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| Entry: PS50225 |
General information about the entry
| Entry name [info] | SOCS |
| Accession [info] | PS50225 |
| Entry type [info] | MATRIX |
| Date [info] |
01-MAY-2002 CREATED;
10-MAY-2017 DATA UPDATE; 02-JUN-2021 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC50225 |
| Associated ProRule [info] | PRU00194 |
Name and characterization of the entry
| Description [info] | SOCS box domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=50; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=45; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.1047000; R2=0.0177183; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2404.3457031; R2=2.7730870; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=474; H_SCORE=3719; N_SCORE=8.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=361; H_SCORE=3405; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: D=-20; I=-20; B1=-20; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='M'; M= -9,-16,-24,-17, -9,-10,-15, -7, -1, -6, 3, 10,-15,-21, 4, -6,-13,-10, -3,-16, 0, -3; /M: SY='L'; M= -9,-29,-19,-30,-21, 8,-29,-19, 21,-27, 42, 23,-29,-29,-19,-19,-26, -9, 15,-21, -1,-20; /M: SY='R'; M= -6, -1,-21, -1, -4,-21, -6,-12,-21, 4,-20,-13, 1,-15, -4, 10, 6, 7,-11,-28,-15, -5; /M: SY='R'; M= -5,-11,-25,-16, -7,-17,-23, -4, -4, 2, -9, -1, -5,-16, 2, 10, -6, -3, -4,-22, -6, -5; /M: SY='P'; M=-11, -9,-31, -2, 0,-24,-18,-12,-20, -2,-19,-15, -9, 31, -4, 2, -5, -6,-21,-29,-20, -5; /M: SY='L'; M=-13,-30,-26,-32,-23, 18,-30,-17, 15,-26, 29, 11,-28,-29,-20,-20,-28,-12, 4, 7, 16,-22; /I: I=-5; MI=0; MD=-28; IM=0; DM=-28; /M: SY='R'; M=-14, -2,-22, -4, 0,-15,-13, 1,-22, 19,-16, -9, 7,-15, 6, 45, -5, -6,-16,-18, -9, 0; D=-5; /I: I=-5; DM=-28; /M: SY='R'; M= -5,-10,-27, -9, -1,-19,-16, -4,-20, 6,-20,-11, -6, 3, 7, 17, -1, -5,-19,-20, -7, 0; /M: SY='S'; M= 7, -3,-15, -6, -2,-19, -9,-12,-19, 2,-22,-14, 3,-11, -1, 3, 20, 17, -9,-30,-15, -2; /M: SY='N'; M= -9, 7,-23, 2, 6,-12,-12, -4,-22, 9,-23,-15, 14,-15, 1, 10, 5, -2,-20,-27,-11, 4; /M: SY='P'; M= 6,-23,-21,-21,-15,-15,-21,-25, 4,-15, -8, -5,-23, 17,-19,-20, -6, -4, 12,-28,-19,-19; /M: SY='H'; M= -9,-15,-27,-15, -7, -8,-20, 9,-15, -5, -7, -4, -9, -1, -5, 7,-12,-11,-15,-21, -4, -9; /M: SY='S'; M= 4, -4,-16, -4, -2,-20, -8,-14,-18,-10,-26,-18, 2, 9, -4,-12, 27, 20,-12,-36,-20, -4; /M: SY='L'; M=-10,-30,-20,-30,-20, 10,-30,-20, 