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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS50114


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PURL: https://purl.expasy.org/prosite/signature/PS50114

Direct ScanProsite submission
General information about the entry

Entry name [info] GATA_ZN_FINGER_2
Accession [info] PS50114
Entry type [info] MATRIX
Date [info] 01-DEC-2001 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00300
Associated ProRule [info] PRU00094

Name and characterization of the entry

Description [info] GATA-type zinc finger domain profile.
Matrix / Profile [info] 
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=54;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=49;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.6125000; R2=0.0131851; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=4579.0708008; R2=3.0117648; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=599; H_SCORE=6383; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=447; H_SCORE=5925; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;

...
 
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='R';  M=-10,-10,-19,-10, -4,-12,-19, -2,-19,  6,-17, -9, -5, -7, -2,  9, -3, -4,-14,-24, -7, -4;
/M: SY='R';  M= -9, -2,-15, -6, -5,-19,-11,  0,-23,  5,-20,-12,  4,-18, -1, 18,  3,  4,-15,-29,-12, -5;
/M: SY='E';  M=  6, -1,-24,  1, 18,-25,-10,-10,-20, -2,-17,-13, -6,  5,  4,-10,  1, -4,-17,-27,-20, 10;
/M: SY='G';  M=  2, -5,-28, -3,-13,-28, 45,-18,-33,-17,-25,-19,  0,-14,-16,-19,  1,-15,-25,-23,-26,-15;
/M: SY='R';  M=-12,-14,-24,-18, -9,-11,-24,-10, -4,  1,  2,  5, -9,-19,  1, 18,-10,  0, -4,-22, -6, -6;
/M: SY='E';  M= -7, -1,-15,  2, 22,-24,-18, -6,-21,  5,-18,-12, -2,-11, 10,  5,  4, -2,-16,-30,-17, 15;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='T';  M=  4,-12,-12,-15,-12,-10,-17,-18,  0,-11, -9, -5, -9,-18, -9,-12, 11, 13, 12,-30,-12,-11;
/M: SY='N';  M=-10, 40,-20, 20,  0,-20,  0, 10,-20,  0,-30,-20, 60,-20,  0,  0, 10,  0,-30,-40,-20,  0;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='G';  M= -5, -6,-27, -9, -8,-19, 17,  5,-27,-10,-20,-10,  1,-18, -1, -7, -3,-12,-23,-20,-11, -5;
/M: SY='T';  M= 13, -6,-12,-13,-10,-14,-12,-20, -9, -7,-11, -9, -5,-12,-10,-11, 12, 24,  2,-27,-14,-10;
/M: SY='T';  M= -3, -6,-16,-13,-10, -9,-20,-12, -4,-10, -8, -3, -2,-14, -6, -8, 10, 25,  0,-28, -8, -9;
/M: SY='T';  M=  3,  3,-15, -4, -4,-17,-12, -4,-15, -4,-18,-11,  8,-12, -2, -6, 16, 21, -9,-31,-12, -4;
/M: SY='T';  M=  0,  0,-10,-10,-10,-10,-20,-20,-10,-10,-10,-10,  0,-10,-10,-10, 20, 50,  0,-30,-10,-10;
/M: SY='P';  M= -5,-13,-30, -9, -2,-25,-18,-19,-18,-10,-26,-18,-12, 57, -9,-17,  2,  6,-21,-31,-25, -9;
/M: SY='L';  M=-10,-29,-20,-29,-19,  8,-30,-20, 18,-26, 46, 19,-29,-29,-19,-18,-29,-10,  9,-20,  0,-19;
/M: SY='W';  M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20;
/M: SY='R';  M=-20, -9,-30, -9,  0,-20,-20,  5,-30, 28,-20, -9,  1,-20, 10, 66,-10,-11,-21,-21, -8,  0;
/M: SY='R';  M=-19, -9,-30, -9,  1,-21,-20, -1,-30, 31,-21,-10,  0,-19, 10, 67,-10,-10,-20,-20,-10,  1;
/M: SY='D';  M= -9, 35,-24, 38,  8,-31,  0, -1,-31, -3,-29,-24, 27,-14, -2, -9,  7, -5,-26,-37,-21,  3;
/M: SY='P';  M=  2,-11,-29, -8, -1,-27, 11,-16,-24,-10,-23,-16, -8, 20, -9,-15, -2,-11,-23,-25,-26, -7;
/M: SY='D';  M= -6, 14,-21, 16, 13,-24,-13, -1,-24, -1,-21,-16,  7, -9,  3, -6, 10, 10,-18,-33,-14,  8;
/M: SY='G';  M= -1, -6,-29, -8,-19,-29, 65,-18,-39,-19,-30,-20,  4,-20,-19,-19,  1,-19,-30,-21,-29,-19;
