PROSITE logo

PROSITE entry PS50800


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] SAP
Accession [info] PS50800
Entry type [info] MATRIX
Date [info] 01-FEB-2003 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50800
Associated ProRule [info] PRU00186

Name and characterization of the entry

Description [info] SAP motif profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=35;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=32;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1756001; R2=0.0199757; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1162.7791748; R2=1.5220884; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=317; H_SCORE=1645; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=217; H_SCORE=1493; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=*; E1=*; MI=-105; MD=-105; IM=-105; DM=-105; M0=-8;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='L';  M=-11,-18,-24,-20, -8,  5,-27,-11,  6, -8, 10,  8,-18,-22,-11, -9,-17, -9,  3,-13,  8,-10;
/M: SY='T';  M=  9, -6,-17,-11, -1,-16,-10,-14, -8, -9, -9, -3, -5,-11, -4,-13,  7, 11, -4,-26,-14, -3;
/M: SY='S';  M= -4,-10,-24, -8, -2,-19, -4, -7,-14,-10,-13, -9, -5, -1, -6,-12,  3, -4,-14,-29,-15, -5;
/M: SY='L';  M= -8,-25,-19,-28,-21,  9,-25,-13, 16,-21, 25, 23,-23,-26,-15,-16,-18, -6, 12,-18,  4,-18;
/M: SY='T';  M= -4, -5, -7,-10, -6,-17,-17,-14,-17,  3,-18,-11, -1,-15, -3,  8, 10, 15, -8,-30,-13, -6;
/M: SY='V';  M= -2,-14,-18,-15,-12, -8,-24,-15,  9,-12,  0,  4,-16,-21, -9,-14, -6,  0, 15,-23, -3,-11;
/M: SY='S';  M=  4, -2,-16, -3,  2,-20, -9, -4,-20, -5,-23,-16,  4, -5,  0, -3, 21, 14,-13,-33,-15,  0;
/M: SY='E';  M= -3,  5,-25,  9, 23,-22,-17, -6,-21,  4,-16,-13, -2, -9, 10, -4, -1, -8,-17,-25,-14, 17;
/M: SY='L';  M=-10,-30,-22,-32,-22,  8,-32,-22, 27,-30, 43, 20,-28,-28,-20,-22,-28,-10, 14,-20,  0,-22;
/M: SY='R';  M=-14, -4,-30, -4,  8,-28,-20,  0,-27, 30,-23, -7,  0,-14, 24, 42, -7,-10,-23,-20,-10, 14;
/M: SY='D';  M= -8, 12,-24, 17,  2,-26, -8, -8,-19, -4,-19,-11,  4,-13,  0, -8,  4, -2,-13,-31,-16,  1;
/M: SY='M';  M= -1,-15,-22,-19, -8, -4,-23,-16,  2, -4,  5,  6,-13,-17, -9, -8,-11, -5,  0,-19, -5, -9;
/M: SY='C';  M= -5,-25, 24,-29,-22, -2,-27,-23,  2,-28, 23,  5,-25,-31,-22,-23,-20, -9,  3,-29,-11,-22;
