PROSITE entry PS50305
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General information about the entry
| Entry name [info] | SIRTUIN |
| Accession [info] | PS50305 |
| Entry type [info] | MATRIX |
| Date [info] |
01-APR-2002 CREATED;
12-OCT-2022 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC50305 |
| Associated ProRule [info] | PRU00236 |
Name and characterization of the entry
| Description [info] | Sirtuin catalytic domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=259; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=254; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.2089150; R2=0.0058253; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=1767; N_SCORE=11.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=909; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-32; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='M'; M= -16, -92, -80, -36, -83, -84, -77, -78, -9, -51, 54, -2, 49, -71, 22, -72, 15, -79, 45, -78; /M: SY='P'; M= -13, -87, -12, 26, -28, -36, 5, -45, -66, -20, -11, -27, 35, -16, 1, -37, 21, -46, -92, -77; /M: SY='D'; M= -73, -29, 23, 19, -38, -82, 5, -14, 9, 6, -67, 2, -29, -20, -17, -7, 7, -42, -92, -73; /M: SY='M'; M= -72, -2, 27, -3, -36, -55, -69, -29, -1, 15, 38, 29, -2, -14, -17, -70, -36, -3, -89, -71; /M: SY='E'; M= -44, -84, 9, 53, -28, -45, -65, -23, -3, -28, -8, 2, 15, 0, 1, 11, -26, -74, -87, -74; /M: SY='E'; M= -44, -80, -2, 25, -14, -52, -10, -13, -30, 7, 9, 15, -77, 14, 17, -13, -7, 4, -85, -67; /I: I=-42; MD=-106; /M: SY='K'; M= -26, -82, 3, -18, -4, -39, -71, -74, 33, -23, 4, -21, -78, 18, -63, 16, 28, -39, -88, -72; D=-42; /I: I=-42; MI=-106; MD=-106; IM=-106; DM=-106; /M: SY='I'; M= -4, -83, -22, -85, -64, -45, -86, 50, -85, 19, 31, -84, -35, -82, -87, -78, -69, 31, -89, -71; D=-42; /I: I=-42; DM=-106; /M: SY='W'; M= 24, -82, -3, 42, -35, -29, 11, -82, 47, -79, -72, -60, -70, 11, 10, -24, -65, -77, 53, -67; /I: I=-31; MD=-79; /M: SY='E'; M= -40, -90, 40, 59, -20, -27, 18, -88, 10, -49, -78, -30, -16, 28, -62, -66, -70, -85, -90, -74; D=-31; /I: I=-31; MD=-79; /M: SY='F'; M= 19, -75, -88, -81, 58, -83, -77, 9, -80, 45, -47, -82, -86, -79, -39, -73, -67, 9, -70, -51; D=-31; /I: I=-31; MD=-79; /M: SY='A'; M= 49, -74, -73, -30, -70, -70, -13, -10, -29, 1, -59, -68, -76, 19, 3, 0, 0, 10, -82, -23; D=-31; /I: I=-31; MD=-79; /M: SY='K'; M= -2, -83, -9, 20, -80, -26, -2, -81, 49, -78, 8, -59, -32, 27, 32, 7, -64, -77, -80, -6; D=-31; /I: I=-31; MI=0; MD=-79; IM=0; DM=-79; /M: SY='W'; M= 18, -25, -76, -1, 27, -79, 1, -8, -4, 32, -8, -74, -79, 0, -69, -67, -24, -8, 42, 2; D=-31; /I: I=-31; DM=-79; /M: SY='I'; M= -25, -74, -86, -80, 0, -84, -77, 48, -78, 40, 43, -79, -81, -74, -78, -9, -61, 38, 17, -57; /M: SY='W'; M= 18, -78, -29, -15, -74, -35, 33, -72, 30, -28, 29, 15, -28, 26, 33, -21, -15, -70, 53, -63; /M: SY='E'; M= -15, -77, -54, 51, -72, -39, -60, -71, 30, -6, -11, -3, -5, 23, 7, 1, 18, -68, -78, -6; /I: I=-38; MI=0; MD=-97; IM=0; DM=-97; /M: SY='C'; M= 44, 78, -70, -67, -32, -63, -4, -38, -25, -71, -3, -8, -76, -15, -69, 50, -55, -33, -85, -22; D=-38; /I: I=-38; DM=-97; /M: SY='K'; M= -24, -30, 29, 22, -78, -35, -56, -76, 60, -73, 20, -20, -12, 16, 48, 16, -56, -72, -78, -66; /M: SY='H'; M= -19, -76, -54, -53, -68, -66, 72, -75, 41, -32, -61, 54, -20, -46, 64, -11, -58, -73, -77, 15; /M: SY='V'; M= 17, -68, -81, -75, -52, -79, -77, 51, -74, 33, 11, -75, -76, -71, -75, -64, -11, 62, -78, -59; /M: SY='V'; M= 21, 0, -79, -36, -4, -77, -76, 25, -72, 22, 19, -74, -76, -71, -74, -63, -22, 70, -78, -58; /M: SY='V'; M= -2, 31, -82, -77, 38, -81, -81, 46, -75, -41, -44, -75, -78, -77, -77, -65, -27, 77, -75, -53; /M: SY='M'; M= -65, -71, -81, -76, 44, -21, 27, 8, -74, 58, 66, -74, -79, -69, -72, -71, -62, 8, -65, 9; /M: SY='T'; M= 10, -63, -61, -62, -66, -65, -69, -9, -60, -60, -57, -51, -63, -62, -67, 30, 94, 20, -85, -65; /M: SY='G'; M= -49, -77, -64, -76, -83, 103, -71, -91, -70, -86, -75, -50, -68, -67, -77, -49, -68, -84, -74, -78; /M: SY='A'; M= 98, -61, -67, -60, -76, -49, -69, -65, -62, -67, -61, -62, -66, -59, -67, -17, -52, -52, -76, -71; /M: SY='G'; M= -49, -77, -64, -76, -83, 103, -71, -91, -70, -86, -75, -50, -68, -67, -77, -49, -68, -84, -74, -78; /M: SY='I'; M= -62, -73, -84, -80, -49, -87, -80, 85, -76, 17, 36, -76, -75, -73, -78, -71, -21, 44, -76, -57; /M: SY='S'; M= -41, -64, -56, -57, -74, -49, -59, -74, -57, -77, -71, -44, -64, -48, -61, 109, -35, -66, -82, -66; /M: SY='T'; M= 60, 6, -64, -62, -69, -61, -69, -55, -34, -60, 19, -56, -64, -61, -66, -41, 81, 4, -82, -67; /M: SY='E'; M= 39, -34, 24, 72, -80, -62, -59, -76, -52, -76, -70, -54, 37, -46, -60, 37, -53, -68, -81, -72; /M: SY='S'; M= 23, 35, -3, -58, -72, -53, -62, -67, -59, -43, -66, -49, -66, -53, -46, 92, -41, -15, -83, -67; /M: SY='G'; M= -49, -76, -34, -73, -82, 100, -69, -90, -68, -86, -75, -13, -68, -66, -75, -10, -65, -83, -75, -77; /M: SY='I'; M= -65, -76, -85, -83, 24, -88, -79, 94, -78, -2, -37, -77, -76, -76, -80, -73, -59, 20, -67, 