PROSITE documentation PDOC00300GATA-type zinc finger domain signature and profile
Description
The GATA family of transcription factors are proteins that bind to DNA sites with the consensus sequence (A/T)GATA(A/G), found within the regulatory region of a number of genes. Proteins currently known to belong to this family are:
- GATA-1 [1] (also known as Eryf1, GF-1 or NF-E1), which binds to the GATA region of globin genes and other genes expressed in erythroid cells. It is a transcriptional activator which probably serves as a general 'switch' factor for erythroid development.
- GATA-2 [2], a transcriptional activator which regulates endothelin-1 gene expression in endothelial cells.
- GATA-3 [3], a transcriptional activator which binds to the enhancer of the T-cell receptor α and delta genes.
- GATA-4 [4], a transcriptional activator expressed in endodermally derived tissues and heart.
- Drosophila protein pannier (or DGATAa) (gene pnr) which acts as a repressor of the achaete-scute complex (as-c).
- Bombyx mori BCFI [5], which regulates the expression of chorion genes.
- Caenorhabditis elegans elt-1 and elt-2, transcriptional activators of genes containing the GATA region, including vitellogenin genes [6].
- Ustilago maydis urbs1 [7], a protein involved in the repression of the biosynthesis of siderophores.
- Fission yeast protein GAF2.
All these transcription factors contain a pair of highly similar 'zinc finger' type domains with the consensus sequence C-x2-C-x17-C-x2-C.
Some other proteins contain a single zinc finger motif highly related to those of the GATA transcription factors. These proteins are:
- Drosophila box A-binding factor (ABF) (also known as protein serpent (gene srp)) which may function as a transcriptional activator protein and may play a key role in the organogenesis of the fat body.
- Emericella nidulans areA [8], a transcriptional activator which mediates nitrogen metabolite repression.
- Neurospora crassa nit-2 [9], a transcriptional activator which turns on the expression of genes coding for enzymes required for the use of a variety of secondary nitrogen sources, during conditions of nitrogen limitation.
- Neurospora crassa white collar proteins 1 and 2 (WC-1 and WC-2), which control expression of light-regulated genes.
- Saccharomyces cerevisiae DAL81 (or UGA43), a negative nitrogen regulatory protein.
- Saccharomyces cerevisiae GLN3, a positive nitrogen regulatory protein.
- Saccharomyces cerevisiae GAT1 to GAT4.
- Saccharomyces cerevisiae GZF3.
April 2006 / Pattern revised.
-------------------------------------------------------------------------------
Technical section
PROSITE methods (with tools and information) covered by this documentation:
References
| 1 | Authors | Trainor C.D. Evans T. Felsenfeld G. Boguski M.S. |
| Title | Structure and evolution of a human erythroid transcription factor. | |
| Source | Nature 343:92-96(1990). | |
| PubMed ID | 2104960 | |
| DOI | 10.1038/343092a0 |
| 2 | Authors | Lee M.E. Temizer D.H. Clifford J.A. Quertermous T. |
| Title | Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells. | |
| Source | J. Biol. Chem. 266:16188-16192(1991). | |
| PubMed ID | 1714909 |
| 3 | Authors | Ho I.-C. Vorhees P. Marin N. Oakley B.K. Tsai S.-F. Orkin S.H. Leiden J.M. |
| Title | Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene. | |
| Source | EMBO J. 10:1187-1192(1991). | |
| PubMed ID | 1827068 |
| 4 | Authors | Spieth J. Shim Y.H. Lea K. Conrad R. Blumenthal T. |
| Title | elt-1, an embryonically expressed Caenorhabditis elegans gene homologous to the GATA transcription factor family. | |
| Source | Mol. Cell. Biol. 11:4651-4659(1991). | |
| PubMed ID | 1875944 |
| 5 | Authors | Drevet J.R. Skeiky Y.A. Iatrou K. |
| Title | GATA-type zinc finger motif-containing sequences and chorion gene transcription factors of the silkworm Bombyx mori. | |
| Source | J. Biol. Chem. 269:10660-10667(1994). | |
| PubMed ID | 8144656 |
| 6 | Authors | Hawkins M.G. McGhee J.D. |
| Title | elt-2, a second GATA factor from the nematode Caenorhabditis elegans. | |
| Source | J. Biol. Chem. 270:14666-14671(1995). | |
| PubMed ID | 7782329 |
| 7 | Authors | Voisard C.P.O. Wang J. McEvoy J.L. Xu P. Leong S.A. |
| Title | urbs1, a gene regulating siderophore biosynthesis in Ustilago maydis, encodes a protein similar to the erythroid transcription factor GATA-1. | |
| Source | Mol. Cell. Biol. 13:7091-7100(1993). | |
| PubMed ID | 8413298 |
| 8 | Authors | Arst H.N. Jr. Kudla B. Martinez-Rossi N. Caddick M.X. Sibley S. Davies R.W. |
| Title | Aspergillus and mouse share a new class of 'zinc finger' protein. | |
| Source | Trends Genet. 5:291-291(1989). | |
| PubMed ID | 2511649 |
| 9 | Authors | Fu Y.-H. Marzluf G.-A. |
| Title | nit-2, the major nitrogen regulatory gene of Neurospora crassa, encodes a protein with a putative zinc finger DNA-binding domain. | |
| Source | Mol. Cell. Biol. 10:1056-1065(1990). | |
| PubMed ID | 2137552 |
Copyright
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
Miscellaneous
View entry in original PROSITE document format
View entry in raw text format (no links)