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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00236


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00236
General rule information [?]

Accession PRU00236
Dates 12-DEC-2003 (Created)
03-SEP-2024 (Last updated, Version 16)
Data class Domain;
Predictors PROSITE; PS50305; SIRTUIN
Name Sirtuin catalytic domain
Function Sirtuins are responsible for a newly classified chemical reaction, NAD- dependent protein deacetylation.
Scope(s) Eukaryota
Archaea
Bacteria
Example(s) P06700;

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTTag:act_site>
Protein name + RecName: EC=2.3.1.286;

Comments [?]

CATALYTIC ACTIVITY Reaction=N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl- ADP-D-ribose + nicotinamide + L-lysyl-[protein]; Xref=Rhea:RHEA:43636, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:61930, ChEBI:CHEBI:83767; EC=2.3.1.286;

Keywords [?]

NAD
Transferase
end case
case <FTGroup:1>
Metal-binding
Zinc
end case

Gene Ontology [?]

GO:0016407; Molecular function:acetyltransferase activity

Features [?]

From: PS50305
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Deacetylase sirtuin-type #"
case <FTGroup:1>
ACT_SITE 129 129 /note="Proton acceptor" act_site H
end case
BINDING 137 137 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 140 140 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 161 161 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 [CH] 1
BINDING 164 164 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1

Additional information [?]

Size range 207-331 amino acids
Related rules None
Fusion None
Repeats 1
Topology Cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]