/M: SY='R';  M= -6, -2,-26,  0, 10,-26, -5, -6,-28, 16,-26,-14,  2,-12,  9, 18,  4, -5,-21,-26,-16,  9;
/M: SY='E';  M=  2, -4,-22, -4,  9,-15,-15, -1,-17,  3,-17,-10, -3,-12,  5, -2,  3, -4,-13,-22, -6,  7;
/M: SY='R';  M= -9,-14,-22,-17, -9, -1,-22, -9, -2, -5,  5,  4,-11,-23, -8,  6,-13, -7,  0,-19, -1,-10;
/M: SY='G';  M=  2, -8,-27, -8,-17,-28, 59,-18,-37,-18,-30,-20,  2,-18,-17,-18,  7,-13,-27,-23,-28,-17;
/M: SY='L';  M=-11,-25,-21,-26,-16,  8,-28,-16, 11,-19, 30, 13,-24,-27,-13, -7,-23, -9,  6,-18,  0,-15;
/M: SY='S';  M= -1, -1,-23,  0,  1,-24, -9, -9,-23, -1,-26,-18,  3, 10, -1,  4, 11,  2,-18,-32,-20, -2;
/M: SY='T';  M=  1, -7, -4,-13,-10,-13,-19,-10,-11, -7,-10, -7, -5,-16, -9, -8,  7, 19, -2,-30,-10,-10;
/M: SY='N';  M= -5, 11,-21,  7,  1,-23, -3,  9,-23, -6,-26,-16, 18, -7,  2, -6, 13,  4,-22,-34,-15,  0;
/M: SY='G';  M=  1, -9,-28, -9,-18,-29, 65,-19,-38,-19,-30,-20,  1,-19,-18,-19,  3,-17,-28,-22,-29,-18;
/M: SY='R';  M= -8, -6,-25, -8, -5,-19,-11, -6,-18,  2,-18,-10, -1,  0, -4,  5, -1,  0,-14,-27,-14, -6;
/M: SY='K';  M=-12, -1,-30,  0, 12,-28,-20, -8,-30, 44,-28,-11,  0,-11, 11, 34, -9,-10,-21,-21,-11, 11;
/M: SY='Q';  M=  1, -7,-25, -9,  2,-26,-16,  5,-18,  6,-17, -5, -5, -6, 16,  8, -3, -8,-16,-23,-10,  7;
/M: SY='E';  M=-12,  0,-25,  3, 12,-14,-21,  3,-12, -3, -6, -7, -2,-16,  0, -1, -8, -8,-11,-25, -5,  5;
/M: SY='L';  M= -9,-29,-20,-31,-22,  7,-30,-20, 23,-27, 42, 23,-28,-28,-19,-20,-27, -9, 15,-21, -1,-21;
/M: SY='I';  M= -8,-20,-11,-24,-13, -8,-30,-19, 15,-19, 11,  8,-18,-22, -7,-17,-13, -5, 10,-25, -7,-12;
/M: SY='D';  M=-11, 11,-25, 15,  8,-26,-19, -8,-19,  6,-18,-12,  2,-12,  4,  2, -1,  1,-13,-29,-13,  5;
/M: SY='R';  M=-12,-13,-15,-15, -6,-17,-21, -8,-20, 16,-12, -7, -7,-22,  0, 40,-10, -9,-11,-23,-11, -6;
/M: SY='L';  M= -6,-16,-14,-19,-16, -4,-26, -2,  7,-21, 12,  6,-15,-24,-13,-19,-16,-10,  2,-21,  4,-17;
/M: SY='R';  M= -2, -5,-21,-10, -6,-14,-17,-11,-10,  6, -5, -4,  0,-19, -5,  9, -6, -2, -6,-24,-11, -6;
/M: SY='E';  M=-10,  8,-27, 10, 16,-29, -8, 12,-29, 10,-25,-13,  9,-11, 13,  4,  1, -9,-26,-28,-12, 14;
/M: SY='Y';  M= -4,-20,-26,-23,-18,  5,-15,  3, -7,-18,  0, -2,-17,-24,-14,-15,-16,-13, -7, 11, 16,-17;
/M: SY='L';  M= -8,-16,-21,-18, -6, -1,-27,-17,  7,-12, 10,  7,-16,-18,-11,-12,-11,  1,  7,-23, -5, -9;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.


