PROSITE logo

PROSITE entry PS50199


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] ZF_RANBP2_2
Accession [info] PS50199
Entry type [info] MATRIX
Date [info] 01-DEC-2001 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50199
Associated ProRule [info] PRU00322

Name and characterization of the entry

Description [info] Zinc finger RanBP2 type profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=30;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=27;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.1729000; R2=0.0112922; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=941.1036377; R2=2.0848954; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=605; H_SCORE=2202; N_SCORE=8.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=472; H_SCORE=1925; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='R';  M= -9, -6,-27, -5,  2,-23,-18, -9,-21, 20,-20, -9, -3, -7,  4, 22, -4, -6,-15,-24,-12,  1;
/M: SY='E';  M=  2, -2,-24,  0, 11,-17,-17,-12,-13, -3,-15,-12, -5, -2, -2,-10,  1, -5,-11,-26,-14,  4;
/M: SY='G';  M= -4,  4,-28,  4, -6,-29, 39,-12,-35, -8,-29,-20,  9,-17,-10,-11,  2,-14,-28,-26,-25, -8;
/I:         I=-8; MI=-5; MD=-10; IM=-5; DM=-10;
/M: SY='D';  M=-11,  9,-27, 15, 11,-21,-15,  0,-25,  1,-22,-16,  2, -9,  8, -4,  1, -5,-23,-18, -5,  9;
/M: SY='W';  M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20;
/M: SY='E';  M= -9,  8,-26, 11, 12,-26,-17,  2,-21,  4,-18,-11,  4, -9, 10, -1, -1, -4,-19,-29,-12, 11;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/I:         MI=-5; MD=-10; IM=-5; II=-9; DM=-10; I=0,0,-30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0;
/M: SY='S';  M= -4,  6,-22,  5,  4,-23,-11, -5,-22, -1,-26,-17,  9,  9, -1, -6, 11,  7,-19,-34,-18,  0;
/M: SY='S';  M=  1, -8,-18, -9, -5,-17,-10,-12,-11, -3,-13, -8, -4,-15, -5, -6,  8,  7, -2,-29,-13, -5;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='T';  M= -5, -6, -7,-11,-12,-10, -3,-13,-14,-14, -8, -9,  0,-21,-12,-13,  1,  3,-11,-26,-11,-12;
/M: SY='V';  M= -7,-13,-18,-17,-15,  4,-24,-14,  8,-14,  6,  2, -9,-25,-18,-12,-10, -2, 12,-22, -1,-16;
/M: SY='Q';  M= -8, -6,-23, -8, -3,-16,-19, -4, -9,  4,-11,  3, -3,-16,  8,  6, -2, -1, -7,-24, -8,  2;
/M: SY='N';  M=-10, 37,-13, 17, -2,-20, -2,  8,-21, -2,-29,-20, 56,-21, -2, -2,  9, -1,-29,-41,-21, -2;
/M: SY='F';  M= -8,-10,-20,-12,  2,  3,-20,-12,-18, -1,-15,-12, -8, -7, -8, -4, -6, -7,-15,-12, -2, -3;
/M: SY='A';  M= 22,-11,-17,-14, -6,-20, -7,-17,-13, -7,-15,-11, -9,  4, -6,-12,  7,  1, -7,-25,-19, -7;
/M: SY='E';  M= -5, -1,-23, -2,  3,-15,-15, -4,-20,  0,-16,-12, -1,-14, -1,  3,  3,  3,-15,-17, -8,  0;
/M: SY='R';  M=  7, -2,-20, -2,  1,-22,-10,-10,-21,  4,-20,-14,  0, -7,  0,  9,  7, -1,-13,-27,-17, -1;
/M: SY='T';  M= -6, -6,-20,-11, -8,-10,-19,-12, -3, -6, -6, -3, -1,-14, -7, -4,  1,  6, -2,-27, -8, -9;
/M: SY='K';  M= -6, -4,-26, -3, 10,-22,-19,  0,-21, 20,-20, -9, -3,-13,  5, 15, -5, -8,-13,-22, -7,  6;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='V';  M= -5,-10,-18,-17,-18,  8,-21,-17,  7,-16,  0, -1, -4,-23,-20,-15, -7, -4, 10,-22, -4,-19;
/M: SY='A';  M=  9, -9,-12,-14, -7,-19,-13,-11,-12,  1,-14, -7, -4,-16,  0,  6,  3, -2, -5,-25,-15, -5;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='G';  M= -7, -2,-29, -3,  2,-25,  8, -8,-27,  0,-24,-13,  2,-15,  8, -2, -1,-10,-26, -8,-14,  5;
/M: SY='S';  M=  9,  2,-13, -7, -7,-14, -4,-12,-15, -8,-17,-13,  8,-14, -8,-10, 13, 13, -9,-28,-14, -8;
/M: SY='P';  M= -3,-12,-27, -7,  0,-21,-17,-12,-14,-10,-15,-12,-11, 28, -7,-12, -1, -2,-15,-30,-19, -6;
/M: SY='K';  M=-10, -1,-28, -2,  4,-25,-16, -7,-27, 34,-25,-11,  3,-14,  7, 34, -7, -9,-18,-22,-12,  4;
/M: SY='P';  M= -8, -8,-29, -4,  1,-21,-10,-13,-21, -1,-20,-13, -7, 17, -4, -7, -3, -5,-20,-25,-16, -3;
/M: SY='D';  M= -3,  3,-24,  4,  1,-24, -2,-11,-20, -6,-19,-14,  1, -3, -3,-10,  3, -1,-16,-29,-19, -2;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.


