PROSITE entry PS50290
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PURL: https://purl.expasy.org/prosite/signature/PS50290
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General information about the entry
| Entry name [info] | PI3_4_KINASE_3 |
| Accession [info] | PS50290 |
| Entry type [info] | MATRIX |
| Date [info] |
01-DEC-2001 CREATED;
23-FEB-2022 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00710 |
| Associated ProRule [info] | PRU00269 |
Name and characterization of the entry
| Description [info] | Phosphatidylinositol 3- and 4-kinases catalytic domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=279; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=274; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.6666881; R2=0.0085123; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=1038; N_SCORE=10.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=568; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-24; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='F'; M= -46, -9, 0, 5, 56, 31, -66, 20, -35, -28, 14, -8, -74, -66, -32, -45, -61, 26, 13, 15; /M: SY='P'; M= -1, -7, 16, -1, -27, -26, -8, 16, -11, -24, -36, -14, 62, -39, -15, 3, -8, 13, -78, -22; /M: SY='E'; M= -38, -78, 45, 46, -2, -33, -33, -74, 10, -40, -68, 18, 41, -5, 3, 7, -23, -73, 39, -7; /M: SY='P'; M= -21, -76, -26, 27, -12, -43, -41, -38, 23, -42, -49, -12, 55, 29, 11, -6, 17, 14, -15, -64; /M: SY='C'; M= -15, 62, -33, 44, 12, -44, -37, 27, -63, -6, -11, -66, -72, -39, -39, -6, -34, 37, -75, -4; /M: SY='R'; M= -29, -32, -15, -8, -66, -40, -37, 27, 27, -3, 0, -13, -4, -27, 47, 14, 31, -47, -77, -39; /M: SY='V'; M= -35, -71, -79, -75, 3, -81, -75, 61, -54, 8, -41, -73, -76, -48, -32, -1, -33, 64, -73, 10; /M: SY='M'; M= 0, -37, -55, -48, 41, -69, -25, 6, -24, 8, 60, -10, -20, 26, 1, 23, -15, -20, -66, 11; /M: SY='S'; M= -24, -74, 9, 5, -52, 20, -23, -76, 37, -67, -68, 17, 19, 17, 15, 39, 13, -72, -79, -68; /M: SY='S'; M= -32, -70, -46, -64, -74, 63, 31, -29, -62, -49, -67, -21, -66, -57, -67, 71, 4, -68, -79, -41; /M: SY='S'; M= 3, -69, -60, -16, -62, -12, -61, -9, 30, 28, -20, 34, -69, -54, -16, 38, 8, -21, -77, -29; /M: SY='Q'; M= -9, -72, -58, -15, -73, 20, -13, -53, 34, -30, 18, -7, -42, 51, -6, 38, 28, -42, -78, -65; /M: SY='G'; M= 6, 9, -37, -22, -36, 40, -9, -48, 39, -9, 5, -57, -70, -22, 32, -16, -38, 2, -73, -4; /M: SY='P'; M= 22, -79, -65, -58, -76, -12, -67, -38, -62, -76, -67, -64, 104, -62, -71, 29, -16, -48, -76, -8; /M: SY='Y'; M= -40, -77, -66, -58, -34, -59, 9, -12, 57, 22, -50, -62, -19, -52, 41, -63, -62, -24, -58, 72; /M: SY='K'; M= -66, -78, -48, -58, 41, -63, -60, 18, 53, -11, 6, -62, -73, 8, 49, -64, -49, -24, 53, 28; /M: SY='I'; M= -31, -8, -81, -44, 13, -22, -73, 51, -55, 42, 47, -75, -48, -70, -39, -52, -59, 36, -5, -54; /M: SY='T'; M= -21, -7, -17, -19, -45, -46, 8, -26, 28, -21, -18, 19, -34, 19, -6, 7, 51, -9, -72, 37; /M: SY='F'; M= -37, 19, 23, -69, 62, -31, -68, 43, -53, 12, 10, 3, -77, -70, -72, -35, -24, -14, 57, -6; /M: SY='R'; M= -61, -44, 1, 17, -27, -50, -1, 10, 31, -27, -35, -8, 26, -21, 53, 3, -5, -11, -77, -26; /I: I=-16; MI=0; MD=-40; IM=0; DM=-40; /M: SY='G'; M= -28, -8, 6, -41, -92, 62, -20, -73, -78, -41, -83, -33, -62, -48, -24, -40, -16, -58, -95, -87; D=-16; /I: I=-16; DM=-40; /M: SY='S'; M= -37, -82, -68, -31, -55, -34, 23, -81, -39, -37, -40, 9, 2, 13, -41, 59, 11, -78, -92, -29; D=-16; /I: I=-16; DM=-40; /M: SY='D'; M= -68, -81, 76, -44, -55, -24, -2, -60, -27, -34, -12, 47, -76, -25, -49, 11, -6, -65, -97, -44; D=-16; /I: I=-16; DM=-40; /M: SY='G'; M= -23, -78, -62, 8, -46, 78, -68, -31, 3, -52, -69, -13, -15, -20, -14, -55, -65, -19, 39, -43; D=-16; /I: I=-16; DM=-40; /M: SY='K'; M= -58, -46, -16, 3, -76, 29, 6, -46, 52, -33, -20, 13, -18, 21, 13, 16, -8, -43, -79, -67; D=-16; /I: I=-16; DM=-40; /M: SY='W'; M= -46, -75, 7, 28, -24, -70, -22, 12, 23, 9, -56, 25, 4, -6, 11, 8, -15, -10, 46, -60; /M: SY='Y'; M= -25, 27, -66, -66, -13, -73, 42, 26, -47, -22, -50, 11, -35, 13, -11, -5, -48, -15, -52, 93; /M: SY='P'; M= 12, -74, -26, -17, -70, -14, -33, 17, 15, -63, -41, -12, 52, -1, 10, 24, -9, 15, -77, -23; /M: SY='F'; M= 24, -13, -75, -70, 53, 4, -67, 23, -69, -13, 1, -68, -75, 17, -70, -26, -38, 33, -9, 34; /M: SY='I'; M= -27, -71, -83, -78, -46, -84, -74, 66, -76, 46, 36, -78, -78, -72, -76, -71, -58, 44, -73, 1; /M: SY='F'; M= -13, 42, -83, -78, 85, -80, -32, -12, -76, 20, -29, -75, -82, -79, -75, -68, -29, 42, -2, -15; /M: SY='K'; M= -62, -77, -55, -42, -78, -69, -57, -75, 105, -75, -7, -18, -64, 12, -26, -57, -57, -45, -73, -65; /M: SY='P'; M= -27, 0, -61, -60, -70, 37, 6, -51, 24, -42, -64, 30, 67, -59, -42, -3, -4, -5, -75, 14; /M: SY='G'; M= -56, -76, 20, -16, -76, 66, 28, -20, 27, -55, -9, -10, 3, -34, -15, -8, -14, -36, -79, -68; /M: SY='D'; M= -8, -76, 95, 35, -82, -62, -35, -44, -41, -78, -75, 29, -65, -50, -61, 11, -33, -43, -93, -70; /I: I=-15; MD=-38; /M: SY='D'; M= -44, -4, 