ProRule PRU00269

General rule information [?]

Accession PRU00269
Dates 12-DEC-2003 (Created)
26-OCT-2021 (Last updated, Version 9)
Data class Domain;
Predictors PROSITE; PS50290; PI3_4_KINASE_3
Name PI3K/PI4K catalytic domain
Function Phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring.
Scope(s) Eukaryota
Example(s) P22543 (VPS34_YEAST);

Propagated annotation [?]

Keywords [?]

Gene Ontology [?]

GO:0016740; Molecular function:transferase activity
GO:0016301; Molecular function:kinase activity

Cross-references [?]

PROSITE PS00915; PI3_4_KINASE_1; 1;
PROSITE PS00916; PI3_4_KINASE_2; 1;

Features [?]

From: PS50290
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="PI3K/PI4K catalytic #"
REGION 7 13 /note="G-loop #"
REGION 144 152 /note="Catalytic loop #"
REGION 164 188 /note="Activation loop #"

Additional information [?]

Size range 240-390 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]