Total number of hits 174 in 103 different sequences
Number of true positive hits 174 in 103 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 12
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 93.55 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 8
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Feature key [info] ZN_FING
Feature description [info] RanBP2-type
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
103 sequences

ARI8_ARATH  (Q8W468), CAN15_HUMAN (O75808), CAN15_MOUSE (Q9JLG8), 
CAND_DROME  (P27398), CAZ_DROME   (Q27294), DRI1_SCHPO  (O13801), 
DRI1_YEAST  (P32770), EWS_HUMAN   (Q01844), EWS_MOUSE   (Q61545), 
FUS_BOVIN   (Q28009), FUS_HUMAN   (P35637), FUS_MOUSE   (P56959), 
HOIL1_DANRE (A9JTG5), HOIL1_DICLA (E6ZIJ1), HOIL1_HUMAN (Q9BYM8), 
HOIL1_MOUSE (Q9WUB0), HOIL1_RAT   (Q62921), MDM2_CANLF  (P56950), 
MDM2_DANRE  (O42354), MDM2_FELCA  (Q7YRZ8), MDM2_HORSE  (P56951), 
MDM2_HUMAN  (Q00987), MDM2_MESAU  (Q60524), MDM2_MOUSE  (P23804), 
MDM2_XENLA  (P56273), MDM4_BOVIN  (Q2HJ21), MDM4_DANRE  (Q7ZUW7), 
MDM4_HUMAN  (O15151), MDM4_MOUSE  (O35618), MDM4_RAT(Q5XIN1), 
MDM4_XENLA  (Q7ZYI3), NEIL3_BOVIN (Q3MHN7), NEIL3_HUMAN (Q8TAT5), 
NEIL3_MOUSE (Q8K203), NEIL3_XENLA (A0A1L8HU22), NPL41_CAEEL (H2KYU6), 
NPL42_CAEEL (Q95QZ9), NPL4_DROME  (Q9VBP9), NPL4_HUMAN  (Q8TAT6), 
NPL4_MOUSE  (P60670), NPL4_RAT(Q9ES54), NU153_DROME (Q9VXE6), 
NU153_HUMAN (P49790), NU153_RAT   (P49791), NU153_XENLA (Q640Z6), 
RBL14_ARATH (Q8RXW0), RBM10_HUMAN (P98175), RBM10_MOUSE (Q99KG3), 
RBM10_RAT   (P70501), RBM5A_XENLA (A0JMV4), RBM5B_XENLA (Q6DDU9), 
RBM5_BOVIN  (Q1RMU5), RBM5_HUMAN  (P52756), RBM5_MOUSE  (Q91YE7), 
RBM5_RAT(B2GV05), RBM5_XENTR  (A4IGK4), RBP2_DROME  (A0A0B4K7J2), 
RBP2_HUMAN  (P49792), RBP2_MOUSE  (Q9ERU9), RBP2_PANTR  (H2QII6), 
RBP56_HUMAN (Q92804), RNF31_HUMAN (Q96EP0), RNF31_MOUSE (Q924T7), 
RYBPA_DANRE (Q7SYB3), RYBPB_DANRE (Q5EG55), RYBP_HUMAN  (Q8N488), 
RYBP_MOUSE  (Q8CCI5), SHRPN_BOVIN (E1BDF2), SHRPN_HUMAN (Q9H0F6), 
SHRPN_MOUSE (Q91WA6), SHRPN_RAT   (Q9EQL9), SUA_ARATH   (F4JCU0), 
TA15B_ARATH (Q94KD0), TAB2_DANRE  (Q5RFW2), TAB2_HUMAN  (Q9NYJ8), 
TAB2_MOUSE  (Q99K90), TAB2_RAT(Q5U303), TAB3_HUMAN  (Q8N5C8), 
TAB3_MOUSE  (Q571K4), TAB3_XENLA  (Q7ZXH3), TAF15_ARATH (Q9AST1), 
TRBID_DROME (Q9VH90), TX13A_HUMAN (Q9BXU3), VAR3_ARATH  (Q8S9K3), 
YAF2_HUMAN  (Q8IY57), YAF2_MOUSE  (Q99LW6), YDMD_SCHPO  (P87143), 
ZRAB2_CHICK (Q5ZLX5), ZRAB2_HUMAN (O95218), ZRAB2_MOUSE (Q9R020), 
ZRAB2_PIG   (Q19QU3), ZRAB2_PONAB (Q5R580), ZRAB2_RAT   (O35986), 
ZRAB3_BOVIN (E1BB03), ZRAB3_HUMAN (Q5FWF4), ZRAB3_MOUSE (Q6NZP1), 
ZRAN1_BOVIN (A6QP16), ZRAN1_HUMAN (Q9UGI0), ZRAN1_MOUSE (Q7M760), 
ZRAN1_XENTR (B1H2Q2), ZRN1A_XENLA (Q5U595), ZRN1B_DANRE (A0JMQ9), 
ZRN1B_XENLA (Q6NUB7)
» more