11; /I: I=-45; MD=-115; /M: SY='P'; M= -66, -89, -68, -28, -83, -40, -71, -68, -26, -79, -68, -72, 115, -23, -7, -65, -61, 3, -81, -80; D=-45; /I: I=-45; MI=-115; IM=-115; DM=-115; /M: SY='D'; M= -59, -71, 94, -42, -78, -64, -58, -73, -55, -75, -72, 4, -64, -56, -64, 7, 71, -68, -96, -68; /M: SY='F'; M= -74, -76, -83, -80, 102, -81, -58, -52, -74, -46, -52, -77, -85, -78, -72, -72, -68, -31, 75, 82; /I: I=-6; MD=-16; /M: SY='R'; M= -19, -84, -65, -53, -78, -77, -55, -84, 1, -77, -66, -58, -76, -43, 111, -62, -67, -77, -78, -65; D=-6; /I: I=-6; MD=-16; /M: SY='S'; M= -36, -76, 18, -64, -85, 51, -68, -86, -11, -87, -79, -52, -72, -60, -69, 74, -54, -79, -87, -76; D=-6; /I: I=-6; MD=-16; /M: SY='P'; M= -27, -94, -3, 7, -90, -82, -79, -83, -19, -9, -78, -76, 74, -71, -29, 15, -70, -84, -95, -87; D=-6; /I: I=-6; MD=-16; /M: SY='H'; M= -12, -82, -1, 21, -79, 10, 26, -76, 24, 6, -68, 10, -22, -59, -26, 2, -18, -75, -88, -73; D=-6; /I: I=-6; MD=-16; /M: SY='T'; M= -72, -88, 15, -12, -91, 17, -80, -80, -2, -87, -82, 17, -83, -74, -77, -18, 38, 3,-102, -86; D=-6; /I: I=-6; MD=-16; /M: SY='G'; M= -57, -83, -68, -17, -88, 87, -75, -48, -71, -89, -79, -58, 2, -69, -31, -9, -71, -86, -81, -83; D=-6; /I: I=-6; MD=-16; /M: SY='L'; M= -6, -78, 4, -76, -19, -86, -76, 37, -79, 51, -45, -79, -85, -22, -80, -75, -66, 18, -78, -4; D=-6; /I: I=-6; MD=-16; /M: SY='W'; M= 4, -89, -83, -77, 11, -20, -67, -71, -19, -69, -68, -22, -85, -3, -72, -71, -75, -40, 118, 79; D=-6; /I: I=-6; MD=-16; /M: SY='D'; M= 20, -78, 48, -56, -85, -67, 9, -81, -17, -82, -75, -28, 1, 7, -16, 41, 27, -74, -93, -74; D=-6; /I: I=-6; MD=-16; /M: SY='R'; M= -69, -84, -62, 12, -82, 7, -63, -80, 18, -32, 23, 44, -77, -15, 52, -26, -9, -78, -88, -75; D=-6; /I: I=-6; MD=-16; /M: SY='L'; M= -74, -80, -83, -8, 7, -92, -77, 5, -80, 53, -48, -27, -87, -77, -82, -76, 15, 2, -79, -3; D=-6; /I: I=-6; MI=0; MD=-16; IM=0; DM=-16; /M: SY='W'; M= -23,-101, -79, 12, -97, -35, -8, -95, -4, -95, -87, -44, -25, 22, 20, -77, 1, -43, 44, -85; D=-6; /I: I=-6; DM=-16; /M: SY='G'; M= -24,-100, -9, 8, -96, 27, -83, -97, -27, -26, -87, -31, -26, -4, -3, -50, -85, -94, -98, -30; D=-6; /I: I=-6; MI=0; MD=-16; IM=0; DM=-16; /M: SY='P'; M= -29, 1, -1, -3, -4, -87, -77, -79, -78, -18, -76, -2, 55, -21, -84, -78, -77, -45, 45, 31; D=-6; /I: I=-6; DM=-16; /M: SY='Y'; M= -72, -87, 46, -59, -65, -20, 25, -82, 11, -46, -72, 8, -44, -5, 13, 5, -67, -82, -73, 62; D=-6; /I: I=-6; DM=-16; /M: SY='P'; M= -21, -6, -4, 22, -84, -10, -67, -77, -56, -79, 16, -67, 91, -20, 33, -64, -64, -48, -83, -78; D=-6; /I: I=-6; DM=-16; /M: SY='E'; M= -21, -82, -55, 58, -74, -76, -63, -20, -1, -5, -63, 1, 35, 40, -22, -61, -11, -22, -80, -9; D=-6; /I: I=-6; DM=-16; /M: SY='D'; M= 28, -79, 57, 43, -74, -70, -61, 18, -58, -67, 20, -3, -70, 29, -64, -58, -62, -62, -82, 5; D=-6; /I: I=-6; DM=-16; /M: SY='L'; M= -9, -80, -4, -13, -60, -88, -6, 19, -79, 42, 33, -80, -85, -74, -80, -76, -68, 23, -84, -12; D=-6; /I: I=-6; DM=-16; /M: SY='F'; M= 24, -78, -87, -83, 65, -20, -81, -12, -81, -2, -59, -78, -86, -81, -83, 3, -66, 23, -72, -53; D=-6; /I: I=-6; DM=-16; /M: SY='S'; M= -4, 2, 42, 28, -78, -66, -62, -73, -58, -76, -71, 6, -69, 20, -64, 46, 35, -21, -87, -15; D=-6; /I: I=-6; DM=-16; /M: SY='H'; M= -68, -80, -75, -40, 1, -82, 44, 34, -70, 18, -52, -70, 31, -69, -14, -9, 27, -19, -75, 28; D=-6; /I: I=-6; DM=-16; /M: SY='Q'; M= 26, -76, 13, -3, -75, 0, -63, -48, -58, -10, -64, 8, 23, 50, -27, 23, -7, -67, 44, -67; D=-6; /I: I=-6; MI=0; MD=-16; IM=0; DM=-16; /M: SY='F'; M= 25, 21, 11, 15, 43, 15, -61, -33, -60, -66, -63, -60, -73, 37, -18, -8, -23, -66, -65, 36; D=-6; /I: I=-6; DM=-16; /M: SY='F'; M= -43, -76, 16, -74, 91, -2, -66, -54, -75, -10, -55, -70, -82, -77, -75, -32, -66, -7, 52, 42; D=-6; /I: I=-6; DM=-16; /M: SY='F'; M= -7, -77, -37, -31, 60, -77, -2, -56, 17, -23, 20, -66, -77, 30, 22, -65, -64, 5, 25, 48; D=-6; /I: I=-6; MI=0; MD=-16; IM=0; DM=-16; /M: SY='R'; M= -67, -82, -32, 13, -29, -29, 31, -84, 47, -80, -70, 25, -73, 6, 61, -6, -25, -80, -83, -67; D=-6; /I: I=-6; DM=-16; /M: SY='D'; M= -66, -79, 71, 16, -81, -65, 47, -85, -11, -84, -76, 66, -72, -53, -24, 12, -57, -82, -94, -13; D=-6; /I: I=-6; DM=-16; /M: SY='P'; M= -20, -90, -66, -19, -83, -70, -69, -76, -29, -45, -71, 23, 107, 3, -72, -64, -63, -80, 46, -78; D=-6; /I: I=-6; DM=-16; /M: SY='E'; M= 5, -82, -26, 54, -84, -73, -64, -78, 26, -37, -70, -61, 2, 46, 1, 14, -62, -39, -84, -74; D=-6; /I: I=-6; DM=-16; /M: SY='P'; M= -5, -3, -73, 1, -77, -19, -73, -21, 14, -7, 32, -72, 55, -34, 15, -28, -67, -25, -86, -76; D=-6; /I: I=-6; DM=-16; /M: SY='F'; M= -67, -78, -81, -79, 61, -24, -71, -21, -70, -35, -7, -1, -85, -75, 16, -9, -64, 48, -68, 25; D=-6; /I: I=-6; DM=-16; /M: SY='W'; M= -76, -90, -82, -70, 37, -81, -6, -68, -61, -9, -63, -19, -84, 41, 33, -74, -76, -41, 123, 30; D=-6; /I: I=-6; DM=-16; /M: SY='R'; M= 33, -77, 7, 24, -81, 0, -64, -32, 26, -75, -31, -18, -70, 4, 37, -27, 10, -69, -82, -72; D=-6; /I: I=-6; DM=-16; /M: