PRU00350

General rule information [?]

Accession	PRU00350
Dates	26-JUL-2004 (Created) 21-NOV-2019 (Last updated, Version 9)

Data class

Domain

Predictors

PROSITE; PS50958; SMB_2

Name	Somatomedin B (SMB) domain

Function

The SMB domain of vitronectin has been demonstrated to interact with both the urokinase receptor and the plasminogen activator inhibitor-1 (PAI-1) and the conserved cysteines of the NPP1 somatomedin B-like domain have been shown to mediate homodimerization.

Propagated annotation [?]

Cross-references [?]

PROSITE

PS00524; SMB_1; 1;

Keywords [?]

case <FTTag:disulf>

Disulfide bond

end case

Features [?]

From: PS50958

Key From To Description Tag Condition FTGroup

DOMAIN from to SMB #

DISULFID 5 9 Alternate disulf C-x*-C

DISULFID 5 21 Alternate disulf C-x*-C

DISULFID 9 39 Alternate disulf C-x*-C

DISULFID 19 21 Alternate disulf C-x*-C

DISULFID 19 32 Alternate disulf C-x*-C

DISULFID 25 31 disulf C-x*-C

DISULFID 32 39 Alternate disulf C-x*-C

Additional information [?]

Size range	35-55 amino acids
Related rules	None
Repeats	2
Topology	Not cytoplasmic
Example	Q9GZM7 (TINAL_HUMAN)
Scope	Eukaryota; Metazoa

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Eukaryota [38]
Retrieve set of proteins with 3D structure for this domain