We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

PROSITE entry PS50225

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PURL: https://purl.expasy.org/prosite/signature/PS50225

Direct ScanProsite submission

General information about the entry

Entry name [info]	SOCS
Accession [info]	PS50225
Entry type [info]	MATRIX
Date [info]	01-MAY-2002 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50225
Associated ProRule [info]	PRU00194

Name and characterization of the entry

Description [info]

SOCS box domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=50;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=45;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.1047000; R2=0.0177183; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2404.3457031; R2=2.7730870; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=474; H_SCORE=3719; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=361; H_SCORE=3405; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-20; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='M';  M= -9,-16,-24,-17, -9,-10,-15, -7, -1, -6,  3, 10,-15,-21,  4, -6,-13,-10, -3,-16,  0, -3;
/M: SY='L';  M= -9,-29,-19,-30,-21,  8,-29,-19, 21,-27, 42, 23,-29,-29,-19,-19,-26, -9, 15,-21, -1,-20;
/M: SY='R';  M= -6, -1,-21, -1, -4,-21, -6,-12,-21,  4,-20,-13,  1,-15, -4, 10,  6,  7,-11,-28,-15, -5;
/M: SY='R';  M= -5,-11,-25,-16, -7,-17,-23, -4, -4,  2, -9, -1, -5,-16,  2, 10, -6, -3, -4,-22, -6, -5;
/M: SY='P';  M=-11, -9,-31, -2,  0,-24,-18,-12,-20, -2,-19,-15, -9, 31, -4,  2, -5, -6,-21,-29,-20, -5;
/M: SY='L';  M=-13,-30,-26,-32,-23, 18,-30,-17, 15,-26, 29, 11,-28,-29,-20,-20,-28,-12,  4,  7, 16,-22;
/I:         I=-5; MI=0; MD=-28; IM=0; DM=-28;
/M: SY='R';  M=-14, -2,-22, -4,  0,-15,-13,  1,-22, 19,-16, -9,  7,-15,  6, 45, -5, -6,-16,-18, -9,  0; D=-5;
/I:         I=-5; DM=-28;
/M: SY='R';  M= -5,-10,-27, -9, -1,-19,-16, -4,-20,  6,-20,-11, -6,  3,  7, 17, -1, -5,-19,-20, -7,  0;
/M: SY='S';  M=  7, -3,-15, -6, -2,-19, -9,-12,-19,  2,-22,-14,  3,-11, -1,  3, 20, 17, -9,-30,-15, -2;
/M: SY='N';  M= -9,  7,-23,  2,  6,-12,-12, -4,-22,  9,-23,-15, 14,-15,  1, 10,  5, -2,-20,-27,-11,  4;
/M: SY='P';  M=  6,-23,-21,-21,-15,-15,-21,-25,  4,-15, -8, -5,-23, 17,-19,-20, -6, -4, 12,-28,-19,-19;
