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PROSITE entry PS50800


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General information about the entry

Entry name [info] SAP
Accession [info] PS50800
Entry type [info] MATRIX
Date [info] 01-FEB-2003 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50800
Associated ProRule [info] PRU00186

Name and characterization of the entry

Description [info] SAP motif profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=35;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=32;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1756001; R2=0.0199757; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1162.7791748; R2=1.5220884; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=317; H_SCORE=1645; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=217; H_SCORE=1493; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=*; E1=*; MI=-105; MD=-105; IM=-105; DM=-105; M0=-8;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='L';  M=-11,-18,-24,-20, -8,  5,-27,-11,  6, -8, 10,  8,-18,-22,-11, -9,-17, -9,  3,-13,  8,-10;
/M: SY='T';  M=  9, -6,-17,-11, -1,-16,-10,-14, -8, -9, -9, -3, -5,-11, -4,-13,  7, 11, -4,-26,-14, -3;
/M: SY='S';  M= -4,-10,-24, -8, -2,-19, -4, -7,-14,-10,-13, -9, -5, -1, -6,-12,  3, -4,-14,-29,-15, -5;
/M: SY='L';  M= -8,-25,-19,-28,-21,  9,-25,-13, 16,-21, 25, 23,-23,-26,-15,-16,-18, -6, 12,-18,  4,-18;
/M: SY='T';  M= -4, -5, -7,-10, -6,-17,-17,-14,-17,  3,-18,-11, -1,-15, -3,  8, 10, 15, -8,-30,-13, -6;
/M: SY='V';  M= -2,-14,-18,-15,-12, -8,-24,-15,  9,-12,  0,  4,-16,-21, -9,-14, -6,  0, 15,-23, -3,-11;
/M: SY='S';  M=  4, -2,-16, -3,  2,-20, -9, -4,-20, -5,-23,-16,  4, -5,  0, -3, 21, 14,-13,-33,-15,  0;
/M: SY='E';  M= -3,  5,-25,  9, 23,-22,-17, -6,-21,  4,-16,-13, -2, -9, 10, -4, -1, -8,-17,-25,-14, 17;
/M: SY='L';  M=-10,-30,-22,-32,-22,  8,-32,-22, 27,-30, 43, 20,-28,-28,-20,-22,-28,-10, 14,-20,  0,-22;
/M: SY='R';  M=-14, -4,-30, -4,  8,-28,-20,  0,-27, 30,-23, -7,  0,-14, 24, 42, -7,-10,-23,-20,-10, 14;
/M: SY='D';  M= -8, 12,-24, 17,  2,-26, -8, -8,-19, -4,-19,-11,  4,-13,  0, -8,  4, -2,-13,-31,-16,  1;
/M: SY='M';  M= -1,-15,-22,-19, -8, -4,-23,-16,  2, -4,  5,  6,-13,-17, -9, -8,-11, -5,  0,-19, -5, -9;
/M: SY='C';  M= -5,-25, 24,-29,-22, -2,-27,-23,  2,-28, 23,  5,-25,-31,-22,-23,-20, -9,  3,-29,-11,-22;
