PROSITE logo

PROSITE entry PS50178


View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] ZF_FYVE
Accession [info] PS50178
Entry type [info] MATRIX
Date [info] 01-DEC-2001 CREATED;
10-MAY-2017 DATA UPDATE;
03-MAY-2023 INFO UPDATE.
PROSITE Doc. [info] PDOC50178
Associated ProRule [info] PRU00091

Name and characterization of the entry

Description [info] Zinc finger FYVE/FYVE-related type profile.
Matrix / Profile [info] 
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=61;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=56;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.9551001; R2=0.0082987; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=4153.7788086; R2=3.1326315; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=789; H_SCORE=6625; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=548; H_SCORE=5870; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;

...
 
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='D';  M=-12,  7,-32, 13,  4,-23, -4,-12,-31,  0,-26,-21, -2,-15, -4, -7, -6,-10,-26,  7, -9,  1;
/M: SY='D';  M= -8,  7,-26,  8,  4,-25,-10, -9,-16,  4,-19,-11,  6,-14,  1, -1, -2, -7,-14,-28,-15,  2;
/M: SY='D';  M= -6, 13,-27, 21, 15,-31,  4, -8,-32, -1,-26,-21,  5, -5, -1, -8,  4, -6,-25,-31,-22,  7;
/M: SY='V';  M=  5, -7,-16, -7,-10,-16,-12,-17, -5, -6,-13, -8, -7,-18,-11, -8,  6,  2,  8,-30,-15,-11;
/M: SY='B';  M= -3,  7,-22,  7,  2,-23, -8, -9,-20, -2,-21,-15,  7, -4, -2, -7,  7,  3,-16,-32,-18,  0;
/M: SY='H';  M= -8, -5, -7, -8,  3,-16,-20,  7,-18, -2,-15, -6, -2,-17,  2, -1, -3, -6,-15,-28, -8,  1;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='M';  M= -4,-11,-23,-15, -9,-10,-14,  3, -6, -9, -5,  7, -6,-13,  0, -6, -6, -6, -9,-21, -3, -6;
/M: SY='I';  M= -8, -8,-23,-12,-11, -7,-22,-10,  2, -8, -1, -1, -3,-20, -8, -4, -6, -1, -1,-21,  0,-12;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='H';  M= -8,  3,-26,  3, -2,-27, 10, 11,-29, -4,-24,-11,  7,-16,  3, -2,  2,-10,-24,-27,-13, -1;
/M: SY='K';  M= -6, -3,-24, -5,  8,-21,-20,-11,-17, 16,-16, -8, -3,-11,  5, 10, -2,  2,-11,-24,-11,  6;
/M: SY='E';  M= -7, -2,-25, -1, 10,-20,-16,-11,-19, -3,-19,-13, -4,  9,  3, -7,  4,  7,-17,-27,-16,  6;
/M: SY='F';  M=-16,-24,-21,-31,-21, 49,-28,-18, -2,-19,  9,  1,-17,-26,-27,-13,-18, -7, -2,  0, 18,-21;
/M: SY='G';  M= -3,  0,-21, -9,-14, -2, 11,-12,-18,-15,-18,-13, 11,-20,-16,-14,  4, -3,-16,-22,-12,-14;
/M: SY='I';  M=  0,-14,-20,-21,-16, -2,-19,-16,  5,-13,  5,  4,-10,-21,-13,-11, -9, -4,  4,-15, -5,-15;
/M: SY='L';  M=-11,-11,-22,-14,-16,  5,-24,-17,  6,-20, 12,  2,-10,-24,-18,-17,-15, -4,  2,-14, -1,-16;
/I:         MD=-16;
/M: SY='S';  M= -1, -6,-19,-10, -9,-15, -1,-15, -9, -9,-10, -7, -1,-17,-10, -9,  2,  1, -4,-26,-15,-10; D=-3;
/I:         I=-5; MI=0; IM=0; DM=-16;
/M: SY='R';  M=-12,-13,-19,-15, -8,-16,-15, -7,-20, 12,-15, -8, -6,-22, -1, 37, -9,-10,-12,-19, -7, -8;
/M: SY='R';  M= -3, -7,-17, -9, -2,-26, -3,-10,-28, 17,-23,-11, -3,-16,  4, 20, -5,-10,-19,-22,-16,  0;
/M: SY='H';  M=-12, -6,-27, -7, -5,-18,-20, 63,-18,-12,-16, -1,  2,-14,  2, -6, -7,-14,-17,-29, 10, -5;
/M: SY='H';  M=-16, -2,-27, -4, -3,-17,-20, 60,-20, -4,-14,  3,  6,-20,  4,  0,-10,-15,-19,-28, 10, -3;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='R';  M=-14,-12,-26,-12, -2,-12,-21, -7,-18, 15,-12, -7, -5,-20,  1, 39, -8, -7,-10,-21, -8, -3;
/M: SY='B';  M= -3,  6,-23,  6, -1,-18,-14,  6,-17, -1,-16,-10,  4,-15,  0, -5,  0, -4,-15,-23, -1, -2;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='G';  M= -3, -8,-29, -8,-12,-29, 45,-15,-36, -7,-28,-17,  1,-18, -9, -4,  0,-15,-27,-21,-25,-11;
