PROSITE entry PS50958

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PURL: https://purl.expasy.org/prosite/signature/PS50958

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General information about the entry

Entry name [info]	SMB_2
Accession [info]	PS50958
Entry type [info]	MATRIX
Date [info]	01-JUN-2004 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00453
Associated ProRule [info]	PRU00350

Name and characterization of the entry

Description [info]

Somatomedin B (SMB) domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=43;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=43;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.7050011; R2=0.0046693; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1596.1196289; R2=4.5231690; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=813; H_SCORE=5273; N_SCORE=6.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=813; H_SCORE=5273; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-9; D=-50; I=-50; B1=-100; E1=-100; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='E';  M= -4, 10,-26, 15, 19,-28,-14,  8,-28,  8,-21,-15,  4,-10,  7,  6, -2, -9,-22,-28,-13, 12;
/M: SY='Q';  M= -2,-13,-25,-13,  2,-20,-23,-12,  0, -8, -4,  0,-13, -5,  9,-10, -7, -7, -3,-24,-12,  4;
/M: SY='G';  M= -5, -2,-27, -5, -3,-21, 11,-13,-27, -2,-26,-18,  3,-16, -6, -6,  1, -5,-24, -5,-14, -4;
/M: SY='S';  M=  4, -1,-12, -4, -2,-18, -7,-11,-19, -5,-24,-16,  6,-11, -1, -1, 29, 24, -9,-35,-16, -2;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/I:         I=-12; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='K';  M= -7,  2,-26,  3,  5,-27,-18,  5,-23, 19,-22, -9,  0,-14,  9, 15, -6, -9,-16,-24, -8,  6;
/M: SY='G';  M= -7, -5,-30, -3,-11,-17, 28,-17,-32,-10,-25,-18, -2, -6,-16,-14, -5,-15,-25,-20,-19,-13;
/M: SY='R';  M= -8, -9,-28,-10, -3,-22, -7, -6,-29, 21,-21,-11, -1,-18,  4, 44, -6,-10,-19,-20,-14, -3;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='F';  M= -8,-16,-22,-21,-20, 20,  5,-15,-16,-20,-10,-10, -8,-22,-23,-17, -2, -3,-11, -7,  7,-20;
/M: SY='E';  M= -3,  7,-25, 14, 37,-26,-18, -6,-21,  3,-16,-16, -3, -6,  8, -6,  0, -8,-17,-30,-19, 22;
/I:         I=-12; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='S';  M=  1,-10,-23,-12, -7,-20,  1,-14,-18, -8,-14,-10, -6, -3, -4, -4,  2,  1,-15,-25,-17, -7;
/M: SY='F';  M=-18,-20,-23,-24,-22, 42,-29,-15,  4,-25, 11,  1,-17,-26,-27,-19,-19,-10,  0, -1, 22,-23;
/M: SY='S';  M= -4,  6,-19,  5, -1,-22, -3, -7,-24,  0,-25,-18, 12,-14, -1,  8, 16,  9,-17,-33,-17, -2;
/I:         I=-13; MD=-27;
/M: SY='R';  M= -5, -9,-14, -9, -8,-10, -5,-10, -6,  4, -8, -3, -7,-13, -6,  9, -5, -5,  2,-14, -8, -8; D=-13;
/I:         I=-13; MI=-27; MD=-27; IM=-27; DM=-27;
/M: SY='H';  M=-13,  7,-23,  9, -2,-13, -8, 10,-19, -3,-11, -9,  7,-17, -3,  2, -7, -9,-18,-19,  1, -4; D=-13;
/I:         I=-13; DM=-27;