SY='W'; M= -42, -80, -86, -79, 81, -84, -68, -26, -69, 11, -6, -79, -86, -74, 24, -75, -71, -29, 84, 45; D=-6; /I: I=-6; DM=-16; /M: SY='W'; M= 32, -80, -75, -71, 2, -72, 3, 2, -69, -25, -58, -14, -80, 5, -69, -19, -66, -61, 89, 84; D=-6; /I: I=-6; DM=-16; /M: SY='N'; M= 19, -76, -4, -37, -78, -65, 20, -74, 39, -23, 5, 47, -72, 32, 10, 19, -57, -71, -84, -68; D=-6; /I: I=-6; DM=-16; /M: SY='W'; M= -4, -80, -20, 50, 5, -75, -21, -66, -50, 2, 22, -64, -71, 38, 39, -61, -28, -66, 68, 27; D=-6; /I: I=-6; DM=-16; /M: SY='R'; M= -13, -75, -71, -67, -1, -21, -64, 24, -54, 30, 18, 13, -77, -59, 60, -5, -60, -1, -76, -59; D=-6; /I: I=-6; DM=-16; /M: SY='R'; M= -46, -91, -87, -80, 30, -93, 2, -12, -67, -41, -7, -81, 5, -75, 47, -79, -35, 14, -77, 30; D=-6; /I: I=-6; MI=0; MD=-16; IM=0; DM=-16; /M: SY='K'; M= 5, -84, -74, 11, -73, -44, -75, -4, 23, -4, -20, -74, -1, -65, 14, -25, -68, 14, -84, -9; D=-6; /I: I=-6; DM=-16; /M: SY='F'; M= -42, -84, 17, -41, 23, 3, -72, -67, -24, 9, -27, 11, -84, 22, 0, -31, -28, -7, -84, -67; D=-6; /I: I=-6; MI=0; MD=-16; IM=0; DM=-16; /M: SY='P'; M= -90,-102, -91, -15, -89, -49, -90, -37, -56, 8, 17, -9, 24, -86, -6, -88, -6, -57,-106, -92; D=-6; /I: I=-6; DM=-16; /M: SY='Y'; M= -43, -84, -46, -71, 26, -82, -65, -37, -41, -9, -63, -1, -31, 34, 5, -14, 9, -19, -67, 59; D=-6; /I: I=-6; DM=-16; /M: SY='P'; M= -37, -77, 8, -64, 46, -40, -2, -34, -31, -61, 36, -5, 47, -10, -68, 33, -25, -2, -69, 22; D=-6; /I: I=-6; DM=-16; /M: SY='P'; M= 23, -80, -1, -4, -40, 27, -68, -75, -22, -8, -68, -15, 36, -32, 1, 15, -63, -72, -81, -14; D=-6; /I: I=-6; DM=-16; /M: SY='N'; M= -22, -79, 34, 36, -29, -46, -24, -83, 3, -82, -74, 54, -71, 43, -25, 31, -57, -79, -87, -71; D=-6; /I: I=-6; DM=-16; /M: SY='A'; M= 60, 10, -72, -65, 17, -66, 34, 5, -5, -39, -56, -65, -74, 5, -41, -55, -24, 17, -72, 12; D=-6; /I: I=-6; DM=-16; /M: SY='Q'; M= -19, -5, -1, 39, -79, -72, -57, -16, 34, -42, -5, -56, 2, 77, 36, -57, -62, -70, -78, -67; D=-6; /I: I=-6; DM=-16; /M: SY='P'; M= -66, -87, -69, -58, -74, -71, -70, -28, -65, -6, -62, -74, 119, -67, -75, -65, -59, -17, -77, -18; /M: SY='N'; M= -57, -66, -15, -57, -75, -12, -50, -72, -52, -77, -68, 104, -68, -53, -60, 17, 56, -69, -92, -70; /M: SY='P'; M= 14, -76, -5, 14, -23, -69, 0, 11, 27, -5, -56, -17, 57, 13, -4, -31, -36, -8, -75, -26; /I: I=-14; MD=-34; /M: SY='C'; M= 48, 54, -64, -68, 23, 31, -67, -14, -65, -40, -62, 33, -71, -65, -71, -7, 27, -59, -76, -63; D=-14; /I: I=-14; MD=-34; /M: SY='H'; M= -70, -82, -55, -55, -65, -72, 146, -85, -59, -68, -54, -44, -71, -49, -53, -60, -69, -85, -96, 14; D=-14; /I: I=-14; MD=-34; /M: SY='Y'; M= -65, -78, -30, -1, -49, -77, -55, -38, 3, 22, 37, -65, -75, 42, 30, -30, -30, -5, 48, 67; D=-14; /I: I=-14; MD=-34; /M: SY='A'; M= 63, -68, -6, -64, 49, -63, -68, 10, 2, 0, 7, -25, -72, -63, -65, -12, -57, -50, -68, -53; D=-14; /I: I=-14; MD=-34; /M: SY='L'; M= -67, -73, -86, -80, -11, -88, -73, 61, -78, 70, 39, -81, -81, -72, -77, -77, -62, -33, -72, -54; D=-14; /I: I=-14; MD=-34; /M: SY='A'; M= 63, -6, -63, -59, -29, -34, -65, -64, 18, -68, -63, 8, -69, -55, 24, 30, -7, 0, -79, -67; D=-14; /I: I=-14; MD=-34; /M: SY='Q'; M= -18, -77, -5, 50, -70, -73, -56, -65, 21, 17, -4, -20, -67, 66, 19, -57, -3, -65, -75, -18; D=-14; /I: I=-14; MD=-34; /M: SY='W'; M= -68, 22, -87, -79, 23, -83, -74, 6, -78, 73, -37, -83, -84, -73, -76, -34, -66, -45, 93, -47; D=-14; /I: I=-14; MD=-34; /M: SY='E'; M= 5, -83, -15, 76, -83, -75, 47, -81, 10, -28, -68, -59, -66, 49, -54, -59, -65, -76, -84, -69; D=-14; /I: I=-14; MD=-34; /M: SY='R'; M= 9, -81, 41, 43, -84, -39, -60, -82, 0, -78, -8, -22, -70, 13, 55, -17, -23, -76, -86, -72; D=-14; /I: I=-14; MI=0; MD=-34; IM=0; DM=-34; /M: SY='K'; M= -2, -78, -16, 7, -71, -42, -19, -64, 44, 14, 39, -61, -73, 14, 24, -32, 6, -36, -81, -67; D=-14; /I: I=-14; DM=-34; /M: SY='G'; M= -63, -84, 20, -46, -35, 65, -72, -83, 24, -13, -73, -18, -76, -23, -37, -25, -70, -82, 45, -72; D=-14; /I: I=-14; MI=0; MD=-34; IM=0; DM=-34; /M: SY='K'; M= -46, -80, -3, -30, -38, -12, -67, -3, 43, 30, -54, -66, 25, -59, 29, -67, -64, -6, -77, -12; D=-14; /I: I=-14; DM=-34; /M: SY='L'; M= -63, -72, -5, -9, -17, -39, -8, 20, -65, 57, -42, 11, -77, -64, 3, -25, -11, 16, -77, -58; D=-14; /I: I=-14; DM=-34; /M: SY='H'; M= -63, -74, -9, -31, 2, -38, 57, -48, 26, 35, -12, -62, -75, 17, -26, -20, -28, 27, -72, 23; D=-14; /I: I=-14; DM=-34; /M: SY='W'; M= 7, 2, -70, -64, 16, -38, 53, -67, -52, -23, -61, -61, -75, -58, 59, -5, 29, -18, 74, -54; D=-14; /I: I=-14; DM=-34; /M: SY='V'; M= -62, 30, -80, -77, -46, -83, -71, 35, -75, 48, -39, 0, -81, -73, -75, -70, -58, 56, -72, 33; D=-14; /I: I=-14; DM=-34; /M: SY='Y'; M= -63, -8, -82, -79, -41, -84, -69, 63, -74, -43, -45, -77, -79, -72, -75, -70, -28, 53, 74, 74; D=-14; /I: I=-14; DM=-34; /M: SY='T'; M= -52, -62, -58, -61, -69, -67, -68, -61, -58, -65, -62, -47, -60, -61, -66, 19, 110, -53, -89, -66; D=-14; /I: I=-14; DM=-34; /M: SY='Q'; M= -58, -81, -55, -36, -86, -67, -49, -73, -41, -70, -58, -49, -65, 