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annotation rule: PRU00350 |
Accession | PRU00350 |
Dates | 26-JUL-2004 (Created) 21-NOV-2019 (Last updated, Version 9) |
Data class | Domain |
Predictors | PROSITE; PS50958; SMB_2 |
Name | Somatomedin B (SMB) domain |
Function | The SMB domain of vitronectin has been demonstrated to interact with both the urokinase receptor and the plasminogen activator inhibitor-1 (PAI-1) and the conserved cysteines of the NPP1 somatomedin B-like domain have been shown to mediate homodimerization. |
PROSITE | PS00524; SMB_1; 1; |
From: PS50958 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | SMB # | |||||||||
DISULFID | 5 | 9 | Alternate | disulf | C-x*-C | |||||||
DISULFID | 5 | 21 | Alternate | disulf | C-x*-C | |||||||
DISULFID | 9 | 39 | Alternate | disulf | C-x*-C | |||||||
DISULFID | 19 | 21 | Alternate | disulf | C-x*-C | |||||||
DISULFID | 19 | 32 | Alternate | disulf | C-x*-C | |||||||
DISULFID | 25 | 31 | disulf | C-x*-C | ||||||||
DISULFID | 32 | 39 | Alternate | disulf | C-x*-C |
Size range | 35-55 amino acids |
Related rules | None |
Repeats | 2 |
Topology | Not cytoplasmic |
Example | Q9GZM7 (TINAL_HUMAN) |
Scope | Eukaryota; Metazoa |
Eukaryota | [37] |