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ProRule PRU00091


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU00091
Accession PRU00091
Dates 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 10)
Data class Domain;
Predictors PROSITE; PS50178; ZF_FYVE
Name Zinc finger FYVE/FYVE-related type
Function The FYVE domain target signal-transducing proteins to cell membranes through binding to the membrane lipid phosphatidylinositol-3-phosphate (PtdIns(3)P) with high specificity.
Scope(s) Eukaryota
Example(s) P40343 (VPS27_YEAST);

Propagated annotation [?]

Keywords [?]

case (<Feature:PS50178:7=[CH]> and <Feature:PS50178:10=[CH]> and <Feature:PS50178:31=[CH]> and <Feature:PS50178:34=[CH]>) and (<Feature:PS50178:23=[CH]> and <Feature:PS50178:26=[CH]> and <Feature:PS50178:53=[CH]> and <Feature:PS50178:56=[CH]>)
Zinc
Metal-binding
end case
Zinc-finger

Features [?]

From: PS50178
Key From To Description Tag Condition FTGroup
case (<Feature:PS50178:7=C> and <Feature:PS50178:10=C> and <Feature:PS50178:31=C> and <Feature:PS50178:34=C>) and (<Feature:PS50178:23=C> and <Feature:PS50178:26=C> and <Feature:PS50178:53=C> and <Feature:PS50178:56=C>)
ZN_FING from to /note="FYVE-type #"
else case (<Feature:PS50178:7=[CH]> and <Feature:PS50178:10=[CH]> and <Feature:PS50178:31=[CH]> and <Feature:PS50178:34=[CH]>) and (<Feature:PS50178:23=[CH]> and <Feature:PS50178:26=[CH]> and <Feature:PS50178:53=[CH]> and <Feature:PS50178:56=[CH]>)
ZN_FING from to /note="FYVE-type #; atypical"
else
ZN_FING from to /note="FYVE-type #; degenerate"
end case
BINDING 7 7 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 10 10 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 23 23 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 26 26 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 31 31 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 34 34 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 53 53 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 56 56 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2

Additional information [?]

Size range 43-83 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]