98, 46, -87, -33, -57, -84, -31, -82, -80, -15, -67, -17, -62, -57, -34, -49, -96, -73; D=-15; /I: I=-15; MI=0; MD=-38; IM=0; DM=-38; /M: SY='L'; M= -19, 41, -16, -72, 28, -78, -69, -14, -74, 68, -4, -73, -56, -70, -74, 1, -43, 4, -71, -52; /M: SY='R'; M= -62, -80, -61, -14, -75, 9, 19, -80, -13, -74, -3, -54, -33, -44, 100, 3, -23, -74, -77, -63; /M: SY='Q'; M= -61, -81, -59, -42, -78, -70, -52, -68, 8, -10, -56, -29, -9, 105, 55, -25, -39, -28, -74, -62; /M: SY='D'; M= -63, -79, 102, 37, -82, -9, -54, -83, -53, -81, -78, -19, -36, -51, -62, -4, -12, -79, -92, -21; /M: SY='M'; M= 24, 55, -57, 43, -69, -6, -21, -36, -56, -22, 55, 9, -68, 49, -60, -11, -41, -4, -79, -34; /M: SY='R'; M= -66, -76, -71, -14, 6, -81, -25, 10, -37, 51, -23, -68, -21, -2, 71, -68, -63, -14, -72, -55; /M: SY='M'; M= 18, -68, -76, -72, -7, -1, -71, 31, -24, -20, 67, -68, -73, -67, -70, -60, 7, 58, -75, -14; /M: SY='M'; M= -63, 0, -67, 28, -18, -39, -62, -22, -64, 45, 84, -27, 35, -2, -67, -58, -40, -10, -73, -25; /M: SY='Q'; M= -60, -81, -33, 19, -86, -66, -48, -77, 19, -73, -61, 32, -66, 116, -41, -34, -59, -77, -75, -63; /M: SY='M'; M= -63, -71, -78, -70, 34, -81, -24, 21, -27, 46, 62, -71, -77, 14, -14, -67, -2, 31, -70, -50; /M: SY='F'; M= -36, -72, -74, -75, 64, 23, -69, 47, -41, 25, -46, 3, -76, -71, -45, -16, -18, -18, -63, -16; /M: SY='Y'; M= -24, -35, -2, 6, -40, 14, -56, -32, 8, -56, -63, 1, -68, 18, 41, 32, 14, -37, -28, 41; /M: SY='L'; M= -31, -72, -73, -47, -52, -54, 22, 23, -17, 51, 50, -68, -40, 23, 7, -34, -16, 5, -73, -5; /M: SY='M'; M= -58, 44, -77, -21, 29, -77, -68, 14, -70, 9, 87, -70, -76, -67, -71, 7, -36, 50, -74, -53; /I: I=-23; MD=-58; /M: SY='N'; M= -50, -39, 55, 25, -56, 5, -51, -77, -14, -80, -72, 86, -69, -8, -33, -4, -34, -34, -89, -51; D=-23; /I: I=-23; MD=-58; /M: SY='T'; M= 8, -87, -14, 21, -31, -56, -13, -49, 0, -82, -78, -16, -24, -28, -21, -11, 22, -24, -91, -6; D=-23; /I: I=-23; MD=-58; /M: SY='L'; M= -18, 5, -95, -93, -38, 8, -87, 13, -91, 26, 17, -87, -94, -86, -92, -28, -48, -15, -89, -7; D=-23; /I: I=-23; MI=0; MD=-58; IM=0; DM=-58; /M: SY='K'; M= 28, -74, -3, -54, -79, -13, -19, -50, 48, -40, -67, 46, -71, 9, 16, 4, -9, -70, -83, -70; D=-23; /I: I=-23; DM=-58; /M: SY='D'; M= -57, -16, 56, -58, -25, -58, -4, 51, -31, -3, -28, 31, -74, -25, -28, 3, -36, -23, -77, 20; D=-23; /I: I=-23; DM=-58; /M: SY='W'; M= -21, -17, -49, -43, 11, -74, -28, -31, 14, 19, -56, -37, 2, -20, 47, -19, -15, -15, 104, -51; D=-23; /I: I=-23; DM=-58; /M: SY='E'; M= -1, -77, -23, 73, -74, -73, -59, -54, 37, -5, -61, -39, -44, 33, -13, -38, -37, 1, -79, -68; D=-23; /I: I=-23; DM=-58; /M: SY='T'; M= -11, 39, 29, -12, -51, -65, -62, -37, 10, -16, -34, 12, -28, 20, -45, 24, 57, -4, -84, -66; /M: SY='R'; M= 30, -15, -44, 35, -19, -40, -32, -29, -30, -57, -24, 2, -68, 33, 57, 8, -6, -20, -21, -34; /M: SY='R'; M= 3, -75, -40, -19, -76, 33, -57, -42, 49, -36, -64, 33, -68, 26, 52, -16, -45, -59, -76, -67; /M: SY='R'; M= -47, -76, -70, -30, -53, -59, -20, -24, -20, 46, -2, -66, -40, -20, 76, -33, -62, -16, -68, 33; /M: SY='D'; M= -47, -1, 63, 8, -9, 7, 45, -19, 11, -17, -64, 39, 2, -41, -6, -17, -58, -70, -83, -62; /M: SY='L'; M= -27, -13, -83, -75, -3, -83, -67, -13, -54, 80, 33, -79, -81, -70, -73, -73, -35, -4, -70, -12; /M: SY='W'; M= -45, 16, 29, -53, 1, 0, 46, -73, 12, -70, -25, 24, -71, 32, 20, 12, 1, -72, 63, 29; /M: SY='I'; M= -9, -72, -80, -75, 16, -81, 24, 58, -73, 39, 46, -73, -77, -69, -73, -68, -24, 23, -69, 11; /M: SY='R'; M= -49, -24, -39, -45, 0, -72, -5, -26, 3, -34, -57, 4, 34, 32, 56, -32, 34, 20, -75, -12; /M: SY='P'; M= -53, -75, -64, -59, -71, -35, 20, 3, -23, -45, -21, -27, 80, -33, 11, -14, 61, -1, -82, -67; /M: SY='Y'; M= -68, -79, -70, -69, 26, -76, -44, -56, -20, -38, 7, -69, 24, -61, -23, -26, -14, -36, -37, 117; /M: SY='K'; M= 18, -72, -59, -23, -74, 24, -37, -41, 41, -28, -63, -1, 6, -11, 29, 25, 23, -54, -77, -67; /M: SY='V'; M= -18, 56, -39, -69, -59, -52, -76, 25, -4, -22, -48, -18, -39, -4, -68, -13, -25, 74, -84, -64; /M: SY='V'; M= -45, -70, -81, -75, -37, -83, -75, 55, -29, 40, 35, -74, -76, -70, -27, -68, -3, 55, -77, -57; /M: SY='P'; M= 31, -76, -67, -58, -76, -63, -69, -29, -29, -70, -63, -65, 97, -62, -15, 23, -33, 18, -80, -74; /M: SY='T'; M= -61, -22, -74, -70, 7, -77, -41, 6, -69, 48, 41, -67, 8, -68, -71, -21, 56, 7, 26, -21; /M: SY='S'; M= -18, -69, -22, -63, -36, 49, -64, -10, -61, -18, -63, 0, -21, -59, -29, 60, 39, -49, -79, -67; /I: I=-10; MI=0; MD=-26; IM=0; DM=-26; /M: SY='P'; M= 5, -76, 22, 26, -73, -57, -16, -72, 23, -64, -19, -29, 64, -9, -12, 29, 9, -54, -76, 7; /M: SY='Q'; M= -38, -28, 22, 15, -69, 2, 16, -24, 8, -3, -3, 26, -7, 37, 30, -29, -20, -2, -79, -31; /M: SY='C'; M= 7, 57, -51, -20, -3, 13, -12, 7, -62, -35, 33, -57, -70, -15, -16, 41, 25, 5, -79, -62; /M: SY='G'; M= -37, -75, -62, -68, -80, 88, -65, -84, -40, -81, -13, -15, -68, -59, 27, 28, -61, -78, -75, -73; /M: SY='M'; M= -44, -22, -83, -76, 