ProRule PRU00236
General rule information
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Accession | PRU00236 |
Dates | 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 14) |
Data class | Domain; |
Predictors |
PROSITE; PS50305; SIRTUIN |
Name | Sirtuin catalytic domain |
Function | Sirtuins are responsible for a newly classified chemical reaction, NAD- dependent protein deacetylation. |
Scope(s) |
Eukaryota Archaea Bacteria |
Example(s) | P06700 (SIR2_YEAST); |
Propagated annotation
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Identifier, protein and gene names
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case <FTTag:act_site> | |
Protein name | + RecName: EC=2.3.1.286; |
Comments
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CATALYTIC ACTIVITY | Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:43636, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:61930, ChEBI:CHEBI:83767; EC=2.3.1.286; |
Keywords
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NAD | |
Transferase | |
end case | |
case <FTGroup:1> | |
Metal-binding | |
Zinc | |
end case |
Gene Ontology
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GO:0016407; Molecular function:acetyltransferase activity |
Features
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From: PS50305 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | /note="Deacetylase sirtuin-type #" | |||||||||
case <FTGroup:1> | ||||||||||||
ACT_SITE | 129 | 129 | /note="Proton acceptor" | act_site | H | |||||||
end case | ||||||||||||
BINDING | 137 | 137 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
BINDING | 140 | 140 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
BINDING | 161 | 161 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
[CH] | 1 | |||||||
BINDING | 164 | 164 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 |
Additional information
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Size range | 207-331 amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1 |
Topology | Cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [16] Bacteria [109] Eukaryota [88] All [ 213 ]
- Retrieve set of proteins with 3D structure for this domain