PROSITE entry PS50818

View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission

General information about the entry

Entry name [info]	INTEIN_C_TER
Accession [info]	PS50818
Entry type [info]	MATRIX
Date [info]	01-MAY-2002 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00687

Name and characterization of the entry

Description [info]

Intein C-terminal splicing motif profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=22;
/DISJOINT: DEFINITION=PROTECT; N1=3; N2=20;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.8533000; R2=0.0226396; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=656.6232910; R2=0.7982063; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=290; H_SCORE=888; N_SCORE=7.4; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=250; H_SCORE=856; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-20; I=-20; B0=-60; B1=-60; E0=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B0=0; B1=0; BI=-105; BD=-105;
/M: SY='Y';  M=-15,-11,-29, -9, -6,  3,-23, -5,-14, -1,-13,-10,-10, -2, -9,  0,-12, -8,-15, -5, 12, -9;
/M: SY='V';  M=  1,-25,-13,-27,-26, -1,-24,-27, 20,-18,  7,  6,-24,-26,-25,-17, -8,  1, 34,-27, -9,-26;
/M: SY='Y';  M=-19,-17,-28,-18,-17, 29,-28,  9, -2,-11, -1, -1,-16,-27,-11, -9,-18,-10, -9, 17, 55,-17;
/M: SY='D';  M=-13, 27, -1, 33,  5,-29,-12, -6,-30, -8,-25,-23, 15,-17, -6,-12,  4, -3,-22,-41,-21, -1;
/M: SY='L';  M= -6,-25,-20,-27,-22,  3,-30,-24, 23,-25, 26, 13,-24,-25,-21,-21,-18, -4, 20,-23, -3,-23;
/M: SY='T';  M= -1,  1,-18, -1,  4,-16,-10,-10,-14, -7,-16,-13,  3,-12, -3, -9, 11, 12, -9,-28,-11,  0;
/M: SY='V';  M=  3,-18, -3,-21,-22, -8,-21,-25, 10,-18,  1,  0,-17,-24,-22,-19, -4,  4, 23,-30,-13,-22;
/I:         I=-5; MD=-27;
/M: SY='E';  M=-10,  0,-25,  7, 15,-17,-19, -7,-21,  2,-19,-15, -5, 11,  0, -6, -6, -9,-21,-21, -9,  6; D=-5;
/I:         I=-5; MD=-27;
/M: SY='N';  M= -2, 10,-17,  7,  0,-18,  5, -1,-18, -2,-18,-12, 13,-11, -3, -3,  2, -3,-16,-22,-13, -2; D=-5;
/I:         I=-5; MI=-27; MD=-27; IM=-27; DM=-27;
/M: SY='H';  M=-12,  0,-26,  1,  5,-22, -6, 42,-25, -8,-18, -6,  5,-16,  7, -4, -4,-13,-24,-27,  0,  4; D=-5;
/I:         I=-5; DM=-27;
/M: SY='N';  M= -5, 14,-19,  2, -5,-10, -8, -2,-13, -4,-15,-11, 27,-20, -5, -2,  3,  0,-17,-30,-13, -5;
/M: SY='F';  M=-16,-25,-24,-30,-25, 40,-25, -8,  5,-22,  9,  3,-20,-29,-25,-17,-20,-10,  0,  8, 37,-25;
/I:         I=-6; MD=-32;
/M: SY='V';  M= -6,-27,-18,-30,-25,  7,-30,-20, 24,-24, 18, 12,-23,-26,-23,-20,-16, -4, 25,-21, -1,-25; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='A';  M= 15,-14,-14,-20,-15, -7,-14,-20,  1,-15, -2, -3,-12,-17,-13,-17,  4,  8,  8,-23,-11,-14;
/I:         I=-5; MD=-25;
/M: SY='N';  M= -1,  8,-22,  1, -3,-17,  1, -4,-18, -4,-20,-14, 15,-15, -5, -3,  1, -6,-17,-22,-12, -5; D=-5;
/I:         I=-5; MD=-25;
/M: SY='G';  M= -5, -1,-21, -5, -7,-13, 14, -8,-19, -9,-17,-12,  6,-16, -7, -8,  2, -5,-17,-19,-11, -7; D=-5;
/I:         I=-5; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='I';  M= -6,-28,-15,-34,-27,  9,-30,-27, 27,-27, 16, 11,-22,-25,-24,-25,-17, -8, 22,-20, -1,-27;
/M: SY='V';  M= -6,-28,-20,-31,-25,  8,-30,-24, 22,-23, 16, 11,-25,-23,-24,-21,-17, -5, 23,-15,  0,-25;
/M: SY='V';  M=  5,-15, -9,-20,-18, -7,-21,-23,  7,-16,  1, -1,-14,-20,-18,-17,  3, 14, 18,-29,-11,-18;
/M: SY='H';  M=-12, -3,-28, -3, -3,-20, -5, 62,-30, -7,-21, -5,  6,-19,  3, -2, -7,-17,-27,-26,  7, -3;
/M: SY='N';  M=-10, 35,-21, 17,  3,-23, -3, 10,-20,  1,-29,-17, 52,-19,  8,  1,  9, -1,-30,-37,-19,  5;
/M: SY='C';  M= -3,-11, 63,-18,-18,-18,-20,-23,-24,-21,-21,-18, -8,-27,-18,-21,  9,  8, -8,-44,-24,-18;
/I:         E0=0; E1=0; IE=-105; DE=-105;

» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_04 which contains 571'864 sequence entries.