/M: SY='H';  M= -9,-15,-27,-15, -7, -8,-20,  9,-15, -5, -7, -4, -9, -1, -5,  7,-12,-11,-15,-21, -4, -9;
/M: SY='S';  M=  4, -4,-16, -4, -2,-20, -8,-14,-18,-10,-26,-18,  2,  9, -4,-12, 27, 20,-12,-36,-20, -4;
/M: SY='L';  M=-10,-30,-20,-30,-20, 10,-30,-20, 20,-30, 50, 20,-30,-30,-20,-20,-30,-10, 10,-20,  0,-20;
/M: SY='Q';  M= -5, -4,-27, -5, 13,-33,-19,  4,-15,  4,-11,  1, -4,-12, 45,  4, -2, -9,-23,-20,-10, 29;
/M: SY='H';  M=-19,  7,-30, 11,  7,-19,-19, 67,-29, -6,-20, -7,  8,-17,  8, -2, -8,-17,-28,-26, 16,  4;
/M: SY='L';  M=-11,-30,-21,-32,-22, 15,-31,-21, 21,-30, 44, 18,-28,-29,-22,-21,-28,-10, 11,-18,  2,-22;
/M: SY='C';  M= -8,-18,106,-27,-27,-20,-27,-28,-29,-28,-21,-20,-17,-37,-27,-28, -5, -7,-10,-49,-29,-27;
/M: SY='R';  M=-18,-12, -7,-13, -5,-20,-22, -5,-30, 21,-20,-12, -3,-23,  4, 55,-10,-10,-18,-25,-13, -5;
/M: SY='L';  M= -6,-18,-24,-20, -9, -9,-23,-12,  3, -4, 12, 11,-15,-20, -1,  3,-16, -9, -1,-20, -6, -6;
/M: SY='T';  M=  4,-11, -1,-15,-10,-17,-17,-15,-11, -4,-13, -8, -8,-18, -4,  1,  5,  7,  0,-29,-15, -8;
/M: SY='I';  M= -6,-30,-22,-36,-30,  0,-36,-30, 42,-26, 16, 16,-24,-24,-24,-26,-16, -6, 38,-24, -4,-30;
/M: SY='R';  M=-11, -3, -8, -9,-10,-15,-18, -8,-12,  4,-15, -9,  6,-24, -7, 19, -5, -5, -4,-31,-15,-10;
/M: SY='R';  M= -4,  0,-25,  0,  0,-25, -4,  3,-28, 11,-24,-13,  3,-15,  2, 17,  2, -7,-20,-26,-12, -1;
/M: SY='C';  M= -3, -8, 29,-17,-17,-14,-21, -8,-14,-18,-10, -9, -5,-26,-16,-17, -2,  3, -4,-36,-15,-17;
/M: SY='V';  M= -4,-19,-15,-24,-20, -1,-27,-21, 15,-19, 14, 12,-18,-21,-17,-17, -6, 12, 19,-26, -6,-19;
/M: SY='G';  M= -2, -4,-29, -1, -5,-29, 17,-15,-28,-11,-26,-18, -4, 12, -6,-15,  0, -7,-25,-26,-25, -7;
/I:         I=-5; MI=0; MD=-28; IM=0; DM=-28;
/M: SY='V';  M= -6,-13,-14,-16,-13,  0,-20,-11,  6, -9,  5,  3,-12,-16,-10, -4, -6,  6,  8,-13,  3,-13; D=-5;
/I:         I=-5; DM=-28;
/M: SY='H';  M= -7,  5,-20,  8,  9,-22, -2, 12,-22,  2,-19,-10,  4, -9,  8,  0,  1, -7,-19,-21, -8,  8; D=-5;
/I:         I=-5; DM=-28;
/M: SY='E';  M= -7,  1,-23,  2,  7,-18, -9, -7,-15, -8, -6, -8,  1,-15,  3, -8,  0, -2,-16,-28,-14,  5;
/M: SY='V';  M= -8,-28,-19,-30,-26,  8,-32,-18, 26,-22, 17, 12,-26,-28,-22,-20,-18, -6, 27,-14, 12,-26;
/M: SY='D';  M= -7, 17,-27, 25, 14,-30,-12, -5,-29,  3,-25,-20,  5,-11,  7, -5,  1, -7,-24,-17,-14, 11;
/M: SY='K';  M= -1, -4,-14, -7,  0,-24, -3,-14,-26,  9,-22,-13, -2,-14, -3,  5,  0,  0,-16,-25,-17, -2;