/M: SY='H';  M= -9, 12,-24, 12,  9,-24,-13, 29,-24, -4,-21,-12, 15,-14,  8, -3,  4, -5,-24,-33, -6,  7;
/M: SY='P';  M=-12,-17,-30,-15,-11, -3,-24, -6, -7,-11, -9, -6,-16, 20,-11,-15,-11, -2,-13,-10, 12,-14;
/M: SY='L';  M= -7,-30,-19,-31,-24,  6,-31,-24, 27,-27, 35, 17,-29,-29,-23,-21,-23, -7, 23,-23, -3,-24;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='N';  M=-10, 38,-20, 19,  0,-20, -1, 10,-20,  1,-30,-20, 58,-20,  0,  2,  9,  0,-30,-39,-20,  0;
/M: SY='A';  M= 48,-10,-11,-20,-10,-20, -1,-19,-11, -9,-10,-10,-10,-10, -9,-17,  9,  0, -1,-20,-20,-10;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='G';  M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='L';  M=-10,-30,-20,-30,-20, 12,-30,-20, 19,-30, 49, 19,-30,-30,-21,-20,-30,-10, 10,-19,  1,-20;
/M: SY='Y';  M=-20,-22,-28,-24,-22, 40,-30, 12,  0,-14,  2,  0,-20,-30,-16,-12,-20,-10, -8, 26, 70,-22;
/M: SY='H';  M=-15,-13,-25,-17,-11,  6,-24, 20, -3,-14,  2,  7, -7,-23, -2, -9,-14,-10, -9,-12, 18, -8;
/M: SY='K';  M=-10,  0,-30,  0, 10,-30,-20,-10,-30, 49,-30,-10,  0,-10, 10, 31,-10,-10,-20,-20,-10, 10;
/M: SY='L';  M= -9,-23,-21,-27,-18,  2,-25, -5, 16,-21, 29, 28,-21,-24,-11,-16,-20, -9,  7,-22,  0,-15;
/M: SY='H';  M=-17, 12,-27,  6,  0,-20,-14, 61,-27, -2,-23, -7, 25,-20,  7,  6, -4,-13,-29,-32,  4,  0;
/M: SY='G';  M= -3, -4,-28, -5,-11,-28, 41, -7,-34, -9,-29,-17,  6,-18, -9,-10,  3,-14,-27,-24,-22,-10;
/M: SY='V';  M= -6,-16,-19,-19,-13,-10,-26, -6,  9,-11,  1,  8,-14,-20, -5,-11, -7,  0, 14,-26, -5,-10;
/M: SY='N';  M= -3,  8,-23,  1, -3,-19,-10,  9,-15, -6,-21,-11, 17,  0, -3, -8,  2, -2,-18,-33,-14, -5;
/M: SY='R';  M=-20,-10,-30,-10,  0,-20,-20,  0,-30, 30,-20,-10,  0,-20, 10, 70,-10,-10,-20,-20,-10,  0;
/M: SY='P';  M= -9,-19,-38, -9,  0,-29,-19,-19,-20,-10,-30,-20,-18, 83, -9,-19, -7, -8,-29,-31,-29, -9;
/M: SY='L';  M= -4,-28,-19,-30,-21,  5,-29,-22, 21,-27, 36, 16,-26,-27,-20,-21,-22, -6, 16,-22, -3,-21;
/I:         I=-6; MI=-32; MD=-32; IM=-32;
/M: SY='T';  M=  4, -9,-17,-14,-10,-13,-14,-18, -2,-10,-12, -6, -3,-13, -8,-12, 13, 14,  2,-29,-12,-10;
/I:         DM=-32;
/M: SY='M';  M=-10,-12,-22,-17, -9, -9,-20, -5,  1,  2,  8, 22,-10,-19,  2,  3,-16, -9, -3,-21, -5, -4; D=-6;
/M: SY='K';  M=-12, -8,-33, -5,  5,-28,-20,-12,-27, 26,-28,-13, -7, 23,  3, 19,-10,-10,-23,-23,-17,  2;
/M: SY='K';  M= -8, -3,-25, -5,  4,-23,-20,-10,-21, 25,-19, -7, -2,-12,  9, 17, -2,  3,-15,-23,-10,  6;
/M: SY='D';  M=-10, 17,-27, 25, 17,-31,-13, -4,-32, 14,-26,-20,  8,-10,  6, 11,  1, -6,-23,-31,-17, 11;
/I:         I=-10; MI=0; IM=0; DM=-25; MD=-25;
/M: SY='V';  M=  0,-19,-18,-22,-19, -8, -8,-20,  6,-20,  6,  4,-16,-22,-16,-18, -5, -2, 10,-25,-11,-18;
/M: SY='I';  M= -6,-18,-26,-22,-17, -8,-28,-22, 23,-21,  6,  7,-12,-14,-12,-20, -9, -5, 13,-25, -7,-18;
/M: SY='Q';  M=  4, -3,-23, -5,  5,-28,-14, -7,-17, 14,-20, -7, -1,-12, 18,  6,  2, -4,-14,-23,-13, 11;
/M: SY='T';  M=  5, -2,-16, -6, -2,-20,-12,-13,-19,  7,-21,-13,  2,-11, -1,  6, 15, 16, -9,-29,-14, -2;
/M: SY='R';  M=-20,-10,-30,-10,  0,-20,-20,  0,-30, 30,-20,-10,  0,-20, 10, 70,-10,-10,-20,-20,-10,  0;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 212 in 162 different sequences
Number of true positive hits 211 in 161 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 18
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 99.53 %
Recall (true positives / (true positives + false negatives)) 92.14 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Feature key [info] ZN_FING
Feature description [info] GATA-type
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 161 sequences 