125, -42, -46, 31, -73, -74, -61; /M: SY='N'; M= -62, -67, -35, -57, -77, -50, -43, -76, -48, -84, -70, 125, -73, -50, -56, -44, -47, -78, -96, -72; /M: SY='I'; M= -17, 19, -82, -79, -48, -84, -78, 78, -75, -38, -41, -75, -77, -74, -78, -68, -56, 63, -72, 33; /M: SY='D'; M= -68, -81, 119, -31, -88, -64, -53, -86, -55, -85, -84, -35, -67, -54, -63, -56, -57, -83,-103, -70; /M: SY='G'; M= -5, -73, 25, -9, -21, 61, -59, -77, -54, -75, -7, 52, -68, -56, 23, -49, 26, -72, -80, -69; /M: SY='L'; M= -19, -69, -84, -76, -41, -84, -68, -33, -77, 90, -29, -83, -83, -70, -75, -75, -63, -40, -71, -54; /M: SY='H'; M= -67, -80, -11, 47, -3, -74, 127, 7, -56, -36, -55, -49, -67, -47, -55, -60, -65, -69, -89, -44; /M: SY='E'; M= -60, -78, -51, 63, -71, -74, -57, -67, -41, -15, -61, -57, -65, 52, 58, -17, 25, -12, 46, -63; /M: SY='R'; M= -7, -77, -62, -24, -71, -73, -58, -26, 56, -67, -59, -57, -71, 22, 80, -58, -60, 17, -74, -14; /I: I=-21; MI=0; MD=-53; IM=0; DM=-53; /M: SY='A'; M= 88, -63, -66, -61, -77, -30, -68, -68, -63, -71, -64, -59, -67, -58, -67, 42, -50, -56, -78, -72; D=-21; /I: I=-21; DM=-53; /M: SY='G'; M= -51, -77, -66, -75, -77, 97, -71, -80, -70, -8, -68, -53, 11, -67, -77, -52, -67, -78, -74, -75; /I: I=-31; MI=0; MD=-79; IM=0; DM=-79; /M: SY='S'; M= -14, 24, -64, -65, 5, -63, -63, 24, -63, 0, -55, 19, -3, -20, -67, 66, -3, -19, 26, 9; /M: SY='P'; M= -61, -9, 35, 12, -80, -68, -59, -74, 40, -76, -67, -52, 64, 45, 21, -10, 24, -44, -80, -69; /I: I=-18; MD=-45; /M: SY='R'; M= -32, -97, -17, -32, -93, -90, -6, -82, -33, -86, -9, 1, 24, -13, 49, -77, -32, 1,-102, -85; D=-18; /I: I=-18; MI=0; MD=-45; IM=0; DM=-45; /M: SY='N'; M= -25, -85, 24, -63, -84, -46, 8, -20, 32, -38, -73, 48, -16, -20, -30, -12, -23, -19, -96, -77; D=-18; /I: I=-18; DM=-45; /M: SY='V'; M= -59, -69, -82, -77, -49, -85, -78, 43, -75, 47, -37, -77, -78, -74, -76, -68, 3, 70, -79, -58; /M: SY='I'; M= -12, -71, -76, -74, 2, -78, 3, 61, -71, 4, -43, -69, -74, -69, -73, -3, 18, 47, -70, 33; /M: SY='H'; M= -35, -80, 4, 81, -79, -71, 86, -82, 14, -75, -66, -19, -13, 29, -49, -24, -60, -78, -84, -60; /M: SY='M'; M= 24, 26, -81, -74, 1, -76, -67, 16, -73, 62, 76, -75, -78, -67, -72, -67, -60, -41, -72, -54; /M: SY='H'; M= -69, -81, -53, -52, -68, -71, 147, -86, -57, -68, -54, -43, -70, 9, -51, -58, -68, -85,-101, -37; /M: SY='G'; M= -49, -77, -64, -76, -83, 103, -71, -91, -70, -86, -75, -50, -68, -67, -77, -49, -68, -84, -74, -78; /M: SY='N'; M= -54, 38, 29, 23, -23, -59, -55, -74, -52, -75, -69, 65, -67, -51, -8, 58, 33, -69, -87, -67; /M: SY='M'; M= -35, -70, -83, -77, 52, -43, -66, 17, -74, 51, 70, -76, -79, -71, -73, -70, -29, 18, -63, 12; /M: SY='F'; M= 24, -75, 14, 34, 56, -17, 28, -62, -20, -9, -57, -62, -18, -58, -22, -59, -62, -47, 13, 52; /M: SY='H'; M= -39, -74, -57, 28, -68, -73, 62, -1, 32, -23, -56, -54, -67, 10, 42, -24, 36, 12, -81, -59; /M: SY='W'; M= 29, 45, -67, 15, 3, -69, -69, -22, -65, -8, 7, -30, 2, -63, -69, -5, 6, 42, 46, 4; /M: SY='H'; M= -59, -74, -22, 13, -27, -71, 53, -33, 12, -23, -57, -55, -69, 9, 52, 28, 10, 13, -74, 20; /I: I=-19; MI=0; MD=-49; IM=0; DM=-49; /M: SY='C'; M= -65, 150, -85, -85, -75, -81, -85, -82, -81, -73, -73, -71, -96, -88, -87, -68, -65, -70,-105, -86; D=-19; /I: I=-19; DM=-49; /M: SY='T'; M= -9, 1, -70, -68, -64, -44, -11, -10, -67, 26, -2, -11, 6, 3, -71, 14, 55, 8, -84, -66; D=-19; /I: I=-19; DM=-49; /M: SY='K'; M= -34, -77, 8, -28, -79, -4, 14, -32, 40, -75, -67, 2, -70, 34, 13, 37, 10, -15, -84, -68; D=-19; /I: I=-19; MI=0; MD=-49; IM=0; DM=-49; /M: SY='C'; M= -65, 147, -84, -85, -76, -80, -85, -83, -81, -74, -74, -71, -95, -87, -87, -24, -65, -70,-105, -86; D=-19; /I: I=-19; DM=-49; /M: SY='H'; M= -26, -81, 2, 13, -79, 34, 56, -32, 9, -23, -67, 18, -74, -4, 30, -24, -65, -50, -86, -68; D=-19; /I: I=-19; DM=-49; /M: SY='Q'; M= -13, -5, -62, 13, -3, -34, 24, -71, 17, -71, -11, 9, -3, 29, 4, -11, 22, -21, 19, 11; D=-19; /I: I=-19; DM=-49; /M: SY='Q'; M= -26, -76, -57, 31, -70, -72, -10, 24, -8, -34, -57, 13, 11, 50, 16, -10, 21, 15, -81, -65; D=-19; /I: I=-19; DM=-49; /M: SY='Y'; M= -1, -73, -27, -10, 26, -43, -59, -55, -2, -26, -56, -63, -73, -61, 4, -56, 48, 15, 43, 71; D=-19; /I: I=-19; DM=-49; /M: SY='P'; M= -14, -76, 7, 35, -70, -70, -5, -34, 5, -67, -62, -5, 67, -56, -62, -28, 34, 22, -79, 7; D=-19; /I: I=-19; DM=-49; /M: SY='W'; M= -39, 0, 6, -34, 8, 10, -7, -27, -8, 16, -28, 18, -9, -20, 46, -62, -63, -25, 69, 6; D=-19; /I: I=-19; DM=-49; /M: SY='D'; M= -22, -76, 46, 46, -70, 1, -57, 8, -28, -45, -63, 8, -28, 29, -9, 15, -14, -19, -78, 6; /I: I=-3; MD=-9; /M: SY='W'; M= -21, -77, 37, 26, -40, -16, -62, -65, 35, -12, -63, -56, 11, -53, 21, -36, 21, -5, 54, -10; D=-3; /I: I=-3; MD=-9; /M: SY='D'; M= -44, -4, 38, 4, 21, -75, -7, 5, -65, 6, 26, -23, 3, -26, -69, -13, -6, 27, -73, 23; D=-3; /I: I=-3; MI=0; MD=-9; IM=0; DM=-9; /M: SY='Q'; M= -38, -79, 9, -12, 9, -79, -68, -8, 21, 5, -1, -66, 20, 39, -1, -66, -63, 33, 19, -61; D=-3; /I: I=-3; DM=-9; /M: SY='E'; M= -7, -85, 15, 29, 