/M: SY='H';  M=  0, -1,-19, -2,  3,-19, -2,  9,-21, -1,-18,-10,  2,-11,  0, -4,  6,  1,-16,-24, -9,  1; D=-13;
/I:         I=-13; DM=-27;
/M: SY='N';  M= -8,  0,-21, -8, -6,-12,-19, -9, -3, -6, -1, -2,  6,-18, -1, -5, -3,  5, -8,-27, -9, -4;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='R';  M= -8, -3,-25, -9, -5, -4,-16, 11,-17,  1,-15, -7,  6,-20,  3, 12, -5, -8,-18,-15,  6, -3;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='D';  M=-15, 43,-26, 56, 15,-35, -8,  0,-35, -1,-30,-28, 23,-11,  0, -9,  6, -5,-27,-40,-20,  8;
/M: SY='E';  M=  3, -1,-23,  2,  9,-16,-17, -3,-14, -3,-12,-10, -7,-13,  4, -9, -2, -6,-11,-17,  0,  6;
/M: SY='A';  M=  8,  2,-19, -4, -7, -7,-10,-10,-13, -7, -8,-10,  4,-17,-10, -6, -1, -5,-10,-22,-11, -8;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='K';  M=-10, -2,-24,  0,  2,-18,-19, -7,-17, 11,-18, -8, -2,-16,  8, 10, -2, -5,-11,-24, -9,  5;
/M: SY='D';  M=-13,  4,-26, 11,  8,-16,-19,  6,-18, -2,-10,-10, -2,-16,  0,  1, -6, -8,-14,-24, -1,  3;
/M: SY='Y';  M=-15, -6,-25, -6, -8,  2,-23,  3,-12, -2, -4, -4, -7,-21, -7,  2,-11, -4,-11,-11, 15, -9;
/M: SY='G';  M= -4, -3,-29, -1,-11,-29, 42,-12,-32,-13,-24,-11,  0,-18, -7,-15, -2,-17,-26,-22,-24, -9;
/I:         I=-14; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='D';  M=-13, 35,-25, 41, 20,-31, -8,  1,-31,  1,-28,-25, 25,-11,  4, -6,  7, -4,-28,-38,-20, 12;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='P';  M=-11,-20,-30,-22,-13, -1,-25,-20, -4, -8, -4, -4,-18,  3,-14,-11,-15, -6, -8, -2, -3,-14;
/M: SY='D';  M=-19, 49,-29, 64, 17,-37, -9,  1,-37,  0,-30,-29, 25,-11,  0, -9,  1, -9,-30,-40,-20,  9;
/M: SY='Y';  M=-20,-25,-25,-29,-25, 53,-30,  2,  0,-19,  5,  0,-20,-30,-24,-15,-20,-10, -5, 21, 57,-25;
/M: SY='E';  M= -9,  8,-25, 12, 22,-28,-16, -3,-26, 11,-22,-15,  4, -8, 16,  9,  5,  0,-22,-29,-15, 18;
/M: SY='S';  M= -1,  7,-21, 11, 11,-25, -9, -6,-26,  3,-24,-19,  6,-11,  4,  8, 13,  2,-18,-32,-18,  7;
/M: SY='V';  M=  1,-16,-16,-21,-12,  3,-24,-21,  6,-16,  4,  0,-15,-19,-17,-16, -3,  8, 11,-22, -6,-14;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/I:         I=-11; MI=0; MD=-23; IM=0; DM=-23;
/M: SY='G';  M=  2,-13,-20,-14,-14,-15,  5, -7, -7,-14,-11, -5, -9, -5,-13,-15, -4, -9, -3,-20,-13,-15; D=-11;
/I:         I=-11; DM=-23;
/M: SY='E';  M= -9,  5,-25, 11, 38,-25,-16,  1,-24, 11,-16,-13,  0, -3, 20,  9, -1, -8,-24,-22,-14, 28; D=-11;
/I:         I=-11; DM=-23;
/M: SY='P';  M= -3,-15,-19,-13, -9,-14,-18,-17, -1, -4,-11, -5,-14, 11,-11, -9, -3, -2,  5,-25,-15,-11; D=-11;
/I:         I=-11; DM=-23;
/M: SY='T';  M= -1,  5,  1,  3,  0,-20,-13,-14,-21,-10,-21,-18,  3,-13, -6,-12, 19, 21,-10,-37,-18, -3;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	60 in 38 different sequences
Number of true positive hits	60 in 38 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	2
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	SMB
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