AMS2_SCHPO  (Q9URT4), AREA_ASPNG  (O13412), AREA_ASPOR  (O13415), 

AREA_EMENI  (P17429), AREA_FUSFU  (P78688), AREA_PENCH  (Q01582), 
AREA_PENRO  (O13508), ASD4_NEUCR  (Q9HEV5), ASH1_CANAL  (Q5A5Q6), 
ASH1_YEAST  (P34233), BRG1_CANAL  (Q59LY1), CGA1_ORYSJ  (Q6YW48), 
CGPB_FUSVN  (Q00858), DAL80_YEAST (P26343), ECM23_YEAST (Q02710), 
EGL18_CAEEL (G5EGF4), EGL27_CAEEL (Q09228), ELT1_CAEEL  (P28515), 
ELT2_CAEEL  (Q10655), ELT3_CAEEL  (B7WN96), ELT4_CAEEL  (Q8MQA7), 
ELT6_CAEEL  (G5EGN3), ELT7_CAEEL  (O61924), FEP1_SCHPO  (Q10134), 
FIL1_SCHPO  (O94720), GAF1_SCHPO  (Q10280), GAT10_ARATH (Q8VZP4), 
GAT11_ARATH (Q6DBP8), GAT12_ARATH (P69781), GAT13_ARATH (Q9SKN6), 
GAT14_ARATH (Q9M1U2), GAT15_ARATH (Q8LG10), GAT15_ORYSI (B8AX51), 
GAT15_ORYSJ (Q6L5E5), GAT16_ARATH (Q9FJ10), GAT17_ARATH (Q9LIB5), 
GAT17_ORYSJ (Q6Z433), GAT18_ARATH (Q8LC79), GAT18_ORYSI (A2XKR7), 
GAT18_ORYSJ (Q10F25), GAT19_ARATH (Q6QPM2), GAT1A_XENLA (P23767), 
GAT1B_XENLA (P23768), GAT1_CANAL  (Q5A432), GAT1_YEAST  (P43574), 
GAT20_ARATH (Q9ZPX0), GAT20_ORYSJ (Q5Z4U5), GAT21_ARATH (Q5HZ36), 
GAT22_ARATH (Q9SZI6), GAT23_ARATH (Q8LC59), GAT24_ARATH (Q8GXL7), 
GAT25_ARATH (Q9LRH6), GAT26_ARATH (Q8W4H1), GAT27_ARATH (Q5PP38), 
GAT28_ARATH (Q8H1G0), GAT29_ARATH (Q9LT45), GAT2_YEAST  (P40209), 
GAT3_YEAST  (Q07928), GAT4_YEAST  (P40569), GAT5A_XENLA (P43695), 
GAT5B_XENLA (P43696), GAT6A_XENLA (Q91678), GAT6B_XENLA (P70005), 
GATA1_ARATH (Q8LAU9), GATA1_BOVIN (A2VDY6), GATA1_CHICK (P17678), 
GATA1_HUMAN (P15976), GATA1_MOUSE (P17679), GATA1_RAT   (P43429), 
GATA2_ARATH (O49741), GATA2_CHICK (P23824), GATA2_HUMAN (P23769), 
GATA2_MOUSE (O09100), GATA2_RAT   (Q924Y4), GATA2_XENLA (P23770), 
GATA3_ARATH (Q8L4M6), GATA3_BOVIN (Q08DV0), GATA3_CHICK (P23825), 
GATA3_DANRE (Q91428), GATA3_HUMAN (P23771), GATA3_MOUSE (P23772), 