/M: SY='R';  M=-12, -2,-28, -1,  1,-21,-14, -1,-23, 12,-18, -8,  0,-16,  7, 17, -6, -7,-19,-14, -8,  3;
/M: SY='I';  M= -6,-20,-22,-24,-20, -3,-28,-18, 17,-12,  8,  7,-15,-23,-15, -8,-14, -6, 16,-21, -2,-20;
/M: SY='F';  M=-10,-28,-17,-32,-27, 32,-29,-21, 14,-24, 12,  5,-23,-28,-29,-19,-14, -5, 18,-10, 13,-27;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='Q';  M=  0,  1,-24,  1,  2,-27,  3, -8,-24,  3,-21,-10,  0,-13,  6,  0,  2, -5,-19,-24,-17,  3;
/M: SY='R';  M=-10,  5,-26,  7,  8,-20,-15, -5,-27, 18,-24,-15,  6,-13,  4, 20,  0, -5,-19,-25,-12,  5;
/I:         I=-7; MI=-8; IM=-8; DM=-15; MD=-15;
/M: SY='C';  M=-12,-17, 95,-25,-25,-20,-28, -8,-30,-27,-20,-17,-15,-37,-23,-25,-10,-12,-13,-47,-22,-25;
/M: SY='S';  M= -1,-11, -6,-13,-13,-12,  4,-17,-17,-15,-11,-10, -5,-20,-13,-14,  6,  1,-11,-28,-16,-13;
/M: SY='G';  M= -3, -3,-23, -3, -4,-22,  4,-12,-19, -4,-20,-13,  1, -9, -5, -5,  2, -6,-13,-28,-19, -5;
/M: SY='R';  M=-14,  7,-27,  6, 13,-20,-13,  5,-25,  9,-19,-13, 11,-15,  8, 16, -4, -9,-24,-26,-11,  9;
/M: SY='T';  M= -3,-11,-22,-17,-10,-10,-19,-14, -7, -2,-10, -3, -8,-17, -6,  2, -3,  4, -4, -6, -4, -9;
/M: SY='T';  M=  1,-12,-19,-15,-10, -7,-18,-16, -1,-13, -5, -4, -8,-10, -8,-12,  2,  4,  0,-25, -9,-10;
/M:         M= -5, -4,-23, -7, -7,-10,-13,-10,-11, -6, -9, -8,  0, -9, -8, -4, -2, -1,-11,-23, -7, -9;
/I:         MD=-15;
/M: SY='L';  M= -6,-17,-14,-17,-13,  2,-15,-11, 10,-14, 17,  8,-15,-18,-12, -8,-14, -6,  7,-11,  1,-13; D=-2;
/I:         I=-4; MI=0; MD=-15; IM=0; DM=-15;
/M: SY='P';  M= -5, -2,-18,  1,  1,-12, -7, -5,-10, -4,-12, -8, -3,  7,  0, -7, -1, -3,-12,-13, -5, -1; D=-2;
/I:         DM=-15;
/M: SY='D';  M= -4,  5,-19,  6,  4,-18,-13, -8,-11, -3,-12,-10,  3, -6,  0, -5,  3,  2,-10,-25,-12,  1; D=-2;
/I:         DM=-15;
/M: SY='N';  M= -9, -2,-21, -5, -5, -3, -7, -7,-11, -7, -9, -6,  1, -5, -8, -8, -5, -4,-13,-17, -5, -7; D=-2;
/I:         DM=-15;
/M: SY='G';  M= -7, -1,-25,  0, -2,-20, 15, -4,-25, -4,-21,-14,  2,-10, -6, -4, -2,-11,-21,-20,-13, -5; D=-2;
/I:         DM=-15;
/M: SY='N';  M=-11,  7,-21,  4,  0,-20,-13, -2,-16,  5,-19,-11, 11,-17, -2,  2, -4, -8,-16,-27, -9, -2;
/M:         M= -6, -4,-25, -5,  0,-14, -6, -1,-19, -3,-18,-11,  0, -5, -5, -6, -2, -7,-17,-24, -9, -3;
/M: SY='K';  M= -7, -5,-24, -6,  5,-21,-21, -4,-16, 15,-17, -6, -3,-13,  6, 12, -3,  0,-10,-24, -9,  4;
/M: SY='P';  M= -2,-12,-27,-10,  0,-21,-17,-16,-16,  2,-18,-12,-12, 14, -3, -6, -4, -4,-15,-14,-14, -2;
/M: SY='V';  M= -4,-19,-12,-23,-20, -6,-26,-11, 13,-14,  2,  9,-16,-24,-13,-14,-11, -6, 18,-23, -2,-18;
/M: SY='R';  M=-18, -7,-31,-11, -7, -9,-17, -5,-25, 13,-21,-13,  3,-22,  0, 34,-12,-12,-22,  9, -2, -5;
/M: SY='V';  M=  1,-27, -5,-31,-26, -2,-29,-27, 23,-23, 14,  9,-26,-27,-25,-22,-13, -4, 31,-27, -9,-26;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='D';  M=-10, 19,-25, 23, 11,-26,-12,  4,-28,  9,-27,-18, 14,-12,  3,  1,  4, -2,-22,-31,-11,  7;
/M: SY='D';  M= -8,  2,-24,  5, -1,-18,-19, -4, -9,-10, -9, -8, -1, -8, -6,-11, -3, -2, -8,-30,-11, -5;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='Y';  M=-13,-15,-23,-20,-15, 18,-24, -1, -2,-14,  1,  1, -9,-23,-11, -8, -9, -4, -5, -7, 19,-14;
/M: SY='E';  M= -2,  6,-23, 10, 14,-24,-17,-10,-17,  6,-17,-13, -1,-11,  0, -3, -1, -4, -9,-29,-16,  7;
/M: SY='Q';  M= -4,  1,-23,  0,  6,-22,-15,  0,-17,  4,-14, -4,  2,-14, 11,  8,  0, -2,-16,-26,-11,  7;
/M: SY='M';  M=-10,-16,-24,-18, -9, -6,-23,  0, -2, -3,  8, 12,-14,-22,  1,  3,-16,-10, -5,-16,  4, -5;
/M: SY='E';  M= -9,  7,-26, 10, 15,-20,-16,  6,-22,  0,-20,-14,  4, -5,  7, -4,  0, -7,-22,-26, -8, 10;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_02 which contains 569'516 sequence entries.


