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annotation rule: PRU00091

General rule information [?]

Accession PRU00091
Dates 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 10)
Data class Domain
Predictors PROSITE; PS50178; ZF_FYVE
Name Zinc finger FYVE/FYVE-related type
Function The FYVE domain target signal-transducing proteins to cell membranes through binding to the membrane lipid phosphatidylinositol-3-phosphate (PtdIns(3)P) with high specificity.

Propagated annotation [?]


Keywords [?]

case (<Feature:PS50178:7=[CH]> and <Feature:PS50178:10=[CH]> and <Feature:PS50178:31=[CH]> and <Feature:PS50178:34=[CH]>) and (<Feature:PS50178:23=[CH]> and <Feature:PS50178:26=[CH]> and <Feature:PS50178:53=[CH]> and <Feature:PS50178:56=[CH]>)
Zinc
Metal-binding
end case

Zinc-finger

Features [?]

case (<Feature:PS50178:7=C> and <Feature:PS50178:10=C> and <Feature:PS50178:31=C> and <Feature:PS50178:34=C>) and (<Feature:PS50178:23=C> and <Feature:PS50178:26=C> and <Feature:PS50178:53=C> and <Feature:PS50178:56=C>)
From: PS50178
Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING     from     to       FYVE-type #        
else case (<Feature:PS50178:7=[CH]> and <Feature:PS50178:10=[CH]> and <Feature:PS50178:31=[CH]> and <Feature:PS50178:34=[CH]>) and (<Feature:PS50178:23=[CH]> and <Feature:PS50178:26=[CH]> and <Feature:PS50178:53=[CH]> and <Feature:PS50178:56=[CH]>)
ZN_FING     from     to       FYVE-type #; atypical        
else
ZN_FING     from     to       FYVE-type #; degenerate        
end case

BINDING     7     7       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     10     10       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     23     23       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2     [CH]   2
BINDING     26     26       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2     [CH]   2
BINDING     31     31       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     34     34       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     53     53       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2     [CH]   2
BINDING     56     56       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2     [CH]   2

Additional information [?]

Size range 43-83 amino acids
Related rules None
Repeats 1-2
Topology Undefined
Example P40343 (VPS27_YEAST)
Scope
Eukaryota

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]