GATA3_XENLA (P23773), GATA4_ARATH (O49743), GATA4_CANLF (Q0Q0E4), 
GATA4_CHICK (P43691), GATA4_HUMAN (P43694), GATA4_MOUSE (Q08369), 
GATA4_RAT   (P46152), GATA4_XENLA (Q91677), GATA5_ARATH (Q9FH57), 
GATA5_BOVIN (Q3SZJ5), GATA5_CHICK (P43692), GATA5_HUMAN (Q9BWX5), 
GATA5_MOUSE (P97489), GATA6_ARATH (Q9SD38), GATA6_CHICK (P43693), 
GATA6_HUMAN (Q92908), GATA6_MOUSE (Q61169), GATA6_PIG   (Q95JA5), 
GATA6_RAT   (P46153), GATA7_ARATH (O65515), GATA8_ARATH (Q9SV30), 
GATA9_ARATH (O82632), GATAB_BOMMO (P52167), GATAC_DROME (P91623), 
GATD1_DANRE (Q1L8G7), GATD1_HUMAN (Q8WUU5), GATD1_MOUSE (Q920S3), 
GATD1_XENLA (Q7ZXY4), GLN3_YEAST  (P18494), GTAA_DICDI  (Q550D5), 
GTAB_DICDI  (Q54V32), GTAC_DICDI  (Q75JZ1), GTAD_DICDI  (Q54L72), 
GTAE_DICDI  (Q55GK0), GTAF_DICDI  (Q55EQ0), GTAG_DICDI  (Q55C49), 
GTAH_DICDI  (Q75JZ0), GTAI_DICDI  (Q54TM6), GTAJ_DICDI  (Q54TE3), 
GTAK_DICDI  (Q5KSV0), GTAL_DICDI  (Q54NM5), GTAN_DICDI  (Q54KX0), 
GTAO_DICDI  (Q54HA4), GTAP_DICDI  (B0G188), GTAQ_DICDI  (Q54L80), 
GTAR_DICDI  (Q54WY0), GTAT_DICDI  (Q54V37), GTAU_DICDI  (Q54US7), 
GTAW_DICDI  (Q54L82), GTAX_DICDI  (Q54FV1), GZF3_CANAL  (Q5A201), 
GZF3_YEAST  (P42944), LREA_ASPFL  (A0A364LYQ6), LREB_ASPFL  (A0A5N6H279), 
NIT2_NEUCR  (P19212), NRFA_PENUR  (Q92269), NUT1_PYRO7  (Q01168), 
P66A_HUMAN  (Q86YP4), P66B_HUMAN  (Q8WXI9), P66B_MOUSE  (Q8VHR5), 
PNR_DROME   (P52168), RCORA_CAEEL (Q95Y41), RCORB_CAEEL (Q18919), 
SFU1_CANAL  (Q5AP95), SREA_AJECA  (B4XXY3), SREA_ARTBC  (D4B3J8), 
SREA_ASPFU  (Q4WV91), SREA_COCH4  (N4XMB0), SREA_EMENI  (G5EB20), 
SREA_NEUCR  (Q1K8E7), SREP_PENCH  (Q92259), SRP_DROME   (P52172), 
TRPS1_HUMAN (Q9UHF7), TRPS1_MOUSE (Q925H1), TRPS1_XENLA (Q90ZS6), 
URB1_MYCMD  (P40349), WC1_NEUCR   (Q01371), WC2_NEUCR   (P78714), 
ZGLP1_HUMAN (P0C6A0), ZGLP1_MOUSE (Q1WG82)
» more