5, 5, -5, 9, -8, 0, -66, -22, -79, -28, -71, -22, -69, -67, -83, -19; D=-3; /I: I=-3; DM=-9; /M: SY='R'; M= -71, 21, 39, -35, -84, -80, -69, -25, 34, -78, 0, -61, -27, -13, 39, 8, -9, -23, -92, -76; D=-3; /I: I=-3; DM=-9; /M: SY='M'; M= -29, 7, -87, -34, 21, -47, -82, 11, -33, 3, 24, -82, 1, 17, -26, -77, -13, -13, 4, -67; D=-3; /I: I=-3; DM=-9; /M: SY='M'; M= -5, -89, 0, 22, 15, -15, -73, -79, -70, -49, 45, 16, -44, -3, -11, -71, -13, -79, -90, -73; D=-3; /I: I=-3; DM=-9; /M: SY='N'; M= -20, -89, -19, -22, -79, -23, -8, -15, -35, -3, -71, 12, 2, -74, -14, 12, -71, -6, -94, -18; D=-3; /I: I=-3; MI=0; MD=-9; IM=0; DM=-9; /M: SY='Q'; M= 15, -82, 22, 24, 29, -23, -12, -14, 1, -32, -66, -63, -36, 49, -63, -34, -40, -44, -79, -63; D=-3; /I: I=-3; MI=0; MD=-9; IM=0; DM=-9; /M: SY='T'; M= -17, -81, 5, -9, -73, -80, -73, 17, 4, -11, -60, -66, 25, 26, -12, -42, 26, 19, -87, -72; D=-3; /I: I=-3; DM=-9; /M: SY='P'; M= -65, -80, 5, -45, -32, 5, -77, 32, -71, -4, 17, -71, 38, -72, -12, -67, 7, 36, -85, -69; D=-3; /I: I=-3; DM=-9; /M: SY='P'; M= -39, -92, -40, -59, -88, -75, -12, -78, -11, -85, -73, -71, 106, -23, 18, -66, -6, -49, -85, -81; D=-3; /I: I=-3; MI=0; MD=-9; IM=0; DM=-9; /M: SY='H'; M= -21, -26, -27, 4, -72, -39, 43, -34, 28, 4, -59, -60, -28, 8, 41, -5, -3, 0, -84, -65; D=-3; /I: I=-3; DM=-9; /M: SY='C'; M= -65, 148, -83, -83, -75, -80, 16, -82, -80, -73, -72, -70, -94, -86, -85, -67, -65, -70,-105, -82; D=-3; /I: I=-3; DM=-9; /M: SY='P'; M= 8, -82, 28, 25, -78, -46, 55, -75, -60, -32, -68, -60, 72, -58, -15, -23, 9, -53, -86, -28; D=-3; /I: I=-3; MD=-9; DM=-9; /M: SY='K'; M= -26, 39, 23, 14, -77, -43, -11, -67, 40, -46, -67, -18, -76, 11, 16, -30, -63, 20, -86, -16; D=-3; /I: I=-3; MI=0; MD=-9; IM=0; DM=-9; /M: SY='C'; M= -65, 150, -85, -85, -75, -81, -85, -82, -81, -73, -73, -71, -96, -88, -87, -68, -65, -70,-105, -86; D=-3; /I: I=-3; MI=0; MD=-9; IM=0; DM=-9; /M: SY='G'; M= -39, -76, -26, 6, -77, 67, 34, -79, -31, -77, -68, -9, -35, 31, 0, 19, -12, -31, -77, -15; D=-3; /I: I=-3; DM=-9; /M: SY='G'; M= 14, -72, -60, 15, -36, 73, -66, -14, -26, -72, -13, -53, -66, -58, -68, 31, -20, -35, -74, -35; /M: SY='P'; M= -62, 4, -22, -4, -58, -11, -27, 13, 6, 36, -9, -4, 41, 18, -63, -64, -59, 26, -76, -14; /I: I=-38; MI=0; MD=-97; IM=0; DM=-97; /M: SY='M'; M= -38, -69, -81, -76, 17, -81, -69, 28, -74, 59, 62, -6, -79, -70, -73, -71, -59, 36, -72, -52; /M: SY='R'; M= -65, -81, -2, -4, -78, -73, -54, -81, 71, -76, -65, -51, -68, 8, 87, -58, -61, -76, -75, -64; /M: SY='P'; M= -66, -88, 22, -54, -80, -69, -1, -14, -63, -31, -66, -67, 117, -65, -73, -63, -23, -71, -81, -77; /M: SY='D'; M= -4, -75, 72, -19, -7, -5, 56, -76, -52, -73, -67, 43, -69, -17, 14, -52, 19, -73, -82, 10; /M: SY='I'; M= -58, -72, -81, -77, -53, -84, -83, 81, -14, -37, -40, -73, -75, -72, -74, -17, -54, 68, -79, -59; /M: SY='V'; M= -55, -68, -78, -72, -55, -82, -79, 25, -12, -10, -43, -72, -76, -70, -8, -63, 18, 86, -84, -61; /M: SY='W'; M= -20, -77, -1, -72, 70, -22, 15, -54, -71, 26, 20, -1, -79, -70, -71, -69, -67, -60, 116, -3; /M: SY='F'; M= -73, -74, -81, -13, 107, -81, -5, -50, -74, 1, -50, -75, -83, -78, -72, -73, -67, -56, 56, 44; /I: I=-45; MD=-115; /M: SY='G'; M= -53, -78, -57, 24, -84, 88, -67, -89, -14, -86, -76, 12, -68, -60, -69, -7, -65, -83, -78, -78; D=-45; /I: I=-45; MI=-115; IM=-115; DM=-115; /M: SY='E'; M= -59, -81, 35, 101, -84, 12, -55, -85, -45, -78, -74, -53, -58, -38, -55, -56, -61, -78, -82, -74; /M: SY='N'; M= -12, -73, 32, -32, -72, -32, -58, -11, -8, -64, 45, 45, 40, 11, 2, 14, 21, -9, -83, -67; /M: SY='L'; M= -32, -71, -78, -72, -50, 2, 29, -19, -74, 69, -37, -74, 24, -69, -74, -69, -61, 29, -76, -57; /I: I=-12; MD=-31; /M: SY='P'; M= -71, -89, 16, -64, -84, -75, -73, -18, -70, -76, 31, 17, 91, -71, -79, -11, -10, -18, -91, -81; D=-12; /I: I=-12; MI=0; MD=-31; IM=0; DM=-31; /M: SY='P'; M= 7, -81, 20, 25, -79, -71, -11, -70, -61, -5, -67, -20, 63, 12, -32, 15, -24, -24, -87, -74; D=-12; /I: I=-12; DM=-31; /M: SY='D'; M= -4, -81, 55, 31, -33, 11, -10, -38, -25, -54, -72, -35, -72, -11, 36, 8, -62, -46, -86, -70; D=-12; /I: I=-12; DM=-31; /M: SY='F'; M= 6, -78, 0, -8, 63, -48, -66, -12, 7, -34, 34, -67, -15, 1, 12, -65, -18, -29, -67, -6; D=-12; /I: I=-12; DM=-31; /M: SY='W'; M= -35, -79, 17, -36, 10, -45, 47, 3, -34, 24, 13, -30, -4, -68, -72, -4, -64, 14, 50, -57; D=-12; /I: I=-12; DM=-31; /M: SY='D'; M= -20, -81, 44, 31, 16, -78, -66, -6, 14, -4, -65, -60, -74, -19, 10, -36, 11, -66, -80, -23; D=-12; /I: I=-12; DM=-31; /M: SY='E'; M= -17, -11, -60, 31, -2, -10, 24, 10, -25, -7, -60, 11, -73, 20, 28, 7, -15, -32, -80, -63; D=-12; /I: I=-12; DM=-31; /M: SY='W'; M= 48, 34, -74, -8, -61, -69, -71, -2, -12, -45, 40, -70, -75, -64, -69, -10, -39, 19, 67, 27; D=-12; /I: I=-12; DM=-31; /M: SY='M'; M= 9, -76, 0, 28, -24, -37, 21, 14, -28, 13, 42, -65, -73, -22, -27, -9, -35, -1, -78, 0; D=-12; /I: I=-12; DM=-31; /M: SY='A'; M= 42, 4, 1, 34, -77, -39, -61, -75, 6, -42, -18, -7, -70, 37, 28, -31, -25, -69, -80, -14; D=-12; /I: I=-12; DM=-31; /M: SY='D'; M= 34, -75, 41, 24, 1, -69, -62, -65, -27, 19, -60, -10, -73, -19, -2, 0, -60, -64, -76, 8; D=-12; /I: I=-12; DM=-31; /M: SY='V'; M= -5, -74, 2, 23, -30, -73, -68, 12, -28, 2, -9, 8, -3, -10, -67, 16, 9, 24, -84, -67; D=-12; /I: I=-12; DM=-31; /M: SY='A'; M= 39, -76, 27, 31, -13, -67, -63, -73, 19, -39, 13, -2, -71, 18, -8, -3, -60, -47, -82, -69; D=-12; /I: I=-12; DM=-31; /M: SY='W'; M= -25, -88, -37, 31, -5, -42, -9, -53, -14, -3, -20, -71, -81, 0, -2, 21, -20, -76, 34, -71; D=-12; /I: I=-12; MI=0; MD=-31; IM=0; DM=-31; /M: SY='C'; M= 61, 72, -73, -67, -77, -64, -75, -23, -12, -69, -65, -66, -17, -5, -70, 11, -8, 3, -86, -75; D=-12; /I: I=-12; DM=-31; /M: SY='D'; M= -64, -78, 107, -36, -84, -64, -55, -78, 12, -80, -77, -9, -7, -53, -59, 3, -55, -20, -96, -70; /M: SY='L'; M= 8, 46, -76, -72, -50, -37, -70, -14, -72, 64, -40, -70, -77, -69, -73, -22, 30, 11, -75, -18; /M: SY='F'; M= -65, 35, -82, -77, 62, -81, -67, 22, -75, 47, 53, -75, -80, -72, -74, -8, -60, 8, -62, 13; /M: SY='I'; M= -64, -72, -85, -80, -1, -87, -76, 67, -78, 57, 4, -80, -79, -74, -78, -74, -60, 29, 18, -53; /M: SY='V'; M= -13, 37, -74, -12, 22, -76, -77, 38, -70, -45, -48, -68, -74, -70, -73, 8, 13, 70, -78, -57; /M: SY='V'; M= -2, -70, -83, -77, -50, -82, -78, 60, -75, 28, 40, -77, -77, -72, -76, -68, -56, 63, -78, -58; /M: SY='G'; M= -49, -77, -64, -76, -83, 103, -71, -91, -70, -86, -75, -50, -68, -67, -77, -49, -68, -84, -74, -78; /M: SY='T'; M= -51, -63, -59, -62, -1, -65, -65, -58, -59, -63, -60, -49, -62, -60, -65, 46, 98, -12, -79, 5; /M: SY='S'; M= -41, -64, -56, -57, -75, -10, -59, -74, -57, -78, -71, -44, -64, -49, -62, 107, -36, -67, -82, -67; /M: SY='L'; M= -12, 5, -76, -73, 38, 29, 20, -46, -73, 64, -42, -68, -78, -68, -73, 1, -61, -51, -68, -51; /M: SY='Q'; M= 10, -72, -56, 30, -71, -69, 5, -7, 35, -61, 9, -22, -66, 59, -23, -28, 27, 25, -79, -63; /M: SY='V'; M= -31, -68, 17, -69, -57, -80, -80, 27, -71, -43, -45, -69, -75, -73, -75, -62, 9, 89, -87, -62; /I: I=-45; MD=-115; /M: SY='Y'; M= -37, -82, -66, -6, -48, -39, 21, -64, -57, -3, -4, -66, 45, 34, 13, -12, -29, -67, 23, 85; D=-45; /I: I=-45; MI=-115; IM=-115; DM=-115; /M: SY='P'; M= -60, -83, -7, -55, -83, -8, -65, -75, -13, -82, -71, 2, 110, -61, -68, 26, -20, -76, -81, -78; /M: SY='A'; M= 55, -67, -71, -65, 50, 14, -69, -51, -15, -2, -54, -64, -72, 5, -66, -4, -56, 27, -68, -53; /M: SY='A'; M= 66, 22, -3, -12, 13, 3, -60, -67, -3, -65, -61, -20, -70, -59, -63, -23, -21, -60, -63, 55; /M: SY='N'; M= -34, -26, -20, 3, -65, 20, -55, -14, -37, -31, -8, 40, -2, 21, 39, 38, -55, -66, -72, 32; /M: SY='L'; M= -68, -73, -82, -76, 54, -85, -70, 56, -14, 57, -37, -76, -80, -71, -12, -74, -62, -37, -62, -4; /M: SY='P'; M= 13, 32, -73, -66, -62, -72, 19, 32, -69, 11, -50, -70, 74, -68, -74, -29, -15, 33, -80, -65; /M: SY='H'; M= -8, -74, -26, 17, -28, -19, 50, -31, -22, 18, -56, 3, 26, -15, 11, 38, -56, -63, 42, -12; /I: I=-33; MI=0; MD=-84; IM=0; DM=-84; /M: SY='C'; M= 4, 39, -28, 33, 13, -73, -2, 1, 11, 8, -4, -24, -71, 21, 17, -26, 1, -59, -76, -60; D=-33; /I: I=-33; DM=-84; /M: SY='A'; M= 65, -67, -73, -67, -59, -64, -72, 22, -28, -52, 16, -67, -70, -64, -68, -52, 11, 43, 46, 7; /I: I=-42; MD=-106; /M: SY='R'; M= -36, 0, -62, -52, -74, -71, 43, -70, 53, -25, -61, -56, 43, 19, 56, -8, -9, -20, -10, -63; D=-42; /I: I=-42; MD=-106; /M: SY='R'; M= 8, -76, -14, 16, -73, -68, 22, -29, 26, -14, 16, -21, -70, 23, 40, 30, -57, -19, -81, -65; D=-42; /I: I=-42; MI=-106; IM=-106; DM=-106; /M: SY='R'; M= 7, -75, -61, -5, -68, -67, 46, -64, 11, 1, -9, -9, 14, 27, 51, 21, -57, -16, 41, -59; /I: I=-28; MD=-70; /M: SY='G'; M= -34, -80, -70, -69, -74, 51, -11, -69, 27, -73, 13, -19, -18, -63, 7, -1, -26, 13, -79, 7; D=-28; /I: I=-28; MI=0; MD=-70; IM=0; DM=-70; /M: SY='A'; M= 43, -75, -71, -68, -74, 26, -72, -3, 13, -22, -7, -4, -3, -64, -6, -56, -1, 4, -82, -73; D=-28; /I: I=-28; DM=-70; /M: SY='P'; M= -11, -81, -63, -55, -32, -70, 63, -25, 39, -26, -61, -14, 82, -55, 19, -60, -24, -45, -77, -10; D=-28; /I: I=-28; DM=-70; /M: SY='V'; M= -61, -73, -72, -27, 1, -80, -65, 44, -32, 9, 0, -68, -75, 8, 34, -31, 7, 44, -68, 33; /M: SY='C'; M= 23, 66, -80, -74, 0, -76, -75, 42, -30, 17, -44, -73, -78, -72, -73, -63, -56, 53, -74, 5; /M: SY='E'; M= -19, -74, -20, 52, -2, -80, -67, 47, -63, 36, -45, -69, -71, -59, -68, -65, -6, 9, 26, -3; /M: SY='I'; M= -32, 13, -84, -80, 23, -85, -79, 70, -77, 33, -38, -78, -79, -76, -78, -71, -58, 50, -73, -53; /M: SY='N'; M= -61, -68, -37, -56, -77, -52, -44, -76, -5, -83, -69, 120, -72, -49, -7, -10, -47, -78, -93, -71; /M: SY='P'; M= -35, -75, -69, -60, -58, -39, 20, 21, 34, 39, -1, -64, 41, -13, 22, -30, -9, -37, -73, -8; /M: SY='E'; M= -57, -77, 35, 72, -81, 26, -57, -76, 4, -75, -69, -17, -62, 46, -53, -2, -6, -22, -81, -70; /I: I=-6; MD=-16; /M: SY='P'; M= -48, -83, -27, 35, -76, -72, 20, -70, 0, -24, 4, -3, 88, -18, -28, -61, 6, -48, 41, -69; D=-6; /I: I=-6; MD=-16; /M: SY='T'; M= -44, -69, -64, -64, -64, -37, -67, -30, -58, -21, -58, -20, 