/M: SY='L';  M= -9,-30,-20,-31,-22,  8,-31,-22, 24,-29, 42, 19,-29,-29,-21,-21,-27, -9, 16,-21, -1,-22;
/I:         I=-8; MI=-8; MD=-33; IM=-8; DM=-33;
/M: SY='P';  M=-10,-18,-39, -9,  2,-31,-20,-17,-20, -8,-29,-18,-18, 79, -2,-17, -9,-10,-30,-29,-28, -4;
/M: SY='L';  M=-10,-30,-22,-32,-22,  8,-32,-22, 26,-30, 44, 20,-28,-28,-20,-22,-28,-10, 14,-20,  0,-22;
/M: SY='P';  M=-10,-14,-38, -7,  0,-29,-18,-17,-20, -9,-30,-20,-12, 79, -9,-18, -8, -9,-30,-31,-29, -9;
/M: SY='P';  M= -4,-11,-27,-10, -4,-21, -1,-16,-14,-11,-19,-12, -5,  8, -8,-11,  4, -1,-14,-28,-20, -8;
/M: SY='R';  M=  3,-14,-23,-16, -8,-14,-17,-10,-10,  5,-11, -2,-12, -6, -4,  9, -7, -6, -5,-18, -6, -8;
/M: SY='L';  M=-10,-28,-21,-31,-21,  7,-29,-18, 23,-26, 41, 27,-27,-27,-16,-19,-27,-10, 12,-20,  0,-19;
/M: SY='R';  M= -9,-10,-28,-12, -1,-20,-21, -8,-15, 19,-11, -3, -6,-17,  8, 29,-11, -9,-12,-20, -9,  1;
/M: SY='D';  M= -7, 17,-25, 25, 19,-29,-12, -3,-30,  6,-24,-21,  8,-10,  5,  7,  5, -5,-22,-32,-18, 11;
/M: SY='Y';  M=-20,-20,-27,-23,-20, 38,-28, 20, -5,-16,  0,  0,-15,-28,-16,-12,-18,-12,-10, 15, 55,-20;
/M: SY='L';  M=-10,-30,-20,-30,-20, 10,-30,-20, 20,-30, 50, 20,-30,-30,-20,-20,-30,-10, 10,-20,  0,-20;
/M: SY='K';  M= -8,  0,-24,  3,  7,-21,-17, -9,-19, 12,-13, -9, -2,-14,  2,  8, -2, -4,-14,-27,-12,  4;
/M: SY='Y';  M= -7, -5,-25, -3,  7,-11,-10,  3,-18, -4,-17,-10, -3,-15, 10, -5,  4, -3,-19,-12, 11,  7;
/M: SY='Y';  M=-17,-18,-27,-19, -9, 23,-27,  1, -6, -9,  1, -1,-15,-24, -6, -2,-16,-10,-11,  5, 32, -9;
/M: SY='P';  M= -9,  0,-27,  0, -3,-21,-18, -1,-10, -6,-18,-10,  3,  5, -4,-10,  0, -5,-13,-31,-12, -6;
/M: SY='F';  M= -5,-20,-21,-26,-18, 22,-22,-11, -1,-16,  1,  7,-16,-10,-18,-16,-10, -2, -3, -7, 12,-18;
/M: SY='Q';  M=  1, -5,-28, -5,  9,-32,-16, -5,-21, 13,-22, -7, -5,  4, 25,  5, -2, -8,-22,-21,-15, 16;
/I:         E1=0;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	117 in 117 different sequences
Number of true positive hits	117 in 117 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	2
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	98.32 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	K_Hofmann
Feature key [info]	DOMAIN
Feature description [info]	SOCS box
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