47, -83, -71, 52, -74, 46, 54, -76, -79, -5, -74, -55, -60, 18, -67, -47; /M: SY='I'; M= -11, -74, -76, -70, -32, -58, -73, 80, -69, 7, 6, -23, -73, 40, -71, -30, -37, 24, -75, -58; /M: SY='E'; M= -40, -79, 9, 89, -78, 7, 23, -54, -24, -17, -36, -4, -61, 27, -54, -42, -60, -72, -80, -68; /M: SY='W'; M= -65, 3, 16, -71, 62, -31, -76, 9, -71, -33, 19, -71, -31, -73, -74, -46, -3, 35, 114, -40; /M: SY='V'; M= -48, 8, -76, -54, -56, -31, -76, 36, -42, 0, 5, -7, 13, -30, -73, -38, -54, 76, -82, -62; /M: SY='P'; M= -38, -79, 10, 17, -13, -37, 11, -67, 16, -31, -33, 10, 88, -21, -40, -29, 2, -20, -79, -68; /I: I=-31; MD=-79; /M: SY='N'; M= -34, -74, 32, -34, -80, 36, 39, -81, -57, -83, -72, 82, -2, -56, -56, 7, 2, -79, -91, -71; D=-31; /I: I=-31; MI=0; MD=-79; IM=0; DM=-79; /M: SY='S'; M= 19, 46, -45, -38, 0, -62, -61, -32, -40, -43, -59, -3, -69, -59, -41, 54, 45, -5, -69, 46; /M: SY='K'; M= -16, 20, 30, 12, -67, -40, 4, 18, 33, -26, 22, -21, -68, -35, -8, -28, 25, 24, -82, -63; /M: SY='T'; M= -32, -69, -9, -16, -72, -16, -64, -63, -25, -38, -63, -25, 51, -18, -38, 51, 68, -12, -83, -68; /M: SY='L'; M= 9, -70, -47, -72, -1, -79, 1, 34, -69, 61, 32, -74, -78, -66, 2, -68, -45, 4, -72, -34; /M: SY='H'; M= 15, -75, 32, -13, 13, -18, 81, -34, 7, -46, -9, -43, -32, 3, 28, -25, -13, -35, -76, -2; /M: SY='E'; M= -1, -73, 17, 46, -32, -14, 8, -73, 25, -72, -21, 0, -47, 33, -38, 39, -9, -42, -75, 9; /M: SY='I'; M= -39, -75, -81, -78, 31, -83, -73, 74, -51, 19, -1, -42, -76, -72, -43, -69, -6, 13, 57, 22; /M: SY='L'; M= -64, -12, -70, -64, 27, -16, 7, 14, 13, 45, -16, -8, -39, 40, -60, -26, -61, -43, 15, 36; /M: SY='K'; M= -20, -3, 8, -10, -68, -53, 26, -43, 41, -10, 9, 21, -44, -2, 41, 16, -28, -1, -78, -18; /M: SY='Q'; M= -42, -76, 3, 34, -44, 11, -15, -44, 33, -53, -13, 21, 19, 38, 11, 9, 3, -41, -79, -66; /M: SY='Y'; M= 3, -13, -63, 0, 30, -50, 34, -20, 8, -4, -55, 7, -38, -22, -24, 9, 10, -30, 44, 56; /M: SY='Y'; M= -60, 40, -1, 4, -59, 21, 51, -25, -18, -53, 26, -55, 5, 12, 12, 9, -7, -33, -68, 53; /I: I=-2; MD=-6; /M: SY='K'; M= 14, -43, -9, 20, -72, 6, -64, -28, 21, -12, -23, 16, -72, 15, -21, 8, -12, -42, 4, -6; D=-2; /I: I=-2; MD=-6; /M: SY='K'; M= -40, -25, -39, -16, -55, -35, -17, -5, 30, -63, -3, 6, -14, 12, 15, 20, -11, -19, -89, -74; D=-2; /I: I=-2; MD=-6; /M: SY='K'; M= -20, -22, 2, -4, -46, 11, -38, -56, 14, -60, 14, -15, -83, -22, -2, -15, 1, -81, -89, -1; D=-2; /I: I=-2; MD=-6; /M: SY='G'; M= -10, -92, -21, -19, -73, 21, -2, -53, 13, -91, -10, 6, -86, -17, -54, 2, -22, -87, -96, -27; D=-2; /I: I=-2; MD=-6; /M: SY='I'; M= -21,-101, -68, -68, -18, -68, -50, 28, -7, -27, -21, -93, 1, -89, -40, -89, -30, -21, -23, -20; D=-2; /I: I=-2; MI=0; MD=-6; IM=0; DM=-6; /M: SY='F'; M= -60,-102, -51, -69, 20, -10, -10, -88, 2, -50, -28, -1, -49, -16, -22, -46, -70, -19, -99, -81; D=-2; /I: I=-2; DM=-6; /M: SY='F'; M= -62, -42, -51, -49, 35, -96, -17, -23, -3, -85, -84, 5, 28, -45, -62, -56, -16, -55, -22, -16; D=-2; /I: I=-2; DM=-6; /M: SY='P'; M= -86,-103, 22, -14, -99, -92, 5, -42, 27, -57, -23, -75, 33, -29, -4, -21, -58, -92,-104, -89; D=-2; /I: I=-2; DM=-6; /M: SY='P'; M= -67, -51, 13, -38, -3, -90, -35, -36, -45, -17, -79, -39, 65, -83, -64, -23, -30, -29, -97, -83; D=-2; /I: I=-2; DM=-6; /M: SY='V'; M= 0, -39, -32, -64, -77, -1, -85, -20, -45, -27, 28, -79, -13, -26, -63, -61, 3, 36, -94, -27; D=-2; /I: I=-2; DM=-6; /M: SY='M'; M= -75, -83, -89, -83, 24, -89, -25, -14, -20, 42, 51, -83, -37, -77, -47, -1, -71, -17, -77, 4; D=-2; /I: I=-2; DM=-6; /M: SY='H'; M= -31, -83, -74, -33, -23, -58, 42, -52, 28, 23, -58, -49, -82, -40, 37, -23, -69, -8, -76, 29; D=-2; /I: I=-2; DM=-6; /M: SY='Q'; M= -58, -84, 26, 26, -71, -75, 51, -76, 6, -12, -16, 27, -75, 56, -27, -62, -36, -77, -80, 29; D=-2; /I: I=-2; DM=-6; /M: SY='W'; M= -31, -87, -86, -76, 45, -80, -3, -49, -8, -36, 17, -80, -83, -21, -27, -45, -75, -34, 128, 59; D=-2; /I: I=-2; DM=-6; /M: SY='F'; M= -20, -3, -85, -39, 97, -83, -71, -12, -78, 31, -26, -78, -85, -81, -77, -44, -22, -52, -55, -34; D=-2; /I: I=-2; MI=0; MD=-6; IM=0; DM=-6; /M: SY='M'; M= -70, -80, -78, -53, -11, -85, 1, 7, 22, 22, 27, -72, -81, -19, 6, -26, 6, 13, 9, 6; D=-2; /I: I=-2; DM=-6; /M: SY='E'; M= -2, -35, 14, 39, -84, -32, -4, -56, 27, -66, -73, -28, -5, 30, -6, 15, -5, -76, -86, -45; D=-2; /I: I=-2; DM=-6; /M: SY='H'; M= -51, -35, -44, -9, -71, -68, 64, -43, 37, -49, 5, 42, -69, 20, 10, 12, 32, -55, -35, -7; D=-2; /I: I=-2; DM=-6; /M: SY='F'; M= -42, -8, 38, -4, 74, -51, -7, -62, -61, -59, -61, 48, -74, -40, -65, 20, -19, -36, -59, 45; /M: SY='P'; M= -36, -77, -62, -9, -3, 30, -7, -53, -15, -10, -41, -27, 76, -38, -3, 18, 11, -48, -74, -18; /M: SY='D'; M= -32, -72, 65, 11, -50, -5, -14, -27, -43, -4, -64, 29, -67, -36, -25, 46, 18, -65, -86, -66; /M: SY='P'; M= 26, 33, -22, 37, -54, -65, -64, -71, -16, -51, -66, -49, 90, -56, -65, 0, -34, -48, -76, 0; /I: I=-21; MD=-53; /M: SY='E'; M= -2, -16, 17, 