UniProtKB/Swiss-Prot
False negative sequences		 18 sequences 

GAT19_ORYSI (B8AR30), GAT19_ORYSJ (Q0DNU1), GTAM_DICDI  (Q54L83), 

GTAV_DICDI  (Q54UG8), GTAY_DICDI  (Q54X31), MTA1_HUMAN  (Q13330), 
MTA1_MOUSE  (Q8K4B0), MTA1_RAT(Q62599), MTA2_HUMAN  (O94776), 
MTA2_MOUSE  (Q9R190), MTA3_BOVIN  (A6QL72), MTA3_HUMAN  (Q9BTC8), 
MTA3_MOUSE  (Q924K8), P66A_MOUSE  (Q8CHY6), RERE_HUMAN  (Q9P2R6), 
RERE_MOUSE  (Q80TZ9), RERE_RAT(Q62901), SRD1_YEAST  (P09007)
» more

UniProtKB/Swiss-Prot
False positive sequences		 1 sequence 

IF2B_THEAC  (Q9HKJ3)


				
	

	

		PDB
[Detailed view]		
		
			31 PDB
			


			pdb_00001gat; pdb_00001gau; pdb_00001gnf; pdb_00001y0j; pdb_00002gat; pdb_00002l6y; pdb_00002l6z; pdb_00002m9w; pdb_00002vus; pdb_00002vut; pdb_00002vuu; pdb_00003dfv; 
			
				pdb_00003dfx; pdb_00003gat; pdb_00003vd6; pdb_00003vek; pdb_00004gat; pdb_00004hc7; pdb_00004hc9; pdb_00004hca; pdb_00005gat; pdb_00005o9b; pdb_00006gat; pdb_00006zfv; 
				pdb_00007ao8; pdb_00007ao9; pdb_00007aoa; pdb_00007gat; pdb_00008j48; pdb_00008vg0; pdb_00008vg1
			
			

			» more