/M: SY='R';  M= -6, -2,-26,  0, 10,-26, -5, -6,-28, 16,-26,-14,  2,-12,  9, 18,  4, -5,-21,-26,-16,  9;
/M: SY='E';  M=  2, -4,-22, -4,  9,-15,-15, -1,-17,  3,-17,-10, -3,-12,  5, -2,  3, -4,-13,-22, -6,  7;
/M: SY='R';  M= -9,-14,-22,-17, -9, -1,-22, -9, -2, -5,  5,  4,-11,-23, -8,  6,-13, -7,  0,-19, -1,-10;
/M: SY='G';  M=  2, -8,-27, -8,-17,-28, 59,-18,-37,-18,-30,-20,  2,-18,-17,-18,  7,-13,-27,-23,-28,-17;
/M: SY='L';  M=-11,-25,-21,-26,-16,  8,-28,-16, 11,-19, 30, 13,-24,-27,-13, -7,-23, -9,  6,-18,  0,-15;
/M: SY='S';  M= -1, -1,-23,  0,  1,-24, -9, -9,-23, -1,-26,-18,  3, 10, -1,  4, 11,  2,-18,-32,-20, -2;
/M: SY='T';  M=  1, -7, -4,-13,-10,-13,-19,-10,-11, -7,-10, -7, -5,-16, -9, -8,  7, 19, -2,-30,-10,-10;
/M: SY='N';  M= -5, 11,-21,  7,  1,-23, -3,  9,-23, -6,-26,-16, 18, -7,  2, -6, 13,  4,-22,-34,-15,  0;
/M: SY='G';  M=  1, -9,-28, -9,-18,-29, 65,-19,-38,-19,-30,-20,  1,-19,-18,-19,  3,-17,-28,-22,-29,-18;
/M: SY='R';  M= -8, -6,-25, -8, -5,-19,-11, -6,-18,  2,-18,-10, -1,  0, -4,  5, -1,  0,-14,-27,-14, -6;
/M: SY='K';  M=-12, -1,-30,  0, 12,-28,-20, -8,-30, 44,-28,-11,  0,-11, 11, 34, -9,-10,-21,-21,-11, 11;
/M: SY='Q';  M=  1, -7,-25, -9,  2,-26,-16,  5,-18,  6,-17, -5, -5, -6, 16,  8, -3, -8,-16,-23,-10,  7;
/M: SY='E';  M=-12,  0,-25,  3, 12,-14,-21,  3,-12, -3, -6, -7, -2,-16,  0, -1, -8, -8,-11,-25, -5,  5;
/M: SY='L';  M= -9,-29,-20,-31,-22,  7,-30,-20, 23,-27, 42, 23,-28,-28,-19,-20,-27, -9, 15,-21, -1,-21;
/M: SY='I';  M= -8,-20,-11,-24,-13, -8,-30,-19, 15,-19, 11,  8,-18,-22, -7,-17,-13, -5, 10,-25, -7,-12;
/M: SY='D';  M=-11, 11,-25, 15,  8,-26,-19, -8,-19,  6,-18,-12,  2,-12,  4,  2, -1,  1,-13,-29,-13,  5;
/M: SY='R';  M=-12,-13,-15,-15, -6,-17,-21, -8,-20, 16,-12, -7, -7,-22,  0, 40,-10, -9,-11,-23,-11, -6;
/M: SY='L';  M= -6,-16,-14,-19,-16, -4,-26, -2,  7,-21, 12,  6,-15,-24,-13,-19,-16,-10,  2,-21,  4,-17;
/M: SY='R';  M= -2, -5,-21,-10, -6,-14,-17,-11,-10,  6, -5, -4,  0,-19, -5,  9, -6, -2, -6,-24,-11, -6;
/M: SY='E';  M=-10,  8,-27, 10, 16,-29, -8, 12,-29, 10,-25,-13,  9,-11, 13,  4,  1, -9,-26,-28,-12, 14;
/M: SY='Y';  M= -4,-20,-26,-23,-18,  5,-15,  3, -7,-18,  0, -2,-17,-24,-14,-15,-16,-13, -7, 11, 16,-17;
/M: SY='L';  M= -8,-16,-21,-18, -6, -1,-27,-17,  7,-12, 10,  7,-16,-18,-11,-12,-11,  1,  7,-23, -5, -9;
/I:         E1=0; IE=-105; DE=-105;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_03 which contains 571'609 sequence entries.