Total number of hits 123 in 120 different sequences
Number of true positive hits 123 in 120 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 24
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 83.67 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 2
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] SAP
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
120 sequences

049L_FRG3G  (Q6GZS7), ACINU_HUMAN (Q9UKV3), ACINU_MOUSE (Q9JIX8), 
AIM34_EREGS (Q75CC0), AIM34_KLULA (Q6CUC1), AIM34_LACTC (C5DEP0), 
AIM34_YARLI (Q6CFD4), AIM34_YEAS1 (B3LLQ4), AIM34_YEAS2 (C7GLB5), 
AIM34_YEAS6 (B5VPC6), AIM34_YEAS7 (A6ZM65), AIM34_YEAS8 (C8ZEK9), 
AIM34_YEAST (Q03673), AIM34_ZYGRC (C5DTC6), ARP_ARATH   (P45951), 
CCAR1_HUMAN (Q8IX12), CCAR1_MOUSE (Q8CH18), CCAR1_XENLA (Q641G3), 
CCE1_SCHPO  (Q10423), DPPA2_HUMAN (Q7Z7J5), ERI1_CAEEL  (O44406), 
ERI1_HUMAN  (Q8IV48), ERI1_MOUSE  (Q7TMF2), ERI1_RAT(Q5FVR4), 
ERI1_SCHPO  (Q08I43), HNRL1_HUMAN (Q9BUJ2), HNRL1_MOUSE (Q8VDM6), 
HNRL2_HUMAN (Q1KMD3), HNRL2_MOUSE (Q00PI9), HNRPU_HUMAN (Q00839), 
HNRPU_MOUSE (Q8VEK3), HNRPU_RAT   (Q6IMY8), KU70_ARATH  (Q9FQ08), 
KU70_ASPOR  (Q2MHH4), KU70_ASPSO  (Q2MHH3), KU70_CHAGB  (Q2H0I3), 
KU70_COCIM  (Q1DU75), KU70_EMENI  (Q5AVC7), KU70_NEUCR  (Q7SA95), 
KU70_ORYSJ  (Q7F1M0), KU70_PHANO  (Q0U5F2), KU70_RHIAP  (Q26228), 
KU70_SCHPO  (O94395), LOT1_ARATH  (Q6IDA6), MASTR_BOVIN (A7E346), 
MASTR_HUMAN (Q6ZN01), MASTR_MOUSE (Q0ZCJ7), MRTFA_HUMAN (Q969V6), 
MRTFA_MOUSE (Q8K4J6), MRTFA_XENLA (Q8AYC2), MRTFB_HUMAN (Q9ULH7), 
MRTFB_MOUSE (P59759), MRTFB_XENLA (Q8AYC1), MYCD_HUMAN  (Q8IZQ8), 
MYCD_MOUSE  (Q8VIM5), MYCD_PIG(Q7YR76), MYCD_RAT(Q8R5I7), 
PARP1_MAIZE (Q9ZSV1), PARP1_ORYSJ (Q7EYV7), PARP2_ARATH (Q11207), 
PARP2_MAIZE (O50017), PARP3_SOYBN (Q9SWB4), PHM2_CAEEL  (O62203), 
PIAS1_HUMAN (O75925), PIAS1_MOUSE (O88907), PIAS2_HUMAN (O75928), 
PIAS2_MOUSE (Q8C5D8), PIAS2_RAT   (Q6AZ28), PIAS3_HUMAN (Q9Y6X2), 
PIAS3_MOUSE (O54714), PIAS3_RAT   (O70260), PIAS4_HUMAN (Q8N2W9), 
PIAS4_MOUSE (Q9JM05), PIS4A_DANRE (F1R4C4), PLI1_SCHPO  (O94451), 
PRP2A_ORYSJ (Q5Z8Q9), RAD18_ASPFU (Q4WZJ6), RAD18_CANAL (Q5A4N5), 
RAD18_CANGA (Q6FPI4), RAD18_DEBHA (Q6BLM3), RAD18_EMENI (Q02398), 
RAD18_EREGS (Q75EN0), RAD18_HUMAN (Q9NS91), RAD18_KLULA (Q6CTZ8), 
RAD18_MOUSE (Q9QXK2), RAD18_NEUCR (P33288), RAD18_SCHPO (O74747), 
RAD18_YARLI (Q6CHI1), RAD18_YEAST (P10862), RRC1_ARATH  (Q9C5J3), 
SAFB1_HUMAN (Q15424), SAFB1_MOUSE (D3YXK2), SAFB1_PONAB (Q5R452), 
SAFB1_RAT   (O88453), SAFB2_HUMAN (Q14151), SAFB2_MOUSE (Q80YR5), 
SARNP_HUMAN (P82979), SARNP_MOUSE (Q9D1J3), SARNP_PONAB (Q5R4V4), 
SARNP_RAT   (Q498U4), SF3B2_HUMAN (Q13435), SF3B2_MOUSE (Q3UJB0), 
SIZ1_ARATH  (Q680Q4), SIZ1_ORYSJ  (Q6L4L4), SIZ1_YEAST  (Q04195), 
SIZ2_ORYSJ  (Q6ASW7), SIZ2_YEAST  (Q12216), SLTM_HUMAN  (Q9NWH9), 
SLTM_MOUSE  (Q8CH25), SLTM_XENLA  (Q498L2), THO1_YEAST  (P40040), 
XRCC6_CHICK (O93257), XRCC6_HUMAN (P12956), XRCC6_MOUSE (P23475), 
Y0785_DICDI (Q54UW0), Y0787_DICDI (Q54UV9), Y0809_DICDI (Q54UV8), 
Y1095_DICDI (Q54UG3), Y1301_DICDI (Q54UG2), YCW3_SCHPO  (O74871)
» more