Total number of hits 170 in 165 different sequences
Number of true positive hits 169 in 164 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 23
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 99.41 %
Recall (true positives / (true positives + false negatives)) 88.02 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 2
Feature key [info] ZN_FING
Feature description [info] FYVE-type
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 164 sequences 

ADCA_DICDI  (Q54CH1    ), ADCD_DICDI  (Q54LD5    ), ANCHR_HUMAN (Q96K21    ), 

ANCHR_MOUSE (Q9DAZ9    ), ANFY1_HUMAN (Q9P2R3    ), ANFY1_MOUSE (Q810B6    ), 
EEA1_HUMAN  (Q15075    ), EEA1_MOUSE  (Q8BL66    ), FAB1A_ARATH (Q0WUR5    ), 
FAB1B_ARATH (Q9LUM0    ), FAB1_SCHPO  (O59722    ), FAB1_YEAST  (P34756    ), 
FGD1_HUMAN  (P98174    ), FGD1_MOUSE  (P52734    ), FGD2_HUMAN  (Q7Z6J4    ), 
FGD2_MOUSE  (Q8BY35    ), FGD3_HUMAN  (Q5JSP0    ), FGD3_MOUSE  (O88842    ), 
FGD3_PONAB  (Q5R5T1    ), FGD4_HUMAN  (Q96M96    ), FGD4_MOUSE  (Q91ZT5    ), 
FGD4_RAT    (O88387    ), FGD5_HUMAN  (Q6ZNL6    ), FGD5_MOUSE  (Q80UZ0    ), 
FGD6_HUMAN  (Q6ZV73    ), FGD6_MOUSE  (Q69ZL1    ), FGDH_CAEEL  (X5LX76    ), 
FREE1_ARATH (Q9ASS2    ), FYCO1_HUMAN (Q9BQS8    ), FYCO1_MOUSE (Q8VDC1    ), 
FYV1_DICDI  (B0G126    ), FYV1_DROME  (O96838    ), FYV1_HUMAN  (Q9Y2I7    ), 
FYV1_MOUSE  (Q9Z1T6    ), HGS_BOVIN   (Q0V8S0    ), HGS_HUMAN   (O14964    ), 
HGS_MOUSE   (Q99LI8    ), HGS_RAT     (Q9JJ50    ), HRS_DROME   (Q960X8    ), 
LST2_AEDAE  (Q17AN2    ), LST2_ANOGA  (Q7QAJ2    ), LST2_BRUMA  (A8QCE4    ), 
LST2_CAEBR  (A8XJZ8    ), LST2_CAEEL  (Q9TZD0    ), LST2_CULQU  (B0WAQ0    ), 
LST2_DANRE  (A0JMD2    ), LST2_DROAN  (B3MT31    ), LST2_DROER  (B3P851    ), 
LST2_DROGR  (B4JHI7    ), LST2_DROME  (Q9VB70    ), LST2_DROMO  (B4K982    ), 
LST2_DROPE  (B4G2G5    ), LST2_DROSE  (B4IC49    ), LST2_DROVI  (B4M140    ), 
LST2_DROWI  (B4NFJ7    ), LST2_DROYA  (B4PRU6    ), LST2_HUMAN  (Q9HCC9    ), 
LST2_MOUSE  (Q6ZPK7    ), LST2_XENTR  (Q0P4S0    ), MTMR3_CAEEL (Q22712    ), 
MTMR3_HUMAN (Q13615    ), MTMR3_MOUSE (Q8K296    ), MTMR3_RAT   (Q5PQT2    ), 
MTMR4_HUMAN (Q9NYA4    ), MTMR4_MOUSE (Q91XS1    ), MTMR4_XENLA (Q7ZXF1    ), 
PEP7_SCHPO  (O13786    ), PEP7_YEAST  (P32609    ), PIB1_YEAST  (Q06651    ), 
PIB2_SCHPO  (Q9Y7M3    ), PIB2_YEAST  (P53191    ), PKHF1_DROME (O76902    ), 