117 sequences

ASB10_HUMAN (Q8WXI3), ASB10_MOUSE (Q91ZT7), ASB11_BOVIN (Q3SZE4),

ASB11_DANRE (Q70X92), ASB11_HUMAN (Q8WXH4), ASB11_MOUSE (Q9CQ31), 
ASB11_PONAB (Q5RFS1), ASB13_HUMAN (Q8WXK3), ASB13_MOUSE (Q8VBX0), 
ASB14_HUMAN (A6NK59), ASB14_MOUSE (Q8C6Y6), ASB14_RAT   (P0C927), 
ASB15_BOVIN (Q8HXA6), ASB15_HUMAN (Q8WXK1), ASB15_MOUSE (Q8VHS6), 
ASB16_HUMAN (Q96NS5), ASB16_MOUSE (Q8VHS5), ASB17_BOVIN (Q32KY8), 
ASB17_CANLF (Q8HYV8), ASB17_HUMAN (Q8WXJ9), ASB17_MACFA (Q95LR4), 
ASB17_MOUSE (Q8VHP9), ASB18_HUMAN (Q6ZVZ8), ASB18_MOUSE (Q8VHA6), 
ASB1_HUMAN  (Q9Y576), ASB1_MOUSE  (Q9WV74), ASB2_BOVIN  (Q3SX45), 
ASB2_HUMAN  (Q96Q27), ASB2_MOUSE  (Q8K0L0), ASB2_RAT(Q5U2S6), 
ASB3_BOVIN  (Q08DV6), ASB3_HUMAN  (Q9Y575), ASB3_MOUSE  (Q9WV72), 
ASB4_HUMAN  (Q9Y574), ASB4_MOUSE  (Q9WV71), ASB5_BOVIN  (Q17QS6), 
ASB5_HUMAN  (Q8WWX0), ASB5_MOUSE  (Q9D1A4), ASB5_RABIT  (Q862Z2), 
ASB6_HUMAN  (Q9NWX5), ASB6_MOUSE  (Q91ZU1), ASB6_PONAB  (Q5R4M7), 
ASB7_HUMAN  (Q9H672), ASB7_MACFA  (Q9BGT9), ASB7_MOUSE  (Q91ZU0), 
ASB7_PONAB  (Q5RCK5), ASB8_BOVIN  (Q08E43), ASB8_HUMAN  (Q9H765), 
ASB8_MACFA  (Q4R544), ASB8_MOUSE  (Q91ZT9), ASB8_PONAB  (Q5R6D7), 
ASB9_HUMAN  (Q96DX5), ASB9_MOUSE  (Q91ZT8), CISH_BOVIN  (Q2HJ53), 
CISH_CHICK  (Q9PW70), CISH_HUMAN  (Q9NSE2), CISH_MOUSE  (Q62225), 
CISH_RAT(O70512), DYH12_BOVIN (Q58CT0), GUS_DROME   (A1Z6E0), 
NEUL2_HUMAN (Q9BR09), NEUL2_MOUSE (Q9D0S4), RB40A_HUMAN (Q8WXH6), 
RB40B_HUMAN (Q12829), RB40B_MOUSE (Q8VHP8), RB40C_HUMAN (Q96S21), 
RB40C_MOUSE (Q8VHQ4), RB40L_HUMAN (P0C0E4), SOCS1_HUMAN (O15524), 
SOCS1_MOUSE (O35716), SOCS1_RAT   (Q9QX78), SOCS2_BOVIN (Q861R0), 
SOCS2_HUMAN (O14508), SOCS2_MOUSE (O35717), SOCS2_PIG   (Q7YRV6), 
SOCS2_RAT   (O88582), SOCS3_BOVIN (Q9BEG9), SOCS3_CANLF (Q68AM8), 
SOCS3_CHICK (Q90X67), SOCS3_HUMAN (O14543), SOCS3_MOUSE (O35718), 
SOCS3_RAT   (O88583), SOCS4_BOVIN (Q0VC91), SOCS4_HUMAN (Q8WXH5), 
SOCS4_MOUSE (Q91ZA6), SOCS4_PONAB (Q5RDX2), SOCS5_BOVIN (Q29RN6), 
SOCS5_HUMAN (O75159), SOCS5_MOUSE (O54928), SOCS6_HUMAN (O14544), 
SOCS6_MOUSE (Q9JLY0), SOCS6_PONAB (Q5RCM6), SOCS7_HUMAN (O14512), 
SOCS7_MOUSE (Q8VHQ2), SPSB1_BOVIN (Q5E9X6), SPSB1_HUMAN (Q96BD6), 
SPSB1_MOUSE (Q9D5L7), SPSB2_HUMAN (Q99619), SPSB2_MOUSE (O88838), 
SPSB2_RAT   (Q5M877), SPSB3_BOVIN (Q3MHZ2), SPSB3_HUMAN (Q6PJ21), 
SPSB3_MOUSE (Q571F5), SPSB3_XENLA (Q5M9B1), SPSB3_XENTR (Q28DT9), 
SPSB4_HUMAN (Q96A44), SPSB4_MOUSE (Q8R5B6), TULP4_HUMAN (Q9NRJ4), 
TULP4_MOUSE (Q9JIL5), WSB1_DANRE  (Q7T2F6), WSB1_HUMAN  (Q9Y6I7), 
WSB1_MOUSE  (O54927), WSB1_TAKRU  (Q9W5Z5), WSB1_XENTR  (Q6P1V3), 
WSB2_BOVIN  (Q0V8J1), WSB2_HUMAN  (Q9NYS7), WSB2_MOUSE  (O54929)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

2 sequences

ASB12_HUMAN (Q8WXK4), ASB12_MOUSE (Q9D738)

PDB
[Detailed view]

21 PDB

pdb_00002c9w; pdb_00002izv; pdb_00002jz3; pdb_00003zkj; pdb_00003zng; pdb_00004jgh; pdb_00005bo4; pdb_00006i4x; pdb_00006i5j; pdb_00006i5n; pdb_00006v9h; pdb_00007m6t; pdb_00007zlm; pdb_00007zln; pdb_00007zlo; pdb_00007zlp; pdb_00007zlr; pdb_00007zls; pdb_00008okx; pdb_00008ol1; pdb_00008y1u
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