UniProtKB/Swiss-Prot
False negative sequences
24 sequences

C3H62_ORYSJ (Q338N2), DEK_HUMAN   (P35659), DEK_MOUSE   (Q7TNV0), 
DEK_RAT (Q6AXS3), DPPA2_MOUSE (Q9CWH0), KU70_DICDI  (Q54MA9), 
NEW25_SCHPO (G2TRT4), PARP3_MEDTR (Q1SGF1), RFFL_HUMAN  (Q8WZ73), 
RFFL_MOUSE  (Q6ZQM0), RFFL_RAT(Q8CIN9), RNF34_BOVIN (Q5E9J6), 
RNF34_HUMAN (Q969K3), RNF34_MOUSE (Q99KR6), RNF34_PONAB (Q5NVC7), 
RNF34_RAT   (Q6AYH3), RRC1L_ARATH (F4KIA8), SDE2_DANRE  (Q7T293), 
SDE2_HUMAN  (Q6IQ49), SDE2_MOUSE  (Q8K1J5), SDE2_PONAB  (Q5RET9), 
SDE2_RAT(Q5BJN8), SDE2_XENLA  (Q6NRI5), SDE2_XENTR  (Q07G43)
» more

PDB
[Detailed view]
85 PDB

1H1J; 1JEQ; 1JEY; 1JJR; 1KCF; 1V66; 1ZBH; 1ZBU; 1ZRJ; 2DO1; 2DO5; 2JX3; 2KVU; 2KW9; 2RNN; 2RNO; 2WQG; 4L8R; 4QOZ; 4UZW; 5Z56; 5Z57; 5Z58; 6AH0; 6AHD; 6FF4; 6FF7; 6QX9; 6Y50; 6Y53; 6Y5Q; 6ZHA; 6ZHE; 7ABG; 7ABH; 7ABI; 7AXZ; 7DVQ; 7EVO; 7K0Y; 7K1J; 7K1K; 7K1N; 7LSY; 7LT3; 7NFC; 7NFE; 7ONB; 7Q3L; 7Q4O; 7Q4P; 7QTT; 7SGL; 7SU3; 7VPX; 7Z6O; 7Z87; 7Z88; 7ZT6; 7ZVT; 7ZWA; 7ZYG; 8AG4; 8AG5; 8BH3; 8BHV; 8BHY; 8BOT; 8CH6; 8EZA; 8EZB; 8H6E; 8H6J; 8H6K; 8H6L; 8HK1; 8QO9; 8QXD; 8QZS; 8R08; 8R09; 8R0A; 8R0B; 8RM5; 8Y7E
» more