Total number of hits	111 in 98 different sequences
Number of true positive hits	111 in 98 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	8
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	93.28 %

Comments [info]

Taxonomic range [info]	Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info]	3
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

98 sequences

DNAB_GUITH  (O78411), DNAB_MYCBO  (P59966), DNAB_MYCTO  (P9WMR2),

DNAB_MYCTU  (P9WMR3), DNAB_NEOYE  (Q1XDF3), DNAB_NOSS1  (Q8YZA1), 
DNAB_PORPU  (P51333), DNAB_RHOMR  (O30477), DNAB_SYNY3  (Q55418), 
DP2L_METHJ  (Q2FSF9), DP2L_METMJ  (A3CXE7), DP2L_PYRAB  (Q9V2F4), 
DP2L_PYRHO  (O57861), DP2L_THEKO  (Q5JET0), DPO3A_SYNY3 (P74750), 
DPOL_BPAPS  (Q9T1Q3), DPOL_CEV01  (A7U6F1), DPOL_METJA  (Q58295), 
DPOL_MIMIV  (Q5UQR0), DPOL_PYRHO  (O59610), DPOL_PYRSD  (Q51334), 
DPOL_THEAG  (O33845), DPOL_THEFM  (P74918), DPOL_THEG8  (Q9HH84), 
DPOL_THEHY  (Q9HH05), DPOL_THEKO  (P77933), DPOL_THELI  (P30317), 
EF2_METKA   (Q8TXJ4), GLMS_METJA  (Q58815), GYRA_MYCFV  (Q49166), 
GYRA_MYCGO  (Q49467), GYRA_MYCKA  (Q49608), GYRA_MYCLE  (Q57532), 
GYRA_MYCMA  (O33149), GYRA_MYCXE  (P72065), GYRB_SYNY3  (P77966), 
HELS_METJA  (Q58524), HELS_THEKO  (Q5JGV6), IF2P_METJA  (Q57710), 
IF2P_PYRAB  (Q9UZK7), IF2P_PYRFU  (Q8U1R8), IF2P_PYRHO  (O58822), 
IF2P_THEKO  (Q5JGR9), LONB_PYRAB  (Q9UYC6), LONB_PYRHO  (O58221), 
NDRZ_PYRFU  (E7FHX6), NRDEB_BACSU (O31875), NRDEB_BPSPB (O64173), 
PPSA_METJA  (Q57962), RADA_PYRHO  (O58001), RADA_THEKO  (Q5JET4), 
RECA_MYCBO  (P0A5U5), RECA_MYCCI  (Q9F417), RECA_MYCFA  (Q9F416), 
RECA_MYCFV  (Q9F415), RECA_MYCGS  (Q9F414), RECA_MYCLE  (P35901), 
RECA_MYCSH  (Q9F410), RECA_MYCT3  (Q9F407), RECA_MYCTO  (P9WHJ2), 
RECA_MYCTU  (P9WHJ3), RFCS_HALWD  (Q18E75), RFCS_METJA  (Q58817), 
RFCS_METKA  (Q8TZC4), RFCS_PYRAB  (Q9V2G4), RFCS_PYRFU  (Q8U4J3), 
RFCS_PYRHO  (O57852), RFCS_THEKO  (Q5JHP2), RGYR_METJA  (Q58907), 
RGYR_PYRHO  (O58530), RGYR_THEKO  (Q6F598), RIR2_AQUAE  (O67475), 
RPC2_DICDI  (Q54IZ9), RPO1C_METJA (Q58446), RPO1N_METJA (Q58445), 
RTCB_METJA  (Q58095), RTCB_METKA  (Q8TUS2), RTCB_PYRAB  (Q9V168), 
RTCB_PYRFU  (Q8U0H4), RTCB_PYRHO  (O59245), TF2B_METJA  (Q58192), 
TOP1_PYRFU  (O73954), VATA_PYRAB  (Q9UXU7), VATA_PYRFU  (Q8U4A6), 
VATA_PYRHO  (O57728), VATA_THEAC  (Q9P997), VATA_THEVO  (Q97CQ0), 
VATA_YEAST  (P17255), VATB_METKA  (Q8TUT0), Y043_METJA  (Q60348), 
Y1054_METJA (Q58454), Y1461_MYCTO (P9WFP6), Y1461_MYCTU (P9WFP7), 
Y1496_MYCBO (P67126), Y450_MYCPN  (Q50362), Y593_MYCLE  (Q49689), 
Y781_METJA  (Q58191), Y832_METJA  (Q58242)

» more

Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

8 sequences

CLPP_CHLMO  (P42379), DNAB_MYCIT  (Q9F5P4), DNAB_MYCLE  (P46394),

DP2L_HALMA  (Q5UZ40), DP2L_HALSA  (Q9HMX8), DP2L_HALWD  (Q18ER3), 
RIR1_IIV6   (O55716), VATA_CANTR  (P38078)

» more

PDB
[Detailed view]

27 PDB

1AM2; 1DQ3; 1EF0; 1MI8; 2CW7; 2CW8; 2IMZ; 2IN0; 2IN9; 2L8L; 2LQM; 3IFJ; 3IGD; 4E2T; 4E2U; 4O1S; 4OZ6; 5BKH; 5I0A; 5K08; 5O9J; 5OL1; 5OL5; 6FRE; 6FRG; 6FRH; 7QST
» more