20,-30, 50, 20,-30,-30,-20,-20,-30,-10, 10,-20, 0,-20; /M: SY='Q'; M= -5, -4,-27, -5, 13,-33,-19, 4,-15, 4,-11, 1, -4,-12, 45, 4, -2, -9,-23,-20,-10, 29; /M: SY='H'; M=-19, 7,-30, 11, 7,-19,-19, 67,-29, -6,-20, -7, 8,-17, 8, -2, -8,-17,-28,-26, 16, 4; /M: SY='L'; M=-11,-30,-21,-32,-22, 15,-31,-21, 21,-30, 44, 18,-28,-29,-22,-21,-28,-10, 11,-18, 2,-22; /M: SY='C'; M= -8,-18,106,-27,-27,-20,-27,-28,-29,-28,-21,-20,-17,-37,-27,-28, -5, -7,-10,-49,-29,-27; /M: SY='R'; M=-18,-12, -7,-13, -5,-20,-22, -5,-30, 21,-20,-12, -3,-23, 4, 55,-10,-10,-18,-25,-13, -5; /M: SY='L'; M= -6,-18,-24,-20, -9, -9,-23,-12, 3, -4, 12, 11,-15,-20, -1, 3,-16, -9, -1,-20, -6, -6; /M: SY='T'; M= 4,-11, -1,-15,-10,-17,-17,-15,-11, -4,-13, -8, -8,-18, -4, 1, 5, 7, 0,-29,-15, -8; /M: SY='I'; M= -6,-30,-22,-36,-30, 0,-36,-30, 42,-26, 16, 16,-24,-24,-24,-26,-16, -6, 38,-24, -4,-30; /M: SY='R'; M=-11, -3, -8, -9,-10,-15,-18, -8,-12, 4,-15, -9, 6,-24, -7, 19, -5, -5, -4,-31,-15,-10; /M: SY='R'; M= -4, 0,-25, 0, 0,-25, -4, 3,-28, 11,-24,-13, 3,-15, 2, 17, 2, -7,-20,-26,-12, -1; /M: SY='C'; M= -3, -8, 29,-17,-17,-14,-21, -8,-14,-18,-10, -9, -5,-26,-16,-17, -2, 3, -4,-36,-15,-17; /M: SY='V'; M= -4,-19,-15,-24,-20, -1,-27,-21, 15,-19, 14, 12,-18,-21,-17,-17, -6, 12, 19,-26, -6,-19; /M: SY='G'; M= -2, -4,-29, -1, -5,-29, 17,-15,-28,-11,-26,-18, -4, 12, -6,-15, 0, -7,-25,-26,-25, -7; /I: I=-5; MI=0; MD=-28; IM=0; DM=-28; /M: SY='V'; M= -6,-13,-14,-16,-13, 0,-20,-11, 6, -9, 5, 3,-12,-16,-10, -4, -6, 6, 8,-13, 3,-13; D=-5; /I: I=-5; DM=-28; /M: SY='H'; M= -7, 5,-20, 8, 9,-22, -2, 12,-22, 2,-19,-10, 4, -9, 8, 0, 1, -7,-19,-21, -8, 8; D=-5; /I: I=-5; DM=-28; /M: SY='E'; M= -7, 1,-23, 2, 7,-18, -9, -7,-15, -8, -6, -8, 1,-15, 3, -8, 0, -2,-16,-28,-14, 5; /M: SY='V'; M= -8,-28,-19,-30,-26, 8,-32,-18, 26,-22, 17, 12,-26,-28,-22,-20,-18, -6, 27,-14, 12,-26; /M: SY='D'; M= -7, 17,-27, 25, 14,-30,-12, -5,-29, 3,-25,-20, 5,-11, 7, -5, 1, -7,-24,-17,-14, 11; /M: SY='K'; M= -1, -4,-14, -7, 0,-24, -3,-14,-26, 9,-22,-13, -2,-14, -3, 5, 0, 0,-16,-25,-17, -2; /M: SY='L'; M= -9,-30,-20,-31,-22, 8,-31,-22, 24,-29, 42, 19,-29,-29,-21,-21,-27, -9, 16,-21, -1,-22; /I: I=-8; MI=-8; MD=-33; IM=-8; DM=-33; /M: SY='P'; M=-10,-18,-39, -9, 2,-31,-20,-17,-20, -8,-29,-18,-18, 79, -2,-17, -9,-10,-30,-29,-28, -4; /M: SY='L'; M=-10,-30,-22,-32,-22, 8,-32,-22, 26,-30, 44, 20,-28,-28,-20,-22,-28,-10, 14,-20, 0,-22; /M: SY='P'; M=-10,-14,-38, -7, 