Total number of hits 123 in 120 different sequences
Number of true positive hits 123 in 120 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 24
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 83.67 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 2
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] SAP
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
120 sequences

049L_FRG3G  (Q6GZS7), ACINU_HUMAN (Q9UKV3), ACINU_MOUSE (Q9JIX8), 
AIM34_EREGS (Q75CC0), AIM34_KLULA (Q6CUC1), AIM34_LACTC (C5DEP0), 
AIM34_YARLI (Q6CFD4), AIM34_YEAS1 (B3LLQ4), AIM34_YEAS2 (C7GLB5), 
AIM34_YEAS6 (B5VPC6), AIM34_YEAS7 (A6ZM65), AIM34_YEAS8 (C8ZEK9), 
AIM34_YEAST (Q03673), AIM34_ZYGRC (C5DTC6), ARP_ARATH   (P45951), 
CCAR1_HUMAN (Q8IX12), CCAR1_MOUSE (Q8CH18), CCAR1_XENLA (Q641G3), 
CCE1_SCHPO  (Q10423), DPPA2_HUMAN (Q7Z7J5), ERI1_CAEEL  (O44406), 
ERI1_HUMAN  (Q8IV48), ERI1_MOUSE  (Q7TMF2), ERI1_RAT(Q5FVR4), 
ERI1_SCHPO  (Q08I43), HNRL1_HUMAN (Q9BUJ2), HNRL1_MOUSE (Q8VDM6), 
HNRL2_HUMAN (Q1KMD3), HNRL2_MOUSE (Q00PI9), HNRPU_HUMAN (Q00839), 
HNRPU_MOUSE (Q8VEK3), HNRPU_RAT   (Q6IMY8), KU70_ARATH  (Q9FQ08), 
KU70_ASPOR  (Q2MHH4), KU70_ASPSO  (Q2MHH3), KU70_CHAGB  (Q2H0I3), 
KU70_COCIM  (Q1DU75), KU70_EMENI  (Q5AVC7), KU70_NEUCR  (Q7SA95), 
KU70_ORYSJ  (Q7F1M0), KU70_PHANO  (Q0U5F2), KU70_RHIAP  (Q26228), 
KU70_SCHPO  (O94395), LOT1_ARATH  (Q6IDA6), MASTR_BOVIN (A7E346), 
MASTR_HUMAN (Q6ZN01), MASTR_MOUSE (Q0ZCJ7), MRTFA_HUMAN (Q969V6), 
MRTFA_MOUSE (Q8K4J6), MRTFA_XENLA (Q8AYC2), MRTFB_HUMAN (Q9ULH7), 
MRTFB_MOUSE (P59759), MRTFB_XENLA (Q8AYC1), MYCD_HUMAN  (Q8IZQ8), 
MYCD_MOUSE  (Q8VIM5), MYCD_PIG(Q7YR76), MYCD_RAT(Q8R5I7), 
PARP1_MAIZE (Q9ZSV1), PARP1_ORYSJ (Q7EYV7), PARP2_ARATH (Q11207), 
PARP2_MAIZE (O50017), PARP3_SOYBN (Q9SWB4), PHM2_CAEEL  (O62203), 
PIAS1_HUMAN (O75925), PIAS1_MOUSE (O88907), PIAS2_HUMAN (O75928), 
PIAS2_MOUSE (Q8C5D8), PIAS2_RAT   (Q6AZ28), PIAS3_HUMAN (Q9Y6X2), 
PIAS3_MOUSE (O54714), PIAS3_RAT   (O70260), PIAS4_HUMAN (Q8N2W9), 
PIAS4_MOUSE (Q9JM05), PIS4A_DANRE (F1R4C4), PLI1_SCHPO  (O94451), 
PRP2A_ORYSJ (Q5Z8Q9), RAD18_ASPFU (Q4WZJ6), RAD18_CANAL (Q5A4N5), 
RAD18_CANGA (Q6FPI4), RAD18_DEBHA (Q6BLM3), RAD18_EMENI (Q02398), 
RAD18_EREGS (Q75EN0), RAD18_HUMAN (Q9NS91), RAD18_KLULA (Q6CTZ8), 
RAD18_MOUSE (Q9QXK2), RAD18_NEUCR (P33288), RAD18_SCHPO (O74747), 
RAD18_YARLI (Q6CHI1), RAD18_YEAST (P10862), RRC1_ARATH  (Q9C5J3), 
SAFB1_HUMAN (Q15424), SAFB1_MOUSE (D3YXK2), SAFB1_PONAB (Q5R452), 
SAFB1_RAT   (O88453), SAFB2_HUMAN (Q14151), SAFB2_MOUSE (Q80YR5), 
SARNP_HUMAN (P82979), SARNP_MOUSE (Q9D1J3), SARNP_PONAB (Q5R4V4), 
SARNP_RAT   (Q498U4), SF3B2_HUMAN (Q13435), SF3B2_MOUSE (Q3UJB0), 
SIZ1_ARATH  (Q680Q4), SIZ1_ORYSJ  (Q6L4L4), SIZ1_YEAST  (Q04195), 
SIZ2_ORYSJ  (Q6ASW7), SIZ2_YEAST  (Q12216), SLTM_HUMAN  (Q9NWH9), 
SLTM_MOUSE  (Q8CH25), SLTM_XENLA  (Q498L2), THO1_YEAST  (P40040), 
XRCC6_CHICK (O93257), XRCC6_HUMAN (P12956), XRCC6_MOUSE (P23475), 
Y0785_DICDI (Q54UW0), Y0787_DICDI (Q54UV9), Y0809_DICDI (Q54UV8), 
Y1095_DICDI (Q54UG3), Y1301_DICDI (Q54UG2), YCW3_SCHPO  (O74871)
» more

