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annotation rule: PRU00350

General rule information [?]

Accession PRU00350
Dates 26-JUL-2004 (Created)
16-DEC-2016 (Last updated, Version 8)
Data class Domain
Predictors PROSITE; PS50958; SMB_2
Name Somatomedin B (SMB) domain
Function The SMB domain of vitronectin has been demonstrated to interact with both the urokinase receptor and the plasminogen activator inhibitor-1 (PAI-1) and the conserved cysteines of the NPP1 somatomedin B-like domain have been shown to mediate homodimerization.

Propagated annotation [?]


Cross-references [?]

PROSITE PS00524; SMB_1; 1;

Keywords [?]

case <FTTag:disulf>
Disulfide bond
end case


Features [?]

From: PS50958
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       SMB #        
DISULFID     5     9       Alternate   disulf   C-x*-C  
DISULFID     5     21       Alternate   disulf   C-x*-C  
DISULFID     9     39       Alternate   disulf   C-x*-C  
DISULFID     19     21       Alternate   disulf   C-x*-C  
DISULFID     19     32       Alternate   disulf   C-x*-C  
DISULFID     25     31           disulf   C-x*-C  
DISULFID     32     39       Alternate   disulf   C-x*-C  

Additional information [?]

Size range 35-55 amino acids
Related rules None
Repeats 2
Topology Not cytoplasmic
Example Q9GZM7 (TINAL_HUMAN)
Scope
Eukaryota; Metazoa

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]