11, -62, 16, 11, 83, 14, -81, 8; D=-6; /I: I=-6; MD=-16; /M: SY='P'; M= -10, -81, -63, -12, -25, 22, -62, -75, 9, -75, -7, -2, 65, -7, 54, -31, -21, -45, -76, -13; D=-6; /I: I=-6; MI=0; MD=-16; IM=0; DM=-16; /M: SY='H'; M= 22, -74, -14, -60, -7, -70, 55, 11, 28, 21, -52, -24, 24, -11, -59, -10, -37, -12, -78, -59; D=-6; /I: I=-6; DM=-16; /M: SY='D'; M= -9, -77, 72, 13, 5, -29, -62, -73, -60, -24, -32, -7, 15, -14, -67, 9, 30, -70, -86, -67; D=-6; /I: I=-6; DM=-16; /M: SY='D'; M= -14, -80, 39, 31, -74, -35, 35, -73, 4, -27, -66, 24, 16, 9, 19, -14, -61, -22, -82, 2; D=-6; /I: I=-6; DM=-16; /M: SY='W'; M= -5, -77, -70, -9, 1, -22, -9, 11, -5, 16, -2, -32, 22, -31, 27, -4, -33, -4, 53, -23; D=-6; /I: I=-6; MI=0; MD=-16; IM=0; DM=-16; /M: SY='F'; M= 42, 25, -77, -72, 52, -43, -70, 3, -46, -58, -2, -12, -80, -69, 23, -61, -34, 9, -68, 13; D=-6; /I: I=-6; DM=-16; /M: SY='D'; M= 2, 15, 82, -46, -24, -69, -11, -71, -15, -30, -69, -49, -21, 18, -7, -17, 9, -17, -90, -68; D=-6; /I: I=-6; DM=-16; /M: SY='L'; M= -64, -73, -2, 26, 13, -82, -67, 9, -68, 48, 1, -72, -77, -64, -35, -14, -60, 33, -72, 13; D=-6; /I: I=-6; MI=0; MD=-16; IM=0; DM=-16; /M: SY='K'; M= -8, -4, -7, -23, -5, -70, 33, -36, 53, -12, -9, 3, -28, -54, 4, 7, -26, 9, -75, 9; D=-6; /I: I=-6; DM=-16; /M: SY='W'; M= -66, -76, -73, -11, 20, -81, -2, 31, -16, 36, -4, -1, -78, 9, -32, -69, -32, 17, 70, 12; D=-6; /I: I=-6; DM=-16; /M: SY='Y'; M= -65, -2, 7, -10, -51, -75, 61, -27, -59, 28, -5, -13, -41, 20, 12, 0, -61, -16, -67, 61; D=-6; /I: I=-6; DM=-16; /M: SY='G'; M= -8, 1, -62, 3, -72, 68, -66, -31, -64, -47, 39, 3, -69, -5, -70, 5, 7, -68, 17, -15; D=-6; /I: I=-6; DM=-16; /M: SY='D'; M= -34, -82, 59, 28, -74, -42, -58, -42, 33, -77, -70, -53, 53, -51, 27, -59, -3, -74, -77, 24; D=-6; /I: I=-6; MI=0; MD=-16; IM=0; DM=-16; /M: SY='C'; M= 47, 96, -76, -72, -66, -70, 18, 32, -31, -23, -55, -67, -77, -70, -73, -35, -26, 21, -85, -68; D=-6; /I: I=-6; DM=-16; /M: SY='G'; M= -33, -74, 45, -25, -23, 47, -12, 2, -63, -68, -65, -52, -69, 15, -69, 22, 24, 12, -83, -67; D=-6; /I: I=-6; DM=-16; /M: SY='E'; M= -18, -80, 36, 65, -81, -73, 11, -15, -17, -72, -67, -55, -20, 53, -57, -13, 10, -20, -85, -69; D=-6; /I: I=-6; DM=-16; /M: SY='V'; M= 13, -13, -73, -1, 4, 3, -75, 34, -29, -18, -52, -70, -75, 4, -71, -62, -7, 50, -77, -20; D=-6; /I: I=-6; DM=-16; /M: SY='L'; M= -3, 33, -84, -77, 14, -80, -72, 12, -76, 56, 50, -78, -81, -72, -76, -21, -61, 24, -75, -56; D=-6; /I: I=-6; DM=-16; /M: SY='P'; M= 11, -26, 18, -2, -81, -70, -65, -15, -15, -33, -66, -18, 79, 40, 3, -59, -7, -69, -82, -74; D=-6; /I: I=-6; DM=-16; /M: SY='R'; M= 12, -76, -57, 44, -72, -30, 25, -70, 13, 3, -5, -58, -13, 4, 50, -3, -10, -67, -79, -65; D=-6; /I: I=-6; DM=-16; /M: SY='I'; M= 10, -72, -27, -76, 30, -81, -75, 50, -76, 48, 18, -77, -79, -73, -77, -70, -61, 15, 14, -52; D=-6; /I: I=-6; MI=0; MD=-16; IM=0; DM=-16; /M: SY='M'; M= 8, 1, -5, -10, -61, -76, -69, -6, -26, 22, 59, -67, -74, 1, -29, -62, 21, 38, -82, -63; /M: SY='E'; M= -4, -80, 15, 52, -81, -41, 0, -36, 16, -49, -68, 23, 19, 25, 26, -20, -30, -73, -83, -71; /I: I=-45; MD=-115; /M: SY='H'; M= -38, 8, -61, 23, -30, -41, 43, -12, 7, 13, -58, 17, -21, 35, 16, -62, -7, -65, -78, 4; D=-45; /I: I=-45; MI=-115; IM=-115; DM=-115; /M: SY='L'; M= -70, 36, -35, -16, 0, -49, 18, 21, -77, 59, -6, -78, -85, -73, -48, -76, -67, 2, -79, -59; /M: SY='G'; M= -67, -86, -2, 0, -76, 46, -70, -42, 20, -8, -3, -64, -15, -7, 6, -34, -71, -45, -80, 6; /M: SY='W'; M= 10, -84, -75, -18, -26, -16, -28, -39, 21, -3, -15, -44, -78, 5, -27, -16, 12, -71, 95, -62; /M: SY='E'; M= -23, -91, -3, 39, -90, -20, -12, -43, 28, -27, -79, -69, -18, -26, -31, -26, -1, -82, -95, -83; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 213 in 213 different sequences |
| Number of true positive hits | 213 in 213 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Archaea, Eukaryotes, Prokaryotes (Bacteria) |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | Deacetylase sirtuin-type |
| Version [info] | 7 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
213 sequences
HST1_CANAL (Q5AQ47), HST1_EMENI (C8V3W5), HST1_YEAST (P53685), HST21_EMENI (Q5AW69), HST22_EMENI (P0CS88), HST2_CANAL (Q5A985), HST2_SCHPO (Q9USN7), HST2_YEAST (P53686), HST3_CANAL (Q5A1W9), HST3_YEAST (P53687), HST4_EMENI (Q5BE04), HST4_SCHPO (Q9UR39), HST4_YEAST (P53688), NDP_MYCS2 (A0R2N3), NPD1_ARCFU (O28597), NPD1_BRADU (Q89LY4), NPD1_CALS4 (Q8R9N6), NPD1_COREF (Q8FUC8), NPD1_GEOKA (Q5L014), NPD1_MYCA1 (A0QDH4), NPD1_PSEAE (Q9I4L0), NPD1_PSESM (Q88A13), NPD1_PYRAE (Q8ZU41), NPD1_STRCO (Q9RL35), NPD2_ARCFU (O30124), NPD2_BRADU (Q89EA6), NPD2_CALS4 (Q8R984), NPD2_COREF (Q8FRV5), NPD2_GEOKA (Q5KZE8), NPD2_MYCA1 (A0QC96), NPD2_PSEAE (Q9I4E1), NPD2_PSESM (Q885X7), NPD2_PYRAE (Q8ZT00), NPD2_STRCO (Q8CJM9), NPD3_PSESM (Q882K4), NPD4_PSESM (Q87W79), NPD_AERPE (Q9YB13), NPD_AGGAC (Q9ZAB8), NPD_AQUAE (O67919), NPD_BACAN (Q81NT6), NPD_BACC1 (Q735N7), NPD_BACCR (Q81BT4), NPD_BACCZ (Q639M6), NPD_BACHK (Q6HH09), NPD_BACSU (O07595), NPD_BACTN (Q8A3H9), NPD_BDEBA (Q6MJJ2), NPD_BORBR (Q7WLE5), NPD_BORPE (Q7VX46), NPD_CALMQ (A8MBU4), NPD_CAMJE (Q9JN05), NPD_CAMJR (Q5HU51), NPD_CAUVC (Q9A2S6), NPD_CHRVO (Q7P1B9), NPD_CLOAB (Q97MB4), NPD_CLOPE (Q8XNS6), NPD_CLOTE (Q899G3), NPD_CORGL (Q8NSM4), NPD_CUTAK (Q6A5T5), NPD_DEIRA (Q9RYD4), NPD_DESOH (A9A0B2), NPD_ECO57 (Q8X8E0), NPD_ECOL6 (Q8FIM4), NPD_ECOLI (P75960), NPD_ENTFA (Q839C6), NPD_FUSNN (Q8REC3), NPD_HALH5 (Q9KEE5), NPD_HALMA (Q5V4Q5), NPD_HELHP (Q7VIN2), NPD_HELPJ (Q9ZJW8), NPD_HELPY (O25849), NPD_LACPL (Q88ZA0), NPD_LARHH (C1DBX3), NPD_LEPIC (Q72RR0), NPD_LEPIN (Q8F3Z6), NPD_LISIN (Q927A7), NPD_LISMF (Q71W25), NPD_LISMO (Q8Y3U2), NPD_METCA (Q607X6), NPD_METKA (Q8TWG0), NPD_MYCBO (P66814), NPD_MYCLE (Q9CBW6), NPD_MYCPA (Q73WM7), NPD_MYCTA (A5U1J9), NPD_MYCTO (P9WGG2), NPD_MYCTU (P9WGG3), NPD_OCEIH (Q8ELR0), NPD_PASMU (Q9CM50), NPD_PROMH (B4EVF5), NPD_PSEPK (Q88BY5), NPD_PYRAB (Q9UZE7), NPD_PYRFU (Q8U1Q1), NPD_PYRHO (O58669), NPD_RALN1 (Q8Y015), NPD_RHOBA (Q7UFQ9), NPD_RHOPA (Q6N6U0), NPD_SACS2 (Q97VX5), NPD_SALTI (P0A2F3), NPD_SALTY (P0A2F2), NPD_SHEON (Q8EFN2), NPD_SHIFL (Q83RR8), NPD_SHOC1 (Q5WKC8), NPD_STAA8 (Q53700), NPD_STAAC (Q5HE07), NPD_STAAM (P66815), NPD_STAAN (P66816), NPD_STAAR (Q6GEN2), NPD_STAAS (Q6G7B7), NPD_STAAW (Q8NVC8), NPD_STAEQ (Q5HM33), NPD_STAES (Q8CNF4), NPD_SULAC (Q4JBN2), NPD_SULTO (Q974M6), NPD_SYMTH (Q67KQ0), NPD_THEKO (Q5JG47), NPD_THEMA (Q9WYW0), NPD_THESM (C6A243), NPD_THET2 (Q72IV5), NPD_THET8 (Q5SIH7), NPD_THEYD (B5YJW3), NPD_TREDE (Q73KE1), NPD_VIBCH (Q9KRX4), NPD_VIBPA (Q87PH8), NPD_VIBVU (Q8D9J9), NPD_VIBVY (Q7MKT7), NPD_XANAC (Q8PQK3), NPD_XANC8 (Q4UZX0), NPD_XANCB (B0RM75), NPD_XANCP (Q8PDM9), NPD_YERPE (Q8ZFR1), NPD_YERPS (Q669P6), SIR1_ARATH (Q9FE17), SIR1_HUMAN (Q96EB6), SIR1_MOUSE (Q923E4), SIR1_RAT(A0A0G2JZ79), SIR24_CAEEL (Q95Q89), SIR2A_DICDI (Q54QE6), SIR2A_PLAF7 (Q8IE47), SIR2B_DICDI (Q54LF0), SIR2B_PLAF7 (Q8IKW2), SIR2C_DICDI (Q54P49), SIR2D_DICDI (Q54GV7), SIR2E_DICDI (Q55DB0), SIR2_CAEBR (Q60L58), SIR2_CAEEL (Q21921), SIR2_CANAL (O59923), SIR2_CANGA (Q6FWI7), SIR2_DANRE (Q7ZVK3), SIR2_EREGS (Q757M7), SIR2_HUMAN (Q8IXJ6), SIR2_KLULA (P33294), SIR2_LEIMA (Q25337), SIR2_MACFA (Q4R834), SIR2_MOUSE (Q8VDQ8), SIR2_PONAB (Q5RBF1), SIR2_RAT(Q5RJQ4), SIR2_SCHPO (O94640), SIR2_TRYB2 (Q57V41), SIR2_YEAST (P06700), SIR3_HUMAN (Q9NTG7), SIR3_MOUSE (Q8R104), SIR41_CAEEL (Q20480), SIR42_CAEEL (Q20481), SIR4_ARATH (Q94AQ6), SIR4_BATDJ (F4P804), SIR4_BOVIN (Q1JQC6), SIR4_DROME (Q8IRR5), SIR4_HUMAN (Q9Y6E7), SIR4_LEIMA (Q4QB33), SIR4_MONBE (A9UVV1), SIR4_MOUSE (Q8R216), SIR4_TRYB2 (Q57YZ9), SIR5A_XENLA (Q5HZN8), SIR5B_XENLA (Q68F47), SIR5_BOVIN (Q3ZBQ0), SIR5_CANAL (Q5AI90), SIR5_CANLF (E2RDZ6), SIR5_CHICK (E1BRE2), SIR5_COPC7 (A8NWP2), SIR5_DANRE (Q6DHI5), SIR5_DAPPU (E9GD30), SIR5_FUSO4 (A0A0J9UVG7), SIR5_HUMAN (Q9NXA8), SIR5_LEIMA (Q4Q2Y6), SIR5_MACMU (F7EZ75), SIR5_MONDO (F7D4X9), SIR5_MOUSE (Q8K2C6), SIR5_PHYPA (A9SDL4), SIR5_PONAB (Q5R6G3), SIR5_RAT(Q68FX9), SIR5_TRYB2 (Q584D5), SIR5_XENTR (F7DKV7), SIR6_CASCN (A0A250YGJ5), SIR6_DROME (Q9VH08), SIR6_HUMAN (Q8N6T7), SIR6_MACFA (A0A2K5TU92), SIR6_MOUSE (P59941), SIR7_BOVIN (Q0P595), SIR7_DROME (Q9VAQ1), SIR7_HUMAN (Q9NRC8), SIR7_MOUSE (Q8BKJ9), SIR7_RAT(B2RZ55), SIRT1_DROME (Q9VK34), SIRT2_DROME (Q9I7I7), SIRTM_STAAM (A0A0H3JQ59), SIRTM_STRPG (P0DN71), SRT1_ORYSI (B8ARK7), SRT1_ORYSJ (Q7XWV4), THSA_ACIB7 (P0DW59), THSA_BACCS (J8G6Z1), THSA_CYTDA (A0A5B8Z1N3), THSA_ENTFC (P0DW60), THSA_STRE4 (C0MAL8)» more
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| PDB [Detailed view] |
226 PDB
1ICI; 1J8F; 1M2G; 1M2H; 1M2J; 1M2K; 1M2N; 1MA3; 1Q14; 1Q17; 1Q1A; 1S5P; 1S7G; 1SZC; 1SZD; 1YC2; 1YC5; 2B4Y; 2H2D; 2H2F; 2H2G; 2H2H; 2H2I; 2H4F; 2H4H; 2H4J; 2H59; 2HJH; 2NYR; 2OD2; 2OD7; 2OD9; 2QQF; 2QQG; 3D4B; 3D81; 3GLR; 3GLS; 3GLT; 3GLU; 3JR3; 3JWP; 3K35; 3PDH; 3PKI; 3PKJ; 3RIG; 3RIY; 3U31; 3U3D; 3ZG6; 3ZGO; 3ZGV; 4BN4; 4BN5; 4BUZ; 4BV2; 4BV3; 4BVB; 4BVE; 4BVF; 4BVG; 4BVH; 4C78; 4C7B; 4F4U; 4F56; 4FVT; 4FZ3; 4G1C; 4HD8; 4HDA; 4I5I; 4IAO; 4IF6; 4IG9; 4JSR; 4JT8; 4JT9; 4KXQ; 4L3O; 4O8Z; 4R8M; 4RMG; 4RMH; 4RMI; 4RMJ; 4TWI; 4TWJ; 4UTN; 4UTR; 4UTV; 4UTX; 4UTZ; 4UU7; 4UU8; 4UUA; 4UUB; 4X3O; 4X3P; 4Y6L; 4Y6O; 4Y6Q; 4ZZH; 4ZZI; 4ZZJ; 5A3A; 5A3B; 5A3C; 5BTR; 5BWL; 5BWN; 5BWO; 5D7N; 5D7O; 5D7P; 5D7Q; 5DY4; 5DY5; 5FYQ; 5G4C; 5H4D; 5MAR; 5MAT; 5MF6; 5MFP; 5MFZ; 5MGN; 5OJO; 5X16; 5XHS; 5Y0Z; 5Y2F; 5Y4H; 5Y5N; 5YQL; 5YQM; 5YQN; 5YQO; 5YTK; 5Z93; 5Z94; 5ZGC; 6ACE; 6ACL; 6ACO; 6ACP; 6ENX; 6EO0; 6EQS; 6FKY; 6FKZ; 6FLG; 6HOY; 6ISO; 6L65; 6L66; 6L71; 6L72; 6LHX; 6LJK; 6LJM; 6LJN; 6NR0; 6QCD; 6QCE; 6QCH; 6QCJ; 6QCN; 6RXJ; 6RXK; 6RXL; 6RXM; 6RXO; 6RXP; 6RXQ; 6RXR; 6RXS; 6XUY; 6XV1; 6XV6; 6XVG; 6ZU4; 7BOS; 7BOT; 7CL0; 7CL1; 7F4E; 7F51; 7T1D; 7UXT; 7X3P; 8AK5; 8AK6; 8AK7; 8AK8; 8AK9; 8AKA; 8AKB; 8AKC; 8AKD; 8AKE; 8AKF; 8AKG; 8BBK; 8BL0; 8BL1; 8BTO; 8BTP; 8CCW; 8CCZ; 8CNM; 8CNO; 8F86; 8G57; 8HLW; 8HLY; 8HN9; 8I2B; 8OF4; 8OWZ; 8PY3; 8TGP; 8V15; 8V2N; 8XE7 » more |