38 sequences

ENDOU_BOVIN (A6QLQ8), ENDOU_HUMAN (P21128), ENDOU_MOUSE (Q3V188),

ENDOU_PAROL (Q9PTU6), ENPP1_HUMAN (P22413), ENPP1_MOUSE (P06802), 
ENPP1_RAT   (Q924C3), ENPP2_BOVIN (A1A4K5), ENPP2_HUMAN (Q13822), 
ENPP2_MOUSE (Q9R1E6), ENPP2_RAT   (Q64610), ENPP3_BOVIN (P15396), 
ENPP3_HUMAN (O14638), ENPP3_MOUSE (Q6DYE8), ENPP3_PONAB (Q5R5M5), 
ENPP3_RAT   (P97675), PDE1_CROAD  (J3SEZ3), PDE2_CROAD  (J3SBP3), 
PDE_CRODO   (P0DQQ4), PDE_MACLB   (W8E7D1), PDE_NAJAT   (A0A2D0TC04), 
PRG4_HUMAN  (Q92954), PRG4_MOUSE  (Q9JM99), SBSPO_BOVIN (Q32L50), 
SBSPO_HUMAN (Q8IVN8), SBSPO_MOUSE (Q3UPR9), SUSD2_HUMAN (Q9UGT4), 
SUSD2_MOUSE (Q9DBX3), TINAG_BOVIN (Q3SZI1), TINAG_HUMAN (Q9UJW2), 
TINAL_HUMAN (Q9GZM7), TINAL_MOUSE (Q99JR5), TINAL_RAT   (Q9EQT5), 
VTNC_HUMAN  (P04004), VTNC_MOUSE  (P29788), VTNC_PIG(P48819), 
VTNC_RABIT  (P22458), YCF2E_CAEEL (P90850)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