PKHF1_HUMAN (Q96S99    ), PKHF1_MOUSE (Q3TB82    ), PKHF1_RAT   (Q68FU1    ), 
PKHF2_CHICK (Q5ZLY5    ), PKHF2_DANRE (Q7ZUV1    ), PKHF2_HUMAN (Q9H8W4    ), 
PKHF2_MOUSE (Q91WB4    ), PRAF1_ARATH (Q947D2    ), RBF1_CAEEL  (P41885    ), 
RBNS5_HUMAN (Q9H1K0    ), RBNS5_MOUSE (Q80Y56    ), RIMS1_HUMAN (Q86UR5    ), 
RIMS1_MOUSE (Q99NE5    ), RIMS1_RAT   (Q9JIR4    ), RIMS2_HUMAN (Q9UQ26    ), 
RIMS2_MOUSE (Q9EQZ7    ), RIMS2_RAT   (Q9JIS1    ), RIM_CAEEL   (Q22366    ), 
RP3A_BOVIN  (Q06846    ), RP3A_HUMAN  (Q9Y2J0    ), RP3A_MOUSE  (P47708    ), 
RP3A_RAT    (P47709    ), RPH3L_BOVIN (Q58D79    ), RPH3L_HUMAN (Q9UNE2    ), 
RPH3L_MOUSE (Q768S4    ), RPH3L_RAT   (O54880    ), RUFY1_HUMAN (Q96T51    ), 
RUFY1_MOUSE (Q8BIJ7    ), RUFY2_HUMAN (Q8WXA3    ), RUFY2_MOUSE (Q8R4C2    ), 
RUFY2_PONAB (Q5R5R4    ), RUFY4_HUMAN (Q6ZNE9    ), RUFY4_MOUSE (Q3TYX8    ), 
SLOB1_DICDI (Q54TC3    ), UGT52_DICDI (Q54IL5    ), UPA1_USTMA  (A0A0D1E015), 
VPS27_ASHGO (Q755J9    ), VPS27_ASPCL (A1CEK1    ), VPS27_ASPFU (Q4WHN8    ), 
VPS27_ASPNC (A2QWA2    ), VPS27_ASPTN (Q0CJV3    ), VPS27_CANAL (Q5ABD9    ), 
VPS27_CANGA (Q6FQJ1    ), VPS27_CHAGB (Q2GS33    ), VPS27_CRYNB (P0CS27    ), 
VPS27_CRYNJ (P0CS26    ), VPS27_DEBHA (Q6BSD6    ), VPS27_EMENI (Q5BBK9    ), 
VPS27_KLULA (Q6CL17    ), VPS27_MAGO7 (A4QTV1    ), VPS27_NEOFI (A1DFP5    ), 
VPS27_NEUCR (Q7RZJ2    ), VPS27_PHANO (Q0U4Z8    ), VPS27_PICST (A3LX75    ), 
VPS27_SCHPO (O13821    ), VPS27_USTMA (Q4P7Q1    ), VPS27_YARLI (Q6CFT4    ), 
VPS27_YEAST (P40343    ), WDFY1_BOVIN (Q2KIY3    ), WDFY1_HUMAN (Q8IWB7    ), 
WDFY1_MOUSE (E9Q4P1    ), WDFY2_CAEBR (A8XXC7    ), WDFY2_CAEEL (Q18964    ), 
WDFY2_HUMAN (Q96P53    ), WDFY2_MOUSE (Q8BUB4    ), WDFY3_HUMAN (Q8IZQ1    ), 
WDFY3_MOUSE (Q6VNB8    ), YL615_MIMIV (Q5UR69    ), YO45_SCHPO  (Q9HGN5    ), 
YOTB_CAEEL  (P34657    ), ZFY16_HUMAN (Q7Z3T8    ), ZFY16_MOUSE (Q80U44    ), 
ZFY21_BOVIN (Q05B78    ), ZFY21_HUMAN (Q9BQ24    ), ZFY21_MOUSE (Q8VCM3    ), 
ZFY21_RAT   (D3ZVP7    ), ZFY26_AILME (D2H5P6    ), ZFY26_BOVIN (E1BLZ4    ), 
ZFY26_DROME (Q9VGP1    ), ZFY26_HUMAN (Q68DK2    ), ZFY26_MOUSE (Q5DU37    ), 
ZFY26_RAT   (D4A8G9    ), ZFY27_BOVIN (Q5BIM5    ), ZFY27_CHICK (Q5ZL36    ), 
ZFY27_HUMAN (Q5T4F4    ), ZFY27_MOUSE (Q3TXX3    ), ZFY27_PONAB (Q5R7K2    ), 
ZFY27_RAT   (Q6P7B7    ), ZFYV1_HUMAN (Q9HBF4    ), ZFYV1_MOUSE (Q810J8    ), 
ZFYV1_PONAB (Q5RFL4    ), ZFYV9_HUMAN (O95405    )
» more

