ProRule PRU00091
General rule information
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Accession | PRU00091 |
Dates | 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 10) |
Data class | Domain; |
Predictors |
PROSITE; PS50178; ZF_FYVE |
Name | Zinc finger FYVE/FYVE-related type |
Function | The FYVE domain target signal-transducing proteins to cell membranes through binding to the membrane lipid phosphatidylinositol-3-phosphate (PtdIns(3)P) with high specificity. |
Scope(s) |
Eukaryota |
Example(s) | P40343 (VPS27_YEAST); |
Propagated annotation
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Keywords
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case (<Feature:PS50178:7=[CH]> and <Feature:PS50178:10=[CH]> and <Feature:PS50178:31=[CH]> and <Feature:PS50178:34=[CH]>) and (<Feature:PS50178:23=[CH]> and <Feature:PS50178:26=[CH]> and <Feature:PS50178:53=[CH]> and <Feature:PS50178:56=[CH]>) | |
Zinc | |
Metal-binding | |
end case | |
Zinc-finger |
Features
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From: PS50178 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
case (<Feature:PS50178:7=C> and <Feature:PS50178:10=C> and <Feature:PS50178:31=C> and <Feature:PS50178:34=C>) and (<Feature:PS50178:23=C> and <Feature:PS50178:26=C> and <Feature:PS50178:53=C> and <Feature:PS50178:56=C>) | ||||||||||||
ZN_FING | from | to | /note="FYVE-type #" | |||||||||
else case (<Feature:PS50178:7=[CH]> and <Feature:PS50178:10=[CH]> and <Feature:PS50178:31=[CH]> and <Feature:PS50178:34=[CH]>) and (<Feature:PS50178:23=[CH]> and <Feature:PS50178:26=[CH]> and <Feature:PS50178:53=[CH]> and <Feature:PS50178:56=[CH]>) | ||||||||||||
ZN_FING | from | to | /note="FYVE-type #; atypical" | |||||||||
else | ||||||||||||
ZN_FING | from | to | /note="FYVE-type #; degenerate" | |||||||||
end case | ||||||||||||
BINDING | 7 | 7 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
BINDING | 10 | 10 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
BINDING | 23 | 23 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" |
[CH] | 2 | |||||||
BINDING | 26 | 26 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" |
[CH] | 2 | |||||||
BINDING | 31 | 31 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
BINDING | 34 | 34 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
BINDING | 53 | 53 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" |
[CH] | 2 | |||||||
BINDING | 56 | 56 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" |
[CH] | 2 |
Additional information
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Size range | 43-83 amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1-2 |
Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [186] Viruses [1] All [ 187 ]
- Retrieve set of proteins with 3D structure for this domain