284 PDB

pdb_00001oc0; pdb_00001s4g; pdb_00001ssu; pdb_00002cqw; pdb_00002jq8; pdb_00002xr9; pdb_00002xrg; pdb_00002ys0; pdb_00003bt1; pdb_00003bt2; pdb_00003nkm; pdb_00003nkn; pdb_00003nko; pdb_00003nkp; pdb_00003nkq; pdb_00003nkr; pdb_00003wav; pdb_00003waw; pdb_00003wax; pdb_00003way; pdb_00004b56; pdb_00004gtw; pdb_00004gtx; pdb_00004gty; pdb_00004gtz; pdb_00004k24; pdb_00004zg6; pdb_00004zg7; pdb_00004zg9; pdb_00004zga; pdb_00005dlt; pdb_00005dlv; pdb_00005dlw; pdb_00005gz4; pdb_00005gz5; pdb_00005hrt; pdb_00005ijq; pdb_00005ijs; pdb_00005inh; pdb_00005kxa; pdb_00005l0b; pdb_00005l0e; pdb_00005l0k; pdb_00005lia; pdb_00005lqq; pdb_00005m0d; pdb_00005m0e; pdb_00005m0m; pdb_00005m0s; pdb_00005m7m; pdb_00005mhp; pdb_00005ohi; pdb_00005olb; pdb_00005s9l; pdb_00005s9m; pdb_00005s9n; pdb_00006c01; pdb_00006c02; pdb_00006g4g; pdb_00006leh; pdb_00006wet; pdb_00006weu; pdb_00006wev; pdb_00006wew; pdb_00006wfj; pdb_00006xkd; pdb_00006y5m; pdb_00007cba; pdb_00007g2e; pdb_00007g2f; pdb_00007g2g; pdb_00007g2h; pdb_00007g2i; pdb_00007g2j; pdb_00007g2k; pdb_00007g2l; pdb_00007g2m; pdb_00007g2n; pdb_00007g2o; pdb_00007g2p; pdb_00007g2q; pdb_00007g2r; pdb_00007g2s; pdb_00007g2t; pdb_00007g2u; pdb_00007g2v; pdb_00007g2w; pdb_00007g2x; pdb_00007g2y; pdb_00007g2z; pdb_00007g30; pdb_00007g31; pdb_00007g32; pdb_00007g33; pdb_00007g34; pdb_00007g35; pdb_00007g36; pdb_00007g37; pdb_00007g38; pdb_00007g39; pdb_00007g3a; pdb_00007g3b; pdb_00007g3c; pdb_00007g3d; pdb_00007g3e; pdb_00007g3f; pdb_00007g3g; pdb_00007g3h; pdb_00007g3i; pdb_00007g3j; pdb_00007g3k; pdb_00007g3l; pdb_00007g3m; pdb_00007g3n; pdb_00007g3o; pdb_00007g3p; pdb_00007g3q; pdb_00007g3r; pdb_00007g3s; pdb_00007g3t; pdb_00007g3u; pdb_00007g3v; pdb_00007g3w; pdb_00007g3x; pdb_00007g3y; pdb_00007g3z; pdb_00007g40; pdb_00007g41; pdb_00007g42; pdb_00007g43; pdb_00007g44; pdb_00007g45; pdb_00007g46; pdb_00007g47; pdb_00007g48; pdb_00007g49; pdb_00007g4a; pdb_00007g4b; pdb_00007g4c; pdb_00007g4d; pdb_00007g4e; pdb_00007g4f; pdb_00007g4g; pdb_00007g4h; pdb_00007g4i; pdb_00007g4j; pdb_00007g4k; pdb_00007g4l; pdb_00007g4m; pdb_00007g4n; pdb_00007g4o; pdb_00007g4p; pdb_00007g4q; pdb_00007g4r; pdb_00007g4s; pdb_00007g4t; pdb_00007g4u; pdb_00007g4v; pdb_00007g4w; pdb_00007g4x; pdb_00007g4y; pdb_00007g4z; pdb_00007g50; pdb_00007g51; pdb_00007g52; pdb_00007g53; pdb_00007g54; pdb_00007g55; pdb_00007g56; pdb_00007g57; pdb_00007g58; pdb_00007g59; pdb_00007g5a; pdb_00007g5b; pdb_00007g5c; pdb_00007g5d; pdb_00007g5e; pdb_00007g5f; pdb_00007g5g; pdb_00007g5h; pdb_00007g5i; pdb_00007g5j; pdb_00007g5k; pdb_00007g5l; pdb_00007g5m; pdb_00007g5n; pdb_00007g5o; pdb_00007g5p; pdb_00007g5q; pdb_00007g5r; pdb_00007g5s; pdb_00007g5t; pdb_00007g5u; pdb_00007g5v; pdb_00007g5w; pdb_00007g5x; pdb_00007g5y; pdb_00007g5z; pdb_00007g60; pdb_00007g61; pdb_00007g62; pdb_00007g63; pdb_00007g64; pdb_00007g65; pdb_00007g66; pdb_00007g67; pdb_00007g68; pdb_00007g69; pdb_00007g6a; pdb_00007g6b; pdb_00007g6c; pdb_00007g6d; pdb_00007g6e; pdb_00007g6f; pdb_00007g6g; pdb_00007g6h; pdb_00007g6i; pdb_00007g6j; pdb_00007g6k; pdb_00007g6l; pdb_00007g6m; pdb_00007g6n; pdb_00007g6o; pdb_00007g6p; pdb_00007g6q; pdb_00007g6r; pdb_00007g6s; pdb_00007g6t; pdb_00007g6u; pdb_00007g6v; pdb_00007g6w; pdb_00007g6x; pdb_00007g6y; pdb_00007g6z; pdb_00007g70; pdb_00007g71; pdb_00007g72; pdb_00007g73; pdb_00007g74; pdb_00007g75; pdb_00007g76; pdb_00007g77; pdb_00007g78; pdb_00007g79; pdb_00007g7a; pdb_00007g7b; pdb_00007g7c; pdb_00007g7d; pdb_00007g7e; pdb_00007g7f; pdb_00007g7g; pdb_00007g7h; pdb_00007g7i; pdb_00007g7j; pdb_00007g7k; pdb_00007g7l; pdb_00007g7m; pdb_00007g7n; pdb_00007g7o; pdb_00007g7p; pdb_00007g7q; pdb_00007g7r; pdb_00007g7s; pdb_00007g7t; pdb_00007g7u; pdb_00007g7v; pdb_00007g7w; pdb_00007g7x; pdb_00007g7y; pdb_00007g7z; pdb_00007mfh; pdb_00007p0k; pdb_00007p4j; pdb_00007p4o; pdb_00007z0n; pdb_00007z3k; pdb_00007z3l; pdb_00008c3o; pdb_00008c3p; pdb_00008c4w; pdb_00008c7r; pdb_00009ent; pdb_00009eu5; pdb_00009ftw
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