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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00091


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00091
General rule information [?]

Accession PRU00091
Dates 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 11)
Data class Domain;
Predictors PROSITE; PS50178; ZF_FYVE
Name Zinc finger FYVE/FYVE-related type
Function The FYVE domain target signal-transducing proteins to cell membranes through binding to the membrane lipid phosphatidylinositol-3-phosphate (PtdIns(3)P) with high specificity.
Scope(s) Eukaryota
Example(s) P40343;

Propagated annotation [?]

Keywords [?]

case (<Feature:PS50178:7=[CH]> and <Feature:PS50178:10=[CH]> and <Feature:PS50178:31=[CH]> and <Feature:PS50178:34=[CH]>) and (<Feature:PS50178:23=[CH]> and <Feature:PS50178:26=[CH]> and <Feature:PS50178:53=[CH]> and <Feature:PS50178:56=[CH]>)
Zinc
Metal-binding
end case
Zinc-finger

Features [?]

From: PS50178
Key From To Description Tag Condition FTGroup
case (<Feature:PS50178:7=C> and <Feature:PS50178:10=C> and <Feature:PS50178:31=C> and <Feature:PS50178:34=C>) and (<Feature:PS50178:23=C> and <Feature:PS50178:26=C> and <Feature:PS50178:53=C> and <Feature:PS50178:56=C>)
ZN_FING from to /note="FYVE-type #"
else case (<Feature:PS50178:7=[CH]> and <Feature:PS50178:10=[CH]> and <Feature:PS50178:31=[CH]> and <Feature:PS50178:34=[CH]>) and (<Feature:PS50178:23=[CH]> and <Feature:PS50178:26=[CH]> and <Feature:PS50178:53=[CH]> and <Feature:PS50178:56=[CH]>)
ZN_FING from to /note="FYVE-type #; atypical"
else
ZN_FING from to /note="FYVE-type #; degenerate"
end case
BINDING 7 7 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 10 10 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 23 23 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 26 26 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 31 31 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 34 34 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 53 53 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 56 56 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2

Additional information [?]

Size range 43-83 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]