0,-29,-18,-17,-20, -9,-30,-20,-12, 79, -9,-18, -8, -9,-30,-31,-29, -9; /M: SY='P'; M= -4,-11,-27,-10, -4,-21, -1,-16,-14,-11,-19,-12, -5, 8, -8,-11, 4, -1,-14,-28,-20, -8; /M: SY='R'; M= 3,-14,-23,-16, -8,-14,-17,-10,-10, 5,-11, -2,-12, -6, -4, 9, -7, -6, -5,-18, -6, -8; /M: SY='L'; M=-10,-28,-21,-31,-21, 7,-29,-18, 23,-26, 41, 27,-27,-27,-16,-19,-27,-10, 12,-20, 0,-19; /M: SY='R'; M= -9,-10,-28,-12, -1,-20,-21, -8,-15, 19,-11, -3, -6,-17, 8, 29,-11, -9,-12,-20, -9, 1; /M: SY='D'; M= -7, 17,-25, 25, 19,-29,-12, -3,-30, 6,-24,-21, 8,-10, 5, 7, 5, -5,-22,-32,-18, 11; /M: SY='Y'; M=-20,-20,-27,-23,-20, 38,-28, 20, -5,-16, 0, 0,-15,-28,-16,-12,-18,-12,-10, 15, 55,-20; /M: SY='L'; M=-10,-30,-20,-30,-20, 10,-30,-20, 20,-30, 50, 20,-30,-30,-20,-20,-30,-10, 10,-20, 0,-20; /M: SY='K'; M= -8, 0,-24, 3, 7,-21,-17, -9,-19, 12,-13, -9, -2,-14, 2, 8, -2, -4,-14,-27,-12, 4; /M: SY='Y'; M= -7, -5,-25, -3, 7,-11,-10, 3,-18, -4,-17,-10, -3,-15, 10, -5, 4, -3,-19,-12, 11, 7; /M: SY='Y'; M=-17,-18,-27,-19, -9, 23,-27, 1, -6, -9, 1, -1,-15,-24, -6, -2,-16,-10,-11, 5, 32, -9; /M: SY='P'; M= -9, 0,-27, 0, -3,-21,-18, -1,-10, -6,-18,-10, 3, 5, -4,-10, 0, -5,-13,-31,-12, -6; /M: SY='F'; M= -5,-20,-21,-26,-18, 22,-22,-11, -1,-16, 1, 7,-16,-10,-18,-16,-10, -2, -3, -7, 12,-18; /M: SY='Q'; M= 1, -5,-28, -5, 9,-32,-16, -5,-21, 13,-22, -7, -5, 4, 25, 5, -2, -8,-22,-21,-15, 16; /I: E1=0;» more |
Numerical results [info]
| Total number of hits | 116 in 116 different sequences |
| Number of true positive hits | 116 in 116 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 2 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 98.31 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | K_Hofmann |
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Feature key [info] | DOMAIN |
| Feature description [info] | SOCS box |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
116 sequences
ASB10_HUMAN (Q8WXI3 ), ASB10_MOUSE (Q91ZT7 ), ASB11_BOVIN (Q3SZE4 ), ASB11_HUMAN (Q8WXH4 ), ASB11_MOUSE (Q9CQ31 ), ASB11_PONAB (Q5RFS1 ), ASB13_HUMAN (Q8WXK3 ), ASB13_MOUSE (Q8VBX0 ), ASB14_HUMAN (A6NK59 ), ASB14_MOUSE (Q8C6Y6 ), ASB14_RAT (P0C927 ), ASB15_BOVIN (Q8HXA6 ), ASB15_HUMAN (Q8WXK1 ), ASB15_MOUSE (Q8VHS6 ), ASB16_HUMAN (Q96NS5 ), ASB16_MOUSE (Q8VHS5 ), ASB17_BOVIN (Q32KY8 ), ASB17_CANLF (Q8HYV8 ), ASB17_HUMAN (Q8WXJ9 ), ASB17_MACFA (Q95LR4 ), ASB17_MOUSE (Q8VHP9 ), ASB18_HUMAN (Q6ZVZ8 ), ASB18_MOUSE (Q8VHA6 ), ASB1_HUMAN (Q9Y576 ), ASB1_MOUSE (Q9WV74 ), ASB2_BOVIN (Q3SX45 ), ASB2_HUMAN (Q96Q27 ), ASB2_MOUSE (Q8K0L0 ), ASB2_RAT (Q5U2S6 ), ASB3_BOVIN (Q08DV6 ), ASB3_HUMAN (Q9Y575 ), ASB3_MOUSE (Q9WV72 ), ASB4_HUMAN (Q9Y574 ), ASB4_MOUSE (Q9WV71 ), ASB5_BOVIN (Q17QS6 ), ASB5_HUMAN (Q8WWX0 ), ASB5_MOUSE (Q9D1A4 ), ASB5_RABIT (Q862Z2 ), ASB6_HUMAN (Q9NWX5 ), ASB6_MOUSE (Q91ZU1 ), ASB6_PONAB (Q5R4M7 ), ASB7_HUMAN (Q9H672 ), ASB7_MACFA (Q9BGT9 ), ASB7_MOUSE (Q91ZU0 ), ASB7_PONAB (Q5RCK5 ), ASB8_BOVIN (Q08E43 ), ASB8_HUMAN (Q9H765 ), ASB8_MACFA (Q4R544 ), ASB8_MOUSE (Q91ZT9 ), ASB8_PONAB (Q5R6D7 ), ASB9_HUMAN (Q96DX5 ), ASB9_MOUSE (Q91ZT8 ), CISH_BOVIN (Q2HJ53 ), CISH_CHICK (Q9PW70 ), CISH_HUMAN (Q9NSE2 ), CISH_MOUSE (Q62225 ), CISH_RAT (O70512 ), DYH12_BOVIN (Q58CT0 ), GUS_DROME (A1Z6E0 ), NEUL2_HUMAN (Q9BR09 ), NEUL2_MOUSE (Q9D0S4 ), RB40A_HUMAN (Q8WXH6 ), RB40B_HUMAN (Q12829 ), RB40B_MOUSE (Q8VHP8 ), RB40C_HUMAN (Q96S21 ), RB40C_MOUSE (Q8VHQ4 ), RB40L_HUMAN (P0C0E4 ), SOCS1_HUMAN (O15524 ), SOCS1_MOUSE (O35716 ), SOCS1_RAT (Q9QX78 ), SOCS2_BOVIN (Q861R0 ), SOCS2_HUMAN (O14508 ), SOCS2_MOUSE (O35717 ), SOCS2_PIG (Q7YRV6 ), SOCS2_RAT (O88582 ), SOCS3_BOVIN (Q9BEG9 ), SOCS3_CANLF (Q68AM8 ), SOCS3_CHICK (Q90X67 ), SOCS3_HUMAN (O14543 ), SOCS3_MOUSE (O35718 ), SOCS3_RAT (O88583 ), SOCS4_BOVIN (Q0VC91 ), SOCS4_HUMAN (Q8WXH5 ), SOCS4_MOUSE (Q91ZA6 ), SOCS4_PONAB (Q5RDX2 ), SOCS5_BOVIN (Q29RN6 ), SOCS5_HUMAN (O75159 ), SOCS5_MOUSE (O54928 ), SOCS6_HUMAN (O14544 ), SOCS6_MOUSE (Q9JLY0 ), SOCS6_PONAB (Q5RCM6 ), SOCS7_HUMAN (O14512 ), SOCS7_MOUSE (Q8VHQ2 ), SPSB1_BOVIN (Q5E9X6 ), SPSB1_HUMAN (Q96BD6 ), SPSB1_MOUSE (Q9D5L7 ), SPSB2_HUMAN (Q99619 ), SPSB2_MOUSE (O88838 ), SPSB2_RAT (Q5M877 ), SPSB3_BOVIN (Q3MHZ2 ), SPSB3_HUMAN (Q6PJ21 ), SPSB3_MOUSE (Q571F5 ), SPSB3_XENLA (Q5M9B1 ), SPSB3_XENTR (Q28DT9 ), SPSB4_HUMAN (Q96A44 ), SPSB4_MOUSE (Q8R5B6 ), TULP4_HUMAN (Q9NRJ4 ), TULP4_MOUSE (Q9JIL5 ), WSB1_DANRE (Q7T2F6 ), WSB1_HUMAN (Q9Y6I7 ), WSB1_MOUSE (O54927 ), WSB1_TAKRU (Q9W5Z5 ), WSB1_XENTR (Q6P1V3 ), WSB2_BOVIN (Q0V8J1 ), WSB2_HUMAN (Q9NYS7 ), WSB2_MOUSE (O54929 )» more
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| UniProtKB/Swiss-Prot False negative sequences |
2 sequences
ASB12_HUMAN (Q8WXK4 ), ASB12_MOUSE (Q9D738 ) |
| PDB [Detailed view] |
11 PDB
2C9W; 2IZV; 2JZ3; 3ZKJ; 3ZNG; 4JGH; 5BO4; 6I4X; 6I5J; 6I5N; 6V9H |
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