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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00269


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00269
General rule information [?]

Accession PRU00269
Dates 12-DEC-2003 (Created)
26-OCT-2021 (Last updated, Version 10)
Data class Domain;
Predictors PROSITE; PS50290; PI3_4_KINASE_3
Name PI3K/PI4K catalytic domain
Function Phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring.
Scope(s) Eukaryota
Example(s) P22543;

Propagated annotation [?]

Keywords [?]

Transferase
Kinase

Gene Ontology [?]

GO:0016740; Molecular function:transferase activity
GO:0016301; Molecular function:kinase activity

Cross-references [?]

PROSITE PS00915; PI3_4_KINASE_1; 1;
PROSITE PS00916; PI3_4_KINASE_2; 1;

Features [?]

From: PS50290
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="PI3K/PI4K catalytic #"
REGION 7 13 /note="G-loop #"
REGION 144 152 /note="Catalytic loop #"
REGION 164 188 /note="Activation loop #"

Additional information [?]

Size range 240-390 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]