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ProRule PRU00350


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU00350
Accession PRU00350
Dates 26-JUL-2004 (Created)
21-NOV-2019 (Last updated, Version 9)
Data class Domain;
Predictors PROSITE; PS50958; SMB_2
Name Somatomedin B (SMB) domain
Function The SMB domain of vitronectin has been demonstrated to interact with both the urokinase receptor and the plasminogen activator inhibitor-1 (PAI-1) and the conserved cysteines of the NPP1 somatomedin B-like domain have been shown to mediate homodimerization.
Scope(s) Eukaryota
Metazoa
Example(s) Q9GZM7 (TINAL_HUMAN);

Propagated annotation [?]

Keywords [?]

case <FTTag:disulf>
Disulfide bond
end case

Cross-references [?]

PROSITE PS00524; SMB_1; 1;

Features [?]

From: PS50958
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="SMB #"
DISULFID 5 9 /note="Alternate" disulf C-x*-C
DISULFID 5 21 /note="Alternate" disulf C-x*-C
DISULFID 9 39 /note="Alternate" disulf C-x*-C
DISULFID 19 21 /note="Alternate" disulf C-x*-C
DISULFID 19 32 /note="Alternate" disulf C-x*-C
DISULFID 25 31 disulf C-x*-C
DISULFID 32 39 /note="Alternate" disulf C-x*-C

Additional information [?]

Size range 35-55 amino acids
Related rules None
Fusion None
Repeats 2
Topology Not cytoplasmic

Copyright

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UniProtKB rule member sequences [?]