38, -8, -10, -11, -18, -52, -60, -16, 18, -70, -30, -39, 22, 30, -6, -85, -68; D=-21; /I: I=-21; MD=-53; /M: SY='D'; M= 4, -78, 51, 30, -80, -16, -20, -16, -44, -56, 7, -4, -54, -12, -55, 20, 9, -17, -90, -73; D=-21; /I: I=-21; MI=0; MD=-53; IM=0; DM=-53; /M: SY='W'; M= -66, -91, -63, -30, 54, -84, -75, -69, -77, -28, -67, -85, -87, -48, -79, -26, -13, -75, 127, 61; D=-21; /I: I=-21; DM=-53; /M: SY='W'; M= -37, -78, -22, 29, 52, -59, 10, -23, -29, 16, 15, -46, -15, 16, -1, -43, -64, -40, 84, 33; /M: SY='E'; M= 9, -36, 3, 31, -24, 15, -13, -52, 17, -16, -32, 30, -66, 10, -1, 2, 20, -33, -19, -64; /M: SY='A'; M= 51, -24, -69, -62, 21, -63, -66, -16, 0, -7, 23, -62, 13, -59, 11, 12, 16, -5, -72, -28; /M: SY='R'; M= -62, -77, -64, -55, -69, -25, -56, -7, -6, -13, 19, 1, -73, 30, 88, -11, -15, -4, -77, -62; /M: SY='K'; M= -16, -34, 26, 12, -29, -65, -57, -46, 42, -14, -62, 24, -67, 1, 24, 29, 16, -31, -78, -19; /M: SY='N'; M= 1, -70, -53, -27, 30, -51, 9, -65, -12, -37, 13, 73, -70, 42, 1, 5, 29, -44, -76, -57; /M: SY='F'; M= -72, -75, -77, -76, 93, -79, -55, -52, -71, -4, -50, -28, 24, -74, -70, -69, -26, -57, -41, 86; /M: SY='T'; M= 26, -10, -69, -64, -32, -70, -70, 19, -62, -7, -16, -62, -70, 20, -9, -11, 56, 46, -80, -62; /M: SY='R'; M= -46, -54, -36, -6, -9, -72, 30, -12, 21, -1, -56, -41, -71, 23, 64, 19, -11, -44, -69, 33; /M: SY='S'; M= -34, -30, -54, 7, -77, -8, -58, -74, -53, -75, -68, -47, -49, 52, -58, 90, 9, -68, -80, -66; /M: SY='C'; M= -50, 82, -78, -75, 25, -79, 7, -27, -72, 40, 29, -70, -80, -71, -73, -29, 11, 32, -70, 29; /M: SY='A'; M= 84, -17, -61, 14, -74, -55, 57, -65, -60, -66, -60, -59, -66, -28, -63, -14, -54, -11, -79, -65; /M: SY='G'; M= 11, -3, -68, -65, -66, 44, -68, -30, 14, -7, -56, -59, -71, -60, 23, 2, 5, 39, -77, -26; /M: SY='Y'; M= -36, -13, -77, -74, 3, -77, -56, 34, -69, 20, 79, -52, -77, -64, -69, -8, -27, -45, 52, 81; /M: SY='C'; M= -10, 83, -64, -65, -33, 4, -67, -23, -64, -43, -63, -34, -71, -60, -69, 79, -27, 10, -83, -67; /M: SY='M'; M= -60, -71, -83, -76, 2, -83, -73, 58, -73, 11, 79, -75, -76, -23, -74, -69, -28, 59, -75, -54; /M: SY='V'; M= 20, 2, -79, -74, -30, -73, -24, 42, -73, 35, 11, -73, -76, -70, -74, -22, -37, 55, -76, -16; /M: SY='G'; M= -55, 45, 51, 8, -76, 54, 7, -39, -61, -48, -37, -48, -66, -59, -68, 9, 49, -68, -85, -70; /M: SY='Y'; M= -70, -80, -72, -73, 24, -78, 50, 11, -67, -23, -49, -69, -81, -63, -65, -34, -65, -28, 53, 114; /M: SY='I'; M= -41, -73, -80, -75, 5, -84, 9, 70, -66, 16, 12, -73, -77, -68, 24, -69, -58, 47, -75, -54; /M: SY='L'; M= -64, 14, -84, -77, -11, -84, -69, 32, -76, 72, 56, -79, -80, -70, -75, -38, -61, -2, -72, -53; /M: SY='G'; M= -11, -76, -26, -45, -47, 77, -4, -78, -56, -26, -17, 20, -69, 42, 17, -31, -63, -75, -75, -69; /M: SY='I'; M= -64, -71, -70, -74, -26, -77, -67, 60, -70, 54, -38, 56, -33, -68, -73, -67, -57, 9, -76, -58; /M: SY='G'; M= -11, 10, -60, -65, -77, 77, -66, -77, 29, -45, -68, 9, -67, -60, -61, -28, 38, -71, -77, -72; /M: SY='D'; M= -67, -81, 114, -33, -87, -41, -53, -85, -53, -84, -82, -1, -6, -54, -11, -55, -57, -82,-100, -71; /M: SY='R'; M= -67, -82, -65, -53, -72, -78, -53, -39, -26, -30, 9, -58, -76, -42, 112, -62, -65, -70, -75, -61; /M: SY='H'; M= -65, -78, -23, -55, -69, 6, 137, -49, -58, -70, -57, 18, -69, -50, -55, -34, -17, -81, -98, -43; /M: SY='N'; M= 9, 31, -58, -63, -67, 12, -61, -61, -62, 27, -56, 67, 57, -61, -68, -5, -20, -45, -81, -69; /M: SY='D'; M= -38, -76, 72, 29, -82, 45, 29, -83, -39, -80, -41, 16, -66, 4, -61, 23, -57, -79, -86, -69; /M: SY='N'; M= -62, -68, -38, -55, -76, -52, -44, -74, 5, -79, 11, 119, -72, 1, -53, -46, -48, -76, -92, -70; /M: SY='I'; M= -66, -75, -87, -81, 0, -86, -77, 79, -77, 41, 47, -79, -77, -72, -78, -75, -62, -10, 74, -50; /M: SY='M'; M= -65, -70, -82, -73, -21, -81, -13, -19, -71, 67, 101, -76, -78, -17, -69, -73, -62, -27, -69, 4; /M: SY='I'; M= -63, -71, -84, -79, 26, -86, -75, 60, -76, 45, 30, -78, -79, -74, -77, -72, -37, 47, -71, -36; /M: SY='D'; M= -20, -7, 81, -43, -52, -45, 9, -74, 33, -75, -70, -1, -66, -52, -6, 7, 43, -45, -89, -66; /M: SY='K'; M= -43, -44, 11, 20, -66, -55, -18, -17, 52, -21, 36, -29, -21, 31, 30, 1, -17, -53, -72, 22; /M: SY='D'; M= -50, 15, 56, 23, -34, -33, -18, -13, 10, -13, -43, 30, -67, 12, -25, 4, 28, -40, -82, -16; /I: I=-9; MD=-23; /M: SY='T'; M= -70, -16, 1, -20, -84, -39, -28, -84, -25, -64, -81, -45, -80, -73, -78, 26, 65, -77, -35, -9; D=-9; /I: I=-9; MI=0; MD=-23; IM=0; DM=-23; /M: SY='G'; M= -11, -24, -68, -75, -36, 90, -72, -6, -70, -17, -23, -55, -70, -68, -76, -52, -40, -14, -74, -71; /M: SY='H'; M= -49, -78, -4, 49, -75, -16, 78, -72, 55, -38, -61, -23, -65, 22, 7, -48, -39, -8, -81, -59; /M: SY='L'; M= -44, 27, -82, -76, 4, -83, -73, 46, -75, 51, 38, -77, 7, -72, -76, -71, -41, 36, -73, -20; /M: SY='F'; M= -3, -70, -77, -76, 53, -48, -74, 53, -72, 2, -10, 6, -76, -73, -74, -27, -15, 46, 21, -48; /M: SY='H'; M= 2, -78, -56, -56, -70, -20, 