UniProtKB/Swiss-Prot
False negative sequences		 23 sequences 

BPH1_SCHPO  (Q7LKZ7    ), MELPH_FELCA (M3WHG5    ), MELPH_HUMAN (Q9BV36    ), 

MELPH_MOUSE (Q91V27    ), MTMR6_CAEEL (G5ED68    ), MYRIP_DANRE (A8T6P4    ), 
MYRIP_HUMAN (Q8NFW9    ), MYRIP_MOUSE (Q8K3I4    ), MYRIP_RAT   (Q7TNY7    ), 
RFFL_HUMAN  (Q8WZ73    ), RFFL_MOUSE  (Q6ZQM0    ), RFFL_RAT    (Q8CIN9    ), 
RNF34_BOVIN (Q5E9J6    ), RNF34_HUMAN (Q969K3    ), RNF34_MOUSE (Q99KR6    ), 
RNF34_PONAB (Q5NVC7    ), RNF34_RAT   (Q6AYH3    ), SYTL4_HUMAN (Q96C24    ), 
SYTL4_MOUSE (Q9R0Q1    ), SYTL4_RAT   (Q8VHQ7    ), SYTL5_HUMAN (Q8TDW5    ), 
SYTL5_MOUSE (Q80T23    ), SYTL5_RAT   (Q812E4    )
» more

UniProtKB/Swiss-Prot
False positive sequences		 1 sequence 

ZNF12_MOUSE (Q7TSI0    )


				
	

	

		PDB
[Detailed view]		
		
			21 PDB
			


			1DVP; 1HYI; 1HYJ; 1JOC; 1VFY; 1WFK; 1X4U; 1Y02; 1ZBD; 2A20; 2CJS; 2CSZ; 
			
				2YQM; 2YW8; 2ZET; 3MPX; 3T7L; 3ZYQ; 4AVX; 5X6T; 6W9N
			
			

			» more