ProRule PRU00269
General rule information
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| Accession | PRU00269 |
| Dates | 12-DEC-2003 (Created)
26-OCT-2021 (Last updated, Version 9) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50290; PI3_4_KINASE_3 |
Name | PI3K/PI4K catalytic domain |
| Function | Phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. |
| Scope(s) |
Eukaryota |
| Example(s) | P22543 (VPS34_YEAST); |
Propagated annotation
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Keywords
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Gene Ontology
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| GO:0016740; Molecular function:transferase activity |
| GO:0016301; Molecular function:kinase activity |
Cross-references
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Features
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| From: PS50290 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="PI3K/PI4K catalytic #" | |||||||||
| REGION | 7 | 13 | /note="G-loop #" | |||||||||
| REGION | 144 | 152 | /note="Catalytic loop #" | |||||||||
| REGION | 164 | 188 | /note="Activation loop #" | |||||||||
Additional information
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| Size range | 240-390 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [167] Viruses [1] All [ 168 ]
- Retrieve set of proteins with 3D structure for this domain