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annotation rule: PRU00236

General rule information [?]

Accession PRU00236
Dates 12-DEC-2003 (Created)
21-NOV-2019 (Last updated, Version 10)
Data class Domain
Predictors PROSITE; PS50305; SIRTUIN
Names Sirtuin catalytic domain; Sir2 domain
Function Sirtuins are responsible for a newly classified chemical reaction, NAD- dependent protein deacetylation.

Propagated annotation [?]

Description [?]

+ RecName: EC;

Comments [?]

Catalytic activity RHEA:43636: H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide

Gene Ontology [?]

GO:0016407; Molecular function: acetyltransferase activity.

Keywords [?]

case <FTGroup:1>
end case

Features [?]

From: PS50305
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Deacetylase sirtuin-type #        
ACT_SITE     115     115       Proton acceptor     H  
METAL     123     123       Zinc     C   1
METAL     126     126       Zinc     C   1
METAL     147     147       Zinc     C   1
METAL     150     150       Zinc     C   1

Additional information [?]

Size range 207-331 amino acids
Related rules None
Repeats 1
Topology Cytoplasmic
Example P06700 (SIR2_YEAST)


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]