN (Q3SZJ5 ), GATA5_CHICK (P43692 ), GATA5_HUMAN (Q9BWX5 ), GATA5_MOUSE (P97489 ), GATA6_ARATH (Q9SD38 ), GATA6_CHICK (P43693 ), GATA6_HUMAN (Q92908 ), GATA6_MOUSE (Q61169 ), GATA6_PIG (Q95JA5 ), GATA6_RAT (P46153 ), GATA7_ARATH (O65515 ), GATA8_ARATH (Q9SV30 ), GATA9_ARATH (O82632 ), GATAB_BOMMO (P52167 ), GATAC_DROME (P91623 ), GATD1_DANRE (Q1L8G7 ), GATD1_HUMAN (Q8WUU5 ), GATD1_MOUSE (Q920S3 ), GATD1_XENLA (Q7ZXY4 ), GLN3_YEAST (P18494 ), GTAA_DICDI (Q550D5 ), GTAB_DICDI (Q54V32 ), GTAC_DICDI (Q75JZ1 ), GTAD_DICDI (Q54L72 ), GTAE_DICDI (Q55GK0 ), GTAF_DICDI (Q55EQ0 ), GTAG_DICDI (Q55C49 ), GTAH_DICDI (Q75JZ0 ), GTAI_DICDI (Q54TM6 ), GTAJ_DICDI (Q54TE3 ), GTAK_DICDI (Q5KSV0 ), GTAL_DICDI (Q54NM5 ), GTAN_DICDI (Q54KX0 ), GTAO_DICDI (Q54HA4 ), GTAP_DICDI (B0G188 ), GTAQ_DICDI (Q54L80 ), GTAR_DICDI (Q54WY0 ), GTAT_DICDI (Q54V37 ), GTAU_DICDI (Q54US7 ), GTAW_DICDI (Q54L82 ), GTAX_DICDI (Q54FV1 ), GZF3_CANAL (Q5A201 ), GZF3_YEAST (P42944 ), NIT2_NEUCR (P19212 ), NRFA_PENUR (Q92269 ), NUT1_MAGO7 (Q01168 ), P66A_HUMAN (Q86YP4 ), P66B_HUMAN (Q8WXI9 ), P66B_MOUSE (Q8VHR5 ), PNR_DROME (P52168 ), RCORA_CAEEL (Q95Y41 ), RCORB_CAEEL (Q18919 ), SFU1_CANAL (Q5AP95 ), SREA_AJECA (B4XXY3 ), SREA_ARTBC (D4B3J8 ), SREA_ASPFU (Q4WV91 ), SREA_COCH4 (N4XMB0 ), SREA_EMENI (G5EB20 ), SREA_NEUCR (Q1K8E7 ), SREP_PENCH (Q92259 ), SRP_DROME (P52172 ), TRPS1_HUMAN (Q9UHF7 ), TRPS1_MOUSE (Q925H1 ), TRPS1_XENLA (Q90ZS6 ), URB1_USTMA (P40349 ), WC1_NEUCR (Q01371 ), WC2_NEUCR (P78714 ), ZGLP1_HUMAN (P0C6A0 ), ZGLP1_MOUSE (Q1WG82 )» more
|
| UniProtKB/Swiss-Prot False negative sequences |
18 sequences
GAT19_ORYSI (B8AR30 ), GAT19_ORYSJ (Q0DNU1 ), GTAM_DICDI (Q54L83 ), GTAV_DICDI (Q54UG8 ), GTAY_DICDI (Q54X31 ), MTA1_HUMAN (Q13330 ), MTA1_MOUSE (Q8K4B0 ), MTA1_RAT (Q62599 ), MTA2_HUMAN (O94776 ), MTA2_MOUSE (Q9R190 ), MTA3_BOVIN (A6QL72 ), MTA3_HUMAN (Q9BTC8 ), MTA3_MOUSE (Q924K8 ), P66A_MOUSE (Q8CHY6 ), RERE_HUMAN (Q9P2R6 ), RERE_MOUSE (Q80TZ9 ), RERE_RAT (Q62901 ), SRD1_YEAST (P09007 )» more |
| UniProtKB/Swiss-Prot False positive sequences |
1 sequence
IF2B_THEAC (Q9HKJ3 ) |
| PDB [Detailed view] |
28 PDB
1GAT; 1GAU; 1GNF; 1Y0J; 2GAT; 2L6Y; 2L6Z; 2M9W; 2VUS; 2VUT; 2VUU; 3DFV; 3DFX; 3GAT; 3VD6; 3VEK; 4GAT; 4HC7; 4HC9; 4HCA; 5GAT; 5O9B; 6GAT; 6ZFV; 7AO8; 7AO9; 7AOA; 7GAT » more |