UniProtKB/Swiss-Prot
False negative sequences
12 sequences

ARI13_ARATH (Q9FFN9), ARI14_ARATH (Q9FFP1), ARI15_ARATH (Q84RQ8), 
ARI16_ARATH (Q9C5A4), HDA15_ARATH (Q8GXJ1), LUBEL_DROME (Q8IPJ3), 
TAMO_DROME  (Q9W1A4), TX13C_HUMAN (A0A0J9YWL9), TX13D_HUMAN (A0A0J9YY54), 
VPS36_SCHPO (O43038), VPS36_YEAST (Q06696), YZR3_ARATH  (Q8GZ43)
» more

PDB
[Detailed view]
68 PDB

1N0Z; 1NJ3; 1Q5W; 2C6A; 2C6B; 2CR8; 2CRC; 2D9G; 2EBQ; 2EBR; 2EBV; 2GQE; 2K0C; 2K1P; 2LK0; 2LK1; 2MXV; 2WWZ; 2WX0; 2WX1; 3A9J; 3A9K; 3B08; 3B0A; 3CH5; 3G9Y; 3GJ3; 3GJ4; 3GJ5; 3GJ6; 3GJ7; 3GJ8; 4OWF; 4S1Z; 4XXB; 5AF6; 5YVG; 5YVH; 6G99; 7E62; 7MNP; 7MNQ; 7MNR; 7MNS; 7MNT; 7MNU; 7MNV; 7MO1; 7MO2; 7MO3; 7MO4; 7MO5; 7PCV; 7PDV; 7R5J; 7R5K; 7TV4; 7YUI; 8BGU; 8IM5; 8ONS; 8PP6; 9AVT; 9AVW; 9AZJ; 9B0B; 9B0Z; 9B12
» more