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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00350


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00350
General rule information [?]

Accession PRU00350
Dates 26-JUL-2004 (Created)
21-NOV-2019 (Last updated, Version 10)
Data class Domain;
Predictors PROSITE; PS50958; SMB_2
Name Somatomedin B (SMB) domain
Function The SMB domain of vitronectin has been demonstrated to interact with both the urokinase receptor and the plasminogen activator inhibitor-1 (PAI-1) and the conserved cysteines of the NPP1 somatomedin B-like domain have been shown to mediate homodimerization.
Scope(s) Eukaryota
Metazoa
Example(s) Q9GZM7;

Propagated annotation [?]

Keywords [?]

case <FTTag:disulf>
Disulfide bond
end case

Cross-references [?]

PROSITE PS00524; SMB_1; 1;

Features [?]

From: PS50958
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="SMB #"
DISULFID 5 9 /note="Alternate" disulf C-x*-C
DISULFID 5 21 /note="Alternate" disulf C-x*-C
DISULFID 9 39 /note="Alternate" disulf C-x*-C
DISULFID 19 21 /note="Alternate" disulf C-x*-C
DISULFID 19 32 /note="Alternate" disulf C-x*-C
DISULFID 25 31 disulf C-x*-C
DISULFID 32 39 /note="Alternate" disulf C-x*-C

Additional information [?]

Size range 35-55 amino acids
Related rules None
Fusion None
Repeats 2
Topology Not cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]