UniProtKB/Swiss-Prot
False negative sequences
24 sequences

C3H62_ORYSJ (Q338N2), DEK_HUMAN   (P35659), DEK_MOUSE   (Q7TNV0), 
DEK_RAT (Q6AXS3), DPPA2_MOUSE (Q9CWH0), KU70_DICDI  (Q54MA9), 
NEW25_SCHPO (G2TRT4), PARP3_MEDTR (Q1SGF1), RFFL_HUMAN  (Q8WZ73), 
RFFL_MOUSE  (Q6ZQM0), RFFL_RAT(Q8CIN9), RNF34_BOVIN (Q5E9J6), 
RNF34_HUMAN (Q969K3), RNF34_MOUSE (Q99KR6), RNF34_PONAB (Q5NVC7), 
RNF34_RAT   (Q6AYH3), RRC1L_ARATH (F4KIA8), SDE2_DANRE  (Q7T293), 
SDE2_HUMAN  (Q6IQ49), SDE2_MOUSE  (Q8K1J5), SDE2_PONAB  (Q5RET9), 
SDE2_RAT(Q5BJN8), SDE2_XENLA  (Q6NRI5), SDE2_XENTR  (Q07G43)
» more

PDB
[Detailed view]
73 PDB

1H1J; 1JEQ; 1JEY; 1JJR; 1KCF; 1V66; 1ZBH; 1ZBU; 1ZRJ; 2DO1; 2DO5; 2JX3; 2KVU; 2KW9; 2RNN; 2RNO; 2WQG; 4L8R; 4QOZ; 4UZW; 5Z56; 5Z57; 5Z58; 6AH0; 6AHD; 6FF4; 6FF7; 6QX9; 6Y50; 6Y53; 6Y5Q; 6ZHA; 6ZHE; 7ABG; 7ABH; 7ABI; 7AXZ; 7DVQ; 7EVO; 7K0Y; 7K1J; 7K1K; 7K1N; 7LSY; 7LT3; 7NFC; 7NFE; 7ONB; 7Q3L; 7Q4O; 7Q4P; 7QTT; 7SGL; 7SU3; 7VPX; 7Z6O; 7Z87; 7Z88; 7ZT6; 7ZVT; 7ZWA; 7ZYG; 8AG4; 8AG5; 8BH3; 8BHV; 8BHY; 8BOT; 8CH6; 8EZA; 8EZB; 8HK1; 8QO9
» more