129, -44, -59, -48, -56, 10, 35, -52, -58, -34, -35, -39, -93, -47; /M: SY='I'; M= -24, -76, -81, -77, -53, -84, -81, 96, -42, -37, -39, -72, -8, -30, -35, -30, -32, 20, -75, -59; /M: SY='D'; M= -67, -80, 114, -18, -37, -65, -53, -83, -28, -81, -80, -15, -67, -54, -62, -31, -57, -81, -93, 2; /M: SY='F'; M= -47, -72, -73, -74, 97, -77, 61, -51, -71, 18, -48, 24, -82, -72, -69, -68, -64, -56, -51, 37; /M: SY='G'; M= -45, -75, 4, -67, -80, 89, -65, -84, -36, -41, -72, 24, -69, -61, 1, -9, -63, -80, -77, -74; /M: SY='F'; M= -67, 49, 1, -68, 63, -79, 61, 2, -22, 20, -2, -66, -14, -68, -51, -68, -62, 8, -62, 40; /M: SY='C'; M= 35, 85, 3, -19, 15, -69, -70, 40, -69, 3, 21, -65, -75, -67, -73, 3, -57, -32, -76, -34; /M: SY='F'; M= -70, -70, -86, -80, 92, -84, -68, -6, -78, 58, 19, -79, -84, -78, -75, -75, -65, -28, -54, -33; /M: SY='P'; M= -57, -79, 27, 49, -80, 48, -61, -78, -56, -50, -71, 16, 62, -53, -31, 0, -23, -48, -20, -74; /M: SY='Q'; M= -24, -74, 1, 19, -13, -38, 30, -43, 29, -36, -33, 35, -29, 45, 5, 13, 5, -24, 4, -8; /I: I=-28; MI=0; MD=-70; IM=0; DM=-70; /M: SY='G'; M= -46, -1, -24, -6, -79, 53, -69, -51, -17, -73, 42, -57, 35, -27, -70, 17, 35, -59, -83, -74; D=-28; /I: I=-28; DM=-70; /M: SY='D'; M= -43, -82, 50, -8, -1, -45, -12, -72, 42, 0, -65, -12, 46, 3, 14, -62, -29, -73, -81, -66; D=-28; /I: I=-28; DM=-70; /M: SY='C'; M= -27, 39, -5, 17, 15, 16, -67, 8, -32, 3, -33, -25, -74, -43, 18, 3, 8, -15, -77, -39; D=-28; /I: I=-28; DM=-70; /M: SY='W'; M= -63, -75, 34, 4, 14, 23, -63, -58, -64, 41, -53, 23, -74, -15, -68, -23, 0, -61, 74, -21; D=-28; /I: I=-28; DM=-70; /M: SY='P'; M= -30, -81, -67, -19, 27, -53, 43, 9, 8, -25, -14, -65, 76, -35, 29, -63, -26, -16, 13, -31; D=-28; /I: I=-28; DM=-70; /M: SY='N'; M= -10, -72, -13, 6, 10, -15, -59, 8, 28, -28, -55, 38, -51, -12, -20, -20, 0, 23, -69, 37; /M: SY='P'; M= -43, -83, -69, -61, 48, -45, -63, -28, -41, -66, -62, -8, 92, -25, 31, -63, -20, -68, 53, 27; /I: I=-25; MD=-63; /M: SY='E'; M= -67, -85, 18, 91, -23, -81, 9, -80, -33, -11, -38, -61, -65, 5, -59, -64, -66, -77, -85, -71; D=-25; /I: I=-25; MI=0; MD=-63; IM=0; DM=-63; /M: SY='R'; M= -21, -45, -68, -17, -69, -77, 10, -7, 14, -2, -40, -11, 31, -6, 36, -12, 10, -30, -79, 12; D=-25; /I: I=-25; DM=-63; /M: SY='W'; M= 19, -76, -85, -75, -63, -78, -84, -14, -75, -55, 15, -79, 0, -5, -78, -24, -61, 69, 83, -63; D=-25; /I: I=-25; DM=-63; /M: SY='P'; M= -38, -94, -41, -61, -87, -73, -18, -76, -68, -38, -72, -77, 118, -71, -80, -68, -64, -81, -84, -85; D=-25; /I: I=-25; DM=-63; /M: SY='F'; M= -75, -77, -86, -77, 105, -85, -68, -8, -75, -25, 29, -76, -85, 37, -73, -74, -69, -56, -50, -15; D=-25; /I: I=-25; DM=-63; /M: SY='R'; M= 9, -81, -68, -56, -76, -76, -62, -9, 44, -71, -64, -61, -75, -49, 86, -40, -64, -7, -80, -68; D=-25; /I: I=-25; DM=-63; /M: SY='L'; M= -65, -71, -79, -71, 17, -80, -67, -27, -31, 77, 0, -76, 25, -67, -24, -5, -61, -45, -69, -53; /M: SY='T'; M= -54, -9, -59, -26, 7, -69, -65, -27, -36, -37, -58, -14, -28, -61, -38, 0, 99, -26, -79, -4; /M: SY='P'; M= -45, -82, -18, -30, -73, -28, 42, -37, -3, -74, -63, -57, 75, 36, 56, 2, -23, -57, -75, 10; /M: SY='W'; M= -64, -77, 52, 42, 19, -44, -30, -54, -53, -69, 25, 67, -31, 25, -59, -56, -35, -72, 74, -6; /M: SY='M'; M= -11, -71, -79, -75, 39, -52, -66, 48, -71, 26, 84, -70, -75, -67, -71, 9, -37, -8, -66, 7; /M: SY='W'; M= -10, -34, -14, 3, -38, -45, -70, 23, -38, -3, 8, -66, -39, 3, -17, 2, -2, 55, 56, -23; /M: SY='D'; M= -35, -76, 61, 46, -41, -69, 15, -16, -28, -2, 10, 30, -67, -2, -35, -20, -9, -51, -76, 30; /M: SY='P'; M= 30, -71, -69, -3, 25, 25, -70, -7, -67, 9, -53, -66, 36, -66, -72, -47, -1, 31, -71, -17; /M: SY='M'; M= -47, -72, -81, -72, 18, -81, -64, 44, -69, 36, 100, -73, -76, 22, -37, -70, -61, -2, -70, -50; /I: I=-22; MD=-55; /M: SY='G'; M= -4, -80, 13, -25, -84, 75, -69, -85, -43, -37, -74, -14, -73, 3, -14, -12, -38, -80, -82, -77; D=-22; /I: I=-22; MD=-55; /M: SY='Y'; M= -85,-105, -48, -35, -84, 34, -84, -62, -5, -46, -89, -50, -39, -25, -87, -29, -66, -97, -88, 39; D=-22; /I: I=-22; MI=0; MD=-55; IM=0; DM=-55; /M: SY='D'; M= -33,-100, 26, 4,-101, -43, -84, -92, -2, -77, 12, -17, 17, -45, -47, -78, 4, -47,-108, -94; D=-22; /I: I=-22; DM=-55; /M: SY='P'; M= -31, -3, 15, 1, 22, -48, -2, 20, -3, -41, -57, 15, 60, -13, -65, -23, -14, 29, -77, -60; /M: SY='S'; M= -6, -35, -25, 2, -6, -24, -33, -15, -60, -4, 15, -53, -49, -57, -65, 62, 58, -18, -79, -61; /M: SY='G'; M= -38, -16, 5, 30, -53, 56, -13, -57, 37, -52, -67, -51, -13, 54, -35, -33, -30, -75, -74, -20; /M: SY='D'; M= -27, -74, 41, 21, -10, -57, 7, 18, -26, -13, 6, -9, -15, 4, -11, -44, 19, 28, -77, 6; /M: SY='E'; M= -29, 12, -9, 57, 52, -26, -59, 11, -47, -39, 1, -18, -69, -25, -63, -22, 9, -45, 22, 43; /M: SY='G'; M= -24, -77, 21, 20, -81, 68, -2, -82, 4, -48, -69, -12, -67, 39, 14, -31, -41, -77, -77, -70; /M: SY='L'; M= -54, -73, 18, -25, -40, -59, -63, 3, 7, 29, 17, -12, 8, 13, -6, -1, 14, 14, 26, 3; /M: SY='F'; M= -72, -72, -84, -79, 98, -83, -16, -35, -76, 44, -16, -77, -85, -78, -73, -74, -66, -42, -47, 45; /M: SY='R'; M= -34, -45, -37, -45, -14, -46, -60, -7, 37, -22, -1, -17, -72, 11, 70, -21, -25, 19, 36, -18; /M: SY='R'; M= -13, -72, 9, 24, -7, -35, -29, -19, 10, 9, -12, -29, -31, -4, 30, 29, 14, -20, -75, -25; /M: SY='C'; M= -24, 46, -63, -2, -58, -53, 40, -25, -62, 23, 32, 11, 15, -32, -38, 29, 20, -11, -76, 18; /M: SY='C'; M= -19, 122, -76, -73, -51, -7, -71, -10, -16, -4, 57, -64, -80, -69, -32, 2, -44, -29, -85, -41; /M: SY='E'; M= -16, 51, -26, 55, -11, -50, -10, 23, -11, -12, 6, -66, -8, -35, -63, -62, -43, 23, 52, 4; /M: SY='H'; M= 11, -71, -41, 10, -17, -65, 34, -18, 24, -38, 9, 4, -67, 32, 7, 29, 18, 2, -77, -20; /M: SY='T'; M= 41, -14, 3, -64, -65, 5, -71, 25, -65, -33, -15, -58, -68, -64, -70, 6, 50, 32, -81, -66; /M: SY='Y'; M= -6, -7, -74, -46, 34, -57, -57, -48, -34, 34, 58, -70, 20, -32, 6, -26, -25, -27, -57, 64; /M: SY='N'; M= -32, 14, -23, 31, -69, -32, 1, -5, 6, 6, -58, 49, -18, 4, 46, -12, -5, -63, -21, -64; /M: SY='A'; M= 41, 34, -73, -31, 8, -69, -9, 24, -67, 13, -29, -67, -73, -14, -70, 3, 0, 32, 31, -30; /M: SY='M'; M= -5, 43, -82, -75, 18, -78, -69, 12, -74, 56, 59, -75, -79, -70, -73, -31, -34, 13, 31, -21; /M: SY='R'; M= -10, -78, -63, -17, -71, -57, -56, -9, 10, -19, -60, -57, -72, 12, 93, 8, -37, -65, 6, -62; /M: SY='R'; M= -37, -77, 35, 12, -79, -67, -23, -78, 55, -76, -67, 6, -16, 33, 55, 11, -2, -74, -80, -66; /M: SY='H'; M= -61, -44, -10, 18, -63, -32, 62, -61, -56, 5, -57, 59, 28, 13, -44, 5, -18, 3, -78, 22; /M: SY='K'; M= -1, 25, -14, 1, -37, -34, -20, -62, 31, 10, 18, -3, 15, 2, 0, 28, 5, -42, -22, -16; /M: SY='E'; M= -62, -77, 51, 53, -9, -11, 7, -38, -15, -53, -65, 44, -45, 13, 13, -44, -32, -8, -78, 3; /M: SY='L'; M= -7, -72, 28, 0, -60, -46, -20, 12, 12, 29, -16, -40, -51, 5, -20, 11, 6, 10, -77, -11; /M: SY='L'; M= -63, 33, -82, -77, 32, -83, -73, 50, -54, 56, -19, -75, -80, -73, -75, -10, -38, 22, -70, -51; /M: SY='M'; M= -46, -32, -6, -68, -5, -77, -40, 26, -40, 32, 78, -30, -73, -64, -37, -36, 38, 15, -72, 15; /M: SY='N'; M= 0, 2, -27, 7, -69, -32, -31, -4, -54, -39, 43, 59, -68, 11, -7, 32, 34, -14, -83, -65; /M: SY='L'; M= -51, -40, -78, -74, 16, -81, -69, 41, -53, 53, 18, -26, -9, -70, -73, -36, 1, 26, -69, 12; /M: SY='L'; M= -66, -34, -85, -78, 60, -84, -70, 1, -77, 65, 26, -80, -45, -74, -75, -74, -44, 23, 2, -44; /M: SY='E'; M= -16, -20, 23, 61, -77, -34, -36, -74, 42, -34, -66, 20, -63, 12, -9, 22, -27, -41, -80, -48; /M: SY='M'; M= 7, -29, -68, -2, -58, -73, -67, 14, 2, 27, 37, -26, -28, 3, -25, -27, 28, 27, 36, -59; /M: SY='M'; M= -6, -30, 31, -67, 66, -14, -62, -11, -47, 13, 89, -34, -75, -67, -69, -65, -61, -21, -64, -16; /M: SY='V'; M= 9, -71, -69, -8, -58, -74, -67, 23, 10, 31, 7, -66, -26, 27, 8, -18, -42, 40, -77, -61; /M: SY='Y'; M= -2, -31, 28, -1, 10, 10, 33, -53, 2, -58, -28, -18, -43, 12, 17, -14, -33, -49, 41, 63; /M: SY='D'; M= 19, -37, 81, -1, 26, -24, -57, -73, -37, -71, -21, -3, -39, -55, -10, 16, -4, -69, -78, -12; /M: SY='P'; M= -43, -79, 25, 20, -82, 45, -61, -78, -25, -67, -71, 34, 77, -56, -15, -7, -34, -61, -81, -75; /I: I=-18; MD=-45; /M: SY='L'; M= -72, -79, -37, -81, -22, -48, -76, 38, -63, 54, 5, 1, -86, -76, -81, -20, -35, -14, -80, -18; D=-18; /I: I=-18; MI=0; MD=-45; IM=0; DM=-45; /M: SY='P'; M= -79, -92, -89, -81, 35, -89, -36, -15, -82, -21, 22, -87, 70, -83, -86, -80, -27, -3, 28, 30; D=-18; /I: I=-18; DM=-45; /M: SY='C'; M= -68, 69, 52, 27, -84, -49, -5, -25, -28, -81, -77, -3, -76, 27, -68, 16, -30, -78, 29, -74; D=-18; /I: I=-18; DM=-45; /M: SY='W'; M= -69, -11, -80, -23, 27, -71, -19, -1, 2, 39, 25, -77, -34, -64, 0, -73, -69, -56, 127, 0; /M: SY='T'; M= 16, -70, 1, -54, -72, -18, -61, -14, 33, -42, -4, 1, 2, -1, 25, 34, 42, -51, -80, -66; /M: SY='C'; M= 5, 44, -35, 12, -34, -9, -33, -1, 3, 2, 32, 16, -5, -12, -5, 14, 2, -17, 3, -63; /M: SY='F'; M= -38, -74, 7, -9, 59, -2, 19, 8, -9, -23, 12, 1, -31, 28, -43, 21, -36, -21, -65, 1; /M: SY='E'; M= -23, -79, 22, 50, -79, -3, 18, -74, 18, -61, -9, 3, 47, 24, 18, -24, -23, -31, -81, -68; /M: SY='D'; M= -10, -76, 42, 25, -14, -13, -37, 2, 21, -2, -59, 5, 13, 22, 8, -26, -5, -46, -78, -64; /I: I=-20; MD=-51; /M: SY='Q'; M= -68, -16, -56, -62, -51, -1, -68, -41, 37, -33, 20, 1, -77, 46, 14, -6, 23, -74, 2, -72; D=-20; /I: I=-20; MD=-51; /M: SY='M'; M= -20, -88, -81, -35, -84, -17, -79, -38, 0, -34, 57, -23, -37, 10, -59, 14, -4, -16, -96, -80; D=-20; /I: I=-20; MI=0; MD=-51; IM=0; DM=-51; /M: SY='I'; M= -10, -71, -38, -40, -45, -32, -21, 50, -6, 10, -5, -16, -43, -60, -3, 40, 12, 6, -76, -22; /M: SY='K'; M= -11, -75, -26, 18, -46, -21, -35, -14, 34, -25, -28, -28, 25, 17, 31, -15, -42, 31, -75, 1; /M: SY='M'; M= -33, -74, -31, -1, 1, -28, -17, -19, 36, 13, 55, 27, -71, 36, -20, -38, -59, -9, -66, 39; /M: SY='C'; M= -12, 50, -17, -32, -12, -19, -63, -5, 9, 26, -51, 20, -74, 2, 22, -10, -22, 16, -76, -19; /M: SY='R'; M= -18, -78, -31, -4, -26, 34, -15, -8, 29, -18, -61, -19, -3, 29, 56, -19, -48, -66, -73, -30; /M: SY='Q'; M= 7, -76, 36, 42, -79, -23, 15, -59, 12, -41, -64, 16, -35, 69, -22, -7, -28, -32, -81, -66; /M: SY='R'; M= 12, -73, -22, -10, -44, 5, -11, 7, 10, -9, -16, 21, -51, -28, 52, -12, 10, -36, 32, -62; /M: SY='F'; M= -36, -72, -40, 6, 58, -36, -27, -7, -16, 40, 7, -1, -34, -2, -29, -31, -5, -18, -63, 11; /M: SY='N'; M= -13, -4, -16, 6, -39, -7, 41, -37, 5, -70, -3, 48, -2, 26, 31, 16, 2, -24, -14, -63; /M: SY='L'; M= -8, -73, 3, 17, -22, -4, 5, -10, -5, 38, 7, -12, 33, -58, -50, -11, -19, -18, -74, -6; /M: SY='D'; M= -59, -75, 34, 16, -40, 23, -16, 12, -6, -57, -15, 34, 4, 22, -22, -5, 5, 0, -14, -19; /M: SY='M'; M= -44, -71, 11, 24, -65, -33, -57, -56, 9, 18, 61, 33, -35, 20, -45, 32, -19, -12, -80, -63; /M: SY='T'; M= 0, -12, -4, -9, -20, -49, -62, -47, -38, -14, -15, 24, -1, -8, -45, 41, 52, 14, -79, -13; /M: SY='E'; M= -24, -75, 43, 51, -68, -46, -59, 12, -31, 3, 12, 21, -7, -3, -6, -5, -6, -26, -4, -65; /M: SY='E'; M= -6, -76, 1, 68, -75, -60, 13, -48, 23, -27, -45, -37, -29, 32, 11, 3, 3, -32, -16, -65; /M: SY='E'; M= 5, -76, 52, 58, -39, -11, 13, -71, 2, -38, -26, 10, -47, 25, -20, -28, -22, -17, -82, -66; /M: SY='A'; M= 48, 32, -15, -17, -68, 5, -65, -8, -30, 9, -16, 12, 11, -16, -38, 5, -5, -32, -14, -67; /M: SY='W'; M= 10, 23, -12, -46, -61, -33, -67, 18, 22, 8, -52, -7, -36, -15, -2, -4, 26, 20, 32, -28; /M: SY='Q'; M= -31, -72, -18, 22, -21, -43, 25, -27, 13, -2, 14, 9, -46, 34, -14, 33, 20, -5, -76, -11; /M: SY='H'; M= -25, -76, -25, 28, 38, -1, 41, -38, 3, 2, -57, 1, 31, -6, 0, -14, -22, -54, -67, 23; /M: SY='F'; M= 18, -29, -28, -41, 45, -61, -69, 35, -7, -14, 27, -67, -18, -11, 12, -26, -45, 37, -70, -52; /M: SY='Q'; M= -29, -75, 2, 25, -33, -44, 33, 7, 3, 9, 38, -26, -53, 58, 4, -32, 3, -19, -76, -22; /M: SY='D'; M= -2, -34, 36, 8, -74, -10, -12, -51, 30, -14, -62, 25, -48, 28, 16, 18, 1, -22, -81, -66; /M: SY='L'; M= 12, 11, 14, -7, -30, -31, -30, 0, -7, 31, 30, -43, -38, 25, -35, -11, -45, 23, -77, -39; /M: SY='I'; M= -32, 19, -69, -11, -8, -58, -12, 56, -15, 10, -19, -2, -57, 14, -42, -18, 0, 34, -76, -22; /M: SY='M'; M= -48, -8, 19, 31, -40, -19, -3, -16, -10, -16, 31, 21, -18, 24, 11, 22, 8, -29, -79, -12; /M: SY='E'; M= 1, -75, 17, 41, -74, 6, 4, -40, -3, -20, -63, 4, 34, -6, -7, 17, -4, -16, -80, -42; /M: SY='S'; M= 28, 21, -15, -38, -68, -23, -64, 9, 13, -7, -58, -10, 13, -24, 1, 46, -16, -20, -78, -30; /M: SY='V'; M= -29, -71, 7, -25, -10, -57, -3, 19, -41, 13, 32, 1, -36, -34, 3, 1, 21, 34, -76, 7; /M: SY='N'; M= -13, 0, 8, 7, -43, -8, -11, -11, 1, -9, -38, 37, -21, 13, 14, 29, 3, -19, -80, -25; /M: SY='S'; M= 18, -16, -5, 32, -68, 3, -32, -51, -5, 0, -59, -21, -22, 3, 5, 33, -15, 1, -77, -13; /M: SY='W'; M= 14, -73, 23, 20, 5, -38, -6, 5, -7, 15, -55, 4, -18, -28, -6, 14, -27, -12, 27, -59; /M: SY='W'; M= -13, -16, -11, -16, 9, -27, -4, -25, 16, -10, 17, 21, 11, -57, 25, -19, 37, -21, 51, -57; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 168 in 168 different sequences |
| Number of true positive hits | 168 in 168 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes, Eukaryotic viruses |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | PI3K/PI4K catalytic |
| Version [info] | 6 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
168 sequences
AGE1_CAEBR (P0C5E7), AGE1_CAEEL (Q94125), ATM_ARATH (Q9M3G7), ATM_ASPFU (Q4WVM7), ATM_ASPOR (Q2U639), ATM_CAEEL (Q9N3Q4), ATM_CANAL (Q5ABX0), ATM_CANGA (Q6FRZ9), ATM_CRYNB (P0CP61), ATM_CRYNJ (P0CP60), ATM_DEBHA (Q6BV76), ATM_DROME (Q5EAK6), ATM_EMENI (Q5BHE2), ATM_EREGS (Q751J3), ATM_GIBZE (Q4IB89), ATM_HUMAN (Q13315), ATM_KLULA (Q6CP76), ATM_MOUSE (Q62388), ATM_NEUCR (Q7RZT9), ATM_PIG (Q6PQD5), ATM_SCHPO (O74630), ATM_YARLI (Q6CAD2), ATM_YEAST (P38110), ATR1_DICDI (Q54ER4), ATR_ARATH (Q9FKS4), ATR_CAEEL (Q22258), ATR_CANAL (Q59LR2), ATR_CANGA (Q6FX42), ATR_DROME (Q9VXG8), ATR_ENCCU (Q8SSE7), ATR_EREGS (Q75DB8), ATR_HUMAN (Q13535), ATR_KLULA (Q6CT34), ATR_MOUSE (Q9JKK8), ATR_ORYSI (A2YH41), ATR_ORYSJ (Q5Z987), ATR_XENLA (Q9DE14), ATR_YEAST (P38111), LSB6_SCHPO (Q9UT42), LSB6_YEAST (P42951), MTOR_HUMAN (P42345), MTOR_MOUSE (Q9JLN9), MTOR_RAT(P42346), P3C2A_HUMAN (O00443), P3C2A_MOUSE (Q61194), P3C2A_PONAB (Q5RAY1), P3C2B_HUMAN (O00750), P3C2G_HUMAN (O75747), P3C2G_MOUSE (O70167), P3C2G_RAT (O70173), P4K2A_DANRE (Q6PE18), P4K2A_HUMAN (Q9BTU6), P4K2A_MOUSE (Q2TBE6), P4K2A_RAT (Q99M64), P4K2A_XENLA (Q08B31), P4K2A_XENTR (Q505I0), P4K2B_CHICK (Q5ZIK0), P4K2B_DANRE (Q49GP5), P4K2B_HUMAN (Q8TCG2), P4K2B_MOUSE (Q8CBQ5), P4K2B_RAT (Q5XIL2), P4K2B_XENLA (Q6DCQ8), P4K2B_XENTR (Q28G26), P4KA1_ARATH (Q9SXA1), P4KA2_ARATH (Q9C680), P4KB1_ARATH (Q9FMJ0), P4KB2_ARATH (Q0WPX9), P4KG1_ARATH (O22199), P4KG2_ARATH (Q9SGW8), P4KG3_ARATH (Q9FNF8), P4KG4_ARATH (Q9ZPY9), P4KG4_ORYSJ (Q6K881), P4KG5_ARATH (Q9C671), P4KG6_ARATH (Q8W4R8), P4KG7_ARATH (Q9SI52), P4KG8_ARATH (Q0WMZ6), PI3K1_DICDI (P54673), PI3K1_SOYBN (P42347), PI3K2_DICDI (P54674), PI3K2_SOYBN (P42348), PI3K3_DICDI (P54675), PI3K4_DICDI (P54676), PI3K_ARATH (P42339), PI4KA_BOVIN (O02811), PI4KA_HUMAN (P42356), PI4KA_MOUSE (E9Q3L2), PI4KA_RAT (O08662), PI4KB_BOVIN (O02810), PI4KB_CALJA (B0KWC1), PI4KB_DANRE (Q49GP3), PI4KB_HUMAN (Q9UBF8), PI4KB_MOUSE (Q8BKC8), PI4KB_OTOGA (B4UT09), PI4KB_PAPAN (A9X1A0), PI4KB_PLEMO (B1MTG7), PI4KB_RAT (O08561), PI4KB_RHIFE (B2KI64), PI4KB_SORAR (B3EX61), PI4KB_XENLA (Q6GN16), PI4KB_XENTR (A4IID4), PI4K_DICDI (P54677), PI4P2_HUMAN (A4QPH2), PIK1A_CANAL (Q9UW24), PIK1_CANAL (Q9UW20), PIK1_SCHPO (Q10366), PIK1_YEAST (P39104), PIKI1_CAEEL (G5EDY0), PK3C3_CAEEL (Q9TXI7), PK3C3_HUMAN (Q8NEB9), PK3C3_MOUSE (Q6PF93), PK3C3_PIG (Q5D891), PK3C3_RAT (O88763), PK3C3_XENLA (Q6AZN6), PK3CA_BOVIN (P32871), PK3CA_HUMAN (P42336), PK3CA_MOUSE (P42337), PK3CA_RAT (A0A0G2K344), PK3CB_HUMAN (P42338), PK3CB_MOUSE (Q8BTI9), PK3CB_RAT (Q9Z1L0), PK3CD_HUMAN (O00329), PK3CD_MOUSE (O35904), PK3CG_HUMAN (P48736), PK3CG_MOUSE (Q9JHG7), PK3CG_PIG (O02697), PRKDC_CANLF (Q8WN22), PRKDC_CHICK (Q8QGX4), PRKDC_DICDI (Q54UC0), PRKDC_HUMAN (P78527), PRKDC_MOUSE (P97313), PRKDC_XENLA (Q9DEI1), RAD3_SCHPO (Q02099), SMG1_CAEBR (Q61CW2), SMG1_CAEEL (O01510), SMG1_DANRE (C5J7W8), SMG1_DICDI (Q553E9), SMG1_DROME (Q70PP2), SMG1_HUMAN (Q96Q15), SMG1_MOUSE (Q8BKX6), STT4_ENCCU (Q8SQY7), STT4_SCHPO (Q9USR3), STT4_YEAST (P37297), TOR1_SCHPO (O14356), TOR1_YEAST (P35169), TOR2_SCHPO (Q9Y7K2), TOR2_YEAST (P32600), TOR_ARATH (Q9FR53), TOR_CAEEL (Q95Q95), TOR_DICDI (Q86C65), TOR_DROME (Q9VK45), TOR_ORYSJ (Q0DJS1), TRA1_DICDI (Q54T85), TRA1_DROME (Q8I8U7), TRA1_SCHPO (Q9HFE8), TRA1_YEAST (P38811), TRA2_SCHPO (Q10064), TRR1_CAEBR (A8WTE8), TRR1_CAEEL (G5EEV2), TRRAP_DANRE (A0A0R4ITC5), TRRAP_HUMAN (Q9Y4A5), TRRAP_MOUSE (Q80YV3), VPS34_CANAL (A0A1D8PDV7), VPS34_CANAX (Q92213), VPS34_CANGA (Q6FSR7), VPS34_ENCCU (Q8SR56), VPS34_SCHPO (P50520), VPS34_YEAST (P22543), YL615_MIMIV (Q5UR69)» more
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| PDB [Detailed view] |
472 PDB
1E7U; 1E7V; 1E8W; 1E8X; 1E8Y; 1E8Z; 1E90; 1HE8; 2A4Z; 2A5U; 2CHW; 2CHX; 2CHZ; 2RD0; 2V4L; 2WXF; 2WXG; 2WXH; 2WXI; 2WXJ; 2WXK; 2WXL; 2WXM; 2WXN; 2WXO; 2WXP; 2WXQ; 2WXR; 2X38; 2Y3A; 3APC; 3APD; 3APF; 3CSF; 3CST; 3DBS; 3DPD; 3ENE; 3HHM; 3HIZ; 3IBE; 3IHY; 3JBZ; 3L08; 3L13; 3L16; 3L17; 3L54; 3LJ3; 3LS8; 3MJW; 3ML8; 3ML9; 3NZS; 3NZU; 3OAW; 3P2B; 3PRE; 3PRZ; 3PS6; 3QAQ; 3QAR; 3QJZ; 3QK0; 3R7Q; 3R7R; 3S2A; 3SD5; 3T8M; 3TJP; 3TL5; 3ZIM; 3ZVV; 3ZW3; 4A55; 4AJW; 4ANU; 4ANV; 4ANW; 4ANX; 4AOF; 4BFR; 4D0L; 4D0M; 4DK5; 4EZJ; 4EZK; 4EZL; 4F1S; 4FA6; 4FAD; 4FHJ; 4FHK; 4FJY; 4FJZ; 4FLH; 4FUL; 4G11; 4GB9; 4HLE; 4HND; 4HNE; 4HVB; 4J6I; 4JPS; 4JSN; 4JSP; 4JSV; 4JSX; 4JT5; 4JT6; 4KZ0; 4KZC; 4L1B; 4L23; 4L2Y; 4OVU; 4OVV; 4OYS; 4PH4; 4PLA; 4PS3; 4PS7; 4PS8; 4TUU; 4TV3; 4URK; 4UWF; 4UWG; 4UWH; 4UWK; 4UWL; 4V0I; 4WAE; 4WAF; 4WAG; 4WTV; 4WWN; 4WWO; 4WWP; 4XE0; 4XX5; 4XZ4; 4YC4; 4YKN; 4ZOP; 5AE8; 5AE9; 5ANL; 5C46; 5C4G; 5DFZ; 5DXH; 5DXT; 5DXU; 5EDS; 5ENN; 5EUQ; 5EUT; 5FBL; 5FBQ; 5FBR; 5FBV; 5FBW; 5FI4; 5FLC; 5G2N; 5G55; 5H64; 5I0N; 5I4U; 5I6U; 5IS5; 5ITD; 5JHA; 5JHB; 5KAE; 5KC2; 5L72; 5LUQ; 5M6U; 5NCY; 5NCZ; 5NGB; 5NP0; 5NP1; 5O83; 5OJS; 5OQ4; 5SW8; 5SWG; 5SWO; 5SWP; 5SWR; 5SWT; 5SX8; 5SX9; 5SXA; 5SXB; 5SXC; 5SXD; 5SXE; 5SXF; 5SXI; 5SXJ; 5SXK; 5T23; 5T27; 5T28; 5T2B; 5T2D; 5T2G; 5T2I; 5T2L; 5T2M; 5T7F; 5T8F; 5T8I; 5UBR; 5UBT; 5UK8; 5UKJ; 5UL1; 5VLR; 5W1R; 5WBU; 5WBY; 5X6O; 5XGH; 5XGI; 5XGJ; 5Y3R; 5Y81; 5YZ0; 5ZCS; 6AUD; 6BCU; 6BCX; 6BQ1; 6C1S; 6DGT; 6EMK; 6EYZ; 6EZ6; 6FH5; 6G6W; 6GL3; 6GQ7; 6GVF; 6GVG; 6GVH; 6GVI; 6GY0; 6HI9; 6I3U; 6IG9; 6JXA; 6JXC; 6K9K; 6K9L; 6L53; 6L54; 6MUL; 6MUM; 6NCT; 6OAC; 6OCO; 6OCU; 6PYR; 6PYS; 6PYU; 6S8F; 6SB0; 6SB2; 6SYT; 6T3B; 6T3C; 6T9I; 6T9J; 6XRL; 6XRM; 6XRN; 6YKG; 6Z2W; 6Z2X; 6Z3A; 6Z3R; 6ZFP; 6ZH2; 6ZH4; 6ZH6; 6ZH8; 6ZHA; 6ZHE; 6ZWM; 6ZWO; 7BI2; 7BI4; 7BI6; 7BI9; 7BL1; 7JIS; 7JIU; 7JWE; 7JWZ; 7JX0; 7K0Y; 7K10; 7K11; 7K19; 7K1B; 7K1J; 7K1K; 7K1N; 7K6M; 7K6N; 7K6O; 7K71; 7KKE; 7KTR; 7LM2; 7LQ1; 7LT3; 7MEZ; 7MLK; 7MYN; 7MYO; 7NFC; 7NFE; 7NI4; 7NI5; 7NI6; 7OTM; 7OTP; 7OTV; 7OTW; 7OTY; 7OWG; 7PE7; 7PE8; 7PE9; 7PEA; 7PEB; 7PEC; 7PG5; 7PG6; 7PQH; 7PW4; 7PW5; 7PW6; 7PW7; 7PW8; 7PW9; 7R9V; 7R9Y; 7RSJ; 7RSP; 7RSV; 7SGL; 7SIC; 7SID; 7SU3; 7SUD; 7TYR; 7TZ7; 7TZO; 7UXC; 7UXH; 7VVY; 7VVZ; 7WZR; 7WZW; 7YFN; 7YFP; 7Z61; 7Z74; 7Z75; 7Z87; 7Z88; 8A5X; 8A9I; 8AJ8; 8AM0; 8BCY; 8BFU; 8BH3; 8BHV; 8BHY; 8BOT; 8DCP; 8DCX; 8DD4; 8DD8; 8DP0; 8ERA; 8ESC; 8EXL; 8EXO; 8EXU; 8EXV; 8EZ9; 8EZA; 8EZB; 8GUA; 8GUB; 8GUD; 8H7G; 8ILR; 8ILS; 8ILV; 8OW2; 8OXM; 8OXO; 8OXP; 8OXQ; 8Q6F; 8Q6G; 8Q6H; 8QRI; 8RCH; 8RCK; 8RCN; 8RD4; 8RXR; 8S3R; 8SBC; 8SBJ; 8SC8; 8SO9; 8SOA; 8SOB; 8SOC; 8SOD; 8SOE; 8SOR; 8TDU; 8TGD; 8TS7; 8TS8; 8TS9; 8TSA; 8TSB; 8TSC; 8TSD; 8TU6; 8TWY; 8V8H; 8V8I; 8V8J; 8V8U; 8V8V; 8VOF; 8W9A; 8W9B; 8XVG; 8XVV; 9B4S; 9B4T; 9B9G; 9BAX; 9C15; 9C47; 9C82; 9E4V; 9F44; 9F45; 9GCF; 9GDI; 9GG9; 9MHF; 9MHG; 9MHH » more |